Total Body Fluid Volume Determination Based on Urea Kinetics in Hemofiltration as an Index of Basal Body Weight in Uremic Patients

1986 ◽  
Vol 9 (3) ◽  
pp. 159-162 ◽  
Author(s):  
G. Kimura ◽  
M. Satani ◽  
S. Kojima ◽  
F. Saito ◽  
Y. Kawano ◽  
...  
Keyword(s):  
Body Weight ◽  
Basal Body ◽  
Body Fluid ◽  
Fluid Volume ◽  
Artificial Kidney ◽  
Volume Determination ◽  
Urea Kinetics ◽  
Body Fluid Volume ◽  
Uremic Patients ◽  
Total Body

Assuming that urea is distributed uniformly within the total body water, urea-space or total body fluid volume was determined in six uremic patients based on urea kinetics in hemofiltration. The total body fluid volume before hemofiltration was 36.0 ± 3.6 L (61.8 ± 2.6% BW) and after hemofiltration 32.5 ± 3.4 L (59.3 ± 2.8% BW), suggesting that the total body fluid volume was nearly normalized by hemofiltration. It is concluded that urea-space, easily measurable based on urea kinetics during hemofiltration, is useful in evaluating the fluid balance in patients undergoing artificial kidney therapy.

Segment-specific resistivity improves body fluid volume estimates from bioimpedance spectroscopy in hemodialysis patients

2006 ◽  
Vol 100 (2) ◽  
pp. 717-724 ◽  
Author(s):  
F. Zhu ◽  
M. K. Kuhlmann ◽  
G. A. Kaysen ◽  
S. Sarkar ◽  
C. Kaitwatcharachai ◽  
...  
Keyword(s):  
Gold Standard ◽  
Total Body Water ◽  
Body Fluid ◽  
Hemodialysis Patients ◽  
Fluid Volume ◽  
Whole Body ◽  
Bioimpedance Spectroscopy ◽  
Specific Resistivity ◽  
Body Fluid Volume ◽  
Total Body

Discrepancies in body fluid estimates between segmental bioimpedance spectroscopy (SBIS) and gold-standard methods may be due to the use of a uniform value of tissue resistivity to compute extracellular fluid volume (ECV) and intracellular fluid volume (ICV). Discrepancies may also arise from the exclusion of fluid volumes of hands, feet, neck, and head from measurements due to electrode positions. The aim of this study was to define the specific resistivity of various body segments and to use those values for computation of ECV and ICV along with a correction for unmeasured fluid volumes. Twenty-nine maintenance hemodialysis patients (16 men) underwent body composition analysis including whole body MRI, whole body potassium (40K) content, deuterium, and sodium bromide dilution, and segmental and wrist-to-ankle bioimpedance spectroscopy, all performed on the same day before a hemodialysis. Segment-specific resistivity was determined from segmental fat-free mass (FFM; by MRI), hydration status of FFM (by deuterium and sodium bromide), tissue resistance (by SBIS), and segment length. Segmental FFM was higher and extracellular hydration of FFM was lower in men compared with women. Segment-specific resistivity values for arm, trunk, and leg all differed from the uniform resistivity used in traditional SBIS algorithms. Estimates for whole body ECV, ICV, and total body water from SBIS using segmental instead of uniform resistivity values and after adjustment for unmeasured fluid volumes of the body did not differ significantly from gold-standard measures. The uniform tissue resistivity values used in traditional SBIS algorithms result in underestimation of ECV, ICV, and total body water. Use of segmental resistivity values combined with adjustment for body volumes that are neglected by traditional SBIS technique significantly improves estimations of body fluid volume in hemodialysis patients.

MO656CORRELATION BETWEEN CHANGES IN THE BODY FLUID VOLUME CALCULATED BY THE URIC ACID KINETIC MODEL AND CHANGES IN THE BODY WEIGHT*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Shigeru Nakai ◽  
Kiyoshi Ozawa ◽  
Kazuhiko Shibata ◽  
Takahiro Shinzato
Keyword(s):  
Body Weight ◽  
Uric Acid ◽  
Kinetic Model ◽  
Weight Change ◽  
Body Fluid ◽  
Fluid Volume ◽  
The Body ◽  
Body Weight Change ◽  
Before And After ◽  
Body Fluid Volume

Abstract Background and Aims Uric acid (UA) is a solute unable to cross the cell membranes in general tissues by any of simple diffusion, facilitated diffusion or active transport. These facts imply that UA distribution volume (UDiV) equals to the extracellular fluid volume (ECFV). We have developed a method for calculating UDiV from serum uric acid levels before and after hemodialysis based on a uric acid kinetic model (Shinzato T, Int J Artif Organs 2020). Urea is evenly distributed throughout the body fluids. Therefore, the total body fluid volume (TBFV) can be calculated by using the same method as the calculation of UDiV for the serum urea level. The remaining body fluid volume, which is TBFV minus UDiV, is considered to reflect the intracellular fluid volume (ICFV). In this study, we clarified the relationship between the amount of change over time in UDiV and ICFV calculated by the uric acid kinetic model and the amount of change over time in the actual body weight of hemodialysis patients. Method Subjects were 1,101 patients with chronic maintenance hemodialysis. UDiV and ICFV before and after dialysis were calculated for two time points, December 2019 and June 2020. Results The amount of change in UDiV per body during the dialysis session showed a very good correlation with the amount of body weight change during the same dialysis (UDiV change = 0.950 x body weight change - 0.158, R-square 0.90, p < 0.0001). The amount of change in ICFV during the 6 months from December 2019 to June 2020 showed a good correlation with the amount of change in post-dialysis body weight during the same period (ICFV change = 0.270 x post-dialysis body weight change + 0. 240, R-square 0.21, p <0.0001). Conclusion These results suggest that the body fluid volume calculated by the uric acid kinetic model has high accuracy.

