A Case of Malignant Phyllodes Tumor of the Breast Metastasizing to the Ovary

2021 ◽  
pp. 106689692110569
Author(s):  
Yukiko Tada ◽  
Masafumi Yasunaga ◽  
Hiroshi Tomonobe ◽  
Yuichi Yamada ◽  
Emiko Hori ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Differential Diagnosis ◽  
Phyllodes Tumor ◽  
Metastatic Spread ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
The Third

Phyllodes tumors of the breast are uncommon, and 6.2% of phyllodes tumors behave in a malignant fashion. The metastatic spread of malignant phyllodes tumor is mainly hematogenous to lung and bone, and malignant phyllodes tumor metastasizing to the ovary is rare, with only 2 cases reported. We report the third case of metastatic malignant phyllodes tumor to the ovary with a focus on the differential diagnosis of ovarian cancer.

scholarly journals Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Gabriel S. Makar ◽  
Michael Makar ◽  
Joanna Ghobrial ◽  
Kathryn Bush ◽  
Ryan Allen Gruner ◽  
...  
Keyword(s):  
Breast Neoplasms ◽  
Rare Case ◽  
Phyllodes Tumor ◽  
Adolescent Females ◽  
Small Subset ◽  
Review Of The Literature ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Rare Case Report

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0.9%) with malignant phyllodes tumors being even more uncommon. Malignant phyllodes tumors tend to progress rapidly though only 1.5% metastasize. They are also associated with a higher rate of recurrence than their benign counterparts, underlying the importance of adequate surgical margins. It is therefore imperative to be able to identify these tumors early allowing for prompt resection and close follow-up. Here, we present the rare case of a 17-year-old female presenting with a rapidly enlarging breast mass, which was ultimately found to be a malignant phyllodes tumor. We further performed a review of the literature to highlight only 22 other cases reported in adolescent females.

scholarly journals Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
R. A. Amir ◽  
Rola S. Rabah ◽  
S. S. Sheikh
Keyword(s):  
Case Report ◽  
Breast Neoplasms ◽  
Distant Metastasis ◽  
Case Reports ◽  
Phyllodes Tumor ◽  
Pancreatic Metastasis ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases

Breast Cancer ◽  
2009 ◽  
Vol 17 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Satomi Suzuki-Uematsu ◽  
Kazuko Shiraishi ◽  
Taro Ito ◽  
Naoki Adachi ◽  
Yoshihisa Inage ◽  
...  
Keyword(s):  
Case Report ◽  
Phyllodes Tumor ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors

scholarly journals Large Malignant Phyllodes Tumor of the Breast: Case Report of a Young Female and Review of Literature

2020 ◽  
pp. 137-146
Author(s):  
Melissa Kyriakos Saad ◽  
Imad El Hajj ◽  
Elias Saikaly
Keyword(s):  
Malignant Tumors ◽  
Pectoralis Major Muscle ◽  
Phyllodes Tumor ◽  
World Health ◽  
Low Grade ◽  
Accurate Identification ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Post Surgery ◽  
The Right

Background: Phyllodes tumors are rare fibroepithelial neoplasm of the breast, representing 0.3 to 0.5% of all female breast neoplasms. The term ‘‘phyllodes tumor” by the World Health Organization (WHO) categorizes it into benign, borderline, and malignant tumors based on histopathological characteristics. Malignant phyllodes tumor is an uncommon but aggressive breast malignancy and accounts for approximately 25% of all phyllodes tumors.Case Presentation: A 23-year-old female patient Gravida 0 Para 0, previously healthy, with no family history of breast or ovarian cancer was referred to our institution for managing a right breast mass increasing in size over a period of 1 month associated with reddish-brown discoloration of the skin. Breast ultrasound showed an isodense oval mass measuring approximately 16x14x12cm in the right lower outer quadrant of her breast. Core biopsy and FNA done revealed a low grade phyllodes tumor. MRI of breasts showed a huge mass of the right breast occupying all quadrants, measuring 15x14.5 cm in its greatest axis with involvement of the pectoralis major muscle, with no evidence of suspicious axillary lymphadenopathy. Distant metastatic work-up with CT scan of chest abdomen and pelvis and a PET scan did not show distant metastasis. Hence, the patient underwent right total mastectomy with a final pathology compatible with malignant phyllodes tumor. She is on regular follow up and 18 months post-surgery is still disease free.Conclusion: Management of malignant phyllodes tumor remains debatable, especially when it comes to the effect of adjuvant radiotherapy and chemotherapy. From a surgical perspective, whether phyllodes tumors should be considered as epithelial breast cancers or as soft tissue sarcoma is another debate. On the other hand, although challenging, accurate identification of phyllodes tumor initially may aid in decreased recurrence.

