The periodic syndrome in pediatric migraine sufferers

Cephalalgia ◽  
1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 91-93 ◽  
Author(s):  
Giovanni Lanzi ◽  
Umberto Balottin ◽  
Elisa Fazzi ◽  
Francesca Burgio Rosano

The present study takes into consideration some of the symptoms comprised in the Periodic Syndrome. These include motion-sickness, cyclic vomiting, recurrent abdominal pains and paroxysmal vertigo. Particular consideration is given to the chronological and long-term aspects of such symptoms. Among 247 migraine sufferers in the pediatric age group, 173 subjects who complained of at least one of these symptoms were chosen. Results of the data show that motion-sickness is the first to manifest itself (mean age of onset 2 years), and has a tendency to continue into the headache period; cyclic vomiting appears in the third year of life, and terminates sooner than the other symptoms. At the mean age of five years abdominal pains start, and at seven, paroxysmal vertigo. Headache is the final symptom in this group. The sequentiality of such disturbances in each subject leads to the assumption that the Periodic Syndrome is the expression of a single disorder which manifests itself polymorphously as a rather precisely timed process. Parmi les symptômes qui constituent le syndrome periodique de l'enfance, nous prenons en considération, dans cette étude, le mal d'auto, les vomissements cycliques, les douleurs abdominales récurrentes et les vertiges paroxystiques; nous en considérons particulièrement les aspects chronologiques et l'évolution à long terme. Il s'agit de 173 sujets, choisis parmi 247 migraineux en âge évolutif, qui ont présenté au moins un des symptômes que nous avons étudiés. L'analyse des données révèle que le mal d'auto est le premier qui se manifeste (au cours de la 2èMe année) et qu'il tend à continuer au-delà du moment où apparait la céphalée; au cours de la 3eMe année apparaissent les vomissements cycliques cui cessent plus tôt que les autres troubles; par la suite, vers l'âge de 5 ans, commencent les douleurs abdominales et vers 7 ans les vertiges paroxystiques; enfin apparait la céphalée. L'observation de la séquence de ces troubles chez les différents sujets nous amène à penser que le Syndrome périodique est l'expression d'un potentiel pathogène unique qui s'exprime à travers des aspects polymorphes selon une séquence temporelle assez précise. Fra i sintomi che costituiscono la Sindrome periodica dell'infanzia, nel presente studio prendiamo in esame il mal d'auto, i vomiti ciclici, i dolori addominali ricorrenti e le vertigini parossistiche, considerandone in particolare gli aspetti cronologici e di evoluzione a lungo termine. Si tratta di 173 soggetti, scelti fra 247 emicranici in età evolutiva che hanno lamentato almeno uno dei sintomi da noi considerati. Dall'analisi dei dati emerge che il mal d'auto si manifesta per primo (Il anno di vita) e tende a protrarsi oltre il momento d'insorgenza della cefalea; nel III anno compaiono i vomiti ciclici che si estinguono più precocemente degli altri disturbi; successivamente, verso i 5 anni, iniziano i dolori addominali e verso i 7 anni le vertigini parossistiche. Infine compare la cefalea. L'osservazione della sequenzialità di tali disturbi nei singoli soggetti ci fa pensare che la Sindrome periodica sia l'espressione di un unico potenziale patogeno che si estrinseca in aspetti polimorfi con una sequenza temporale abbastanza precisa.

Cephalalgia ◽  
1983 ◽  
Vol 3 (2) ◽  
pp. 115-118 ◽  
Author(s):  
G. Lanzi ◽  
U. Balottin ◽  
A. Ottolini ◽  
F. Rosano Burgio ◽  
E. Fazzi ◽  
...  

A retrospective method was used to estimate the incidence of recurring motion-sickness, cyclic vomiting and abdominal pain considered as different manifestations of a so-called periodic syndrome in 100 migraine sufferers, 100 epileptics and 100 control subjects in the pediatric age group. Such recurrent symptoms are significantly more frequent in those suffering from migraine than in the other two groups. Examination of subgroups of patients affected by particular forms of migraine (classical and common) and of epilepsy (generalized seizures, simple partial seizures, complex partial seizures) contributed little new to our understanding of the nature of periodic syndrome. It is concluded that the above symptoms of periodic syndrome should generally be considered as manifestations of a migrainous rather than of an epileptic disorder.


