Risk factor identification and predictive models for central line requirements for patients on vasopressors

2021 ◽  
pp. 0310057X2110242
Author(s):  
Adrian D Haimovich ◽  
Ruoyi Jiang ◽  
Richard A Taylor ◽  
Justin B Belsky

Vasopressors are ubiquitous in intensive care units. While central venous catheters are the preferred route of infusion, recent evidence suggests peripheral administration may be safe for short, single-agent courses. Here, we identify risk factors and develop a predictive model for patient central venous catheter requirement using the Medical Information Mart for Intensive Care, a single-centre dataset of patients admitted to an intensive care unit between 2008 and 2019. Using prior literature, a composite endpoint of prolonged single-agent courses (>24 hours) or multi-agent courses of any duration was used to identify likely central venous catheter requirement. From a cohort of 69,619 intensive care unit stays, there were 17,053 vasopressor courses involving one or more vasopressors that met study inclusion criteria. In total, 3807 (22.3%) vasopressor courses involved a single vasopressor for less than six hours, 7952 (46.6%) courses for less than 24 hours and 5757 (33.8%) involved multiple vasopressors of any duration. Of these, 3047 (80.0%) less than six-hour and 6423 (80.8%) less than 24-hour single vasopressor courses used a central venous catheter. Logistic regression models identified associations between the composite endpoint and intubation (odds ratio (OR) 2.36, 95% confidence intervals (CI) 2.16 to 2.58), cardiac diagnosis (OR 0.72, CI 0.65 to 0.80), renal impairment (OR 1.61, CI 1.50 to 1.74), older age (OR 1.002, Cl 1.000 to 1.005) and vital signs in the hour before initiation (heart rate, OR 1.006, CI 1.003 to 1.009; oxygen saturation, OR 0.996, CI 0.993 to 0.999). A logistic regression model predicting the composite endpoint had an area under the receiver operating characteristic curve (standard deviation) of 0.747 (0.013) and an accuracy of 0.691 (0.012). This retrospective study reveals a high prevalence of short vasopressor courses in intensive care unit settings, a majority of which were administered using central venous catheters. We identify several important risk factors that may help guide clinicians deciding between peripheral and central venous catheter administration, and present a predictive model that may inform future prospective trials.

Perinatology ◽  
2019 ◽  
Vol 30 (2) ◽  
pp. 60 ◽  
Author(s):  
Young Duck Kim ◽  
Na Mi Lee ◽  
Su Yeong Kim ◽  
Dae Yong Yi ◽  
Sin Weon Yun ◽  
...  

2021 ◽  
Author(s):  
JingMei Li ◽  
JiaFei Zhang ◽  
Bo Feng ◽  
ChunHui Wang ◽  
MeiLing Wang

Abstract Background: The objective of this study was to evaluate incidence and influencing factors of complications related to central venous catheters (CVCs) in the Pediatric intensive care unit (PICU) of Xi'an Children's Hospital.Methods: We analyzed the complications of all children that had CVCs and were hospitalized between June 2020 to February 2021. A total of 334 CVCs were inserted in 310 children.Results: We noted 102 (30.54%) CVCs-related complications. Complications related to CVCs insertion were infection of catheter (13.17%) and malposition of catheter (8.38%), occlusion of CVCs (2.99%), accidental removal (0.6%), puncture site exudate (4.79%), central venous thrombosis (0.6%). Infection mainly due to Staphylococcus epidermidis. 88 cases (24.55%) of CVCs were extubated due to complications. Analysis of the frequency of maintenance-related complications except for center vein thrombosis showed no differences between the jugular, femoral and subclavian vein access (P > 0.05). It was found that the duration of the catheterization use was critical for the occurrence of CVCs-related infections, puncture site exudate, occlusion (P < 0.05). Suture-off, bleeding of insertion site, and the maximum channels of intravenous infusion in patients were dominant risk factors of catheter-related complications. Conclusion: The risk factors of complications during catheter indwelling are suture-off, bleeding of insertion site and the maximum channels of intravenous infusion in patients. Therefore, strict aseptic operation in various operations, control of the infusion channel, effective fixation of the central venous catheter, reduce the malposition and pull of the catheter, and reduce the infiltration of blood at the puncture point, are particularly important to prevent the complications related to the central venous catheter.


