Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19
Keyword(s):
Clinical publications show consistently that headache is a common symptom in the coronavirus disease of 2019 (COVID-19). Several studies specifically investigated headache symptomatology and associated features in patients with COVID-19. The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.
2019 ◽
1970 ◽
Vol 28
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pp. 26-27
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1983 ◽
Vol 41
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pp. 788-789
1982 ◽
Vol 40
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pp. 44-45
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1995 ◽
Vol 53
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pp. 958-959
1996 ◽
Vol 26
(9)
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pp. 1092-1097
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