scholarly journals Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation

2021 ◽  
Vol 8 ◽  
Author(s):  
Junyu Zhai ◽  
Shang Li ◽  
Yinci Zhu ◽  
Yun Sun ◽  
Zi-Jiang Chen ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Ovarian Response ◽  
Controlled Ovarian Hyperstimulation ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Study Cohort ◽  
Ovarian Hyperstimulation ◽  
Hormone Binding ◽  
Serum Samples ◽  
The Relationship

Purpose: Serum concentrations of sex hormone binding globulin (SHBG), a glycated homodimeric plasma transport protein, correlate positively with the total number of follicles in women with infertility. However, the relationship between serum SHBG concentrations and the ovarian response during controlled ovarian hyperstimulation (COH) and whether this relationship differs between women with and without polycystic ovary syndrome (PCOS) remains unclear.Methods: The study cohort included 120 participants (60 non-PCOS and 60 PCOS) undergoing in vitro fertilization. Serum samples were collected from each participant every 2–3 days during the COH cycle. The concentrations of serum SHBG and other sex hormones were determined to investigate the relationship between serum SHBG concentrations and the ovarian response in women with and without PCOS.Results: We found that the serum SHBG concentration was positively correlated with the ovarian response in non-PCOS patients but not in PCOS patients.Conclusion: The serum SHBG concentration may be clinically useful as a predictor of the ovarian response during COH in patients without PCOS.

scholarly journals The Relationship Between Insulin Resistance and Obesity and Serum Anti-mullerian Hormone Level in Chinese Women With Polycystic Ovary Syndrome: A Case-control Study.

2021 ◽  
Author(s):  
Han Zhao ◽  
Dexin Zhou ◽  
Cong Liu ◽  
Le Zhang
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Polycystic Ovary Syndrome ◽  
Multiple Linear Regression ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
The Relationship

Abstract BackgroundAnti-Mullerian Hormone (AMH) has an important role in the pathophysiological process of polycystic ovary syndrome (PCOS) by regulating follicular development and is closely related to the severity of PCOS. Previous studies have suggested that AMH levels in PCOS is related to hyperandrogenemia levels and are affected by obesity and insulin resistance. however, the exact relationship between AMH levels and obesity and insulin resistance remains unclear. We aimed to elucidate the relationship between insulin resistance and obesity and serum AMH levels in women with PCOS. MethodsWe conducted a retrospective study of 220 women with PCOS who had undergone an assortment of physical, endocrine, and metabolic assessments. AMH levels and various other indicators of PCOS in patients with different body mass indices (BMI) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels were compared. Independent sample t-tests were performed to compare two groups. Pearson correlation analysis was performed to study the correlation between AMH and age, obesity, IR, and other indicators of PCOS, and multiple linear regression analysis was performed to determine the factors influencing AMH. Bilateral tests were performed for all statistical tests. The data were analysed using SPSS v25.0. Statistical significance was defined as a two-sided P-value of less than 0.05.ResultsWe found that >50% of patients with PCOS had insulin resistance, obesity, hyperandrogenemia, and abnormal glucose tolerance. AMH, testosterone (T), and HOMA-IR levels were affected by age, and older participants had lower AMH, HOMA-IR, and androgen levels (P < 0.05). Glycated hemoglobin levels were higher and AMH, luteinizing hormone (LH)/follicle-stimulating hormone (FSH), and LH levels were lower in non-obese individuals than in obese individuals (both P < 0.05). Participants in the non-insulin resistant (IR; NIR) group were older than those in the IR group (P < 0.05). AMH, LH, LH/FSH, and T levels in the IR group were significantly higher than those in the NIR group (P < 0.05). AMH levels were positively correlated with LH, LH/FSH, T, fasting insulin (FINS), and HOMA-IR levels as well as the free androgen index and negatively correlated with age, BMI, and sex hormone binding globulin levels (P < 0.05). Through multiple linear regression, we found that AMH levels could be explained by T, LH/FSH, FINS, sex hormone binding globulin, LH levels, and BMI.ConclusionsSerum AMH levels were closely related to metabolic abnormalities in PCOS. In patients with PCOS, AMH levels were positively correlated with HOMA-IR levels and negatively correlated with BMI. Thus, AMH combined with BMI and HOMA-IR levels could help determine the severity of PCOS.

