An Open Study of Procaine Penicillin G, Clavulanate-Potentiated Amoxycillin and Probenecid in the Treatment of Acute Gonorrhoea

1994 ◽  
Vol 22 (4) ◽  
pp. 236-243
Author(s):  
P D Ekwere
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Treatment Failure ◽  
Open Study ◽  
Adverse Reactions ◽  
Bacterial Culture ◽  
Penicillin G ◽  
Purulent Discharge ◽  
Procaine Penicillin ◽  
Gonococcal Urethritis

In an open study 55 patients presenting with acute gonorrhoea were given 4.8 mega units procaine penicillin G, intramuscularly, and oral probenecid (1 g) plus one 375-mg tablet clavulanate-potentiated amoxycillin orally. Before this treatment, 53 patients (96.4%) had presented with a purulent discharge, and dysuria was present in 47 patients (85.5%). The presence of Neisseria gonorrhoeae was confirmed by bacterial culture in 54 patients (98.2%). The majority of pathogens (92.5%) were penicillin resistant. On day 3 after treatment, dysuria was absent in 53 patients (96.4%) and there was no discharge in 40 cases (72.7%). N. gonorrhoeae was eradicated in 53 patients (96.4%). Two further patients were bacteriologically cured, but were suffering from post-gonococcal urethritis. The patients in whom discharge was still apparent were further assessed on day 7; discharge was resolved or resolving in all but one patient. There was one treatment failure. No adverse reactions were reported.

Single-Dose Aqueous Procaine Penicillin G Therapy for Gonorrhea: Use of Probenecid and Cause of Treatment Failure

1973 ◽  
Vol 127 (4) ◽  
pp. 455-460 ◽  
Author(s):  
K. K. Holmes ◽  
W. W. Karney ◽  
J. P. Harnisch ◽  
P. T. Wiesner ◽  
M. Turck ◽  
...  
Keyword(s):  
Single Dose ◽  
Treatment Failure ◽  
Penicillin G ◽  
Procaine Penicillin

Single-Dose Therapy of Anogenital and Pharyngeal Gonorrhoea with Ciprofloxacin

1992 ◽  
Vol 3 (1) ◽  
pp. 49-51 ◽  
Author(s):  
T Balachandran ◽  
A P Roberts ◽  
B A Evans ◽  
B S Azadian
Keyword(s):  
Adverse Reaction ◽  
Single Dose ◽  
Oral Dose ◽  
Neisseria Gonorrhoeae ◽  
Treatment Failure ◽  
Single Oral Dose ◽  
Open Study ◽  
Dose Therapy ◽  
Single Dose Therapy

A single dose of ciprofloxacin, 250 mg by mouth, was used in an open study to treat pharyngeal or rectal gonorrhoea or both in 64 patients (32 men and 32 women). The study also included 151 men with urethral gonorrhoea and 53 women with cervical or urethral gonorrhoea. Ciprofloxacin cured 63 (98%) patients with pharyngeal or rectal gonorrhoea (including 5 patients with penicillinase-producing Neisseria gonorrhoeae; PPNG), 147 (97%) men with urethral gonorrhoea (including 8 with PPNG) and 52 (98%) women with cervical or urethral gonorrhoea. All the isolates of N. gonorrhoeae were sensitive to 0.03 mg/l of ciprofloxacin. Five of the 6 patients with treatment failure were subsequently cured by a single oral dose of ciprofloxacin 250 mg. None of the patients reported an adverse reaction. Ciprofloxacin 250 mg as a single oral dose is effective and safe in treating patients with pharyngeal or rectal gonorrhoea, including those with PPNG strains.

scholarly journals Profil uretritis gonokokus dan non-gonokokus di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari – Desember 2012

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Alson . Sambonu ◽  
Nurdjannah J. Niode ◽  
Herry E.J. Pandeleke
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Sexual Partner ◽  
Ureaplasma Urealyticum ◽  
Burning Sensation ◽  
Purulent Discharge ◽  
Gonococcal Infection ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Gonococcal Urethritis

