Novel treatment for glance necrosis due to priapism; presentation and review of literature

2021 ◽  
pp. 039156032110382
Author(s):  
Abbas Soleimani ◽  
Mohammad Javad Nazarpour ◽  
Hamed Akhavizadegan
Keyword(s):  
Treatment Outcome ◽  
Normal Saline ◽  
Open Surgery ◽  
Necrotic Area ◽  
Case Description ◽  
Review Of Literature ◽  
Novel Treatment ◽  
Heparinized Saline ◽  
Appropriate Treatment

Introduction: Glans necrosis in association with priapism is very rare and its appropriate treatment is not known. There is a secondary cause in most cases. Case description: We treated a 65-year-old man with priapism and glans necrosis using a closed shunt (Winter), continuous penile irrigation with normal saline, and heparin for 48 h and waited for the necrotic area to resolve spontaneously. The treatment outcome was much better compared to previous cases in whom open surgery, irrigation with pure normal saline, and/or resection of the necrotic area were performed. Conclusion: In cases with priapism and glans ischemia, we recommend treating the condition with continuous covernose irrigation with heparinized saline and avoiding open surgery.

scholarly journals Primary Malignant Melanoma of the Vagina without Metastasis: A Rare Case and Review of Literature

2020 ◽  
Author(s):  
Wilson Bizimana ◽  
Gloria Akimana ◽  
Arthur Semedo Insumbo ◽  
Hounayda Jerguigue ◽  
Rachida Latib ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Patient Survival ◽  
Rare Condition ◽  
Primary Malignant Melanoma ◽  
Imaging Features ◽  
Review Of Literature ◽  
Pelvic Magnetic Resonance Imaging ◽  
Improve Patient Survival ◽  
Appropriate Treatment ◽  
Improve Patient

AbstractMalignant melanoma of vagina is a rare condition. Its histogenesis has been debated and the positive diagnosis is based on immunohistochemistry. Pelvic magnetic resonance imaging remains the gold standard for assessing locoregional extension status and post-treatment surveillance of melanoma of vagina. The observation concerned a 53-year-old woman with no specific history who presented a primary malignant melanoma of vagina without secondary locations. To date, the case is the second one reported in the literature. Early diagnosis of the malignant melanoma of vagina may improve patient survival because late diagnoses are punctuated by poor prognosis. We have presented epidemiological with etiopathogenic characteristics and described all imaging features to stage the tumor and to conduct the appropriate treatment.

scholarly journals Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Ho Hong ◽  
M. T. Jeena ◽  
Ok-Hee Kim ◽  
Kee-Hwan Kim ◽  
Ho Joong Choi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antioxidant Enzymes ◽  
Self Assembly ◽  
Carcinoma Cells ◽  
Anticancer Activities ◽  
Anticancer Effects ◽  
Novel Treatment ◽  
Mitochondrial Ros ◽  
Appropriate Treatment ◽  
Apoptotic Effect

AbstractCurrently, there is no appropriate treatment option for patients with sorafenib-resistant hepatocellular carcinoma (HCC). Meanwhile, pronounced anticancer activities of newly-developed mitochondria-accumulating self-assembly peptides (Mito-FF) have been demonstrated. This study intended to determine the anticancer effects of Mito-FF against sorafenib-resistant Huh7 (Huh7-R) cells. Compared to sorafenib, Mito-FF led to the generation of relatively higher amounts of mitochondrial reactive oxygen species (ROS) as well as the greater reduction in the expression of antioxidant enzymes (P < 0.05). Mito-FF was found to significantly promote cell apoptosis while inhibiting cell proliferation of Huh7-R cells. Mito-FF also reduces the expression of antioxidant enzymes while significantly increasing mitochondrial ROS in Huh7-R cells. The pro-apoptotic effect of Mito-FFs for Huh7-R cells is possibly caused by their up-regulation of mitochondrial ROS, which is caused by the destruction of the mitochondria of HCC cells.

scholarly journals Hyperprogression in a Patient With Hepatocellular Cancer Treated With Atezolizumab and Bevacizumab: A Case Report and Review of Literature

