A Trial of Fortagesic and Paramol 118 in Osteoarthritis

1976 ◽  
Vol 4 (6) ◽  
pp. 432-434 ◽  
Author(s):  
C J Andrews ◽  
L Cohen ◽  
R B Crail ◽  
G Douch ◽  
M G Sheldon ◽  
...  
Keyword(s):  
Side Effects ◽  
Crossover Study ◽  
Moderate Pain ◽  
Single Blind ◽  
Blind Crossover Study

Fortagesic was compared with Paramol 118 in a fourteen day single-blind crossover study in patients with moderate pain due to osteoarthritis. Both preparations were shown to be similarly effective. More side-effects were seen with Paramol 118 than with Fortagesic and more patients preferred Fortagesic. These differences were not statistically significant, but it is concluded that Fortagesic is a useful effective analgesic for standard use in moderate pain.

scholarly journals Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study

2012 ◽  
Vol 56 (4) ◽  
pp. 250-258 ◽  
Author(s):  
Andressa Bornschein ◽  
Gilberto Paz-Filho ◽  
Hans Graf ◽  
Gisah A. de Carvalho
Keyword(s):  
Crossover Study ◽  
Primary Hypothyroidism ◽  
Weekly Dose ◽  
Safe Alternative ◽  
Cardiac Symptoms ◽  
Daily Schedule ◽  
Single Blind ◽  
Levothyroxine Treatment ◽  
Randomized Crossover Study ◽  
Blind Crossover Study

OBJECTIVE: Compliance to levothyroxine treatment in hypothyroidism is compromised by daily schedule, and a weekly dose may be an alternative. SUBJECTS AND METHODS: This was a randomized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before and four hours after LT4 intake. RESULTS: In the weekly dose treatment, fT4 levels were higher after taking LT4, and lower seven days after the last dose; by the 6th week there was a small decrease in T3 levels. TSH remained unchanged and there were no hyperthyroidism symptoms or echocardiographic manifestations. CONCLUSION: Weekly dose leads to transient increases in fT4, without hyperthyroidism or cardiac symptoms. That approach seems to be a safe alternative for the treatment of hypothyroidism.

Comparison of Diazepam and Flurazepam in the Treatment of Insomnia in General Practice

1979 ◽  
Vol 7 (5) ◽  
pp. 401-403 ◽  
Author(s):  
Ian MacPhail ◽  
W Alasdair Ogilvie ◽  
C R Purvis
Keyword(s):  
General Practice ◽  
Side Effects ◽  
Sleep Disturbance ◽  
Crossover Study ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

In a double-blind crossover study in general practice, flurazepam was shown to be significantly better (p<0.001) than diazepam in treating sleep disturbance. Fewer patients reported side-effects on flurazepam.

scholarly journals Acute effects of beer on endothelial function and hemodynamics: A single-blind, crossover study in healthy volunteers

Nutrition ◽  
2013 ◽  
Vol 29 (9) ◽  
pp. 1122-1126 ◽  
Author(s):  
Kalliopi Karatzi ◽  
Victoria G. Rontoyanni ◽  
Athanase D. Protogerou ◽  
Aggeliki Georgoulia ◽  
Konstantinos Xenos ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Acute Effects ◽  
Single Blind ◽  
Blind Crossover Study

A Comparative Study of the Effectiveness and Safety of Two Non-Steroidal Anti-Inflammatory Agents, Nabumetone and Naproxen in Rheumatoid Arthritis

1982 ◽  
Vol 10 (4) ◽  
pp. 204-208 ◽  
Author(s):  
G Fostiropoulos ◽  
E A P Croydon
Keyword(s):  
Rheumatoid Arthritis ◽  
Comparative Study ◽  
Crossover Study ◽  
Grip Strength ◽  
Analgesic Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Single Blind ◽  
Blind Crossover Study ◽  
Articular Index

A single-blind crossover study of two non-steroidal anti-inflammatory drugs, nabumetone (1000 mg/day) and naproxen (500 mg/day) was performed in thirty patients suffering from definite or classical rheumatoid arthritis. Nabumetone significantly improved the various parameters assessed, while this was not observed with naproxen. The superiority of nabumetone over naproxen appeared for the anti-inflammatory activity (e.g. E.S.R., articular index, P.I.P. joint circumference, grip strength) as well as for the analgesic activity (patient's opinion). The clinical tolerance appeared equally good for both drugs.

scholarly journals Bioequivalence evaluation of two oral formulations of Dexketoprofen-trometamol (solution and tablets) in healthy subjects: Results from a randomized, single-blind, crossover study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jorge González-Canudas ◽  
Luis Jesús García-Aguirre ◽  
Araceli Medina-Nolasco ◽  
María Isabel Ruíz-Olmedo ◽  
Liz Janet Medina Reyes ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Oral Formulations ◽  
Dexketoprofen Trometamol ◽  
Single Blind ◽  
Blind Crossover Study

scholarly journals Comparison of Patient-Controlled Epidural Analgesia with Patient-Controlled Intravenous Analgesia Using Pethidine or Fentanyl

1997 ◽  
Vol 25 (2) ◽  
pp. 126-132 ◽  
Author(s):  
W. D. Ngan Kee ◽  
K. K. Lam ◽  
P. P. Chen ◽  
T. Gin
Keyword(s):  
Side Effects ◽  
Caesarean Section ◽  
Epidural Analgesia ◽  
Crossover Study ◽  
Double Blind ◽  
Pain Scores ◽  
Intravenous Analgesia ◽  
Fentanyl Consumption ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

We compared patient-controlled epidural analgesia (PCEA) with patient-controlled intravenous analgesia (PCIA) using pethidine or fentanyl in a randomized, double-blind crossover study of 80 patients after caesarean section. Patients received pethidine by PCEA or PCIA, or fentanyl by PCEA or PCIA, with a crossover of the route of administration at 12h. For pethidine, pain scores were lower with PCEA vs PCIA from 4 to 16 h (P<0.05). Pethidine consumption was lower with PCEA vs PCIA from 12 to 24 h (P=0.0005). Patients preferred PCEA to PCIA (P=0.015). For fentanyl, pain scores were lower with PCEA vs PCIA at 12 h (P=0.045). Fentanyl consumption was lower with PCEA vs PCIA from 0 to 12 h (P=0.0007). Patients had similar preference for PCEA and PCIA. Pain scores and side-effects were similar between drugs. Plasma pethidine was similar between groups. Plasma fentanyl was higher with PCIA vs PCEA at 12 h (P=0.002). PCEA has advantages over PCIA and pethidine may be the preferred drug.

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