Abstract: Gonococcal urethritis (GU) is a sexually transmitted infection (STI) which is caused by Neisseria Gonorrhoeae bacteria. In GU, there is an urethral inflammation caused by negative Gram diplococcus ( its natural reservoir is human) and the symptoms are purulent discharge from external urethral orificium, burning sensation during urination, distal urethra itching, dysuria, vaginal or penile discharge, and erection pain. Non-Gonococcal Urethritis (NGU) is an urethral inflammation that is not caused by Gonococcal infection, but due to Chlamydia trachomatis and Ureaplasma urealyticum. The symptoms are penile discharge, burning sensation and pain during urination, and itching. This study aimed to obtain the profiles of gonococcal and non-gonococcal urethritis in Dermatovenereology Clinic of Prof. Dr. R. D. Kandou General Hospital Manado from January to December 2012. This was a retrospective descriptive study based on GU and NGU types, symptoms, sexual partner, occupation, and farmacological therapy. The results showed that of 74 STI cases there were 11 GU cases (14.9%) and 4 UNG cases (5.4%). Most of GU and NGU patients were 25-44 years (n = 10, 66.7%), with dysuria (n = 11, 73.3%), prostitute as sexual partner (n = 10, 66.7%), working as entrepreneur (n = 12, 80%), and farmacological therapy for GU is cefixime (n = 9, 81.8%) and for NGU is doxycyclin (n = 3, 75%). Keywords: gonococcal urethritis, non-gonococcal urethritis Abstrak: Uretritis gonore (UG) merupakan suatu penyakit infeksi menular seksual (IMS) yang disebabkan oleh kuman Neisseria gonorrhoeae. Pada UG terjadi peradangan uretra oleh diplokokus Gram negatif yang reservoir alaminya ialah manusia dan ditandai adanya pus yang keluar dari orifisium uretra eksternum, rasa panas, gatal di bagian distal uretra, disuria, polakisuria, keluar duh tubuh dari ujung uretra yang kadang-kadang disertai darah dalam urin, dan disertai rasa nyeri saat ereksi. Uretritis non Gonore (UNG) adalah suatu peradangan pada uretra yang bukan disebabkan oleh infeksi gonokokus seperti Chlamydia trachomatis dan Ureaplasma urealyticum dengan gejala seperti discharge dari penis, rasa terbakar atau sakit saat buang air kecil dan gatal. Penelitian ini bertujuan untuk mengetahui profil uretritis gonokokus dan non gonokokus di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2012. Jenis penelitian ini deskriptif retrospektif berdasarkan jenis penyakit UG dan UNG, umur, keluhan, pasangan seksual, pekerjaan, dan terapi farmakologis. Hasil penelitian menunjukkan dari 74 kasus IMS terdapat 11 kasus UG (14,9%) dan 4 kasus UNG (5,4%). Penderita UG dan UNG terbanyak pada kelompok umur 25-44 tahun (n = 10, 66,7%), dengan keluhan disuria (n = 11, 73,3%), pasangan seksual dengan WPS (n = 10, 66,7%), pekerjaan wiraswata (n = 12, 80%), serta terapi farmakalogis pada UG ialah cefixime (n = 9, 81,8%) dan pada UNG ialah doxycyclin (n = 3, 75%).Kata kunci: uretritis gonokokus, uretritis non gonokokus

A Report of Four Cases and a Review of the Literature

1974 ◽  
Vol 83 (4) ◽  
pp. 550-554 ◽  
Author(s):  
Gary D. Becker ◽  
Alexander M. Wernicke
Keyword(s):  
World Literature ◽  
Pathogenic Bacteria ◽  
Wide Spectrum ◽  
Carrier State ◽  
Penicillin G ◽  
Physical Finding ◽  
Agar Culture ◽  
Cervical Lymph Nodes ◽  
Procaine Penicillin ◽  
Moderate Elevation

Four cases of gonococcal pharyngotonsillitis have been presented, along with a review of the world literature. This entity is most commonly seen in those individuals practicing fellatio, i.e., females and homosexual males. The infection may be passed to the newborn by the infected genitals of the mother during birth, to the infant from adult molestation, or among sexually promiscuous children. Most gonococcal pharyngeal infections result in a carrier state, and as such, are possible reservoirs of propagated infections. When symptomatic, the most frequent complaint is a sore throat. Physical finding among symptomatic patients reveal a wide spectrum ranging from mild hyperemia of the pharynx or tonsils, to exudative tonsillitis with tender cervical lymph nodes and moderate elevation of temperature. Most authorities agree that the preferred treatment is 4.8 million units of procaine penicillin G I.M., with one gm of probenecid by mouth thirty minutes before the injection. If allergic to penicillin, tetracycline should be given, 1.5 gm by mouth stat, then 0.5 gm four times a day for a total of 9 gm. A routine blood agar culture of the throat will not reveal the presence of the gonococcus. Thayer-Martin (or Transgrow) media must be used. Failure to detect pathogenic bacteria in a routine culture may lead to either no treatment or improper treatment of a gonococcal pharyngotonsillar infection. This may result in a carrier state, or even worse, to a disseminated gonococcal infection.