1979 ◽  
Vol 65 (3) ◽  
pp. 389-399 ◽  
Author(s):  
Fabrizio Lombardi ◽  
Marco Gasparini ◽  
Cristina Gianni ◽  
Raffaele Petrillo ◽  
John David Tesoro-Tess ◽  
...  

All the pertinent radiographs of 83 patients with histologically proven Ewing's sarcoma were reviewed. Forty-nine patients were in the pediatric age group, and 34 were adults. The mean age, the symptoms and time from symptoms to diagnosis were evaluated in the 2 groups. The site of primary involvement was in 54 % the long bones, 35 % the flat bones, 8 % the small bones and 3 % extraosseous. For the primary site we considered the diagnostic results of the standard radiographic investigations and in some cases the usefulness of angiography, xeroradiography and telethermography. At presentation we also evaluated the possible diffusion of the disease with standard radiographic surveys (chest and skeletal, including limbs) and with foot lymphography in selected cases. In this way, 57 patients (69 %) were considered to have localized disease. In this group, we also considered the value of the periodic radiographic follow-up, which enabled us to disclose the appearance of metastases (chest 64 %, bone 54 %, lymph nodes 11 %) in 28 cases (49 %). Finally, we made a comparison of the different radiologic and epidemiologic findings between children and adults.


2018 ◽  
Vol 08 (02) ◽  
pp. 096-099
Author(s):  
Jigar Chauhan ◽  
James Hertzog ◽  
Shirley Viteri ◽  
Nicholas Slamon

AbstractWe report a fatal tracheoinnominate artery fistula (TIF) in a 13-year-old female patient with long-term tracheostomy tube dependence due to chronic respiratory failure. Thirteen years after placement of her tracheostomy tube, the patient experienced two separate episodes of sentinel bleeding prior to a fatal hemorrhagic event. Diagnostic evaluation after the sentinel events was mostly nonconclusive. This case highlights the risk of TIF in pediatric age group, even years after initial tracheostomy tube placement, and the need for a high index of suspicion for TIF when children present with unexplained tracheal bleeding.


2016 ◽  
Vol 21 (2) ◽  
pp. 228-242 ◽  
Author(s):  
Cornelia Lahmann ◽  
Rasmus Steinkrauss ◽  
Monika S Schmid

Aims and objectives/purpose/research questions: The present study investigated which factors would best predict second-language (L2) fluency in a group of long-term L2 speakers of different English varieties with German as their first language. Design/methodology/approach: L2 fluency was conceptualized in terms of utterance fluency for which speed, breakdown and repair fluency were distinguished. Data and analysis: Multiple measures of utterance fluency were applied to four-minute speech fragments originating from 102 spontaneous oral interviews. Interviewees’ ages of onset ranged from 7 to 17, whereas their ages at interview ranged from 57 to 87. Multifactorial analyses yielded significant effects of age at interview. Findings/conclusions: Whereas the mean number of silent pauses and repairs increases, syllable duration decreases. This leaves room for interpretation as to why we find an aging effect. Overall, the evidence suggests that the usual, L2 acquisition-specific factors, such as age of onset or length of residence, are no longer at play to predict L2 fluency. Originality and significance/implications: To this point L2 fluency in very advanced, highly proficient L2 speakers has received little attention. The results point to the need for more research into highly proficient L2 users.


Author(s):  
Abdulrahman F. AlBloushi ◽  
Saad H. AlEnezi ◽  
Adi Mohammed Al Owaifeer ◽  
Omar S. Al-Hadlaq ◽  
Priscilla W. Gikandi ◽  
...  

