Management and Triage of Women with Human Papillomavirus Infection in Follow-up for Low-Grade Cervical Disease: Association of HPV-DNA and RNA-Based Methods

2007 ◽  
Vol 20 (2) ◽  
pp. 341-347 ◽  
Author(s):  
S. Rosini ◽  
R. Zappacosta ◽  
G. Di Bonaventura ◽  
D. Caraceni ◽  
D. Pilla ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Disease Association ◽  
Low Grade ◽  
Hpv Dna ◽  
Dna And Rna ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cervical Disease

Local cytokine therapy in a comprehensive treatment of HPV-associated cervical diseases

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Patimat R Abakarova ◽  
Vera N Prilepskaya ◽  
Elena A Mezhevitinova ◽  
Andrei E Donnikov
Keyword(s):  
Human Papillomavirus ◽  
Radio Wave ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Comprehensive Treatment ◽  
Low Grade ◽  
Local Inflammation ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

Aim. To analyze an efficacy of monotherapy and combined therapy (an immunomodulator + radio wave ablation) in patients with low-grade squamous intraepithelial lesion (L-SIL) caused by HPV infection. Materials and methods. The study included 210 women with human papillomavirus infection which was identified using real-time polymerase chain reaction (PCR). All women underwent a comprehensive examination which included history taking, general and gynecological examinations, extended colposcopy and a bacterioscopy of Gram-stained vaginal smears. A quantitative determination of vaginal microflora composition by PCR was carried out. Conclusion on either inflammatory response is present or absent was made on the basis of an inflammation index magnitude: with a value of more than 60% indicating a presence of local inflammation signs. Based on cervical cytology data a group consisting of 79 women who had L-SIL was formed. Patients were divided into 2 subgroups: the main one (n=45) who received combined treatment with radio wave ablation + an immunomodulator and a control one (n=34) who received only local monodestruction of L-SIL foci followed etiotropic treatment. Results and discussion. An efficacy of combined treatment which included radio wave ablation + an immunomodulator was higher compared to monodestruction only - 86.7% vs 64,7% respectively. It is important that by 6th month of follow-up a relapse of human papillomavirus infection occurred in 4.5 and 23.5% of patients of main and control groups respectively. Local inflammation was assessed as positive with an inflammation index of more than 60%. So after 6 months of follow-up this indicator decreased by 83.3 and 54.2% in the 1st and 2nd groups respectively. Clinical manifestations of an inflammatory process in the cervix was observed only with CIN recurrence. In addition, combined therapy provides a higher rate of human papillomavirus elimination at 6 months and faster cervix epithelization followed treatment by ablation.

scholarly journals Suggestive changes of human papillomavirus infection in students at a public university

2021 ◽  
Vol 106 (106(812)) ◽  
pp. 30-37
Author(s):  
J. Núñez ◽  
A. Romano ◽  
M. Medina ◽  
R.A. Cardozo
Keyword(s):  
Human Papillomavirus ◽  
Standard Procedure ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Health Sciences ◽  
Low Grade ◽  
Global Public Health ◽  
Cross Sectional ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

Introduction: Sexually transmitted infections are a global public health problem. Objective: to analyze the results of cervical-vaginal cytologies with suggestive changes of Human Papillomavirus infection in students of the Faculty of Health Sciences of the University of Carabobo, who was attended the gynecology consultation of the Ambulatory “Nuestra Seora de la Luz” in 2016-2017. Method: descriptive, cross-sectional study. Population consisting of all students of the Faculty of Health Sciences who was attended the Gynecology Consultation at the Ambulatory mentioned above during the period under study. Non-probabilistic and intentional sample, inclusion criteria: age, acceptance to belong to the study by signing informed consent, and not suffering pathologies at the time of sampling or being pregnant. The collection of the information was carried out through the interview and subsequent cytological examination, and the cytological study was expressed according to the BETHESDA 2001 system. The sample for cervical-vaginal cytology was performed according to standard procedure. Results: average age of 21.43-2.47 years, 40.2% belonging to the low mean stratum, 9.2% smokers, sexarquia in ages 18-20 years in 52.6% of cases, 70% with 2 or 3 pairs. As for the cytology result, 9.2% was suggestive for Human Papillomavirus infection, while with the BETHESDA 2001 System, in the epithelial cell abnormalities section, 63.6% showed low-grade Human Papillomavirus -associated. Conclusions: in the sample, the suggestive changes to Human Papillomavirus infection, was higher than that found in other countries, whereas most interviewees presented risk factors to contract it, so emphasis on education is recommended conducting annual cytology to the at-risk population.

A population-based five-year follow-up study of cervical human papillomavirus infection

2000 ◽  
Vol 183 (3) ◽  
pp. 561-567 ◽  
Author(s):  
Kristina Elfgren ◽  
Mina Kalantari ◽  
Birgitta Moberger ◽  
Björn Hagmar ◽  
Joakim Dillner
Keyword(s):  
Human Papillomavirus ◽  
Population Based ◽  
Follow Up Study ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cervical Human Papillomavirus

scholarly journals Usefulness of Hybrid Capture HPV DNA Assay as a Diagnostic Tool for Human Papillomavirus Infection

1998 ◽  
Vol 72 (11) ◽  
pp. 1219-1224 ◽  
Author(s):  
Takeyoshi KUBOTA ◽  
Hisashi ISHIKAZU ◽  
Masaaki SUZUKI ◽  
Sakae UTSUNO ◽  
Jun IGARI
Keyword(s):  
Human Papillomavirus ◽  
Diagnostic Tool ◽  
Hybrid Capture ◽  
Hpv Dna ◽  
Dna Assay ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

scholarly journals Clearance and persistence of the human papillomavirus infection among Cameroonian women

2018 ◽  
Vol 14 ◽  
pp. 174550651880564 ◽  
Author(s):  
Mohamed Akaaboune ◽  
Bruno Kenfack ◽  
Manuela Viviano ◽  
Liliane Temogne ◽  
Rosa Catarino ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Clinical Characteristics ◽  
Point Of Care ◽  
Viral Persistence ◽  
Sampling Techniques ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Hpv Clearance ◽  
The Relationship

Objective: Persistent infection with human papillomavirus is the prerequisite for the development of cervical precancerous and cancerous lesions. The aim of this study was to determine the time-to-viral clearance in a population of human papillomavirus–infected Cameroonian women and to examine the possible predictors of viral persistence. Methods: We conducted a prospective cohort study based on a population of human papillomavirus–positive women having previously been recruited in a self-human papillomavirus-based cervical cancer screening campaign, who were invited for a control visit at 6 and 12 months. We determined human papillomavirus clearance using self-sampling (Self-HPV) and physician-sampling (Dr-HPV), which were analyzed with a point-of-care assay (GeneXpert® IV; Cepheid, Sunnyvale, CA, USA). Logistic regression was performed to assess the relationship between sociodemographic and clinical characteristics with HPV clearance according to the two sampling techniques. Results: A total of 187 participants were included in the study. At the 12 months follow-up, 79.5% (n = 104) and 65.3% (n = 86) had cleared their human papillomavirus infection according to Dr-HPV and self-HPV, respectively (p = 0.001). Only parity (>5 children) was statistically associated with viral persistence (p = 0.033). According to Dr-HPV, clearance of women treated with thermoablation at 12 months was of 84.1% versus 70.2% for non-treated women (p = 0.075). Conclusion: The human papillomavirus clearing rates found in our study are close to those found in other studies worldwide. Parity was significantly associated with human papillomavirus persistence. Larger, prospective studies are needed to confirm our results.

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