Field testing of ICHD-3 beta criteria of periictal headaches in patients with focal epilepsy – a prospective diary study

Cephalalgia ◽  
2016 ◽  
Vol 38 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Doris Lieba-Samal ◽  
Christian Wöber ◽  
Christoph Waiß ◽  
Theresa Kastiunig ◽  
Matthias Seidl ◽  
...  
Keyword(s):  
Focal Epilepsy ◽  
Field Testing ◽  
Daily Basis ◽  
Diary Study ◽  
Seizure Onset ◽  
Prospective Data ◽  
Single Episode ◽  
Headache Onset ◽  
Testing Data ◽  
Video Eeg

Background To date we are lacking prospective data for field testing of ICHD-3 beta criteria for periictal headache (PIH). Methods Patients with focal epilepsy diagnosed by means of prolonged video-EEG monitoring completed a paper-pencil diary for three months and recorded seizures and headaches on a daily basis. According to ICHD-3 beta, we classified PIH, defined as headache present on a day with at least one seizure, as “7.6 headache related to epileptic seizure”, “7.6.1 hemicrania epileptica” or “7.6.2 postictal headache”. In addition, we compared the ICHD-3 beta diagnoses to the diagnoses according to ICHD-2. Results Thirty two patients completed the diary. Data analysis included 2,668 patient days, 300 seizures and 37 episodes of PIH. Two of these episodes (5.4%) were classified as headache related to seizure, three (8.1%) fulfilled both the criteria of headache related to seizure and hemicrania epileptica and four (10.8%) were postictal headaches. Twenty eight episodes (75.7%) did not fulfil any of the ICHD-3 beta criteria of seizure-related headaches, mostly because headache onset was before seizure onset. Applying ICHD-2 criteria allowed only one single episode of PIH to be classified as postictal headache. Discussion Our study is the first to present prospective field testing data of the ICHD-3 beta criteria for three types of seizure-related headaches. The majority of PIH episodes do not fulfil any of these criteria. One quarter can be classified according to ICHD-3 beta, whereas purely clinical diagnosis of PIH is markedly restricted in ICHD-2 because of mandatory electroencephalographic evidence.

Re: Field testing of ICHD-3 beta criteria of periictal headache in patients with focal epilepsy – a prospective diary study

Cephalalgia ◽  
2018 ◽  
Vol 38 (14) ◽  
pp. 2085-2085
Author(s):  
Marta Zawadzka ◽  
Maria Mazurkiewicz-Bełdzińska ◽  
Marta Szmuda ◽  
Ewa Pilarska
Keyword(s):  
Focal Epilepsy ◽  
Field Testing ◽  
Diary Study

scholarly journals Ictal Asystole in Drug-Resistant Focal Epilepsy: Two Decades of Experience from an Epilepsy Monitoring Unit

2020 ◽  
Vol 10 (7) ◽  
pp. 443
Author(s):  
Sara Casciato ◽  
Pier Paolo Quarato ◽  
Addolorata Mascia ◽  
Alfredo D’Aniello ◽  
Vincenzo Esposito ◽  
...  
Keyword(s):  
Focal Epilepsy ◽  
Rare Event ◽  
Cardiac Risk ◽  
Loss Of Consciousness ◽  
Drug Resistant ◽  
Seizure Onset ◽  
Presurgical Evaluation ◽  
History Of ◽  
Epilepsy Monitoring ◽  
Video Eeg

Background: Ictal asystole (IA) is a rare event observed in people with epilepsy (PwE). Clinical and IA video-electroencephalographic findings may be helpful in screening for high-risk subjects. Methods: From all PwE undergoing video-EEG for presurgical evaluation between 2000 and 2019, we retrospectively selected those with at least one IA (R–R interval of ≥3 s during a seizure). Results: IA was detected in eight out of 1088 (0.73%) subjects (mean age: 30 years; mean epilepsy duration: 9.6 years). Four out of them had a history of atonic falls. No patients had cardiac risk factors or cardiovascular diseases. Seizure onset was temporal (n = 5), temporo-parietal (n = 1) or frontal (n = 2), left-sided and right-sided in five and two patients, respectively. In one case a bilateral temporal independent seizure onset was recorded. IA was recorded in 11 out of 18 seizures. Mean IA duration was 13 s while mean IA latency from seizure onset was 26.7 s. Symptoms related to IA were observed in all seizures. Conclusion: IA is a rare and self-limiting event often observed during video-EG in patients with a history of atonic loss of consciousness and/or tardive falls in the course of a typical seizure.