2013 ◽  
Vol 04 (03) ◽  
pp. 071-074 ◽  
Author(s):  
Mayank Jain ◽  
Chandrashekhar Waghmare ◽  
Sagar Adkar ◽  
Shohini Sircar ◽  
Ajay K. Jain

AbstractButton battery ingestion is an emerging hazard. In this retrospective study, we report six cases of lithium button battery ingestion in pediatric age group (mean age 2.8 years). Three button batteries were removed from stomach and three from esophagus. Esophageal site was associated with significant local injury, and one button battery was impacted in the esophagus, requiring rigid esophagoscopy for removal. Small battery size, used batteries, and early removal (<12 h after ingestion) were associated with lesser mucosal injury. No long-term complications were noted. Our study emphasizes that early diagnosis and urgent removal of ingested button battery are the only measures which prevent complications.


2009 ◽  
Vol 1 ◽  
pp. CMT.S1959
Author(s):  
Usha Krishnan ◽  
Leif Lovig

This is a review article that discusses the role of sildenafil in pediatric pulmonary hypertension. The etiopathogenesis as well as prognosis for pediatric pulmonary hypertension (PH) differs from adults. The basic tenets of targeted management of PH however are similar. Sildenafil and other phosphodiesterase-5 inhibitors play a very important role in PH management, especially because of the ease of administration, low adverse effect profile, better tolerability and relative cost effectiveness. This is especially vital in situations where inhaled nitric oxide is not easily available and fills an important therapeutic gap. Large double blinded and controlled studies studying the effects of sildenafil in pediatric PH are not available. Equally vital would be long term efficacy studies, which should be initiated through large multicenter trials, to study the beneficial as well as long term side effects of this medication in the pediatric age group.


2014 ◽  
Vol 14 (4) ◽  
pp. 425-433 ◽  
Author(s):  
Shobhan Vachhrajani ◽  
Anish N. Sen ◽  
Krishna Satyan ◽  
Abhaya V. Kulkarni ◽  
Sherri B. Birchansky ◽  
...  

Object Upper cervical spine injuries in the pediatric age group have been recognized as extremely unstable from ligamentous disruption and as potentially lethal. Few measurement norms have been published for the pediatric upper cervical spine to help diagnose this pathological state. Instead, adult measurement techniques and results are usually applied inappropriately to children. The authors propose using high-resolution reconstructed CT scans to define a range of normal for a collection of selected upper cervical spine measurements in the pediatric age group. Methods Sagittal and coronal reformatted images were obtained from thin axial CT scans obtained in 42 children (< 18 years) in a 2-month period. There were 25 boys and 17 girls. The mean age was 100.9 months (range 1–214 months). Six CT scans were obtained for nontrauma indications, and 36 were obtained as part of a trauma protocol and later cleared for cervical spine injury. Six straightforward and direct linear distances—basion-dental interval (BDI); atlantodental interval (ADI); posterior atlantodental interval (PADI); right and left lateral mass interval (LMI); right and left craniocervical interval (CCI); and prevertebral soft-tissue thickness at C-2—that minimized logistical and technical distortions were measured and recorded. Statistical analysis including interobserver agreement, age stratification, and sex differences was performed for each of the 6 measurements. Results The mean ADI was 2.25 ± 0.24 mm (± SD), the mean PADI was 18.3 ± 0.07 mm, the mean BDI was 7.28 ± 0.10 mm, and the mean prevertebral soft tissue width at C-2 was 4.45 ± 0.43 mm. The overall mean CCI was 2.38 ± 0.44 mm, and the overall mean LMI was 2.91 ± 0.49 mm. Linear regression analysis demonstrated statistically significant age effects for PADI (increased 0.02 mm/month), BDI (decreased 0.02 mm/month), and CCI (decreased 0.01 mm/month). Similarly significant effects were found for sex; females demonstrated on average a smaller CCI by 0.26 mm and a smaller PADI by 2.12 mm. Moderate to high interrater reliability was demonstrated across all parameters. Conclusions Age-dependent and age-independent normal CT measurements of the upper cervical spine will help to differentiate physiological and pathological states in children. The BDI appears to change significantly with age but not sex; on the other hand, the LMI and ADI appear to be age-independent measures. This preliminary study suggests acceptable levels of interrater reliability, and further expanded study will aim to validate these measurements to produce a profile of normal upper cervical spine measurements in children.


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