Experimental Human Gonococcal Urethritis: 250 Neisseria gonorrhoeae MS11mkC Are Infective

1995 ◽  
Vol 172 (1) ◽  
pp. 180-185 ◽  
Author(s):  
H. Schneider ◽  
A. S. Cross ◽  
R. A. Kuschner ◽  
D. N. Taylor ◽  
J. C. Sadoff ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Gonococcal Urethritis

In Vivo Sensitivity Test in Otitis Media: Efficacy of Antibiotics

PEDIATRICS ◽  
1985 ◽  
Vol 75 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Virgil M. Howie ◽  
Ruth Dillard ◽  
Barbara Lawrence
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Penicillin G ◽  
Treatment Results ◽  
Double Blind ◽  
Phenoxymethyl Penicillin ◽  
Procaine Penicillin ◽  
The Poor

During a 10-year period, antibiotics were assigned in random, double-blind fashion in six combinations to treat 948 episodes of otitis media in children. Exudate from the middle ear of all patients was cultured before treatment. Three follow-up visits were conducted; the first follow-up visit was three to five days after the start of therapy, and the second and third visits were 14 and 31 days after onset of treatment. Exudates were recultured for 75% of the patients on the first follow-up visit. Comparison of treatment results showed that triple sulfonamide combined with either phenoxymethyl penicillin, or benzathine and procaine penicillin G given intramuscularly (IM) was as effective as was ampicillin or amoxicillin. Phenoxymethyl penicillin and cyclacillin alone were usually effective against pneumococci but relatively ineffective against Haemophilus influenzae. Cefaclor and trimethoprim-sulfamethoxazole produced unsatisfactory results in about half the cases caused by pneumococci or H influenzae. Although production of β-lactamase by some otitis-causing Haemophilus and Staphylococcus species may explain the ineffectiveness of some treatments, the percentage of organisms positive for β-lactamase was too small to be responsible for the poor results with certain drugs.

STUDIES OF PENICILLIN IN PEDIATRICS

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 664-671
Author(s):  
B. M. KAGAN ◽  
M. NIERENBERG ◽  
D. GOLDBERG ◽  
A. MILZER
Keyword(s):  
Intramuscular Injection ◽  
Room Temperature ◽  
Serum Levels ◽  
Sesame Oil ◽  
Peanut Oil ◽  
Penicillin G ◽  
Procaine Penicillin ◽  
Pertinent Data ◽  
Significant Difference ◽  
Pediatric Use

Table I summarizes most of the pertinent data in this report on the serum penicillin concentrations 12 and 24 hours after intramuscular injection of K penicillin G in peanut oil and beeswax, which is fluid at room temperature, and of three different procaine penicillin preparations. These three preparations are procaine penicillin G in sesame oil, procaine penicillin G in peanut oil with 2% aluminum monostearate, and procaine penicillin G in water with Na-carboxymethylcellulose. When they were given in a dosage of 8000 u./lb. to infants and children, weighing between 4.5 and 18.0 kg., there was no statistically significant difference in the serum levels obtained. A dosage schedule for these preparations is suggested for pediatric use. The aqueous preparation offers some advantages which are discussed. Experiences are reported which emphasize the necessity of avoiding intravenous administration of all these preparations.

scholarly journals The rarity of gonococcal arthritis in association with HIV infection

2014 ◽  
Vol 8 (09) ◽  
pp. 1222-1227 ◽  
Author(s):  
Rasha Maharaj ◽  
Girish M Mody
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Hiv Infection ◽  
Skin Rash ◽  
Throat Swab ◽  
Hiv Positive ◽  
Hiv Patients ◽  
Acute Arthritis ◽  
Gonococcal Urethritis ◽  
The Right

Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the right elbow aspirate. The second patient, a 24-year-old HIV-positive female on zidovudine for one month, presented at 28 weeks gestation with acute oligoarthritis and peroneal tenosynovitis. Neisseria gonorrhoeae was cultured from the throat swab. Both patients responded to ceftriaxone. Gonococcal arthritis must be considered in HIV patients with acute arthritis.

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