Comparative Effect of Food on Absorption of Ampicillin and Pivampicillin

1977 ◽  
Vol 5 (1) ◽  
pp. 71-76 ◽  
Author(s):  
P J Neuvonen ◽  
E Elonen ◽  
P J Pentikäinen
Keyword(s):  
Food Intake ◽  
Serum Concentration ◽  
Urinary Excretion ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Total Absorption ◽  
Comparative Effect ◽  
Concentration Time ◽  
Ampicillin Concentration ◽  
Effect Of Food

The effect of food on the absorption of simultaneously ingested ampicillin or pivampicillin was compared in a crossover study in eight healthy volunteers. The absorption of both ampicillin and pivampicillin was delayed by simultaneous food intake as judged by serum concentration and urinary excretion of ampicillin. The total absorption of ampicillin, but not that of pivampicillin was decreased by simultaneous food intake as indicated by the area under the serum ampicillin concentration-time curves and by 24 hours urinary excretion of ampicillin. The excretion of ampicillin into urine was about 30% of the dose when ampicillin was ingested with water into an empty stomach and about 20% when ingested with food. The respective excretion of ampicillin following the ingestion of pivampicillin was about 60% of the dose taken either with or without food.

Bioavailability of Digoxin and Beta-Methyl-Digoxin

1976 ◽  
Vol 4 (5) ◽  
pp. 352-354
Author(s):  
L Padeletti ◽  
F Fantini ◽  
P Cinelli ◽  
C Gremigni
Keyword(s):  
Single Dose ◽  
Serum Concentration ◽  
Urinary Excretion ◽  
Crossover Study ◽  
Drug Absorption ◽  
Normal Volunteers ◽  
Cumulative Urinary Excretion ◽  
Serial Serum ◽  
Concentration Measurements ◽  
Randomized Crossover Study

In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.

scholarly journals Effect of a Nutritional Supplement on Posaconazole Pharmacokinetics following Oral Administration to Healthy Volunteers

2006 ◽  
Vol 50 (5) ◽  
pp. 1881-1883 ◽  
Author(s):  
Angela Sansone-Parsons ◽  
Gopal Krishna ◽  
Angela Calzetta ◽  
David Wexler ◽  
Bhavna Kantesaria ◽  
...  
Keyword(s):  
Oral Administration ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Maximum Concentration ◽  
Nutritional Supplement ◽  
Healthy Adults ◽  
Time Curve ◽  
Fasted State ◽  
Concentration Time ◽  
Randomized Crossover Study

ABSTRACT We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

scholarly journals Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers.

1996 ◽  
Vol 40 (7) ◽  
pp. 1715-1716 ◽  
Author(s):  
J G Gillum ◽  
D S Israel ◽  
R B Scott ◽  
M W Climo ◽  
R E Polk
Keyword(s):  
Combination Therapy ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Combination Treatment ◽  
Oral Treatment ◽  
Time Curve ◽  
Real Effect ◽  
Concentration Time ◽  
Beta Error ◽  
Randomized Crossover Study

Five adults completed this four-way randomized crossover study to compare the effects of oral treatment with ciprofloxacin, clarithromycin, and a combination of the two drugs on theophylline pharmacokinetics. The area under the concentration-time curve for theophylline during combination therapy was not different from that for ciprofloxacin alone. Beta error may explain this finding, but any real effect from combination treatment appears to be clinically unimportant.

Absorption of Phenoxymethylpenicillin from Mixtures and Tablets in Healthy Volunteers

1983 ◽  
Vol 11 (6) ◽  
pp. 380-384 ◽  
Author(s):  
Kenneth Josefsson ◽  
Lennart Magni
Keyword(s):  
Clinical Practice ◽  
Serum Concentration ◽  
Healthy Volunteers ◽  
Potassium Salt ◽  
Serum Levels ◽  
Relative Bioavailability ◽  
Point Of View ◽  
Peak Serum ◽  
Concentration Time ◽  
Serum Peak

The absorption of the potassium, calcium and benzathine salts of Phenoxymethylpenicillin, given as mixtures, was investigated in twelve healthy volunteers. The potassium salt gave the fas test and highest serum peak levels. Also the relative bioavailability of the potassium salt was greatest, as indicated by the areas under the serum concentration/time curves (AUC). In a second study with twelve other volunteers, the absorption of the mixtures and tablets of the potassium salt was studied. The peak serum levels and AUC were comparable after these preparations. The results in our two studies indicate that, from a pharmacokinetic point of view, the potassium salt of Phenoxymethylpenicillin in mixtures should be preferred in clinical practice. It also appears that the absorption of Phenoxymethylpenicillin from the tablets and mixtures of the potassium salt is comparable, giving the same relative bioavailability.

Effect of Food on Nifedipine Sustained-Release Preparation

DICP ◽  
1989 ◽  
Vol 23 (9) ◽  
pp. 662-665 ◽  
Author(s):  
Kazuyuki Ueno ◽  
Syuichi Kawashima ◽  
Kiyotaka Uemoto ◽  
Tomoko Ikada ◽  
Kazuyoshi Miyai ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Sustained Release ◽  
Time Curve ◽  
Maximum Serum ◽  
Sustained Release Preparation ◽  
Concentration Time ◽  
Release Preparation ◽  
Effect Of Food ◽  
Maximum Serum Concentration ◽  
The Mean

The effect of food on the bioavailability of a nifedipine sustained-release preparation was studied. Each of seven male volunteers received a single oral 20 mg dose with 100 mL of water under two conditions, fasting and after a meal, with a crossover after a seven-day wash-out period. Blood samples were drawn at time zero (just prior to dose), and 1, 2, 3, 4, 6, 8, 10, and 12 hours after dosing. Nifedipine assays were performed by gas chromatography. The area under the serum concentration-time curve (AUC) from 0 to 12 hours and maximum serum concentration (Cmax) were significantly increased by food. Blood pressure was significantly decreased by food. The mean AUC for fasting and meal conditions were 315.0 and 411.4 ng•h/mL, and the mean Cmax were 42.6 and 86.6 μg/mL, respectively. The results indicate that food may increase the bioavailability of nifedipine sustained-release preparation.

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