Proliferative Optic Neuropathy in Horses

1972 ◽  
Vol 9 (5) ◽  
pp. 368-378 ◽  
Author(s):  
L. Z. Saunders ◽  
S. I. Bistner ◽  
L. F. Rubin
Keyword(s):  
Optic Neuritis ◽  
Blood Vessels ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Storage Disease ◽  
Fat Cells ◽  
Affected Area ◽  
Unidentified Lipid

An asymptomatic, ophthalmoscopically visible proliferation affected the optic disc and nerve of two aged horses. The lesion consisted of an accumulation of foamy cells, histologically akin to fat cells, which contained an unidentified lipid-like material. The affected area and its environs were permeated by tortuous, thickened blood vessels with heavy deposits of collagen in their walls. The neuropathy is considered to be a storage disease, and although the product stored is unidentified, the lesion is similar to that of human xanthelasma. The neuropathy seems distinct from the exudative optic neuritis of horses that has been known since 1890.

scholarly journals Optic Neuropathy with Features Suggestive of Optic Neuritis in Cerebrotendinous Xanthomatosis

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Miyuki Miyamoto ◽  
Nobuyuki Ishii ◽  
Hitoshi Mochizuki ◽  
Kazutaka Shiomi ◽  
Tomoko Kaida ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Optic Neuropathy ◽  
Storage Disease ◽  
Elevated Serum ◽  
Brain Magnetic Resonance Imaging ◽  
Cerebrotendinous Xanthomatosis ◽  
Gadolinium Enhancement ◽  
Lipid Storage Disease ◽  
Optic Disc Swelling ◽  
The Right

We describe our encounter with a 39-year-old man who exhibited acute painless visual loss and progressive gait disturbance. He had tendinous xanthoma and several neuroophthalmological findings indicative of optic neuropathy in the right eye, including afferent pupillary defect, cecocentral scotoma, and optic disc swelling. Neurological examination showed cerebellar ataxia and pyramidal weakness. Brain magnetic resonance imaging revealed bilateral swelling in the optic nerves with gadolinium-enhancement suggesting optic neuritis, an enlarged fourth ventricle, atrophy of the cerebellum, and hyperintensities in the bilateral dentate nuclei. The patient was diagnosed with cerebrotendinous xanthomatosis (CTX) based on an elevated serum cholestanol level and a homozygous missense mutation in CYP27A1. CTX is a genetic lipid storage disease caused by dysfunction of the mitochondrial enzyme sterol 27-hydroxylase. With respect to ophthalmological manifestations, juvenile cataracts and optic neuropathy are common findings in patients with CTX, but there have been no reports of optic neuropathy with features suggestive of optic neuritis. Thus, this case illustrates that clinicians should consider a diagnosis of CTX in patients with cardinal features of CTX even if the patients show signs indicative of optic neuritis.

Clinical and Etiological Profile of Patients with Optic Disc Edema in Tertiary Care Centre of Nepal

2019 ◽  
Vol 41 (1) ◽  
pp. 24-30
Author(s):  
Ritish K Shah
Keyword(s):  
Visual Acuity ◽  
Visual Field ◽  
Optic Neuritis ◽  
Color Vision ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Tertiary Care ◽  
Ischemic Optic Neuropathy ◽  
Optic Disc Edema ◽  
Disc Edema

Introduction: Optic disc edema can be a manifestation of various neurological disorders. Identification of those causes is possible in most cases using tests like visual acuity, color vision, visual field and suitable radiological imaging. Study in Nepalese population with regard to optic disc edema is scarce. Hence this study aims to act as a guideline for evaluation of such cases and help in further studies in this regard. Methods: A descriptive, cross-sectional study was conducted in all cases of optic disc edema presenting to neuro-ophthalmology clinic of B.P. Koirala Lions Centre for Ophthalmic Studies from January 2011 to June 2012. A detailed history was obtained and proper ocular and nervous examination was done by ophthalmologist and neuro-physician. Assessment of visual acuity, color vision, contrast sensitivity and visual field along with radiological tests were done in all possible cases. Results: Out of all the cases evaluated, 38 cases where causes of optic disc edema could be established were included in the study. The commonly affected age group was 31 to 40 years (26.3%) and most of them were males. The commonest cause observed was optic neuritis (36.8%). Others were papilledema, idiopathic intracranial hypertension, toxic optic neuropathy, non-arteritic anterior ischemic optic neuropathy (NA-AION), compressive and traumatic optic neuropathy. Conclusion: Optic neuritis and papilledema should be considered as common differential diagnosis in patients with optic disc edema. NA-AION is a relatively uncommon disease among Nepalese population.

scholarly journals Leber’s hereditary optic neuropathy misdiagnosed as optic neuritis and Lyme disease in a patient with multiple sclerosis

