scholarly journals Utility of VSRAD for diagnosing Alzheimer’s disease in patients screened for dementia

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091727 ◽  
Author(s):  
Gaku Oshikubo ◽  
Akihisa Akahane ◽  
Aki Unno ◽  
Yukako Watanabe ◽  
Emi Ikebuchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Roc Curve ◽  
Early Stage ◽  
Regional Analysis ◽  
Mean Value ◽  
Cognitive Status ◽  
Roc Curve Analysis ◽  
Z Scores ◽  
The Mean

Objective To investigate the utility of the voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD). Methods Clinical data from patients who underwent screening for dementia using VSRAD and the Japanese version of COGNISTAT, the Neurobehavioral Cognitive Status Examination, were retrospectively investigated to specify the domains of cognitive function that correlate with the statistical mean value of positive Z-scores in the target volume-of-interest (VOI). A receiver operating characteristic (ROC) curve was constructed to assess the mean value of positive Z-scores in discriminating patients with AD. Results A total of 72 patients were included (18 male and 54 female; 15 patients with AD). The mean value of positive Z-scores in the target VOI was significantly correlated with standardized COGNISTAT scores for Orientation and Memory in all patients (r = –0.35 and –0.38, respectively). ROC curve analysis revealed that a cut-off of 1.57 for mean value of positive Z-scores in the target VOI provided 69.4% accuracy in discriminating patients with AD, with a sensitivity of 0.80 and specificity of 0.67. Conclusions The results evinced the value of VSRAD in diagnosing AD. The degree of atrophy represented by the target VOI may reflect impairments in Orientation and Memory, which are early stage symptoms observed in AD.

scholarly journals Performance of Mattis dementia rating scale-Chinese Version in patients with mild cognitive impairment and Alzheimer's disease

2020 ◽  
Author(s):  
Shuxia Qian ◽  
Keliang Chen ◽  
Qiaobing Guan ◽  
Qihao Guo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Rating Scale ◽  
Chinese Version ◽  
Roc Curve Analysis ◽  
Mattis Dementia Rating Scale ◽  
Sensitive Function ◽  
Dementia Rating Scale

Abstract Background: To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).Methods: The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.Results: The scores of DRS-CV were ranked in the order of NC >MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.Conclusion: The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

scholarly journals Signal and Texture Features from T2 Maps for the Prediction of Mild Cognitive Impairment to Alzheimer’s Disease Progression

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 941
Author(s):  
Alejandro I. Trejo-Castro ◽  
Ricardo A. Caballero-Luna ◽  
José A. Garnica-López ◽  
Fernando Vega-Lara ◽  
Antonio Martinez-Torteya
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Texture Features ◽  
Mean Value ◽  
Absolute Difference ◽  
Imaging Features ◽  
Machine Learning Methods ◽  
The Mean

Early detection of Alzheimer’s disease (AD) is crucial to preserve cognitive functions and provide the opportunity for patients to enter clinical trials. In recent years, some studies have reported that features related to the signal and texture of MRI images can be an effective biomarker of AD. To test these claims, a study was conducted using T2 maps, a sequence not previously studied, of 40 patients with mild cognitive impairment (MCI) from the Alzheimer’s Disease Neuroimaging Initiative database, who either progressed to AD (18) or remained stable (22). From these maps, the mean value and absolute difference of 37 signal and texture imaging features for 40 contralateral pairs of regions were measured. We used seven machine learning methods to analyze whether, by adding these imaging features to the neuropsychological studies currently used for diagnosis, we could more accurately identify patients who will progress to AD. The predictive models improved with the addition of signal and texture features. Additionally, features related to the signal and texture of the images were much more relevant than volumetric ones. Our results suggest that contralateral signal and texture features should be further investigated as potential biomarkers for the prediction of AD.

scholarly journals Altered Plasma Global Arginine Bioavailability Ratio in Early-stage Alzheimer’s Disease

2018 ◽  
Vol 8 (1) ◽  
pp. 34-41
Author(s):  
José M. Martínez-Martos ◽  
María E. Pulido-Navas ◽  
María J. Ramírez-Expósito
Keyword(s):  
Nitric Oxide ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Performance ◽  
Early Stage ◽  
Bioactive Molecules ◽  
No Production ◽  
Arginine Metabolism ◽  
Roc Curve Analysis ◽  
Physiological Functions

Background: L-arginine is an amino acid that can be metabolized to form several bioactive molecules including Nitric Oxide (NO). In the Central Nervous System (CNS), NO regulates various and important physiological functions. However, the involvement of L-arginine metabolism –and by extension of NO- in Alzheimer’s disease (AD) pathogenesis, has been suggested. Objective: To determine the Global L-Arginine Bioavailability Ratio (GABR) and NO levels (as the sum of nitrates and nitrites, NOx) in the plasma of early-stage Alzheimer’s Disease (AD) patients in order to analyze if GABR can reflect an altered NO production, to confirm the importance of L-arginine metabolism in the development of the disease, and to evaluate the putative diagnostic/prognostic value of GABR. Method: GABR index is an indicator of the availability of L-arginine to form NO by nitric oxide synthases. It is calculated as the ratio between the levels of L-arginine and the sum of the levels of L-ornithine and L-citrulline. Plasma amino acids are measured by high-performance liquid chromatography coupled to fluorescence detection. Nitric oxide is measured in plasma as the sum of nitrates and nitrites (NOx). Results: No changes were found in L-arginine levels, whereas L-citrulline and L-ornithine levels were highly increased in AD patients. We also found that GABR decreased significantly by 47.8% in AD patients, whereas NOx levels increased significantly by 46.9%. Receiver Operator Characteristic (ROC) curve analysis for GABR showed a sensitivity of 78.1 and a specificity of 90.5. Conclusion: Low plasma GABR levels in AD patients reflect that the L-arginine-NO pathway has turned towards NO in AD, probably being related to the nitroxidative stress involved in neurodegenerative diseases. Furthermore, increased NOx could also be involved in several altered physiological functions. Therefore, GABR is proposed as a putative useful biomarker of the disease.