scholarly journals Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation

2019 ◽  
Vol 9 ◽  
pp. 10
Author(s):  
Neetu Soni ◽  
Nour T Aly ◽  
Aditi Vidholia ◽  
Fabiana Policeni
Keyword(s):  
Case Report ◽  
Phyllodes Tumor ◽  
Imaging Findings ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Epithelial Component ◽  
Sarcomatous Transformation ◽  
Increased Risk ◽  
Stromal Component ◽  
Proven Case

Phyllodes tumors (PTs) are a rare fibroepithelial tumor of the breast. Histopathological confirmation of stromal and epithelial component is required for making the diagnosis of PT, and stromal component carries an increased risk of sarcomatous transformation. We present imaging findings of a histologically proven case of malignant PT with heterologous liposarcomatous transformation of the breast.

A Case of Malignant Phyllodes Tumor with Muscular and Fatty Differentiations

1992 ◽  
Vol 78 (5) ◽  
pp. 351-352 ◽  
Author(s):  
Giuseppe Isimbaldi ◽  
Maria Sironi ◽  
Paolo Declich ◽  
Carlo Galli ◽  
Agnese Assi
Keyword(s):  
Differential Diagnosis ◽  
Phyllodes Tumor ◽  
Surgical Removal ◽  
Histologic Feature ◽  
Malignant Phyllodes Tumor

A 50-year-old female underwent surgical removal of a mammary phyllodes tumor, whose peculiar histologic feature was the coexistence of areas of liposarcoma and leiomyosarcoma. The morphologic differential diagnosis is briefly discussed.

scholarly journals Phyllodes Tumor of the Breast Metastasizing to the Vulva

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Olusegun Kayode Ajenifuja ◽  
Nonna Kolomeyevskaya ◽  
Fadi Habib ◽  
Adekunle Odunsi ◽  
Shashikant Lele
Keyword(s):  
Mitotic Activity ◽  
Recurrence Rate ◽  
Phyllodes Tumor ◽  
Breast Tumors ◽  
Wide Excision ◽  
Free Margin ◽  
Phyllodes Tumors ◽  
The Third ◽  
Local Metastasis ◽  
Very High

Phyllodes tumors of the breast are rare breast tumors that resemble fibroadenoma. They are composed of two types of tissues: stromal and glandular tissues. Unlike fibroadenoma, they are commonly found in the third decade of life and they tend to grow more rapidly. Depending on the relative components of the cells and mitotic activity, they are classified into benign, borderline, and malignant. They are usually present as a lump in the breast. Phyllodes tumors are usually managed by wide excision. The excision should be wide enough to ensure a tumor-free margin. Recurrence rate is very high and most recurrences are usually local. Metastasis to the vulva has not been reported.

scholarly journals Effective Treatment of a Malignant Breast Phyllodes Tumor with Doxorubicin-Ifosfamide Therapy

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Shinya Yamamoto ◽  
Shigeru Yamagishi ◽  
Toshiro Kohno ◽  
Ryosuke Tajiri ◽  
Toshikazu Gondo ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Left Lung ◽  
Phyllodes Tumor ◽  
Lung Mass ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Malignant Breast ◽  
One Year ◽  
The Right ◽  
Chemotherapy Strategy

Malignant phyllodes tumors of the breast occur infrequently and are difficult to treat with chemotherapy. Here, we present an effective chemotherapy strategy for recurrent malignant breast phyllodes tumors. A 48-year-old woman was diagnosed with a malignant phyllodes tumor in her right breast and underwent total right mastectomy. One year later, the tumor recurred in the right (a 2.2 cm mass) and left (a 10 cm mass) lungs; pleural effusion was also observed in the left lung. Eight courses of doxorubicin-ifosfamide (AI) therapy were administered. After treatment, the right lung mass and pleural effusion regressed completely and the left lung mass regressed to 2 cm. In conclusion, AI therapy is useful for treating recurrent malignant breast phyllodes tumors.