2018 ◽  
Vol 11 (1) ◽  
pp. e227109 ◽  
Author(s):  
Melinda Chang
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
White Matter Lesions ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Intravenous Steroids ◽  
Hereditary Optic Neuropathy

A 28-year-old Caucasian man developed sudden painless vision loss in the right eye. He was diagnosed with optic neuritis. MRI showed white matter lesions consistent with multiple sclerosis (MS), but no optic nerve enhancement. Eight months later, the left eye was affected in the same manner. Examination showed right optic atrophy and apparent left optic disc swelling. Workup revealed positive Lyme IgG. Differential diagnosis included optic neuritis and Lyme optic neuropathy, and he was treated with intravenous steroids, intravenous immunoglobulin, plasmapheresis and intravenous ceftriaxone without improvement. Neuro-ophthalmology consultation led to identification of pseudo-optic disc oedema, and Leber’s hereditary optic neuropathy (LHON) was suspected and confirmed by genetic testing. LHON may occur in association with MS, and should be considered in patients with MS with vision loss atypical for optic neuritis. This is especially important as new treatments for LHON (including gene therapy) are currently undergoing clinical trials.

Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy

2019 ◽  
Vol 39 (3) ◽  
pp. 339-344 ◽  
Author(s):  
Masoud Aghsaei Fard ◽  
Samira Yadegari ◽  
Hosein Ghahvechian ◽  
Sasan Moghimi ◽  
Reza Soltani-Moghaddam ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Optical Coherence Tomography Angiography ◽  
Ischemic Optic Neuropathy ◽  
Optical Coherence

Brief Overview and Experience of Visual Evoked Potential of First 67 cases at Referral Neuroscience Hospital in Bangladesh

2020 ◽  
Vol 6 (2) ◽  
pp. 74-77
Author(s):  
Mohammad Enayet Hussain ◽  
Bithi Debnath ◽  
AFM Al Masum Khan ◽  
Md Ferdous Mian ◽  
Md Nahidul Islam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Clinical Diagnosis ◽  
Optic Neuropathy ◽  
Cross Sectional Study ◽  
P Value ◽  
Pattern Reversal ◽  
Cross Sectional ◽  
The Mean ◽  
Visual Evoked

Background: The visual evoked potentials (VEP) is a valuable tool to document occult lesions of the central visual channels especially within the optic nerve. Objectives: The purpose of the present study was to observe the findings of first few cases of VEP done in the neurophysiology department of the National Institute of Neurosciences (NINS), Dhaka, Bangladesh. Methodology: This cross-sectional study was conducted in the Department of Neurophysiology at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from September 2017 to March 2020. All patients referred to the Neurophysiology Department of NINS for VEP were included. Pattern reversal VEPs were done using standard protocol set by International Federation of Clinical Neurophysiology (IFCN). Results: The mean age of the study population was 30.70 (±12.11) years (6-68 years) with 31 (46.3%) male and 36 (53.7%) female patients. The mean duration of illness was 8.71 (±1.78) months (3 days- 120 months). Most common presenting symptom was blurring of vision (37.3%) and dimness of vision (32.8%). Patterned VEP revealed mixed type (both demyelinating and axonal) of abnormality in most cases [29(43.35)]. The most common clinical diagnosis was multiple sclerosis (29.85%) and optic neuropathy (26.87%). In the clinically suspected cases of multiple sclerosis, optic neuropathy and optic neuritis most of the cases of VEP were abnormal and the p value is 0.04 in optic neuropathy and optic neuritis. Conclusion: The commonest presentation of the patients in this series were blurring of vision and dimness of vision. The most common clinical diagnosis for which VEP was asked for, was optic neuritis and multiple sclerosis. Most abnormalities were of mixed pattern (demyelinating and axonal). Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 74-77

Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis

2018 ◽  
Vol 30 (1) ◽  
pp. 139-140 ◽  
Author(s):  
Proteesh Rana ◽  
Vandana Roy ◽  
Jamshed Ahmad
Keyword(s):  
Pulmonary Tuberculosis ◽  
Optic Neuritis ◽  
Male Patient ◽  
Optic Neuropathy ◽  
High Dose ◽  
Drug Resistant ◽  
Drug Reactions ◽  
Drug Induced ◽  
Toxic Optic Neuropathy ◽  
Extensively Drug Resistant

Abstract We report a 26-year-old male patient diagnosed with extensively drug-resistant pulmonary tuberculosis presenting with reversible bilateral toxic optic neuropathy induced by the use of linezolid along with high-dose isoniazid. The case emphasizes the importance of recognizing toxic optic neuritis in patients on antitubercular therapy. Prompt recognition and treatment of such adverse drug reactions will reduce the associated morbidity.

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