Studio delle alterazioni metaboliche dei pazienti sottoposti a neovescica ortotopica di sostituzione e reservoir urinario

1994 ◽  
Vol 61 (1_suppl) ◽  
pp. 229-234 ◽  
Author(s):  
C. Simeone ◽  
D. Zani ◽  
G. Pezzotti ◽  
T. Zanotelli ◽  
S. Cosciani Cunico
Keyword(s):  
Metabolic Acidosis ◽  
Intestinal Mucosa ◽  
Metabolic Effects ◽  
Augmentation Cystoplasty ◽  
Compensatory Response ◽  
Common Effect ◽  
Bladder Substitution

Urine exposed to intestinal mucosa changes its composition, as some substances are absorbed and others are secreted. Metabolic effects in 57 patients who underwent bladder substitution, augmentation cystoplasty or continent reservoir, were reviewed in our institute. Hyperchloraemic metabolic acidosis was the most common effect. Even if the consequences are often limited by the body's compensatory response, the risk of long-term complications is always present and a close metabolic follow-up is mandatory.

Augmentation Cystoplasty: Long-Term follow up Of 112 Cases

2008 ◽  
Vol 4 ◽  
pp. S41-S42
Author(s):  
Fatih Çanakli ◽  
Serdar Yüksel ◽  
Hasan Serkan Dogan ◽  
Hasan Serkan Dogan ◽  
Fazil Tuncay Aki ◽  
...  
Keyword(s):  
Augmentation Cystoplasty ◽  
Long Term Follow Up

Outcome of Sigmoid Compared to Ileal Orthotopic Bladder Substitution in Terms of Micturition and Defecation Parameters in an 8-Year Long-Term Follow-Up

2009 ◽  
Vol 83 (3) ◽  
pp. 277-280 ◽  
Author(s):  
Patrick Honeck ◽  
Christian Bolenz ◽  
Gunnar Wendt-Nordahl ◽  
Peter Alken ◽  
Maurice S. Michel
Keyword(s):  
Long Term Follow Up ◽  
Bladder Substitution

Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency

2016 ◽  
Vol 29 (4) ◽  
Author(s):  
Mehmet Gündüz ◽  
Özlem Ünal ◽  
Sumru Kavurt ◽  
Emrecan Türk ◽  
Neslihan Önenli Mungan
Keyword(s):  
Metabolic Acidosis ◽  
Sodium Hydrogen Carbonate ◽  
Enzyme Analysis ◽  
Glutathione Synthetase ◽  
Laboratory Findings ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Long Term Follow Up

AbstractGlutathione synthetase (GS) deficiency is a rare inborn error of glutathione (GSH) metabolism manifested by severe metabolic acidosis, hemolytic anemia, neurological problems and massive excretion of pyroglutamic acid (5-oxoproline) in the urine. The disorder has mild, moderate, and severe clinical variants. We aimed to report clinical and laboratory findings of four patients, effect of sodium hydrogen carbonate treatment and long-term follow up of three patients.Urine organic acid analysis was performed with gas chromatography-mass spectrometry. Molecular genetic analysis was performed in three patients, mutation was found in two of them. Enzyme analysis was performed in one patient. Clinical and laboratory findings of four patients were evaluated.One patient died at 4 months old, one patient’s growth and development are normal, two patients have developed intellectual disability and seizures in the long term follow up period. Three patients benefited from sodium hydrogen carbonate treatment.The clinical picture varies from patient to patient, so it is difficult to predict the prognosis and the effectiveness of treatment protocols. We reported long term follow up of four patients and demonstrated that sodium hydrogen carbonate is effective for treatment of chronic metabolic acidosis in GS deficieny.

scholarly journals The role of hyperventilation: hypocapnia in the pathomechanism of panic disorder

2007 ◽  
Vol 29 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Andras Sikter ◽  
Ede Frecska ◽  
Ivan Mario Braun ◽  
Xenia Gonda ◽  
Zoltan Rihmer
Keyword(s):  
Metabolic Acidosis ◽  
Panic Disorder ◽  
Catecholamine Release ◽  
Panic Attacks ◽  
Respiratory Pattern ◽  
Protective Mechanism ◽  
Sudden Increase ◽  
Compensatory Response ◽  
Hypocapnic Alkalosis

OBJECTIVE: The authors present a profile of panic disorder based on and generalized from the effects of acute and chronic hyperventilation that are characteristic of the respiratory panic disorder subtype. The review presented attempts to integrate three premises: hyperventilation is a physiological response to hypercapnia; hyperventilation can induce panic attacks; chronic hyperventilation is a protective mechanism against panic attacks. METHOD: A selective review of the literature was made using the Medline database. Reports of the interrelationships among panic disorder, hyperventilation, acidosis, and alkalosis, as well as catecholamine release and sensitivity, were selected. The findings were structured into an integrated model. DISCUSSION: The panic attacks experienced by individuals with panic disorder develop on the basis of metabolic acidosis, which is a compensatory response to chronic hyperventilation. The attacks are triggered by a sudden increase in (pCO2) when the latent (metabolic) acidosis manifests as hypercapnic acidosis. The acidotic condition induces catecholamine release. Sympathicotonia cannot arise during the hypercapnic phase, since low pH decreases catecholamine sensitivity. Catecholamines can provoke panic when hyperventilation causes the hypercapnia to switch to hypocapnic alkalosis (overcompensation) and catecholamine sensitivity begins to increase. CONCLUSION: Therapeutic approaches should address long-term regulation of the respiratory pattern and elimination of metabolic acidosis.