Malignant Phyllodes Tumor with Lipomatous Differentiation: A Unique Presentation

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S36-S36
Author(s):  
P Johal ◽  
C Sebastiano
Keyword(s):  
Phyllodes Tumor ◽  
Excisional Biopsy ◽  
Surrounding Tissue ◽  
Beta Catenin ◽  
Significant Past Medical History ◽  
Ki 67 ◽  
Complete Excision ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Wide Range

Abstract Casestudy Phyllodes tumors (PT) are uncommon biphasic fibroepithelial neoplasms that account for <1% of all breast tumors. The distinction between benign and malignant PTs is made based on a number of histologic characteristics, including an infiltrative margin, stromal overgrowth, mitotic count, hypercellularity and atypia. 30% of cases show heterologous differentiation, which mostly occurs in stromal elements. This can result in a wide range of tumor histopathology including lipomatous areas. Results We present the case of a 46-year-old female with a 3.1 cm left breast palpated mass and no significant past medical history. Ultrasound guided needle biopsy revealed multiple foci of hypercellular spindle cells with marked atypia and mitoses (ki-67: 40–60%) surrounded by focal fat necrosis. Immunohistochemical staining was negative for CK 5/6, p63, CAM 5.2, SMA, desmin, AE1/3, CD163, nuclear beta-catenin and CD34. The patient subsequently underwent a wire localization excisional biopsy. Microscopic examination revealed a biphasic hypercellular lesion with both stromal and distorted glandular elements and extensive lipomatous differentiation. Although mostly well- circumscribed, some infiltration into the surrounding tissue was identified as well as nuclear atypia and an increased mitotic rate (10 mitoses/HPF). The diagnosis of malignant phyllodes tumor with lipomatous differentiation was made based on these findings. FISH was performed and was negative for MDM2, suggesting that the lipomatous component itself was not malignant (i.e. liposarcoma) Conclusion Malignant phyllodes tumors rarely show heterologous differentiation. A literature review revealed that most lipomatous differentiation was liposarcomatous with rare cases of pure lipomatous metaplasia. Although malignant phyllodes tumor have the highest rate of metastasis relative to their benign counterparts, complete excision has resulted in a mortality rate of approximately 12%. The clinical implications of lipomatous differentiation are currently unknown. However, in these cases ensuring the lack of malignant liposarcomatous tumor growth is imperative.

scholarly journals Advance Malignant Phyllodes Tumor with Active Bleeding in Children: A Rare Case

2021 ◽  
Vol 15 (4) ◽  
pp. 208
Author(s):  
Dedy Hermansyah ◽  
Fernando Silalahi ◽  
Albiner Simarmata ◽  
Denny Rifsal Siregar
Keyword(s):  
Physical Examination ◽  
Rare Case ◽  
Phyllodes Tumor ◽  
Active Bleeding ◽  
Breast Lesions ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Prompt Treatment ◽  
The Right ◽  
Current Guidelines

Introduction: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, there are only a few large pediatric phyllodes tumor series. Current guidelines do not differentiate treatment recommendations between children and adults.Case Presentation: A 12-year-old girl presented with a lump in her right breast which grew rapidly within a month. On physical examination, we found a mass on the right breast sized ± 10 x 10 cm; the lump was fragile and bled easily. The patient’s condition was getting worse and worse. Due to this deterioration, we performed a mastectomy immediately.Conclusions: The incidence of malignant phyllodes tumor in children is very rare and required prompt treatment in emergency cases.

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