Liposarcoma Dell'epididimo: Descrizione di un Caso e Revisione Della Letteratura

1994 ◽  
Vol 61 (1_suppl) ◽  
pp. 134-136
Author(s):  
B. Monica ◽  
P. Salsi ◽  
R. Minari ◽  
A. Barbieri ◽  
F. Poletti
Keyword(s):  
Surgical Management ◽  
Distant Metastases ◽  
Clinical Staging ◽  
Radical Orchiectomy ◽  
Local Involvement

We report a case of epididymis liposarcoma in a 76-year-old man, who about 6 months before had noted an oval, painless, well delimitable, non-light transmitting right hemiscrotal swelling apparently separated from the didymus. There was no inguinal lymphoadenopathy. A radical orchiectomy was performed. On the basis of clinical staging, that displayed neither local involvement, nor distant metastases, we believe, in accordance with literature, this surgical management can achieve definitive cure; other resolutions will be undertaken in case of relapse.

scholarly journals Epidemiology of uveal melanoma in Brazil

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Evandro Lucena ◽  
Daniel Cohen Goldemberg ◽  
Luiz Claudio Santos Thuler ◽  
Andreia Cristina de Melo
Keyword(s):  
Sex Education ◽  
Uveal Melanoma ◽  
Healthcare Access ◽  
Regional Distribution ◽  
Age Distribution ◽  
Treatment Strategies ◽  
Distant Metastases ◽  
Cancer Registries ◽  
Clinical Staging ◽  
Continuous Variables

Abstract Purpose To report the prevalence of uveal melanoma in a Hospital database in Brazil over the period of 16 years (2000 to 2016). Design Descriptive epidemiological study evaluating the Brazilian Hospital Based Cancer Registries. Participants/methods Uveal melanomas were identified based on ICD-O-3 codes C69.3 [choroid], C69.4 [ciliary body and iris], and C69.2 [retina]) derived from the Integrator Registry database. Kolmogorov–Smirnov Test was used for evaluation of normality of data, t-test and Chi square were used for categorical and continuous variables respectively using SPSS Software. Main outcome measures Age, sex, education, regional distribution, clinical staging at the diagnosis, time from diagnosis to treatment (≤ 60 days versus > 60 days) and first-course therapy (surgery, chemotherapy, radiotherapy or a combination of such). Results There were 2166 cases of uveal melanoma representing 5.4% of all cases of melanoma. Histological confirmation of uveal melanoma was available in all cases. Higher prevalence of 1139 cases (52.6%) in women than 1027 cases (47.4%) in men was observed. Age distribution revealed 1411 cases (65.1%) in the group between 41 and 69 years old. A total of 429 (19.8%) patients were classified as initial disease and 334 (15.4%) as advanced (regional or distant metastases). Staging as initial disease was more frequent (113–24.8%) in patients with > 8 school years than in patients with < 8 school years (179–17.6%) reflecting disparities in healthcare access between those two populations. No difference was noticed in terms of diagnosis, staging and treatment after the Brazilian “60 days law” (Federal Law 12.732/12) came into effect in 2013 regulating the maximum period that a patient with cancer has to wait until start the treatment. Conclusion Epidemiological data is critical for planning early treatment strategies and allocating medical resources. This study intended to understand the characteristics of uveal melanoma in Brazil.

Factors affecting survival for floor-of-mouth carcinoma

2000 ◽  
Vol 122 (4) ◽  
pp. 495-498 ◽  
Author(s):  
Douglas W. Klotch ◽  
Carlos Muro-Cacho ◽  
T. J. Gal
Keyword(s):  
Surgical Management ◽  
Statistical Significance ◽  
Retrospective Chart Review ◽  
Lymphatic Invasion ◽  
Clinical Staging ◽  
Factors Affecting ◽  
Therapeutic Modalities ◽  
Floor Of Mouth ◽  
Extranodal Extension ◽  
Neck Disease