The Relationship between Sex Hormones, Sex Hormone Binding Globulin and Peripheral Artery Disease in Older Persons

2011 ◽  
pp. P1-338-P1-338
Author(s):  
Chiara Cattabiani ◽  
Gianpaolo Ceda ◽  
Fulvio Lauretani ◽  
Stefania Bandinelli ◽  
Giulia Schiavi ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Peripheral Artery Disease ◽  
Older Persons ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Ramifications of variability in sex hormone-binding globulin measurement by different immunoassays on the calculation of free testosterone

2019 ◽  
Vol 57 (1) ◽  
pp. 88-94
Author(s):  
Joanne Adaway ◽  
Brian Keevil ◽  
Annmarie Miller ◽  
Phillip J Monaghan ◽  
Nicola Merrett ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Specific Reference ◽  
Reference Ranges ◽  
Hormone Binding ◽  
Serum Samples ◽  
Appropriate Treatment ◽  
Result Interpretation ◽  
Abbott Architect

Objective Sex hormone-binding globulin (SHBG) is a glycoprotein which binds hormones such as testosterone. Around 97% of circulating testosterone is bound to SHBG or albumin and is therefore biologically unavailable; 2–3% of testosterone is free. Free testosterone is very technically challenging to quantify; in order to circumvent this problem, equations using testosterone and SHBG are used to estimate free testosterone. We decided to determine the effect of using different SHBG immunoassays on calculated free testosterone results. Design Anonymized surplus serum samples were analysed for SHBG on four different immunoassay platforms (Abbott Architect, Roche, Beckman and Siemens). The SHBG results were used to generate a Vermeulen calculated free testosterone. Results Beckman Access and Siemens Centaur both gave results close to the overall mean. Roche gave the highest SHBG concentrations with Abbott Architect producing the lowest results. Abbott Architect gave the highest calculated free testosterone results, followed by Beckman. Roche gave the lowest results. Sixty-five per cent of male samples had low calculated free testosterone and 27.5% of the females had high calculated free testosterone using the SHBG from the Abbott assay compared with 69% low male calculated free testosterone and 20% high female calculated free testosterone with the Roche assay. Conclusion Our results have shown significant differences in SHBG results produced by different analysers and subsequently the calculated free testosterone, which may affect result interpretation if method-specific reference ranges for calculated free testosterone are not used. Care should be taken to ensure reference ranges are appropriate for the analyser used to avoid misdiagnosis of hypo or hyperandrogenism, and ensure patients get the most appropriate treatment.

scholarly journals The relationship between components of metabolic syndrome and plasma level of sex hormone-binding globulin

2019 ◽  
Vol 29 (2) ◽  
Author(s):  
Amin Alinezhad ◽  
Fatemeh Jafari
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Level ◽  
Lipid Profiles ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Abnormalities ◽  
Hormone Binding ◽  
Men And Women ◽  
Shbg Level ◽  
The Relationship

Plasma concentration of sex hormone-binding globulin (SHBG), as an androgen binding protein, is impressed by many physiological and environmental factors. Recent studies have shown that plasma level of SHBG is related to some components of metabolic syndrome (MetS); however, in contrast, few articles failed to show any associations between SHBG and MetS. So, this study was conducted to investigate the relationship between Components of Metabolic Syndrome and Plasma Level of Sex Hormone-Binding Globulin. In this study, after measuring the plasma level of SHBG in 84 individuals, the relation between MetS and the plasma level of SHBG was investigated. After evaluating the plasma level of SHBG and metabolic abnormalities in men and women, we investigated the factors which mentioned above in two groups including patients with and without MetS. Also, the metabolic abnormalities which evaluated in this study including plasma level of 25-hydroxyvitamin D, serum uric acid (SUA), Albumin, lipid profiles and etc. according to five components of MetS. Our result shows that SHBG could contributed to some laboratory parameters such as LDL-C (P<0.05), total cholesterol (P<0.05), triglycerides (P<0.05) and etc. in men, but not in women. On the other hand, we observed that concentration of SHBG is higher in patients with MetS (P<0.05); however, results from our experiment showed that there is no relation between lower level of SHBG and five components of MetS such as central obesity, raised fasting plasma glucose (FPG) (P>0.05), reduced HDL-C (P>0.05), raised triglycerides (P>0.05) and raised blood pressure (P>0.05) in both men and women. There is a significant association between SHBG and Log-Hip Circumference (P<0.05), Non-HDL-C (P<0.05) and Log-25(OH)D (P<0.05) was seen in this cross-section study in both men and women. Results obtained from our study suggest that SHBG is not a powerful enough factor to use as a predictor of MetS alone and there is no association between plasma level of SHBG and development of five components of MetS, however, lower SHBG level may contributed to lipid profiles.

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