Body fluid volume determination via body composition spectroscopy in health and disease

2006 ◽  
Vol 27 (9) ◽  
pp. 921-933 ◽  
Author(s):  
Ulrich M Moissl ◽  
Peter Wabel ◽  
Paul W Chamney ◽  
Ingvar Bosaeus ◽  
Nathan W Levin ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fluid ◽  
Fluid Volume ◽  
Volume Determination ◽  
Body Fluid Volume ◽  
Health And Disease

scholarly journals Bioimpedance spectroscopy for the estimation of body fluid volumes in mice

2010 ◽  
Vol 299 (1) ◽  
pp. F280-F283 ◽  
Author(s):  
M. E. Chapman ◽  
L. Hu ◽  
C. F. Plato ◽  
D. E. Kohan
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Body Fluid ◽  
Accurate Method ◽  
Repeated Measurements ◽  
Fluid Volume ◽  
Bioimpedance Spectroscopy ◽  
Body Fluid Volume ◽  
Similar Body ◽  
Resistance Coefficients

Conventional indicator dilution techniques for measuring body fluid volume are laborious, expensive, and highly invasive. Bioimpedance spectroscopy (BIS) may be a useful alternative due to being rapid, minimally invasive, and allowing repeated measurements. BIS has not been reported in mice; hence we examined how well BIS estimates body fluid volume in mice. Using C57/Bl6 mice, the BIS system demonstrated <5% intermouse variation in total body water (TBW) and extracellular (ECFV) and intracellular fluid volume (ICFV) between animals of similar body weight. TBW, ECFV, and ICFV differed between heavier male and lighter female mice; however, the ratio of TBW, ECFV, and ICFV to body weight did not differ between mice and corresponded closely to values in the literature. Furthermore, repeat measurements over 1 wk demonstrated <5% intramouse variation. Default resistance coefficients used by the BIS system, defined for rats, produced body composition values for TBW that exceeded body weight in mice. Therefore, body composition was measured in mice using a range of resistance coefficients. Resistance values at 10% of those defined for rats provided TBW, ECFV, and ICFV ratios to body weight that were similar to those obtained by conventional isotope dilution. Further evaluation of the sensitivity of the BIS system was determined by its ability to detect volume changes after saline infusion; saline provided the predicted changes in compartmental fluid volumes. In summary, BIS is a noninvasive and accurate method for the estimation of body composition in mice. The ability to perform serial measurements will be a useful tool for future studies.

scholarly journals Control of total body fluid amount in uremic patients using the concept of lean body mass

1984 ◽  
Vol 17 (1) ◽  
pp. 63-65
Author(s):  
Akihiro Yamashita ◽  
Kazuhiro Ando ◽  
Katsuo Yoshimoto ◽  
Hideo Hidai ◽  
Kohji Shiraishi ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Body Fluid ◽  
Uremic Patients ◽  
Total Body

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1988 ◽  
Vol 13 ◽  
pp. S62-S68
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

scholarly journals Dehydration increases the density of C receptors for ANF on rat glomerular membranes

1990 ◽  
Vol 258 (4) ◽  
pp. R1084-R1088 ◽  
Author(s):  
M. C. Kollenda ◽  
A. M. Vollmar ◽  
G. A. McEnroe ◽  
A. L. Gerbes
Keyword(s):  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Body Fluid ◽  
Fluid Volume ◽  
Control Group ◽  
Receptor Density ◽  
Lower Plasma ◽  
Short Term ◽  
Salt Loading ◽  
Body Fluid Volume

The present study determined the presence of two types of binding sites for atrial natriuretic factor (ANF), the B and C receptor, on rat glomerular membranes. The effect of short-term salt loading and dehydration on these two receptor populations was investigated consecutively. Salt-loaded rats did not show significant changes in plasma ANF concentrations or in the number of ANF binding sites. Water-deprived rats presented significantly lower plasma ANF concentrations (22.0 +/- 1.9 vs. 34.4 +/- 3.8 fmol/ml, P less than 0.01) and an increase in total receptor density (1,860 +/- 398 vs. 987 +/- 143 fmol/mg protein) as compared with the control group. Differentiation of both receptor populations showed that it was the C receptors that accounted for this increase (1,772 +/- 369 vs. 901 +/- 151 fmol/mg protein, P less than 0.05), whereas B-receptor density was unchanged (89 +/- 31 vs. 87 +/- 44 fmol/mg protein). These data suggest that C receptors for ANF are affected by changes of body fluid volume.

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