2021 ◽  
Vol 9 ◽  
pp. 232470962199220
Author(s):  
Balraj Singh ◽  
Parminder Kaur ◽  
Michael Maroules
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Disease Burden ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Hepatocellular Cancer ◽  
Past Medical History ◽  
Review Of Literature ◽  
Novel Treatment ◽  
Accelerated Growth

Immune checkpoint inhibitors have emerged as a novel treatment in a wide variety of malignancies; however, it is associated with a distinctive array of side effects known as immune-related adverse events. Hyperprogression is defined as an accelerated growth of disease burden in patients treated with immunotherapy. Limited literature is available regarding hyperprogression in hepatocellular cancer. We report a case of a 36-year-old male with no past medical history who presented with nausea, vomiting, and abdominal pain and was diagnosed with unresectable hepatocellular cancer and thereby started on atezolizumab and bevacizumab. The patient got only 1 cycle of treatment and unfortunately had hyperprogression of disease.

scholarly journals Hybrid nerve sheath tumor in the orbit: A case report and review of literature

2019 ◽  
Vol 10 ◽  
pp. 250 ◽  
Author(s):  
Sukwoo Hong ◽  
Takayuki Hara
Keyword(s):  
Case Report ◽  
Nerve Sheath Tumor ◽  
Modified Rankin Scale ◽  
Case Description ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Tumor Mass ◽  
First Report ◽  
Nerve Sheath Tumors ◽  
Nerve Sheath

Background: In neurosurgical practice, we rarely encounter hybrid nerve sheath tumors (HNST) in the orbit. We recently had a patient of this rare tumor. We believe that this is the first report where we resected the tumor transcranially. Case Description: A 54-year-old male presented with the left proptosis and intraconal tumor of 43 mm. We performed fronto-orbital craniotomy to resect the tumor mass. His proptosis completely improved and discharged home with a modified Rankin Scale of 1. Conclusion: Transcranial resection of orbital HNST was a safe and effective way to treat. Since we do not have much data regarding this rare tumor, we need to accumulate more cases.

Nebulized Vasopressin for the Control of Hematemesis and Hemoptysis in a Child With Recurrent, Refractory Stage III Burkitt Lymphoma

2019 ◽  
Vol 35 (2) ◽  
pp. 71-74
Author(s):  
Jennifer D. Dulin ◽  
Patrick J. Coyne
Keyword(s):  
Side Effects ◽  
Small Bowel ◽  
Blood Loss ◽  
End Of Life ◽  
Normal Saline ◽  
Burkitt Lymphoma ◽  
Palliative Chemotherapy ◽  
Case Description ◽  
Goals Of Care ◽  
Intravenous Access

Background: Bleeding occurs with some regularity at the end of life. Patients often endure fatigue, weakness, pain, dyspnea and anxiety. These symptoms are magnified in visually apparent bleeds. Management can be particularly challenging as we attempt to balance therapies with goals of care. Children are at risk for such complications and symptoms; providers must ensure comfort for both the patient and family. Case Description: A 7-year-old male with recurrent, refractory Burkitt lymphoma was frequently hospitalized for palliative chemotherapy and disease complications. On his final admission, he experienced gross hemoptysis and hematemesis: he was short of breath, fatigued and anxious due to his blood loss. His and his family’s angst were heightened by “seeing” his bleed. Potential, especially invasive, treatments were limited by our goals to promote comfort, limit interventions, maintain alertness, poor intravenous access and a small bowel obstruction. Nebulized vasopressin, 10 units in 4ml of normal saline given over 10 minutes provided JC with needed relief. His bleeding remitted and he tolerated its administration. Conclusion: There are many treatments for hemorrhage; however, given the challenges of goals of care, administration, side-effects and tolerability, further investigation into nebulized vasopressin as a potential therapy for hemoptysis and hematemesis at the end-of-life is warranted.