2020 ◽  
Vol 7 (09) ◽  
pp. 4934-4943
Author(s):  
Merve Korkmaz ◽  
Muhammed Şükrü Paksu ◽  
Muhammet Furkan Korkmaz ◽  
Kerim Arslan ◽  
Mustafa Özdemir

Objective: Objective of this study is determination of prevalence of thrombosis and predisposing factors in critically ill patients with central venous catheter (CVC) placement in Pediatric Intensive Care Unit. Material and method: Of 76 cases with CVC placement aged between 1 month to 18 years; venous structures at the extremity where the CVC was placed and their symmetrical equivalents were prospectively examined by using Doppler ultrasonography (DUSG) at days 0, 3, 7, 14 and 28. Results: Median age of the cases included in the study was 19 (2-201) months. Of the cases; 49 (64.5%) was male and 27 (35.5%) was female, with a male/female ratio of 1.81:1. 55 (72.3%) of the cases had an underlying disease. Most common accompanying diseases were neurological and neuromuscular diseases (35.5%), followed by inborn errors of metabolism (14.4%). More than one catheters were placed for 26 (34.2%) of the cases. A total of 107 catheters were placed. Median catheter dwelling time was 12 (2-46) days. Most commonly placed catheters were of Seldinger type (90%). As an early complication, arterial embolism was observed in one (0.9%) case and pneumothorax in one (0.9%) case. As a late complication during the period with a catheter placed, six (7.8%) cases developed catheter infections and 11 (14.4%) cases developed catheter-induced thrombosis. Four (36.3%) of the cases which developed thrombosis were symptomatic. In six (54.4%) of the cases, thrombosis was determined to occur within first three days. When the cases were evaluated in regard to risk factors for thrombosis other than CVC placement, a significant association of CPR application (p= 0.004) and multiple catheter placement (p< 0.001) with thrombosis was determined in uni- and multivariate analyses. 72.7% of the cases with thrombosis were examined for hereditary risk factors and no significant evidence was determined. Conclusion: Our study reveals that multiple catheter placement and CPR application significantly increases risk of thrombosis. Even in absence of any clinical finding, routine evaluation with DSUG within first seven days following catheter placement is useful. Our results suggest that screening for hereditary risk factors which may cause predisposition to thrombosis in all patients with thrombosis in presence of acquired risk factors is unnecessary.


Author(s):  
Sheetal Pearl Charan ◽  
Sister John Mary

Background : A central venous catheter, also called a central line, is a long, thin, flexible tube used to give medicines, fluids, nutrients, or blood products over a long period of time, usually several weeks or more, and is one of the important method of treatment. If central venous catheters are not cared for it can result for serious bloodstream infections. These complications worsen patient’s health, prolong hospital stay and increase the cost of care. In practice it has been found that, although hospitals have guide lines for care of central venous catheters, it is not been followed. Operational Definitions:-1. Effect:- According to Oxford dictionary effect means as a change produced by an action or cause. In the study effect refers to the change in the nursing practice of Intensive care unit nurses with relation to central venous site care. 2. Education program:-According to Oxford dictionary education means providing knowledge; instructive or informative. Program means a planned series of future events or actions. In the study education program refers to lecture cum demonstration methods that was used to educate nurses about central venous site care. 3. Central venous site care:-According to medical dictionary a central venous device also known as a central venous catheter, is a catheter placed into a large vein in the neck (internal jugular vein), chest (subclavian vein or axillary vein) or groin (femoral vein). Site is the entry point. Care is the serious attention or consideration applied to doing something correctly or to avoid damage or risk. In the study central venous site care refers to aseptic measures taken to prevent infection of the central venous site. 4. Intensive care unit (ICU):- According to Oxford dictionary :-Intensive care unit is a specialized department of hospital which provides medical treatment with constant attention for a seriously ill patient. In the study it refers to Intensive care unit where critical patients are taken care of. 5. Intensive care unit (ICU) nurse:-According to Oxford dictionary nurse is a person trained to care for the sick or infirm, especially in a hospital.In the study it refers to the nurses working in the Intensive care unit in selected hospital with an experience of 6 months and above. Objective:1. The aim of the study was to assess the practices of ICU nurses with relation to Central venous site care before and after the education programme 2. To associate the practice score of ICU nurses with selected demographic variables. Methods: The study was an experimental pre-test post- test design done on 60 ICU nurses. The tools used for the study were demographic information and observational checklist of 63 items divided in pre-performance, performance and post performance phase. An observation before implementing the education programme was made. After education programme four observations were made. Results: Most of the samples i.e. 48 (80%) of the ICU nurses were in the age group of 23-27 years, 8 (13.3%) were in the age group of 18-22 years and the remaining i.e. 4 (6.7) were in the age group of 28-32 years. Majority of the samples i.e. 31 (51.7%) of the ICU nurses were BSc qualified, 24 (40%) were GNM qualified and remaining 5 (8.3%) were Pb.Bsc qualified. Most of the samples, 26 (43.3%) of ICU nurses had an experience of 0-2years, 27 (45%) had an experience of 2-4 years and the remaining 7 (11.7%) had an experience of 4-6 years. Majority of samples i.e. 41 (68.3%) of ICU nurses had attended doctor's class for Central venous site care, 16 (26.7%) of them had knowledge regarding Central venous site care from seminar, 2(3.3%) of them had attended workshop and 1 (1.7%) of them did not receive any training regarding Central venous site care. In terms of other sources of information 26 (43.3%) of ICU nurses had knowledge from doctors, 17 (28.3%) of them had knowledge from internet, 16 (26.7%) of them had knowledge from senior staff and 1 (1.7%) of them had information from books. After the education programme in pre- performance phase 2 nurses removed ring and ornament, 34 of them removed only wrist watch and 24 of them did not remove ring and ornaments from their hands, 13 nurses had short nails, In performance phase, 44 nurses wore face mask, majority of nurses didn’t wear sterile gloves, before site care 48 nurses performed hand hygiene using soap and water and remaining 12 with water only, 6 nurses followed few steps of hand hygiene and 54 did not follow any steps. All nurses were found to perform hand hygiene for less than 1 minute. For site cleaning it was observed that 56 nurses cleaned 2 inches in diameter around the site with isopropyl alcohol and povidone iodine. In post - performance phase 58 nurses used soap and water for washing hands. Those who did not wash hands with soap and water applied sterilium, 10 nurses followed few steps of hand hygiene and 50 did not follow any steps. All of the nurses performed hand hygiene for less than 1 minute and none of the nurses documented the procedure.