OBJECTIVES The treatment of extensive floor-of-mouth carcinoma has remained a challenging problem for head and neck surgeons. We have reviewed our experience in the surgical management of floor-of-mouth cancer in an attempt to identify factors influencing survival. METHODS A total of 144 patients with cancer involving the floor of the mouth were treated between March 1988 and November 1995. A retrospective chart review was conducted that captured information including clinical staging, therapeutic modalities, pathologic findings, and patient follow-up. Factors affecting survival were assessed by non-parametric analysis and analysis of variance. RESULTS There was no statistical significance for the effects of vascular invasion ( P = 0.4019), lymphatic invasion ( P = 0.3430), bone invasion ( P = 0.1548), or positive margins ( P = 0.1113) on survival. Extranodal extension and recurrent disease were strongly suggestive of influencing survival but were not statistically significant ( P = 0.0650 and P = 0.0504, respectively). Nodal disease significantly affected survival ( P = 0.0138) but did not affect recurrence ( P = 0.451). CONCLUSION: Mean survival for this cohort was 30.6 months. Positive node status significantly affected mean overall survival in this series, whereas extracapsular disease did not. These data suggest that aggressive surgical management of neck disease is mandated to maximize survival.

Surgical Management of Distant Metastases

2006 ◽  
Vol 15 (2) ◽  
pp. 385-398 ◽  
Author(s):  
David W. Ollila ◽  
Abigail S. Caudle
Keyword(s):  
Surgical Management ◽  
Distant Metastases

scholarly journals The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer

2014 ◽  
Vol 2 (3) ◽  
pp. 125-131
Author(s):  
Joshua Luck
Keyword(s):  
Bladder Cancer ◽  
Surgical Management ◽  
Disease Free Survival ◽  
Standard Of Care ◽  
Clinical Staging ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
History Of ◽  
Muscle Invasive

The management of muscle invasive bladder cancer represents an unresolved clinical challenge. Invasive urothelial carcinomas are associated with high mortality rates and early metastatic disease. Radical cystectomy is a recognized standard of care, although disease-free survival outcomes remain suboptimal. The limitations of pre-operative clinical staging, as well as the complex natural history of the disease, precludes the introduction of simple management protocols. To what degree chemotherapy and radiotherapy may be useful in the surgical management of invasive bladder cancer remains contentious. This literature review critically examines the benefits, risks and difficulties of each approach, with an emphasis on individually tailored therapy.

scholarly journals A Case of Definitive Therapy for Localised Prostate Cancer: Report of a Urological Nightmare

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Andreas Sommerhuber ◽  
Verena Traxlmayr ◽  
Wolfgang Loidl
Keyword(s):  
External Beam Radiotherapy ◽  
Treatment Options ◽  
Neuroendocrine Differentiation ◽  
Distant Metastases ◽  
Clinical Staging ◽  
Infravesical Obstruction ◽  
Hormonal Manipulation ◽  
Local Progression ◽  
Definitive Therapy ◽  
Adenocarcinoma Of The Prostate

Radical prostatectomy, external beam radiotherapy and permanent brachytherapy are the most common treatment options for nonmetastatic localised adenocarcinoma of the prostate (PCa). Accurate pretherapeutic clinical staging is difficult, the number of positive cores after biopsy does not imperatively represent the extension of the cancer. Furthermore postoperative upgrading in Gleason score is frequently observed. Even in a localised setting a certain amount of patients with organ-confined PCa will develop biochemical progression. In case of a rise in PSA level after radiation the majority of patients will receive androgen deprivation therapy what must be considered as palliative. If local or systemic progressive disease is associated with evolving neuroendocrine differentiation hormonal manipulation is increasingly ineffective; radiotherapy and systemic chemotherapy with a platinum agent and etoposide are recommended. In case of local progression complications such as pelvic pain, gross haematuria, infravesical obstruction and rectal invasion with obstruction and consecutive ileus can possibly occur. In this situation palliative radical surgery is a therapy option especially in the absence of distant metastases. A case with local and later systemic progression after permanent brachytherapy is presented here.

scholarly journals Malignant Mesothelioma of the Tunica Vaginalis Testis: Outcomes Following Surgical Management Beyond Radical Orchiectomy

Urology ◽  
2017 ◽  
Vol 107 ◽  
pp. 166-170 ◽  
Author(s):  
Pedro Recabal ◽  
Barak Rosenzweig ◽  
Wassim M. Bazzi ◽  
Brett S. Carver ◽  
Joel Sheinfeld
Keyword(s):  
Surgical Management ◽  
Malignant Mesothelioma ◽  
Tunica Vaginalis ◽  
Tunica Vaginalis Testis ◽  
Radical Orchiectomy

scholarly journals Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Anand Mohapatra ◽  
Aaron M. Potretzke ◽  
Brent A. Knight ◽  
Min Han ◽  
Robert S. Figenshau
Keyword(s):  
Granulosa Cell ◽  
Clinical Presentation ◽  
Granulosa Cell Tumor ◽  
Distant Metastases ◽  
Retroperitoneal Lymph Node Dissection ◽  
Retroperitoneal Lymph Node ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Radical Orchiectomy ◽  
Sex Cord Stromal Tumors

