scholarly journals Bioavailable testosterone is associated with symptoms of depression in adult men

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094171
Author(s):  
Zhongbao Chen ◽  
Xubo Shen ◽  
Kunming Tian ◽  
Yijun Liu ◽  
Shimin Xiong ◽  
...  
Keyword(s):  
Depressive Symptom ◽  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Levels ◽  
Adult Men ◽  
Depressed Group ◽  
The Mean ◽  
Symptom Group ◽  
The Relationship

Objective This study aimed to determine the relationship between serum testosterone levels and depressive symptoms in an adult male population. Methods We conducted a cross-sectional study of 1166 male participants from Zunyi, Guizhou, China. Each participant completed a questionnaire, a brief clinical exam, and had a fasting blood sample taken. We measured serum testosterone, sex hormone-binding globulin, and luteinizing hormone levels. Multiple linear regression was used to evaluate the effect of demographic factors on the relationship between the depressive symptom score and serum sex hormone levels. Results Mean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free testosterone index (FTI) were significantly lower in the depressive symptom group than in the non-depressed group. Additionally, the mean FTI was significantly negatively correlated with the Beck Depression Inventory scale score in the multiple linear regression model (95% confidence interval: −3.274 to −0.406). Conclusions Decreased bioactive testosterone levels might be a contributing factor of depression in adult men. The FTI could be the most sensitive biomarker reflecting the level of bioavailable testosterone in patients with depression.

The Relationship between Sex Hormones, Sex Hormone Binding Globulin and Peripheral Artery Disease in Older Persons

2011 ◽  
pp. P1-338-P1-338
Author(s):  
Chiara Cattabiani ◽  
Gianpaolo Ceda ◽  
Fulvio Lauretani ◽  
Stefania Bandinelli ◽  
Giulia Schiavi ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Peripheral Artery Disease ◽  
Older Persons ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

scholarly journals Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation

2021 ◽  
Vol 8 ◽  
Author(s):  
Junyu Zhai ◽  
Shang Li ◽  
Yinci Zhu ◽  
Yun Sun ◽  
Zi-Jiang Chen ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Ovarian Response ◽  
Controlled Ovarian Hyperstimulation ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Study Cohort ◽  
Ovarian Hyperstimulation ◽  
Hormone Binding ◽  
Serum Samples ◽  
The Relationship

Purpose: Serum concentrations of sex hormone binding globulin (SHBG), a glycated homodimeric plasma transport protein, correlate positively with the total number of follicles in women with infertility. However, the relationship between serum SHBG concentrations and the ovarian response during controlled ovarian hyperstimulation (COH) and whether this relationship differs between women with and without polycystic ovary syndrome (PCOS) remains unclear.Methods: The study cohort included 120 participants (60 non-PCOS and 60 PCOS) undergoing in vitro fertilization. Serum samples were collected from each participant every 2–3 days during the COH cycle. The concentrations of serum SHBG and other sex hormones were determined to investigate the relationship between serum SHBG concentrations and the ovarian response in women with and without PCOS.Results: We found that the serum SHBG concentration was positively correlated with the ovarian response in non-PCOS patients but not in PCOS patients.Conclusion: The serum SHBG concentration may be clinically useful as a predictor of the ovarian response during COH in patients without PCOS.

scholarly journals The relationship between components of metabolic syndrome and plasma level of sex hormone-binding globulin

2019 ◽  
Vol 29 (2) ◽  
Author(s):  
Amin Alinezhad ◽  
Fatemeh Jafari
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Level ◽  
Lipid Profiles ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Abnormalities ◽  
Hormone Binding ◽  
Men And Women ◽  
Shbg Level ◽  
The Relationship

