Suppression of Unspecific Enhancement on Breast Magnetic Resonance Imaging (Mri) by Antiestrogen Medication

2002 ◽  
Vol 88 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Anke Heinig ◽  
Dieter Lampe ◽  
Heinz Kölbl ◽  
Rainer Beck ◽  
Sylvia H Heywang-Köbrunner
Keyword(s):  
Breast Tissue ◽  
Lobular Carcinoma ◽  
Breast Mri ◽  
Tamoxifen Treatment ◽  
Short Term ◽  
Benign Breast Tissue ◽  
Breast Magnetic Resonance ◽  
Antiestrogen Therapy ◽  
Magnetic Resonance Imaging Mri

Aims and Background The value of breast MRI may be impaired by unspecific enhancement. This may leave patients with difficult-to-assess breast tissue with an uncertain diagnosis. We examined whether this unspecific enhancement (which is mostly due to proliferative or hyperplastic changes of benign breast tissue) may be suppressed by antiestrogen medication. Methods In a trial of treatment, 10 peri- or postmenopausal patients who exhibited diffuse and/or focal enhancement on breast MRI before tamoxifen medication agreed to undergo a short-term tamoxifen treatment. MRI monitoring was performed 2, 4 and 8 weeks after onset of antiestrogen therapy (tamoxifen, 30 mg per day). Results Six patients showed a significant decrease of enhancement. Unchanged (n = 3) or increased (n = 1) enhancement was seen in 4 patients. One of the three patients with unchanged enhancement proved to have diffuse lobular carcinoma in situ. Conclusions Part of the unspecific enhancement seen on breast MRI can probably be suppressed by short-term antiestrogen medication.

The Efficacy of MRI as an Adjuvant to Traditional Mammography

2007 ◽  
Vol 73 (10) ◽  
pp. 970-972
Author(s):  
Amy K. Bremner ◽  
James Recabaren
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Retrospective Chart Review ◽  
Breast Mri ◽  
Treatment Change ◽  
Breast Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri ◽  
Made In

The objective of our study is to assess the utility of breast Magnetic Resonance Imaging (MRI) when used for indications other than those published in peer-reviewed studies. A retrospective chart review was conducted of the records of 588 women who underwent both mammography and breast MRI. Patients excluded from the study were those who had breast MRI for accepted indications based on published peer-review studies. Included on the study were the remaining 122 patients. An evaluation was then made in each case as to whether the MRI finding caused a change in the patient's management. In this review, subject age ranged from 27- to 85-years-old. The mean age of the sample was 54.5 years. Of the positive MRI results, 29 (27.7%) had additional findings. There were 25 (20.3%) subjects with a treatment change and 97 (79.5%) without. In conclusion, breast MRI affected the clinical management in 25 (20.3%) of 122 patients. The majority of the 25 patients have invasive ductal carcinoma, followed by ductal carcinoma in situ. We believe this is a significant percentage positively affected by the additional use of breast MRI. We suggest that indications for the use of breast MRI in addition to traditional breast imaging should include all patients with invasive ductal carcinoma.

Prospective study of magnetic resonance imaging (MRI) and multiparameter gene expression assay in ductal carcinoma in situ (DCIS): A trial of the ECOG-ACRIN Cancer Research Group (E4112).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 534-534 ◽  
Author(s):  
Seema Ahsan Khan ◽  
Constantine Gatsonis ◽  
Brad Snyder ◽  
Constance D Lehman ◽  
Joseph A. Sparano ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Breast Mri ◽  
Invasive Disease ◽  
Primary Objective ◽  
Surgical Margins ◽  
Magnetic Resonance Imaging Mri ◽  
Combined Impact ◽  
Clinical Trial Information

