The relationship between migraine and infant colic: A systematic review and meta-analysis

Cephalalgia ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Amy A Gelfand ◽  
Peter J Goadsby ◽  
I Elaine Allen
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Odds Ratio ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Primary Analysis ◽  
Infant Colic ◽  
The Relationship

Context Infant colic is a common and distressing disorder of early infancy. Its etiology is unknown, making treatment challenging. Several articles have suggested a link to migraine. Objective The objective of this article was to perform a systematic review and, if appropriate, a meta-analysis of the studies on the relationship between infant colic and migraine. Data sources Studies were identified by searching PubMed and ScienceDirect and by hand-searching references and conference proceedings. Study selection For the primary analysis, studies specifically designed to measure the association between colic and migraine were included. For the secondary analysis, studies that collected data on colic and migraine but were designed for another primary research question were also included. Data extraction Data were abstracted from the original studies, through communication with study authors, or both. Two authors independently abstracted data. Main outcomes and measures The main outcome measure was the association between infant colic and migraine using both a fixed-effects model and a more conservative random-effects model. Results Three studies were included in the primary analysis; the odds ratio for the association between migraine and infant colic was 6.5 (4.6–8.9, p < 0.001) for the fixed-effects model and 5.6 (3.3–9.5, p = 0.004) for the random-effects model. In a sensitivity analysis wherein the study with the largest effect size was removed, the odds ratio was 3.6 (95% CI 1.7–7.6, p = 0.001) for both the fixed-effects model and random-effects model. Conclusions In this meta-analysis, infant colic was associated with increased odds of migraine. If infant colic is a migrainous disorder, this would have important implications for treatment. The main limitation of this meta-analysis was the relatively small number of studies included.

scholarly journals Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Hernia ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1253-1261 ◽  
Author(s):  
H. Liu ◽  
S. van Steensel ◽  
M. Gielen ◽  
T. Vercoulen ◽  
J. Melenhorst ◽  
...  
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Fixed Effects ◽  
Animal Studies ◽  
Meta Analysis ◽  
Adhesion Formation ◽  
Mean Difference ◽  
Random Effects Model ◽  
Fixed Effects Model

Abstract Purpose Laparoscopic intraperitoneal onlay mesh in hernia repair can result in adhesions leading to intestinal obstruction and fistulation. The aim of this systematic review is to compare the effects of mesh coatings reducing the tissue-to-mesh adhesion in animal studies. Methods Pubmed and Embase were systematically searched. Animal experiments comparing intraperitoneally placed meshes with coatings were eligible for inclusion. Only studies with comparable follow-up, measurements, and species were included for data pooling and subsequent meta-analysis. Results A total of 131 articles met inclusion criteria, with four studies integrated into one comparison and five studies integrated into another comparison. Compared to uncoated polypropylene (PP) mesh, PP mesh coated with hyaluronic acid/carboxymethyl cellulose (HA/CMC) showed significantly reduced adhesion formation at follow-up of 4 weeks measured with adhesion score of extent (random effects model, mean difference,−  0.96, 95% CI − 1.32 to − 0.61, P < 0.001, I2 = 23%; fixed effects model, mean difference,− 0.94, 95% CI − 1.25 to − 0.63, P < 0.001, I2 = 23%). Compared to PP mesh, polyester mesh coated with collagen (PC mesh) showed no significant difference at follow-up of 4 weeks regarding percentage of adhesion-area on a mesh, using random effects model (mean difference − 11.69, 95% CI − 44.14 to 20.76, P = 0.48, I2 = 92%). However, this result differed using fixed effects model (mean difference − 25.55, 95% CI − 33.70 to − 7.40, P < 0.001, I2 = 92%). Conclusion HA/CMC coating reduces adhesion formation to PP mesh effectively at a follow-up of 4 weeks, while the anti-adhesive properties of PC mesh are inclusive comparing all study data.