Neurophysiological seizure-onset predictors of epilepsy surgery outcome: a multivariable analysis

2020 ◽  
Vol 133 (6) ◽  
pp. 1863-1872 ◽  
Author(s):  
Hideaki Tanaka ◽  
Jean Gotman ◽  
Hui Ming Khoo ◽  
André Olivier ◽  
Jeffery Hall ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Focal Epilepsy ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Postoperative Outcome ◽  
Seizure Onset ◽  
Resective Surgery ◽  
Scalp Eeg ◽  
Surgery Outcome ◽  
Intracerebral Eeg

OBJECTIVEThe authors sought to determine which neurophysiological seizure-onset features seen during scalp electroencephalography (EEG) and intracerebral EEG (iEEG) monitoring are predictors of postoperative outcome in a large series of patients with drug-resistant focal epilepsy who underwent resective surgery.METHODSThe authors retrospectively analyzed the records of 75 consecutive patients with focal epilepsy, who first underwent scalp EEG and then iEEG (stereo-EEG) for presurgical assessment and who went on to undergo resective surgery between 2004 and 2015. To determine the independent prognostic factors from the neurophysiological scalp EEG and iEEG seizure-onset information, univariate and standard multivariable logistic regression analyses were used. Since scalp EEG and iEEG data were recorded at different times, the authors matched scalp seizures with intracerebral seizures for each patient using strict criteria.RESULTSA total of 3057 seizures were assessed. Forty-eight percent (36/75) of patients had a favorable outcome (Engel class I–II) after a minimum follow-up of at least 1 year. According to univariate analysis, a localized scalp EEG seizure onset (p < 0.001), a multilobar intracerebral seizure-onset zone (SOZ) (p < 0.001), and an extended SOZ (p = 0.001) were significantly associated with surgical outcome. According to multivariable analysis, the following two independent factors were found: 1) the ability of scalp EEG to localize the seizure onset was a predictor of a favorable postoperative outcome (OR 6.073, 95% CI 2.011–18.339, p = 0.001), and 2) a multilobar SOZ was a predictor of an unfavorable outcome (OR 0.076, 95% CI 0.009–0.663, p = 0.020).CONCLUSIONSThe study findings show that localization at scalp seizure onset and a multilobar SOZ were strong predictors of surgical outcome. These predictors can help to select the better candidates for resective surgery.

The Challenges of Wide Ranging Viscosity Fluids on Liquid Ultrasonic Flowmeters

2006 ◽  
Author(s):  
Jeffrey L. Walters
Keyword(s):  
Elevated Temperature ◽  
Temperature Effects ◽  
Flow Measurement ◽  
Field Testing ◽  
Signal Propagation ◽  
Oil Fields ◽  
Flow Profile ◽  
Fluid Temperature ◽  
Testing Data ◽  
Novel Approaches

Wide ranging viscosities in ultrasonic flow measurement for liquids is a common pipeline scenario. With ever maturing oil fields and the growth in oilsands production, the trend appears to be towards the higher end viscosities and/or novel approaches towards reducing the viscosities for transportation such as heating. The variable viscosities of the fluids provide some unique challenges to ultrasonic flowmeters not only in terms of flow profile modeling, but also in acoustic signal propagation and application to elevated temperature fluids which likewise affect the accuracy or performance of the measurement. The flow profile interrogation techniques will be discussed with an emphasis on a distributed chord model together with the use of a waveguide technology that minimizes acoustic and fluid temperature effects. A combination of R&D, calibration and field testing data will both demonstrate these challenges as well as show the increased performance that results from the application of these approaches.

Estimating concrete strength using field testing data

2014 ◽  
pp. 524-529
Author(s):  
A Colombo ◽  
L Meneghetti ◽  
R Teixeira ◽  
T Bittencourt
Keyword(s):  
Concrete Strength ◽  
Field Testing ◽  
Testing Data

scholarly journals Prone, lateral, or supine positioning at seizure onset determines the postictal body position: A multicenter video-EEG monitoring cohort study