Plasma concentration of sex hormone-binding globulin (SHBG), as an androgen binding protein, is impressed by many physiological and environmental factors. Recent studies have shown that plasma level of SHBG is related to some components of metabolic syndrome (MetS); however, in contrast, few articles failed to show any associations between SHBG and MetS. So, this study was conducted to investigate the relationship between Components of Metabolic Syndrome and Plasma Level of Sex Hormone-Binding Globulin. In this study, after measuring the plasma level of SHBG in 84 individuals, the relation between MetS and the plasma level of SHBG was investigated. After evaluating the plasma level of SHBG and metabolic abnormalities in men and women, we investigated the factors which mentioned above in two groups including patients with and without MetS. Also, the metabolic abnormalities which evaluated in this study including plasma level of 25-hydroxyvitamin D, serum uric acid (SUA), Albumin, lipid profiles and etc. according to five components of MetS. Our result shows that SHBG could contributed to some laboratory parameters such as LDL-C (P<0.05), total cholesterol (P<0.05), triglycerides (P<0.05) and etc. in men, but not in women. On the other hand, we observed that concentration of SHBG is higher in patients with MetS (P<0.05); however, results from our experiment showed that there is no relation between lower level of SHBG and five components of MetS such as central obesity, raised fasting plasma glucose (FPG) (P>0.05), reduced HDL-C (P>0.05), raised triglycerides (P>0.05) and raised blood pressure (P>0.05) in both men and women. There is a significant association between SHBG and Log-Hip Circumference (P<0.05), Non-HDL-C (P<0.05) and Log-25(OH)D (P<0.05) was seen in this cross-section study in both men and women. Results obtained from our study suggest that SHBG is not a powerful enough factor to use as a predictor of MetS alone and there is no association between plasma level of SHBG and development of five components of MetS, however, lower SHBG level may contributed to lipid profiles.

Salivary Free Testosterone in Hirsutism

1989 ◽  
Vol 26 (6) ◽  
pp. 522-526 ◽  
Author(s):  
Joško Osredkar ◽  
Ivan Vrhovec ◽  
Niko Jesenovec ◽  
Andreja Kocijančič ◽  
Janez Preželj
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Human Saliva ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Dehydroepiandrosterone Sulphate ◽  
Hormone Binding ◽  
Salivary Testosterone ◽  
Diagnostic Use

A sensitive, specific and accurate direct radioimmunoassay of testosterone in human saliva is described. A single salivary testosterone result is shown to be of greater diagnostic use in hirsutism than any of the currently used serum androgen assays. Thus, of 50 hirsute patients, salivary testosterone (Sa-T) was elevated in 34 patients, sex hormone-binding globulin (SHBG) was decreased in 30 women, serum testosterone (S-T) elevated in 13, dehydroepiandrosterone sulphate (DHEA-S) was elevated in 14, and androstenedione in three of the investigated group.

scholarly journals Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men

2020 ◽  
Author(s):  
Bu B Yeap ◽  
Ross J Marriott ◽  
Leen Antonio ◽  
Yi X Chan ◽  
Suchitra Raj ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Serum Testosterone ◽  
Cox Proportional Hazards ◽  
Community Dwelling ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Atherosclerotic Cardiovascular Disease ◽  
Hormone Binding ◽  
Baseline Serum ◽  
Related Mortality

Abstract Context Serum testosterone concentrations decline with age, while serum sex hormone-binding globulin (SHBG) concentrations increase. Objective To analyze associations of baseline serum testosterone and SHBG concentrations, and calculated free testosterone (cFT) values, with all-cause and cause-specific mortality in men. Design, Setting, and Participants The UK Biobank prospective cohort study of community-dwelling men aged 40–69 years old, followed for 11 years. Main Outcome Measures All-cause, atherosclerotic cardiovascular disease (CVD) and cancer-related mortality. Cox proportional hazards regression was performed, adjusting for age, waist circumference, medical conditions, and other covariates. Models for testosterone included SHBG and vice versa. Results In a complete case analysis of 149 436 men with 10 053 deaths (1925 CVD and 4927 cancer-related), men with lower testosterone had a higher mortality rate from any cause (lowest vs highest quintile, Q1 vs Q5, fully-adjusted hazard ratio [HR] = 1.14, 95% confidence interval [CI] = 1.06–1.22, overall trend P &lt; 0.001), and cancer (HR = 1.20, CI = 1.09–1.33, P &lt; 0.001), with no association for CVD deaths. Similar results were seen for cFT. Men with lower SHBG had a lower mortality rate from any cause (Q1 vs Q5, HR = 0.68, CI = 0.63–0.73, P &lt; 0.001), CVD (HR = 0.70, CI = 0.59–0.83, P &lt; 0.001), and cancer (HR = 0.80, CI = 0.72–0.89, P &lt; 0.001). A multiply imputed dataset (N = 208 425, 15 914 deaths, 3128 CVD-related and 7468 cancer-related) and analysis excluding deaths within the first 2 years (9261, 1734, and 4534 events) yielded similar results. Conclusions Lower serum testosterone is independently associated with higher all-cause and cancer-related, but not CVD-related, mortality in middle-aged to older men. Lower SHBG is independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation and determination of causality requires mechanistic studies and prospective trials.

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