Terbinafine is More Effective Than Itraconazole in Treating Toenail Onychomycosis: Results from a Meta-analysis of Randomized Controlled Trials

2003 ◽  
Vol 7 (4) ◽  
pp. 306-311 ◽  
Author(s):  
H. Alexander Krob ◽  
Alan B. Fleischer ◽  
Ralph D'Agostino ◽  
Steven R. Feldman
Keyword(s):  
Odds Ratio ◽  
Fixed Effects ◽  
English Language ◽  
Meta Analysis ◽  
Secondary Analysis ◽  
Fixed Effects Model ◽  
Primary Analysis ◽  
Medline Search ◽  
Mycologic Cure ◽  
The Difference

Background: Toenail onychomycosis is a challenge for clinicians to treat, and this challenge is compounded by conflicting information in the medical literature concerning the efficacy of the two principal agents used in its treatment: Terbinafine and itraconazole. Objective: The purpose of this meta-analysis is to compare the efficacy of terbinafine with that of itraconazole in the treatment of toenail onychomycosis caused by dermatophytes. Methods: A Medline search was performed for all English language publications from 1966 to June 1999 on the use of terbinafine and itraconazole in the treatment of toenail onychomycosis. Included were randomized studies in which subjects received no less than 3 months (or cycles) and no more than 4 months (or cycles) of either terbinafine or itraconazole. Data were abstracted and statistical analyses (random effects model, fixed effects model, and Peto's method) were applied. Results: Thirteen studies were included from the original literature review of 1636 total referenced reports; four studies did not fulfill our inclusion or exclusion criteria. The primary analysis of six studies directly comparing terbinafine to itraconazole resulted in an odds ratio ranging from 1.8 (95% CI = 1.8, 2.8) to 2.9 (1.9, 4.1). The secondary analysis of three studies comparing either itraconazole or terbinafine to placebo estimated an odds ratio of 1.1–1.7. The former shows that terbinafine is 80%–190% more likely to result in mycologic cure than is itraconazole; the latter demonstrates a 10%–70% greater likelihood. The difference between the relative efficacies of terbinafine and itraconazole was highly statistically significant ( p < 0.0001). Conclusion: Meta-analysis of the published worldwide literature finds that terbinafine is significantly more effective than itraconazole at achieving mycologic cure of toenail onychomycosis.

Meta Analysis of Study Habits and Academic Achievement

2021 ◽  
Vol 8 (4) ◽  
pp. 139-145
Author(s):  
M Elango ◽  
G Manimozhi
Keyword(s):  
College Students ◽  
Academic Achievement ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Study Habits ◽  
Random Effects Model ◽  
Inclusion Criteria ◽  
Analytical Review ◽  
The Relationship

A Meta analytical review investigated the study habits and academic achievement of school and college students. In this study the sample consists of twenty seven reviews based on study habits and academic achievement/ performance. The sample of the review based on inclusion criteria such as study habits and academic achievement. The review was collected by following details such as title of the study, Name of the author, Sample of the study, correlation Value and findings of the study. The Meta analysis is on the relationship between study habits and academic achievement. The main aim of the study is to find the fixed effects, random effects model values, Heterogeneity and forest plots. A Meta analysis of research paper was formed the conclusion.

scholarly journals A review and meta-analysis of red and processed meat consumption and breast cancer

2010 ◽  
Vol 23 (2) ◽  
pp. 349-365 ◽  
Author(s):  
Dominik D. Alexander ◽  
Libby M. Morimoto ◽  
Pamela J. Mink ◽  
Colleen A. Cushing
Keyword(s):  
Breast Cancer ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Random Effect ◽  
Red Meat ◽  
Processed Meat ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Meat Intake

The relationship between meat consumption and breast cancer has been the focus of several epidemiological investigations, yet there has been no clear scientific consensus as to whether red or processed meat intake increases the risk of breast cancer. We conducted a comprehensive meta-analysis incorporating data from several recently published prospective studies of red or processed meat intake and breast cancer. In the meta-analysis utilising data from the Pooling Project publication (includes data from eight cohorts) combined with data from nine studies published between 2004 and 2009 and one study published in 1996, the fixed-effect summary relative risk estimate (SRRE) for red meat intake (high v. low) and breast cancer was 1·02 (95 % CI 0·98, 1·07; P value for heterogeneity = 0·001) and the random-effects SRRE was 1·07 (95 % CI 0·98, 1·17). The SRRE for each 100 g increment of red meat was 1·04 (95 % CI 1·00, 1·07), based on a fixed-effects model, and 1·12 (95 % CI 1·03, 1·23) based on a random-effects model. No association was observed for each 100 g increment of red meat among premenopausal women (SRRE 1·01; 95 % CI 0·92, 1·11) but a statistically significant SRRE of 1·22 (95 % CI 1·04, 1·44) was observed among postmenopausal women using a random-effects model. However, the association for postmenopausal women was attenuated and non-significant when using a fixed-effects model (SRRE 1·03; 95 % CI 0·98, 1·08). The fixed- and random-effect SRRE for high (v. low) processed meat intake and breast cancer were 1·00 (95 % CI 0·98, 1·01; P value for heterogeneity = 0·005) and 1·08 (95 % CI 1·01, 1·16), respectively. The fixed- and random-effect SRRE for each 30 g increment of processed meat were 1·03 (95 % CI 1·00, 1·06) and 1·06 (95 % CI 0·99, 1·14), respectively. Overall, weak positive summary associations were observed across all meta-analysis models, with the majority being non-statistically significant. Heterogeneity was evident in most analyses, summary associations were sensitive to the choice of analytical model (fixed v. random effects), and publication bias appeared to have produced slightly elevated summary associations. On the basis of this quantitative assessment, red meat and processed meat intake does not appear to be independently associated with increasing the risk of breast cancer, although further investigations of potential effect modifiers, such as analyses by hormone receptor status, may provide valuable insight to potential patterns of associations.

