A Case of Malignant Phyllodes Tumor with Muscular and Fatty Differentiations

A 50-year-old female underwent surgical removal of a mammary phyllodes tumor, whose peculiar histologic feature was the coexistence of areas of liposarcoma and leiomyosarcoma. The morphologic differential diagnosis is briefly discussed.

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A Case of Malignant Phyllodes Tumor of the Breast Metastasizing to the Ovary

International Journal of Surgical Pathology ◽

10.1177/10668969211056912 ◽

2021 ◽

pp. 106689692110569

Author(s):

Yukiko Tada ◽

Masafumi Yasunaga ◽

Hiroshi Tomonobe ◽

Yuichi Yamada ◽

Emiko Hori ◽

...

Keyword(s):

Ovarian Cancer ◽

Differential Diagnosis ◽

Phyllodes Tumor ◽

Metastatic Spread ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

The Third

Phyllodes tumors of the breast are uncommon, and 6.2% of phyllodes tumors behave in a malignant fashion. The metastatic spread of malignant phyllodes tumor is mainly hematogenous to lung and bone, and malignant phyllodes tumor metastasizing to the ovary is rare, with only 2 cases reported. We report the third case of metastatic malignant phyllodes tumor to the ovary with a focus on the differential diagnosis of ovarian cancer.

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Giant Phyllodes Tumor: A Case Report and Review of the Literature?

Journal of Medical - Clinical Research & Reviews ◽

10.33425/2639-944x.1195 ◽

2021 ◽

Vol 5 (2) ◽

Author(s):

Bueno Carolina ◽

Steim Jéssica ◽

Roque Fernanda ◽

Sato Alan ◽

Chambô Danielle ◽

...

Keyword(s):

Differential Diagnosis ◽

Perineural Invasion ◽

Standard Treatment ◽

Immunohistochemical Analysis ◽

Phyllodes Tumor ◽

Left Breast ◽

Definitive Diagnosis ◽

High Grade ◽

Review Of The Literature ◽

Malignant Phyllodes Tumor

Phyllodes tumor is a rare, fast-growing, fibroepithelial neoplasm of the breast that can be classified as benign, borderline or malignant. The case reported here refers to a 25-year old patient with a lump on her left breast that grew rapidly in the postpartum period, reaching 21 cm in size. Core biopsy and immunohistochemical analysis indicated a diagnosis of high-grade phyllodes tumor. The patient underwent mastectomy of the left breast followed by breast reconstruction. Histopathology confirmed a malignant phyllodes tumor with chondrosarcomata’s and fibrosarcomatous differentiation and no angiolymphatic or perineural invasion. Phyllodes tumors are generally benign and differential diagnosis is usually made with fibroadenomas; however, clinical differentiation can be difficult in some cases. The definitive diagnosis is achieved by histopathology, which is able to differentiate benign from malignant forms of the disease. Standard treatment consists of local excision, with mastectomy being necessary in cases of borderline, large, malignant or recurrent tumors.

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Recurrent Malignant Phyllodes Tumor of the Breast: A Rare Occurrence in a Young Nulliparous Woman

RECENT ADVANCES IN PATHOLOGY AND LABORATORY MEDICINE ◽

10.24321/2454.8642.201707 ◽

2017 ◽

Vol 03 (04) ◽

pp. 8-11

Author(s):

Sonam Sharma ◽

Keyword(s):

Phyllodes Tumor ◽

Nulliparous Woman ◽

Rare Occurrence ◽

Malignant Phyllodes Tumor

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Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Breast Care ◽

10.1159/000448236 ◽

2016 ◽

Vol 11 (4) ◽

pp. 291-294 ◽

Cited By ~ 1

Author(s):

Canan Kelten ◽

Ceren Boyaci ◽

Cem Leblebici ◽

Kemal Behzatoglu ◽

Didem C. Trabulus ◽

...

Keyword(s):

Case Report ◽

Bone Cyst ◽

Clinical Breast Examination ◽

Phyllodes Tumor ◽

Breast Cancer Diagnosis ◽

Left Breast ◽

Malignant Phyllodes Tumor ◽

Her Family ◽

Simple Mastectomy ◽

Clinical Breast

Background: Malignant phyllodes tumors of the breast are rare biphasic neoplasms. Only few cases related to pregnancy have been reported. Case Report: A 37-year-old woman presented with swelling and pain in her left breast as well as hyperemia on the breast skin, 4 weeks after labor. In her family history, her aunt and maternal cousin had had a breast cancer diagnosis. Clinical evaluation of the patient was consistent with a breast abscess. Therefore, abscess drainage and biopsy from the cavity wall were performed. However, the biopsy was diagnosed as malignant phyllodes tumor. An evaluation by ultrasonography showed a well-defined hypoechoic mass with many cystic spaces covering the entire breast tissue. Therefore, a simple mastectomy was performed. Microscopic examination revealed a high-grade malignant phyllodes tumor. Additionally, bone cyst-like areas in the form of sponge-like blood-filled non-endothelialized spaces were observed. Conclusions: Since the breasts become larger due to the physiological changes during pregnancy, any underlying breast lesions may be obscured. Therefore, clinical breast examination in the first visit of pregnancy is important.