534 Background: Prior retrospective studies have evaluated breast MRI in DCIS, and prospective-retrospective biomarker studies have shown that the DCIS Score is prognostic for recurrence after BCS alone. E4112 is a prospective cohort study designed to assess the combined impact of breast MRI and DCIS Score on surgical and RT management. Methods: Women diagnosed with screen-detected DCIS on core biopsy, if BCS eligible, underwent breast MRI. Those remaining so following MRI and related biopsies, with no invasive disease, underwent BCS. If final surgical margins were ≥2 mm, the DCIS lesion was submitted for DCIS Score assay. Women with low DCIS Score (≤39, LS) were advised that RT could be avoided; RT was recommended to those with high/intermediate (H/I) scores. The primary objective was to estimate the fraction converting to mastectomy (Mx) following MRI. Secondary objectives included estimation of re-operation rates after first BCS, and DCIS Score distribution.A sample size of 333 evaluable women would allow estimation of Mx rate of 12% with 95% confidence interval 9-16%. Results: 334 enrolled women had completed surgery; the first surgical procedure was Mx in 54 (16.2%) and BCS in 280 (83.8%), of whom 62 (22.1%) required at least one re-excision, and 11 (3.9%) converted to Mx. DCIS Scores were obtained on 171 patients who completed BCS, of whom 82 were LS and 89 were H/I. Demographics were similar between the two groups, other features will be reported. Only 7/82 (8.5%) of the LS group received RT, whereas 82/89 (92.1%) of the H/I group received RT. Of the 98 BCS patients who did not qualify for DCIS Score-based therapy, 23 had invasive disease, 34 had final surgical margins < 2 mm, and 13 had both. There was insufficient tissue for DCIS Score in 11, and 17 did not complete follow-up. Conclusions: In this study, among DCIS patients who were BCS-eligible following MRI, total mastectomy rate was 19.5%; re-excision rate was 22.1% for women who had BCS. Approximately half had low DCIS Scores, and RT recommendations based on the DCIS Score were acceptable to most women. Clinical trial information: E4112.

scholarly journals Segmentation of elongated structures processed on breast MRI for the detection of vessels

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marco Gierlinger ◽  
Dinah M. Brandner ◽  
Bernhard G. Zagar
Keyword(s):  
Breast Magnetic Resonance Imaging ◽  
Breast Mri ◽  
Region Growing ◽  
Seed Region ◽  
Resonance Imaging ◽  
Mr Images ◽  
Pixel Intensity ◽  
Breast Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnosis Of Diseases

Abstract The multi-seed region growing (MSRG) algorithm from previous work is extended to extract elongated segments from breast Magnetic Resonance Imaging (MRI) stacks. A model is created to adjust the MSRG parameters such that the elongated segments may reveal vessels that can support clinicians in their diagnosis of diseases or provide them with useful information before surgery during e. g. a neoadjuvant therapy. The model is a pipeline of tasks and contains user-defined parameters that influence the segmentation result. A crucial task of the model relies on a skeletonization-like algorithm that collects useful information about the segments’ thickness, length, etc. Length, thickness, and gradient information of the pixel intensity along the segment helps to determine whether the extracted segments have a tubular structure, which is assumed to be the case for vessels. In this work, we show how the results are derived and that the MSRG algorithm is capable of extracting vessel-like segments even from noisy MR images.

Efficacy of Screening Breast MRI for High-Risk Women

2016 ◽  
Author(s):  
Christoph I. Lee
Keyword(s):  
High Risk ◽  
Breast Magnetic Resonance Imaging ◽  
Breast Mri ◽  
Resonance Imaging ◽  
Additional Information ◽  
High Risk Women ◽  
Study Methodology ◽  
Breast Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri ◽  
Higher Sensitivity

This chapter, found in the cancer screening and management section of the book, provides a succinct synopsis of a key study examining the efficacy of screening breast magnetic resonance imaging (MRI) for high-risk women. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. Breast MRI screening has higher sensitivity than mammography for high-risk women, but both the specificity and positive predictive value are lower than for mammography screening. In addition to outlining the most salient features of the study, a clinical vignette and imaging example are included in order to provide relevant clinical context.

scholarly journals Fibroadenoma containing lobular carcinoma in situ, an unusual finding in a normally benign mass

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Christie M Brock ◽  
Charles Harper ◽  
Troy Tyler
Keyword(s):  
Carcinoma In Situ ◽  
Breast Tissue ◽  
Lobular Carcinoma ◽  
Left Breast ◽  
Lobular Carcinoma In Situ ◽  
Pathologic Evaluation ◽  
Benign Mass ◽  
Unusual Finding

Abstract This is the case of a 27-year-old female who underwent breast lumpectomy for fibroadenoma of the left breast. Pathologic evaluation of the specimen revealed lobular carcinoma in situ (LCIS) entirely confined to a large fibroadenoma without LCIS in the surrounding breast tissue.

Establishing a Comprehensive Breast Magnetic Resonance Imaging Service in a Community Hospital

2011 ◽  
Vol 62 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Neety Panu ◽  
Elizabeth Morris
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Magnetic Resonance Imaging ◽  
Breast Mri ◽  
Resonance Imaging ◽  
Team Members ◽  
Assessment Centre ◽  
Imaging Service ◽  
Breast Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri

Advances made since the first application of breast magnetic resonance imaging (MRI) in the late 1980s have made it an integral complement to a comprehensive breast assessment centre. Incorporating breast MRI into an existing practice can appear daunting, but a structured and organized approach allows for a smoother transition. With a well thought out plan that engages all team members and experience in interpretation and performing of interventional procedures, breast MRI will serve to add valuable information in patient management.

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