Seizure ◽  
2020 ◽  
Vol 76 ◽  
pp. 173-178 ◽  
Author(s):  
Katharina Mahr ◽  
Marc-Philipp Bergmann ◽  
Lara Kay ◽  
Leona Möller ◽  
Philipp S. Reif ◽  
...  
Keyword(s):  
Cohort Study ◽  
Body Position ◽  
Eeg Monitoring ◽  
Seizure Onset ◽  
Video Eeg

scholarly journals Electroclinical Analysis of Postictal Noserubbing

2000 ◽  
Vol 27 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Richard Wennberg
Keyword(s):  
Temporal Lobe ◽  
Seizure Onset ◽  
Scalp Eeg ◽  
Autonomic Activation ◽  
Ictal Activity ◽  
Primary Generalized Epilepsy ◽  
Generalized Epilepsy ◽  
Temporal Lobe Seizure ◽  
Intracranial Electrodes ◽  
Video Eeg

ABSTRACT:Background:Postictal noserubbing (PIN) has been identified as a good, albeit imperfect, lateralizing and localizing sign in human partial epilepsy, possibly related to ictal autonomic activation.Methods:PIN was studied prospectively in a group of consecutive patients admitted for video-EEG monitoring, with the laterality of noserubbing correlated with electrographic sites of seizure onset, intra- and interhemispheric spread, and sites of seizure termination.Results:PIN was significantly more frequent in temporal than extratemporal epilepsy (p<0.001; 23/41 (56%) patients and 41/197 (21%) seizures in temporal lobe epilepsy compared with 4/34 (12%) patients and 12/167 (7%) seizures in extratemporal epilepsy). The hand used to rub the nose was ipsilateral to the side of seizure onset in 83% of both temporal and extratemporal seizures. Seizures with contralateral PIN correlated with spread to the contralateral temporal lobe on scalp EEG (p<0.04). All extratemporal seizures with PIN showed spread to temporal lobe structures. One patient investigated with intracranial electrodes showed PIN only when ictal activity spread to involve the amygdala: seizures confined to the hippocampus were not associated with PIN. PIN was not observed in 63 nonepileptic events in 17 patients. Unexpectedly, one patient with primary generalized epilepsy showed typical PIN after 1/3 recorded absence seizures.Conclusions:This study confirms PIN as a good indicator of ipsilateral temporal lobe seizure onset. Instances of false lateralization and localization appear to reflect seizure spread to contralateral or ipsilateral temporal lobe structures, respectively. Involvement of the amygdala appears to be of prime importance for induction of PIN.

scholarly journals Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice

2019 ◽  
Vol 28 (17) ◽  
pp. 2952-2964 ◽  
Author(s):  
Christopher J Yuskaitis ◽  
Leigh-Ana Rossitto ◽  
Sarika Gurnani ◽  
Elizabeth Bainbridge ◽  
Annapurna Poduri ◽  
...  
Keyword(s):  
Brain Size ◽  
Focal Epilepsy ◽  
Epileptiform Activity ◽  
Mtor Inhibitors ◽  
Field Testing ◽  
Behavioral Alterations ◽  
Mtor Inhibition ◽  
Protein Levels ◽  
Pathogenic Variants ◽  
Soma Size

Abstract DEPDC5 is now recognized as one of the genes most often implicated in familial/inherited focal epilepsy and brain malformations. Individuals with pathogenic variants in DEPDC5 are at risk for epilepsy, associated neuropsychiatric comorbidities and sudden unexplained death in epilepsy. Depdc5flox/flox-Syn1Cre (Depdc5cc+) neuronal-specific Depdc5 knockout mice exhibit seizures and neuronal mTORC1 hyperactivation. It is not known if Depdc5cc+ mice have a hyperactivity/anxiety phenotype, die early from terminal seizures or whether mTOR inhibitors rescue DEPDC5-related seizures and associated comorbidities. Herein, we report that Depdc5cc+ mice were hyperactive in open-field testing but did not display anxiety-like behaviors on the elevated-plus maze. Unlike many other mTOR-related models, Depdc5cc+ mice had minimal epileptiform activity and rare seizures prior to seizure-induced death, as confirmed by video-EEG monitoring. Treatment with the mTORC1 inhibitor rapamycin starting after 3 weeks of age significantly prolonged the survival of Depdc5cc+ mice and partially rescued the behavioral hyperactivity. Rapamycin decreased the enlarged brain size of Depdc5cc+ mice with corresponding decrease in neuronal soma size. Loss of Depdc5 led to a decrease in the other GATOR1 protein levels (NPRL2 and NPRL3). Rapamycin failed to rescue GATOR1 protein levels but rather rescued downstream mTORC1 hyperactivity as measured by phosphorylation of S6. Collectively, our data provide the first evidence of behavioral alterations in mice with Depdc5 loss and support mTOR inhibition as a rational therapeutic strategy for DEPDC5-related epilepsy in humans.

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