scholarly journals Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110499
Author(s):  
Guangxia Yang ◽  
Naifeng Guo ◽  
Jun Yin ◽  
Jianhua Wu
Keyword(s):  
Glomerular Filtration Rate ◽  
Lupus Nephritis ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Activity Index ◽  
Eastern China ◽  
Chinese Patients ◽  
Important Indicator ◽  
Pathological Classification ◽  
Kaplan Meier

Objective This study investigated the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and the severity and prognosis of renal injury in lupus nephritis (LN). Methods Serum sCD163 levels in 121 Eastern Chinese patients with LN who underwent renal biopsy were determined by enzyme-linked immunosorbent assays. Clinical data were collected, and the glomerular filtration rate and disease activity score of lupus were calculated. Pathological classification was performed, and renal pathological scores were assessed by the activity index (AI) and chronic index (CI). Kaplan–Meier survival curves were drawn to evaluate prognosis. Results The pathological classification, AI and CI scores in the high sCD163 group were increased. The sCD163 levels were positively correlated with serum creatinine, blood urea nitrogen, AI scores and CI scores and negatively correlated with the estimated glomerular filtration rate. Kaplan–Meier survival analysis showed that the incidence of renal endpoint events was increased in the high sCD163 group compared with the normal sCD163 group. Conclusion The serum sCD163 level correlates with the severity of LN and is an important indicator of poor renal prognosis in patients with LN.

scholarly journals Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Huaibin Wan ◽  
Juan Wang ◽  
Yanmin Yang ◽  
Xin Fan ◽  
Dongdong Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Clinical Outcomes ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Heart Diseases ◽  
Chinese Patients ◽  
Valvular Heart Diseases ◽  
All Cause Mortality

Abstract Background Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF). Methods We retrospectively studied 433 consecutive Chinese patients with AF (51.0% males, mean age 65.6 ± 13.2 years) between February 2013 and December 2017. Baseline clinical data were collected according to medical records. eGFR was calculated by MDRD equation for Chinese patients according to baseline age, sex and serum creatinine. The primary clinical outcome of interest was all-cause mortality. Results During a median follow-up period of 3.1 (0.5–4.5) years, 73 deaths (16.9%) were recorded. Multivariate Cox regression analyses indicated that eGFR was independently associated with all-cause death in total population [hazard ratio (HR) 0.984; 95% confidence interval (CI) 0.972–0.995, P = 0.006] and patients free of valvular heart diseases (VHDs) (HR 0.975; 95% CI 0.959–0.992, P = 0.003), but not with VHDs. A receiver operating characteristic (ROC) analysis revealed that reduced eGFR predicted all-cause mortality with areas under the ROC curve of 0.637 (95% CI 0.539–0.735, P = 0.004) in AF patients free of VHDs. Conclusions eGFR is an independent predictor of 3-year all-cause mortality among Chinese patients with AF, especially among those patients free of VHDs.

Effect of Glomerular Filtration Rate at Peritoneal Dialysis Initiation on Clinical Outcomes: A Retrospective Cohort Study

2021 ◽  
Vol 104 (1) ◽  
pp. 10-17
Keyword(s):  
Glomerular Filtration Rate ◽  
Peritoneal Dialysis ◽  
Glomerular Filtration ◽  
Clinical Outcomes ◽  
Filtration Rate ◽  
Optimal Time ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Keywords Peritoneal Dialysis ◽  
Artery Disease

Background: The optimal time for peritoneal dialysis (PD) initiation remains controversial. Objective: To assess the correlation between estimated glomerular filtration rate (eGFR) at PD initiation and clinical outcomes. The primary outcome was the patient’s survival, and the secondary outcomes were PD-related complications and hospitalization. Materials and Methods: The patients that underwent PD between January 1, 2013 and December 31, 2017 were enrolled in the present retrospective study. Demographic, laboratories, PD data, and adequacy of PD were collected from the medical records. Patients were categorized according to their eGFR at the initiation of PD into four groups including: less than 3, 3 to 5.9, 6 to 9.9, and 10 mL/minute/1.73 m² or more for assessing the association with the clinical outcomes. Results: Data from 532 PD patients were analyzed. The mean eGFR at the initiation of PD was 5.07±2.56 mL/minute/1.73 m², residual urine 545.75±481.07 mL/day. One hundred sixty-nine (31.7%) patients died during follow-up period. Kaplan Meier survival analyses showed that patients who started PD at eGFR less than 3 and 3 to 5.9 mL/minute/1.73 m² had a lower mortality risk than the other groups (p<0.001). In multivariate analyses, age, coronary artery disease, and hospitalization were independent factors of death but the level of eGFR at the beginning of PD did not affect the outcome. There was no significant difference among the four groups in hospitalization (p=0.83) and peritonitis (p=0.61). Conclusion: Initiation of PD at extremely-low and low eGFR were associated with better survival outcomes than the higher groups but were similar in the results of hospitalization and peritonitis. Keywords: peritoneal dialysis, glomerular filtration rate, survival rate, peritonitis

scholarly journals Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yiting Wang ◽  
Junlin Zhang ◽  
Geer Teng ◽  
Yucheng Wu ◽  
Qianqian Han ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Chinese Patients ◽  
Multivariable Logistic Regression

Background. The performance of various equations for estimated glomerular filtration rate (eGFR) in patients with diabetes remains controversial. We aimed to evaluate the performance of equations for eGFR in Chinese patients with diabetic nephropathy (DN). Methods. This is a retrospective study included in 308 patients with type 2 diabetes and biopsy-proven DN who were followed up at least one year. eGFR was calculated using chronic kidney disease epidemiology (CKD-EPI) equations based on serum creatinine (eGFRCKD-EPI-Cr), cystatin C (eGFRCKD-EPI-CysC), and joint equations (eGFRCKD-EPI-Cr-CysC), respectively. End-stage kidney disease was defined by initiation of renal replacement therapy. The eGFR concordance between equations was assessed by Bland-Altman plots. Log-rank and multivariable logistic regression were employed to evaluate the performance of equations. Results. Overall, the proportion of patients with eGFR<60 mL/min/1.73m2 was 53%, 70%, and 61% by the equations of eGFRCKD-EPI-Cr, eGFRCKD-EPI-CysC, and eGFRCKD-EPI-Cr-CysC, respectively. Higher disconcordance was observed between equations when eGFR>60 mL/min/1.73m2. Compared with eGFRCKD-EPI-Cr, 39% of patients were reclassified (reclassified group) from CKD 1-2 stages to CKD 3-5 stages by eGFRCKD-EPI-CysC and they presented significantly longer diabetic duration, heavier proteinuria, advanced pathological lesions, and poorer kidney outcomes. Multivariable logistic regression indicated cystatin C was independently associated with advanced glomerular classifications. Conclusion. eGFR equations incorporating cystatin C are superior to eGFR based on creatinine alone for detecting kidney injury in the early stage. The independent association between cystatin C and glomerular classifications might contribute to it.

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