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Hemangiopericytoma of the spinal canal

Journal of Neurosurgery ◽

10.3171/jns.1978.49.6.0914 ◽

1978 ◽

Vol 49 (6) ◽

pp. 914-920 ◽

Cited By ~ 42

Author(s):

Darrell J. Harris ◽

Victor L. Fornasier ◽

Kenneth E. Livingston

Keyword(s):

Endothelial Cells ◽

Differential Diagnosis ◽

High Risk ◽

Spinal Canal ◽

Vertebral Column ◽

Soft Tissues ◽

Surgical Removal ◽

Vascular Neoplasm ◽

Content Type ◽

Fine Print

✓ Hemangiopericytoma is a vascular neoplasm consisting of capillaries outlined by an intact basement membrane that separates the endothelial cells of the capillaries from the spindle-shaped tumor cells in the extravascular area. These neoplasms are found in soft tissues but have rarely been shown to involve the spinal canal. This is a report of three such cases. Surgical removal of the tumor from the spinal canal was technically difficult. A high risk of recurrence has been reported but in these three cases adjunctive radiotherapy appeared to be of benefit in controlling the progression of the disease. These cases, added to the six cases in the literature, confirm the existence of hemangiopericytoma involving the vertebral column with extension into the spinal canal. This entity should be included in the differential diagnosis of lesions of the spinal canal. The risk of intraoperative hemorrhage should be anticipated.

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Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

Surgical Case Reports ◽

10.1186/s40792-021-01113-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Kimihisa Mizoguchi ◽

Kazuhisa Kaneshiro ◽

Makoto Kubo ◽

Yoshihiko Sadakari ◽

Yoshizo Kimura ◽

...

Keyword(s):

Rare Case ◽

Phyllodes Tumor ◽

Left Breast ◽

Lymph Node Biopsy ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Malignant Phyllodes Tumor ◽

Csf Levels ◽

Wbc Count ◽

Stimulating Factor

Abstract Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing tumors have been reported in various organs such as the lung, esophagus, and stomach but rarely in the breast. We report a case of G-CSF-producing malignant phyllodes tumor of the breast. Case presentation An 84-year-old woman visited our hospital complaining of a lump in her left breast without fever and pain. Laboratory tests revealed elevated white blood cell (WBC) count and G-CSF levels. A malignant tumor of the breast was diagnosed by core needle biopsy. We performed a total mastectomy and sentinel lymph node biopsy. The tumor was identified as a G-CSF-producing malignant phyllodes tumor. Within 7 days after surgery, the patient’s WBC count and G-CSF level had decreased to normal levels. She is alive without recurrence 13 months after surgery. Conclusions We encountered a rare case of G-CSF-producing malignant phyllodes tumor of the breast. PET–CT revealed diffuse accumulation of FDG in the bone. Phyllodes tumors need to be differentiated from bone metastasis, lymphoma, and leukemia. We must be careful to not mistake this type of tumor for bone marrow metastasis.

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Malignant Phyllodes Tumor With Liposarcomatous Differentiation

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-421-mptwld ◽

2005 ◽

Vol 129 (3) ◽

pp. 421-422

Author(s):

Phillip A. Isotalo ◽

Ralph L. George ◽

Ross Walker ◽

Sandip K. SenGupta

Keyword(s):

Phyllodes Tumor ◽

Malignant Phyllodes Tumor

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Phyllodes Tumor Metastatic to Thyroid HürthleCell Adenoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-1233-ptmtth ◽

2002 ◽

Vol 126 (10) ◽

pp. 1233-1236

Author(s):

Tamar Giorgadze ◽

Richard M. Ward ◽

Zubair W. Baloch ◽

Virginia A. LiVolsi

Keyword(s):

Tumor Metastasis ◽

Unusual Case ◽

Cellular Proliferation ◽

Phyllodes Tumor ◽

Thyroid Tumor ◽

Cell Adenoma ◽

Malignant Phyllodes Tumor ◽

Hürthle Cell ◽

Thyroid Mass ◽

Tumor To Tumor Metastasis

Abstract We present a case of a malignant phyllodes tumor metastasizing to a Hürthle cell adenoma of the thyroid. A 55-year-old woman underwent mastectomy for a malignant phyllodes tumor. Two years later, she presented with a left thyroid mass, which was a single, circumscribed, soft, deep red-brown nodular lesion with an eccentric area of firmer consistency. Histologically, the thyroid tumor was composed of 2 distinct types of cellular proliferation. Atypical spindle cells were infiltrating between the Hürthle cell cords and follicles in a fibrosarcomatous pattern. A battery of immunohistochemical stains was applied to both the thyroid and breast tumors for comparison. Based on the histologic and immunophenotypic features of the fibrosarcomatous components of both the breast and thyroid tumors, we rendered a diagnosis of cystosarcoma phyllodes metastatic to Hürthle cell adenoma. To the best of our knowledge, this unusual case is a first report of tumor-to-tumor metastasis of a sarcoma to a primary thyroid neoplasm.

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