scholarly journals PD43-11 THE LONG-TERM OUTCOMES OF AUGMENTATION CYSTOPLASTY AT 20-30 YEARS FOLLOW UP

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Anastasia Frost ◽  
Simon Bugeja ◽  
Mariya Dragova ◽  
Daniela Andrich ◽  
Anthony Mundy
Keyword(s):  
Augmentation Cystoplasty ◽  
Long Term Outcomes

153: Long Term Follow-Up of Patients Following Augmentation Cystoplasty

2006 ◽  
Vol 175 (4S) ◽  
pp. 49-49
Author(s):  
Patrick Shenot ◽  
Adam Tyson ◽  
Craig B. Slotoroff
Keyword(s):  
Augmentation Cystoplasty ◽  
Long Term Follow Up

Long term continence rates in patients undergoing augmentation cystoplasty with 30 year follow up

2021 ◽  
Vol 79 ◽  
pp. S38
Author(s):  
A. Frost ◽  
J. Olphert ◽  
N. Jeffery ◽  
M. Dragova ◽  
A. Lomiteng ◽  
...  
Keyword(s):  
Augmentation Cystoplasty

Assessment of Long Term Metabolic Effects of Atypical Antipsychotics in Schizophrenia Patients

2019 ◽  
Vol 26 (3) ◽  
pp. 267-277 ◽  
Author(s):  
Nicolae-Marius Cason ◽  
Petru Aurel Babeş ◽  
Enikő Béres ◽  
Katalin Babeş
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Chronic Schizophrenia ◽  
Metabolic Effects ◽  
Base Line ◽  
The Metabolic Syndrome ◽  
Independent Risk Factors

Abstract Background and aims. Patients with schizophrenia have a shorter life expectancy than normal population partially due to the metabolic side effects of antipsychotic treatment. The aim of this study is to evaluate the long-term evolution of the metabolic syndrome in chronic schizophrenia patients on fixed second generation antipsychotics (SGA). Material and method. The components of metabolic syndrome were evaluated repeatedly in a minimum 6 months and maximum 2 years follow-up period. The presence of metabolic syndrome (MetS) and metabolic risk scores (cMetS) according to National Cholesterol Education Program Adult Treatment Panel III were calculated and compared in time. In the prevalence, incidence and normalization logistic regression studies included all the known risk factors together with the follow-up period. Finally, all these rates were compared depending on the type of SGA. Results. Only cMetS, waist circumference and diastolic blood pressure presented significant increase in the follow-up period which was in average 385.5 days. The prevalence of MetS at base-line was 39.4%, which increased to 48.5% after the follow-up period. The calculated incidence of 30% was associated with a 23.1% rate of normalization. Logistic regression studies revealed as independent risk factors the age and base-line cMetS/weight for incidence and for normalization. In the aripiprazole group the normalization rate exceeded the incidence rate (33.3% vs 20%). Conclusions. The results emphasize the highly dynamic character of the metabolic syndrome even in chronic schizophrenia patients with fixed SGA regimen. The normalization of MetS is a possibility that should not ignored. The age and weight continue to remain independent risk factors, thus close monitoring in elderly and strict weight control plan are necessary. Aripiprazole showed better safety profile, but more extensive studies are required for definitive conclusions.

scholarly journals Long COVID-19 Syndrome: A Comprehensive Review of Its Effect on Various Organ Systems and Recommendation on Rehabilitation Plans

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 966
Author(s):  
Zhipeng Yan ◽  
Ming Yang ◽  
Ching-Lung Lai
Keyword(s):  
Primary Infection ◽  
Healthcare Workers ◽  
Organ Damage ◽  
Metabolic Effects ◽  
Systemic Effects ◽  
Organ Systems ◽  
Number Of Patients ◽  
Initial Symptoms

The majority of people infected with SARS-CoV-2 fully recovered within a few weeks. However, a considerable number of patients of different ages still suffer from long-lasting problems similar to the multi-organ damage in its acute phase of infection, or experience symptoms continuously for a longer term after the recovery. The severity of the primary infection seems not to be associated with the possibility and severity of long-term symptoms. Various unresolved symptoms have been reported in COVID-19 survivors months after hospital discharge. Long COVID-19 Syndrome refers to survivors 4 months after initial symptoms onset. It is important to understand the systemic effects of Long COVID-19 Syndrome, its presentations, and the need for rehabilitations to restore functional recovery in survivors. Government, healthcare workers, and survivor groups should collaborate to establish a self-sustaining system to facilitate follow-up and rehabilitations, with prioritization of resources to more severely Long COVID-19 Syndrome survivors. This review looks into the systemic effects of Long COVID-19 Syndrome in various aspects: respiratory, cardiovascular, hematological, renal, gastrointestinal, neurological, and metabolic effects of Long COVID-19 Syndromes. Recommendations for follow-up and rehabilitations details have been explored to cope with the tremendous Long COVID-19 Syndrome patients.

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