A Comparative Study of Epicillin and Chloramphenicol in the Treatment of Enteric Fever

1977 ◽  
Vol 5 (2) ◽  
pp. 91-95
Author(s):  
A Hassau ◽  
J Sippel ◽  
Z Farid ◽  
S S Tadros ◽  
M Brian
Keyword(s):  
Body Weight ◽  
Blood Culture ◽  
Antibiotic Therapy ◽  
Comparative Study ◽  
Positive Blood Culture ◽  
Enteric Fever ◽  
Stool Culture ◽  
Positive Stool

One hundred patients with acute enteric fever were randomly assigned to treatment with either chloramphenicol 50 mg/kg body-weight or epicillin 1 g six hourly. Eighty-one patients had a positive blood culture for typhoid or paratyphoid bacilli and nineteen had a positive stool culture with a significant Widal titre. All fifty patients in the group treated with chloramphenicol responded, however there was one relapse with bacteraemia. In the group treated with epicillin, six from the total of fifty patients were considered treatment failures. Treatment was considered as a failure if the patient was febrile after ten days treatment or if there was a deterioration despite antibiotic therapy.

scholarly journals Comparative study of blood culture and Staphylococcal coagglutination test in clinically suspected cases of enteric fever

2010 ◽  
Vol 28 (4) ◽  
pp. 417
Author(s):  
MC Baragundi ◽  
G Vishwanath ◽  
AR Hanumanthappa ◽  
K Suresh ◽  
NR Chandrappa ◽  
...  
Keyword(s):  
Blood Culture ◽  
Comparative Study ◽  
Enteric Fever

Comparative Study of Blood Culture and Widal Agglutination Test from the Patients Suspected of Enteric Fever

2016 ◽  
Vol 16 (5) ◽  
pp. 1-9
Author(s):  
Preety Chaudhary ◽  
Vijay Sharma ◽  
Anshu Chaudhary ◽  
Shashi Chaturwedi ◽  
Anima Shrestha
Keyword(s):  
Blood Culture ◽  
Comparative Study ◽  
Enteric Fever ◽  
Agglutination Test

scholarly journals COMPARATIVE STUDY OF TYPHIDOT-M WITH WIDAL AND BLOOD CULTURE IN DIAGNOSIS OF ENTERIC FEVER

2017 ◽  
Vol 04 (01) ◽  
pp. 64-67
Author(s):  
S Udayakumar ◽  
K Pushpalatha ◽  
H M Naveen Sagar ◽  
M Swathi ◽  
Raksha Yoganand ◽  
...  
Keyword(s):  
Blood Culture ◽  
Comparative Study ◽  
Enteric Fever

scholarly journals Bacteremic meningitis due to Pasteurella multocida resistant to first line antibiotic therapy

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Damiano Larnè ◽  
Manuela Ceccarelli ◽  
Fabrizio Condorelli ◽  
Emmanuele Venanzi Rullo ◽  
Giuseppe Nunnari ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Blood Culture ◽  
Antibiotic Therapy ◽  
Positive Blood Culture ◽  
Pasteurella Multocida ◽  
Rare Event ◽  
Etiologic Agent ◽  
First Line ◽  
Antibiotic Drugs ◽  
Professional Exposure

Pasteurella species reside in the gastrointestinal tract of many animals, especially in pets such as cats or dogs. Zoonotic transmission of Pasteurella to human is documented. We describe a case of meningitis in a 66-year-old woman with positive blood culture for Pasteurella multocida. Meningitis caused by zoonosis agents is a rare event, but it should be suspected in patients that have recreational or professional exposure to animals. In this case, not only the etiologic agent was rare, but the microorganism was also resistant to firstline antibiotic drugs.

scholarly journals Current Clinical Profile of Enteric Fever in a Teaching Hospital

1970 ◽  
Vol 15 (2) ◽  
pp. 81-83
Author(s):  
Shahriar Kabir ◽  
MA Azhar ◽  
ARM Saifuddin Ekram ◽  
Quazi Tarikul Islam ◽  
Iftekhar Ahmed
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Enteric Fever ◽  
College Hospital ◽  
Medical College ◽  
Clinical Presentations ◽  
Sensitivity Pattern ◽  
Clinical Profiles ◽  
Bangladeshi Population ◽  
Medical Wards