Side-Effects of Rinsing Fluids on the Rat Femoral Artery

1997 ◽  
Vol 22 (5) ◽  
pp. 568-573 ◽  
Author(s):  
O. DELAERE ◽  
U. MENNEN ◽  
W. VAN HEERDEN ◽  
E. RAUBENHEIMER ◽  
A. M. WIESE ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Femoral Artery ◽  
Normal Saline ◽  
Vessel Wall ◽  
Experimental Conditions ◽  
Femoral Arteries ◽  
Heparinized Saline ◽  
Significant Difference ◽  
Ringer’S Lactate

Rinsing rat femoral arteries with various fluids in experimental conditions similar to those in clinical practice was found to have deleterious effects on the intimal and medial layers of the vessels. No statistically significant difference was found between the effects of Ringer’s lactate and normal saline. Heparinized saline produced significantly less damage to the medial layer and less platelet cell deposition. Lignocaine 2% was found to be extremely damaging to the whole vessel wall, and highly thrombogenic. Nevertheless, all the arteries in each group remained patent 4 days after rinsing.

Efficacy of Normal Saline Versus Heparinized Saline Solution for Locking Catheters of Totally Implantable Long-Term Central Vascular Access Devices in Adult Cancer Patients

2012 ◽  
Vol 35 (4) ◽  
pp. E35-E42 ◽  
Author(s):  
Sergio Bertoglio ◽  
Nicola Solari ◽  
Paolo Meszaros ◽  
Francesca Vassallo ◽  
Maura Bonvento ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Vascular Access ◽  
Normal Saline ◽  
Saline Solution ◽  
Vascular Access Devices ◽  
Heparinized Saline

scholarly journals A Giant Dumbbell Shaped Vesico-Prostatic Urethral Calculus: A Case Report and Review of Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Vinod Kumar Prabhuswamy ◽  
Rahul Tiwari ◽  
Ramakrishnan Krishnamoorthy
Keyword(s):  
Open Surgery ◽  
Lower Urinary Tract ◽  
Surgical Removal ◽  
Review Of Literature ◽  
Urinary Tract Symptoms ◽  
The Status ◽  
Urethral Calculus ◽  
Transvesical Approach ◽  
Membranous Part ◽  
Lower Urinary

Calculi in the urethra are an uncommon entity. Giant calculi in prostatic urethra are extremely rare. The decision about treatment strategy of calculi depends upon the size, shape, and position of the calculus and the status of the urethra. If the stone is large and immovable, it may be extracted via the perineal or the suprapubic approach. In most of the previous reported cases, giant calculi were extracted via the transvesical approach and external urethrotomy. A 38-year-old male patient presented with complaints of lower urinary tract symptoms. Further investigations showed a giant urethral calculus secondary to stricture of bulbo-membranous part of the urethra. Surgical removal of calculus was done via transvesical approach. Two calculi were found and extracted. One was a huge dumbbell calculus and the other was a smaller round calculus. This case was reported because of the rare size and the dumbbell nature of the stone. Giant urethral calculi are better managed by open surgery.

scholarly journals A rare case of intramedullary schwannoma at conus medullaris: A case report with review of literature

2020 ◽  
Vol 11 ◽  
pp. 454
Author(s):  
Rahul Varshney ◽  
Pranjal Bharadwaj ◽  
Ajay Choudhary ◽  
Purnima Paliwal ◽  
Kaviraj Kaushik
Keyword(s):  
Urinary Incontinence ◽  
Rare Case ◽  
Conus Medullaris ◽  
Thoracolumbar Junction ◽  
Case Description ◽  
Total Excision ◽  
Review Of Literature ◽  
Sphincter Function ◽  
Intramedullary Schwannoma ◽  
Primary Spine

Background: Intramedullary spinal schwannomas constitute only 0.3% of primary spine tumors. We could identify only 13 such cases involving the conus that were not associated with neurofibromatosis (NF). Here, we report a 70-year-old male without NF who was found to have a paraparesis due to a schwannoma of the thoracolumbar junction/conus (D11-L2). Case Description: A 70-year-old male presented with an L1-level paraparesis with urinary incontinence. The magnetic resonance showed an intramedullary mass of 85 × 10 mm extending from D11 to L2; it demonstrated significant patchy enhancement. The patient underwent a D12 and L1 laminectomy with gross total excision of the mass that proved to be a schwannoma. Three months postoperatively, he was able to ambulate with support, and regained sphincter function. Conclusion: Intramedullary schwannomas involving the conus/thoracolumbar junction are rare, and can be successfully excised resulting in good outcomes.

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