scholarly journals The effect of cooperative learning on academic achievement: A meta-analysis on the relationship between the study group size and effect size İşbirlikli öğrenmenin başarıya etkisi: Çalışma grubu ile etki büyüklüğü arasındaki ilişkiye dair bir meta analiz çalışması

2017 ◽  
Vol 14 (1) ◽  
pp. 473 ◽  
Author(s):  
Murat Tuncer ◽  
Melih Dikmen
Keyword(s):  
Cooperative Learning ◽  
Random Effects ◽  
Effect Size ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Study Group ◽  
Random Effects Model ◽  
Learning Groups ◽  
The Relationship

The purpose of this study was to determine the effect of cooperative learning on achievement and the relationship between the study group and effect size by means of meta-analysis. Meta-analysis is the method employed in order to statistically analyze the quantitative data collected in independent and multiple studies carried out on similar topics, and to reach a general judgment regarding the results of these studies.  Certain criteria were used in order to decide which researches would be included in the meta-analysis. Based on these criteria, it was decided to include 6 experimental studies in the meta-analysis. As a result, for the six studies, the effect size calculated within 95 % confidence interval has proved to be .518 based on random effects model. When two studies with the largest learning groups are excluded from the research respectively, firstly this effect size increases to .528, later it is calculated as .817 without any model discrimination. When effect size intervals in literature (≥ 0.5: strong, ≥ 0.3: moderate and  ≥ .01 weak) is taken into consideration, the effect of cooperative learning on achievement has been observed as  “Strong”. In addition to this, contrary to some views in literature, it has been seen that large learning groups have higher standard errors and a bigger effect size has been achieved when such studies have been excluded from the analysis. What is more, even the limitation of fixed effects model has disappeared, and the effect size calculated in fixed effects and random effects model has been balanced.  ÖzetBu araştırmanın amacı, işbirlikli öğrenmenin başarı üzerindeki etkisini ve çalışma grubu ile etki büyüklüğü arasındaki ilişkiyi meta-analiz yöntemiyle belirlemektir. Meta-analiz, benzer konularda yapılmış birbirinden bağımsız ve çok sayıda çalışmadan elde edilmiş sayısal verileri istatistiksel olarak analiz etme ve bu çalışmaların sonuçları hakkında genel bir yargıya varma yöntemidir. Hangi araştırmaların meta-analize dâhil edileceğine yönelik seçimlerin yapılmasında belirli ölçütler kullanılmıştır. Bu ölçütlere dayalı olarak 6 adet deneysel araştırmanın meta-analize dâhil edilmesine karar verilmiştir. Sonuç olarak; altı çalışma için %95 güven aralığında hesaplanan etki büyüklüğü rastgele etkiler modeline göre .518’dir. En büyük çalışma grubuna sahip iki araştırma sırasıyla araştırma dışında tutulduğunda bu etki büyüklüğü önce .528’ e çıkmakta, sonrasında ise model ayrımı olmaksızın .817 olarak hesaplanmaktadır. Alan yazındaki etki büyüklüğü aralıkları (≥ 0.5: güçlü, ≥ 0.3: orta düzey ve ≥ .01 zayıf) dikkate alındığında işbirlikli öğrenmenin başarı üzerindeki etkisi “Güçlü” bir etki olarak gözlenmiştir. Ayrıca alan yazındaki bazı görüşlerin aksine büyük çalışma gruplarının standart hatalarının daha yüksek olduğu, bu araştırmaların analiz dışında tutulması ile daha büyük etki büyüklüklerine ulaşıldığı, hatta sabit etki modelinin sınırlılığının bile ortadan kalktığı, sabit etki ve rastgele etki modelinde hesaplanan etki büyüklüğünün eşitlendiği görülmüştür.