2009 ◽  
Vol 18 (6) ◽  
pp. 514-520 ◽  
Author(s):  
Carol Hatler ◽  
Linda Buckwald ◽  
Zoraida Salas-Allison ◽  
Cathleen Murphy-Taylor

Background Catheter-related bloodstream infection remains an important health problem for hospitalized children. Although placement of a central venous catheter is a life-saving intervention for critically ill children, these same central catheters are a potential source of infection. Objectives Few studies that directly address care of central venous catheters for children in intensive care units have been reported. This evaluation was designed to describe the extent of evidence-based practices for care of insertion sites of central venous catheters in the pediatric intensive care unit of an urban tertiary care center. Another goal was to determine the influence of 2 different regimens for dressing changes on rates of catheter-related bloodstream infections and costs. Methods A convenience sample and an exploratory design were used to collect data in 2 phases, including 30 days to establish baseline information and 30 days each during which patients received dressing care for a central venous catheter with a transparent dressing alone and with a transparent dressing plus a chlorhexidine-impregnated dressing. Nurses also participated in a survey of knowledge about infection control practices related to central catheters. Results Few differences were found between the transparent dressing alone and a chlorhexidine-impregnated dressing plus the transparent dressing. A serendipitous finding was the number of times that central catheters were accessed daily. Conclusions The results of this project suggest that infection control efforts may be most appropriately focused on processes rather than on products.


2016 ◽  
Vol 12_2016 ◽  
pp. 114-120
Author(s):  
Lyubasovskaya L.A. Lyubasovskaya ◽  
Priputnevich T.V. Priputnevich ◽  
Nikitina I.V. Nikitina ◽  
Kornienko M.A. Kornienko ◽  
Rodchenko Yu.V. Rodchenko ◽  
...  

2010 ◽  
Vol 31 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Maria Júlia Gonçalves de Mello ◽  
Maria de Fátima Pessoa Militão de Albuquerque ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Heloísa Ramos Lacerda ◽  
Eduardo Jaime Seara Ferraz ◽  
...  

Objective.To evaluate the risk factors that influence time to acquisition of a laboratory-confirmed bloodstream infection (LCBI).Design.Prospective cohort study with an 18-month follow-up.Setting.A 16-bed medical and/or surgical pediatric intensive care unit that cares for patients of the Brazilian Public Health System exclusively.Patients.We included children from 0 to 18 years old who were represented by 875 consecutive admissions to the pediatric intensive care unit from January 1, 2005, through June 30, 2006. The children from all but 5 (0.6%) of the admissions were followed up until discharge or death. The majority (506 [58.2%]) were hospitalized for surgical pathology, and 254 (29.2%) underwent heart surgery.Methods.We used a standardized questionnaire and data collection from daily charts. Information on risk factors was collected before the onset of first LCBI. Survival analysis was performed using the Kaplan-Meier method. The effect of the variables on the risk of LCBI each day was estimated through a Cox model fitting.Results.Fifty-seven children (6.6%) developed an LCBI, 54 (94.7%) of whom made use of a central venous catheter. LCBI incidence was 11.27 episodes/1,000 patient-days and 17.92 episodes/1,000 patient-days when associated with a central venous catheter. Factors associated with time to the first LCBI in the Cox model were age less than 2 years (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.02–3.89), malnutrition (HR, 1.74; 95% CI, 1.01–3.00), use of a central venous catheter (HR, 4.36; 95% CI, 1.30–14.64), use of antibiotics before admission (HR, 0.58; 95% CI, 0.33–0.98), and use of transfused blood products (HR, 0.40; 95% CI, 0.22–0.74).Conclusion.Factors associated with time to acquisition of LCBI were age less than 2 years, weight-for-age z score less than −2, and the use of a central venous catheter. Therefore, intensification of LCBI prevention efforts in patients with these characteristics is fundamental.


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