Granulosa cell tumors (GCTs) of the testis are rare sex cord-stromal tumors that are present in both juvenile and adult subtypes. While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options that have been employed in previous cases include retroperitoneal lymph node dissection (RPLND), radiation, chemotherapy, or a combination thereof. We describe the case of a 57-year-old man who presented with a painless left testicular mass and painful gynecomastia. Serum tumor markers (alpha fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase) and computed tomography of the chest and abdomen were negative. The patient underwent left radical orchiectomy. Immunohistochemical staining was consistent with a testicular GCT. He underwent a left-template laparoscopic RPLND which revealed 2/19 positive lymph nodes. Final pathological stage was IIA. He remains free of disease 32 months after surgery.

scholarly journals Updated Principles of Surgical Management of Pancreatic Neuroendocrine Tumours (pNETs): What Every Surgeon Needs to Know

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5969
Author(s):  
Charles de Ponthaud ◽  
Fabrice Menegaux ◽  
Sébastien Gaujoux
Keyword(s):  
Surgical Management ◽  
Neuroendocrine Tumours ◽  
Pancreatic Neoplasm ◽  
Distant Metastases ◽  
High Volume ◽  
Invasive Approach ◽  
Pancreatic Tumour ◽  
Functional Consequences ◽  
Pancreatic Neuroendocrine Tumours ◽  
Selection Of

Pancreatic neuroendocrine tumours (pNETs) represent 1 to 2% of all pancreatic neoplasm with an increasing incidence. They have a varied clinical, biological and radiological presentation, depending on whether they are sporadic or genetic in origin, whether they are functional or non-functional, and whether there is a single or multiple lesions. These pNETs are often diagnosed at an advanced stage with locoregional lymph nodes invasion or distant metastases. In most cases, the gold standard curative treatment is surgical resection of the pancreatic tumour, but the postoperative complications and functional consequences are not negligible. Thus, these patients should be managed in specialised high-volume centres with multidisciplinary discussion involving surgeons, oncologists, radiologists and pathologists. Innovative managements such as “watch and wait” strategies, parenchymal sparing surgery and minimally invasive approach are emerging. The correct use of all these therapeutic options requires a good selection of patients but also a constant update of knowledge. The aim of this work is to update the surgical management of pNETs and to highlight key elements in view of the recent literature.

P037 Surgical management of renal cell carcinoma (RCC) with venous invasion in patients with distant metastases

2012 ◽  
Vol 11 (5) ◽  
pp. 202-203
Author(s):  
M.I. Davydov ◽  
V.B. Matveev ◽  
K.M. Figurin ◽  
M.I. Volkova ◽  
V.A. Chernyaev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Surgical Management ◽  
Renal Cell ◽  
Venous Invasion ◽  
Distant Metastases

Evolving Principles of Surgical Management and Prognostic Factors for Outcome in Renal Cell Carcinoma

2006 ◽  
Vol 24 (35) ◽  
pp. 5565-5575 ◽  
Author(s):  
John S. Lam ◽  
Alberto Breda ◽  
Arie S. Belldegrun ◽  
Robert A. Figlin
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Surgical Management ◽  
Renal Cell ◽  
Surgical Techniques ◽  
Renal Tumors ◽  
Clinical Staging ◽  
Prognostic Information ◽  
Cross Sectional

The generally accepted principles for the surgical management of renal cell carcinoma (RCC) were first described more than 30 years ago. Since then, much has changed in the understanding of the basic biology and genetics of kidney cancer. Improvements in cross-sectional imaging has allowed for more accurate preoperative clinical staging of renal tumors, and the necessity of completing all the components of the radical nephrectomy have been questioned. Surgical techniques have also evolved, and technology has advanced to make possible new methods of managing renal tumors. The TNM staging system is currently the most extensively used system to provide prognostic information for RCC. However, data published in the last few years has led to significant controversies as to whether further revisions are needed and whether improvements can be made with the introduction of new, more accurate and predictive prognostic factors. Furthermore, the recent discovery of molecular tumor markers are expected to revolutionize the staging of RCC and lead to the development of new therapies based on molecular targeting. This review will examine the evolving principles in the surgical management of RCC as well as provide an update on current staging modalities and prognostic factors.

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