This study was designed to assess the current of clinical presentations, complications andprognosis of enteric fever cases in Bangladeshi population and also to assess the antimicrobialsensitivity of the causative organisms. A total of 65 patients, with either fever of any durationwith positive blood culture for Salmonella, of fever of more than a week with strong clinicalevidence of enteric fever along with single Widal titre TO >160 of AO >160 or BO> 160, wereselected from indoor medical wards of Rajshahi Medical College Hospital from August 2000 toMay 2001. Blood culture with sensitivity pattern, Widal tests and relevant investigations weredone in all patients. Majority (87.70%) of the patients presented on the second or third week oftheir illness. Other clinical profiles of the patients were comparable to different studies done inour country and in abroad. Common complications were pneumonia, meningitis and typhoidpsychosis. Isolated salmonellae from blood culture were 100% sensitive to Ciprofloxacin andPefloxacin. Two out of sixty five patients (3.07%) expired due to complications.doi: 10.3329/taj.v15i2.3914TAJ December 2002; Vol.15(2): 81-83

scholarly journals Rapid Identification of Pathogens in Positive Blood Culture of Patients with Sepsis: Review and Meta-Analysis of the Performance of the Sepsityper Kit

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Nils G. Morgenthaler ◽  
Markus Kostrzewa
Keyword(s):  
Blood Culture ◽  
Antibiotic Therapy ◽  
Positive Blood Culture ◽  
Blood Stream Infection ◽  
Meta Analysis ◽  
Extraction Methods ◽  
Blood Stream ◽  
Rapid Identification ◽  
Maldi Tof

Sepsis is one of the leading causes of deaths, and rapid identification (ID) of blood stream infection is mandatory to perform adequate antibiotic therapy. The advent of MALDI-TOF Mass Spectrometry for the rapid ID of pathogens was a major breakthrough in microbiology. Recently, this method was combined with extraction methods for pathogens directly from positive blood cultures. This review summarizes the results obtained so far with the commercial Sepsityper sample preparation kit, which is now approved forin vitrodiagnostic use. Summarizing data from 21 reports, the Sepsityper kit allowed a reliable ID on the species level of 80% of 3320 positive blood culture bottles. Gram negative bacteria resulted consistently in higher ID rates (90%) compared to Gram positive bacteria (76%) or yeast (66%). No relevant misidentifications on the genus level were reported at a log(score)cut-off of 1.6. The Sepsityper kit is a simple and reproducible method which extends the MALDI-TOF technology to positive blood culture specimens and shortens the time to result by several hours or even days. In combination with antibiotic stewardship programs, this rapid ID allows a much faster optimization of antibiotic therapy in patients with sepsis compared to conventional workflows.

ANTIMICROBIAL SUSCEPTIBILITY IN CULTURE POSITIVE ENTERIC FEVER

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Manish Kulshrestha ◽  
Dr. Anjali Kulshrestha
Keyword(s):  
Bone Marrow ◽  
Blood Culture ◽  
Nalidixic Acid ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Enteric Fever ◽  
Multidrug Resistant ◽  
Bone Marrow Culture ◽  
Diffusion Method ◽  
Culture Positive

INTRODUCTION: Enteric fever includes typhoid and paratyphoid fever. Peak incidence is seen in children 5–15 years of age; but in regions where the disease is highly endemic, as in India, children younger than 5 years of age may have the highest infection rates. There are about 22 million new typhoid cases occur each year. Young children in poor, resource limited areas, who make up the majority of the new cases and there is a mortality figures of 215,000 deaths annually. A sharp decline in the rates of complications and mortality due to typhoid fever is observed as a result of introduction of effective antibiotic therapy since 1950s. MDR-ST became endemic in many areas of Asia, including India soon after multidrug-resistant strains of Salmonella enterica serotype typhi (MDR-ST) that were resistant to all the three first-line drugs then in use, namely chloramphenicol, amoxycillin and co-trimoxazole emerged in early 1990s. MATERIAL AND METHODS: Only blood culture or bone marrow culture positive cases were included. The patients with culture isolated enteric fever were included in the study. Antimicrobial susceptibility testing was carried out by disk diffusion method using antibiotic discs. The analysis of the antimicrobial susceptibility was carried out as per CLSI interpretative guidelines. RESULTS: A total of 82 culture positive cases were included in the present study. 80 culture isolates were from blood culture and 2 from the bone marrow culture. Salmonella entericasubspecies enterica serovartyphi (S typhi) was isolated from 67 (81.70%) patients while Salmonella enterica subspecies entericaserovarparatyphi (S paratyphi A) was isolated from 13 (15.85%) cases and 2 (2.44%) were Salmonella enterica subspecies entericaserovarschottmuelleri (S paratyphi B). Of the 82 cases 65(79.3%) isolates were resistant to ciprofloxacin, 17 (20.7%) were resistant to nalidixic acid, one (1.2%) case each was resistant to Cefotaxime and ceftriaxone, 2 (2.4%) were resistant to chloramphenicol, 10 (12.2%) were resistant and to cotrimoxazole 3 (3.7%) were resistant. CONCLUSION: In a culture positive cases 65(79.3%) isolates were resistant to ciprofloxacin and 17 (20.7%) were resistant to nalidixic acid. Multidrug resistant isolates were 65(79.3%).

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