scholarly journals Aspirin and death in Covid-19 A systematic review and meta-analysis

2021 ◽  
Author(s):  
Nicholas Moore (NO NEW ASSIGNMENTS) ◽  
Nicolas Thurin ◽  
Pauline Bosco-Lévy ◽  
Patrick Blin ◽  
cecile Droz
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Odds Ratio ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Fixed Effect Model ◽  
Random Effects Model ◽  
Risk Of Death ◽  
Relative Risks

Thrombotic events are common during COVID-19 infection. Aspirin might be beneficial. Objective: Systematic review and meta-analysis of deaths in users and non-users of aspirin. Data sources: Pubmed Medline, Google scholar, Clinicaltrials.gov, Cochrane, to June 8, 2021, Study selection: Studies providing adjusted or matched evaluation of association of exposure to aspirin and death in COVID-19 patients were included. Data extraction and synthesis: Data were used as published, as Odds ratio, hazard ratio or relative risks and 95% CI from which log(OR) and SE were recalculated. These were entered in an inverse variance odds ratios random-effects model, using RevMan 5.4 (the Cochrane Collaboration). Main outcomes and measure: The prespecified outcome studied was death. Results: Nine studies (8 observational, one interventional) included 14989 patients exposed to aspirin and 15857 unexposed. Overall Odds Ratio of death in aspirin exposed patients in a random effects model was 0.63, 95% confidence interval [0.40-0.99], I2 94%. Using a fixed-effect model did not change much the result (0.76 [0.71-0.81], removing the Recovery trial (OR 0.43 [0.38-0.49], I271%, or the two largest studies (0.66 [0.47-0.93], I2 38%) reduced heterogeneity without materially altering the results. The funnel plot showed no evident publication bias Conclusion: this meta-analysis suggests that the use of aspirin may be associated with a lower risk of death in COVID-19. Considering the results of the Recovery Study, it would appear preferable to continue aspirin in patients who have a non-covid indication, but possibly useless to add it if they don’t.

scholarly journals Ear mould for congenital auricular deformities: a protocol for systematic review and meta-analysis

2020 ◽  
Author(s):  
Jincheng Huang ◽  
Kun Zou ◽  
Ping Yuan ◽  
Longhao Zhang ◽  
Min Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Evidence Base ◽  
Small Sample ◽  
Cochrane Library ◽  
Random Effects Model ◽  
High Quality ◽  
Effectiveness Rate

Abstract Background: Congenital auricle deformities (CADs) not only affect the appearance, but may also result in social inferiority or difficulties, influence the hearing and mental health of the children. Although some studies have pointed out CADs have a natural improvement trend, there is still a lack of high-quality research to demonstrate the degree of that. Therefore, related studies agree that early treatment are necessary. Ear mold correction is currently main non-surgical treatment for CADs, but the existing research often involves a small sample size, and the research conclusions are inconsistent. More importantly, there is still no systematic review on ear mold correction for CADs. This study aims to systematically evaluate the effectiveness and safety of ear mold correction for CADs, so as to provide an evidence base for further research.Methods: The study has been designed according to the Preferred Reporting program for Systems Evaluation and Meta-analysis Protocol (PRISMA-P). We will search electronic literature databases of PubMed, Embase, Cochrane Library, Web of science, CBM, CNKI, Wanfang and VIP from their initiative to 1 June 2020 for interventional studies on ear mould for children with CADs. The study selection, data extraction and quality assessment will be performed by two authors. Meta-analysis will be conducted on primary outcome effectiveness rate of physician assessment and secondary outcomes of effectiveness rate of parents’ assessment, effectiveness score, hearing assessment, and adverse reactions using relative ratio or mean difference and their 95% confidence intervals. The heterogeneity of the included studies will be tested using Chi square test and I2, and random-effects model will be used when significant heterogeneity was found, otherwise, fixed-effects model will be used. Sensitivity analysis will be performed using trials with high quality and using alternative [1]models (fixed-effects or random effects model). Publication bias will be tested using funnel plot and Egger’s test. Discussion: This study will be the first to systematically evaluate the effectiveness and safety of ear mold correction for CADs, to provide evidence base for clinical guideline making, clinical decision and future research. Systematic review registration : CRD42020190982.