scholarly journals Performance of Mattis dementia rating scale-Chinese Version in patients with mild cognitive impairment and Alzheimer's disease

2020 ◽  
Author(s):  
Shuxia Qian ◽  
Keliang Chen ◽  
Qiaobing Guan ◽  
Qihao Guo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Rating Scale ◽  
Chinese Version ◽  
Roc Curve Analysis ◽  
Mattis Dementia Rating Scale ◽  
Sensitive Function ◽  
Dementia Rating Scale

Abstract Background: To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).Methods: The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.Results: The scores of DRS-CV were ranked in the order of NC >MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.Conclusion: The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

scholarly journals Performance of Mattis dementia rating scale-Chinese Version in patients with mild cognitive impairment and Alzheimer's disease

2020 ◽  
Author(s):  
shuxia QIAN ◽  
keliang CHEN ◽  
qiaobing GUAN ◽  
qihao Guo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Rating Scale ◽  
Chinese Version ◽  
Roc Curve Analysis ◽  
Mattis Dementia Rating Scale ◽  
Sensitive Function ◽  
Dementia Rating Scale

Abstract Background: To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).Methods: The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.Results: The scores of DRS-CV were ranked in the order of NC >MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.Conclusion: The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

scholarly journals Performance of Mattis dementia rating scale-Chinese Version in patients with mild cognitive impairment and Alzheimer's disease 

2020 ◽  
Author(s):  
shuxia QIAN ◽  
keliang CHEN ◽  
qiaobing GUAN ◽  
qihao Guo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Rating Scale ◽  
Chinese Version ◽  
Roc Curve Analysis ◽  
Mattis Dementia Rating Scale ◽  
Sensitive Function ◽  
Dementia Rating Scale

Abstract Background: To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).Methods: The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.Results: The scores of DRS-CV were ranked in the order of NC >MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.Conclusion: The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

scholarly journals Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer's Disease

2015 ◽  
Vol 5 (3) ◽  
pp. 424-434 ◽  
Author(s):  
Ya-Ying Wu ◽  
Jung-Lung Hsu ◽  
Han-Cheng Wang ◽  
Shyh-Jong Wu ◽  
Chen-Jee Hong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Early Stage ◽  
Cognitive Status ◽  
Inflammatory Biomarkers ◽  
Control Group ◽  
Disease Group ◽  
Apoe Genotypes ◽  
Fluid Levels

Objective: We aimed to identify biomarkers of Alzheimer's disease (AD) in order to improve diagnostic accuracy at mild stage. Methods: AD patients aged >50 years were included in the disease group. We evaluated the relationship between potential blood and cerebrospinal fluid inflammatory biomarkers, cognitive status, temporal lobe atrophy and disease severity. Inflammatory biomarkers including interleukin 6 (IL-6), IL-18, fractalkine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels were measured. APOE genotypes were determined. Results: We enrolled 41 subjects in the disease group and 40 subjects in the normal control group. The majority (88.9%) of subjects in the disease group had mild AD. Elevated levels of plasma IL-6 and decreased levels of plasma TRAIL in the disease group were noted. Plasma levels of IL-6 and TRAIL were significantly correlated with their cerebrospinal fluid levels. Conclusion: Plasma IL-6 and TRAIL were identified as potential biomarkers of AD at an early stage.

A mentally stimulating activities program for the treatment of neuropsychiatric symptoms in Alzheimer’s disease

2019 ◽  
Vol 18 (4) ◽  
pp. 27-37
Author(s):  
Angie L. Sardina, PhD ◽  
Suzanne Fitzsimmons, MSN, ARNP, GNP ◽  
Catherine M. Hoyt, BA ◽  
Linda L. Buettner, PhD
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Support Group ◽  
Repeated Measures ◽  
Early Stage ◽  
Neuropsychiatric Symptoms ◽  
Cognitive Status ◽  
Control Group

This study evaluated whether a mentally stimulating activities (MSA) program reduced neuropsychiatric symptoms and improved cognitive status and quality of life, as compared to a support group for persons in the early stage of Alzheimer’s disease (AD). This randomized controlled trial included 81 adults (aged 55+), who were randomly assigned to the MSA group (treatment) or a social support group (control). A repeated measures multivariate analysis of variance (MANOVA) identified that MSA participants significantly reduced apathy (p 0.001) and depressive symptoms (p 0.001), as well as improved cognitive status (p 0.001) and quality of life (p 0.001) as compared to the control group. A structured classroom-style MSA program may be a viable and therapeutic intervention to alleviate neuropsychiatric symptoms, and improve cognitive status and quality of life in early-stage AD.

scholarly journals Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer’s disease

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shuxia Qian ◽  
Keliang Chen ◽  
Qiaobing Guan ◽  
Qihao Guo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Rating Scale ◽  
Chinese Version ◽  
Roc Curve Analysis ◽  
Mattis Dementia Rating Scale ◽  
Sensitive Function ◽  
Dementia Rating Scale

Abstract Background To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV). Methods The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale. Results The scores of DRS-CV were ranked in the order of NC > MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC. Conclusion The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

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