Clinical presentations and outcomes of Takotsubo syndrome in the setting of subarachnoid hemorrhage: A systematic review and meta-analysis

2016 ◽  
Vol 7 (3) ◽  
pp. 236-245 ◽  
Author(s):  
Akram Y Elgendy ◽  
Islam Y Elgendy ◽  
Hend Mansoor ◽  
Ahmed N Mahmoud
Keyword(s):  
Systematic Review ◽  
Subarachnoid Hemorrhage ◽  
Confidence Interval ◽  
Hospital Mortality ◽  
Random Effects ◽  
Odds Ratio ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Takotsubo Syndrome ◽  
Spontaneous Subarachnoid Hemorrhage

Background: Evidence remains inconsistent regarding the incidence and prognosis of Takotsubo syndrome in the setting of subarachnoid hemorrhage. Thus, we aimed to evaluate the clinical presentation and in-hospital mortality of these patients. Methods: A systematic review of the electronic databases was conducted for studies involving patients with spontaneous subarachnoid hemorrhage and concomitant findings of classical Takotsubo syndrome on transthoracic echocardiogram. A meta-analysis was conducted for the primary outcome of in-hospital mortality using the Mantel–Haenszel method for fixed effects and the DerSimonian and Laird method for random effects, with 95% confidence interval and a p-value <0.05 for statistical significance. Results: Ten studies were retrieved with a total of 157 patients presenting with classical Takotsubo syndrome, representing 4.4% of the subarachnoid hemorrhage total population. The overall incidence of in-hospital mortality was 30% in the patients who developed Takotsubo syndrome. Meta-analysis illustrated a significant increase in the odds of in-hospital mortality for the Takotsubo syndrome patients by fixed effects model (odds ratio 2.6, 95% confidence interval 1.16–5.85, p=0.02, I2=39%), with a trend towards increased risk of in-hospital mortality by random effects model (odds ratio 3.00, 95% confidence interval 0.90–9.77, p = 0.07). Conclusions: The incidence of Takotsubo syndrome in patients with spontaneous subarachnoid hemorrhage seems to be high with a trend towards higher risk of in-hospital mortality in those patients. Thus, patients presenting with subarachnoid hemorrhage might benefit from a comprehensive cardiac evaluation upon presentation for early detection and proper triage of this high-risk population.

scholarly journals Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Manas Kotepui ◽  
Kwuntida Uthaisar Kotepui ◽  
Giovanni De Jesus Milanez ◽  
Frederick Ramirez Masangkay
Keyword(s):  
Systematic Review ◽  
Dengue Virus ◽  
Severe Malaria ◽  
Random Effects ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Prevalence Estimate ◽  
Severe Dengue ◽  
Random Effects Model ◽  
Pooled Prevalence

Abstract Background Co-infection with both Plasmodium and dengue virus (DENV) infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment. The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection, the risk of severe diseases due to co-infection, and to describe the complications of severe malaria and severe dengue among patients with co-infection. Methods Relevant studies published between databases between 12 September 1970 and 22 May 2020 were identified and retrieved through a search of the ISI Web of Science, Scopus, and MEDLINE. The pooled prevalence and 95% confidence interval (CI) of severe malaria among patients with Plasmodium and DENV co-infection was estimated with a random-effects model to take into account the between-study heterogeneity of the included studies. The risks of severe malaria and severe diseases due to co-infection were estimated with the pooled odds ratio (OR) and 95% CI with a random-effects model. Results Of the 5653 articles screened, 13 studies were included in the systematic review and meta-analysis. The results demonstrated that the pooled prevalence estimate of severe malaria among patients with co-infection was 32% (95% CI: 18–47%, I2 = 92.3%). Patients with co-infection had a higher risk of severe diseases than those with DENV mono-infection (odds ratio [OR] = 3.94, 95% CI: 1.96–7.95, I2 = 72%). Patients with co-infection had a higher risk of severe dengue than those with DENV mono-infection (OR = 1.98, 95% CI: 1.08–3.63, I2 = 69%). The most severe complications found in severe dengue were bleeding (39.6%), jaundice (19.8%), and shock/hypotension (17.9%), while the most severe complications found in severe malaria were severe bleeding/bleeding (47.9%), jaundice (32.2%), and impaired consciousness (7.43%). Conclusions The present study found that there was a high prevalence of severe malaria among patients with Plasmodium and DENV co-infection. Physicians in endemic areas where these two diseases overlap should recognize that patients with this co-infection can develop either severe malaria or severe dengue with bleeding complications, but a greater risk of developing severe dengue than severe malaria was noted in patients with this co-infection. Trial registration The protocol of this study was registered at PROSPERO: CRD42020196792.

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