scholarly journals Long-Term Anti-TNF-α Treatments Reverse the Endothelial Dysfunction in Rheumatoid Arthritis: The Biological Coherence between Synovial and Endothelial Inflammation

2010 ◽  
Vol 23 (1) ◽  
pp. 255-262 ◽  
Author(s):  
A. Capria ◽  
D. De Nardo ◽  
F.R. Baffetti ◽  
U. Barbini ◽  
A. Violo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Endothelial Inflammation ◽  
Tnf Α

Rheumatoid arthritis and renal light-chain deposition disease: long-term effectiveness of TNF-α blockade with etanercept

2010 ◽  
Vol 43 (3) ◽  
pp. 909-912
Author(s):  
Lorenzo Cavagna ◽  
Vincenzo Sepe ◽  
Francesca Bobbio-Pallavicini ◽  
Filippo Mangione ◽  
Roberto Caporali ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Tnf Α ◽  
Light Chain Deposition

scholarly journals DYNAMICS OF CARDIOVASCULAR STATUS AND SERUM MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS, TREATED WITH INFLIXIMAB

2013 ◽  
Vol 12 (2) ◽  
pp. 80-84
Author(s):  
S. P. Oranskyi ◽  
L. N. Eliseeva ◽  
N. A. Samorodskaya ◽  
I. G. Malkhasyan
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Complex Dynamics ◽  
Interleukin 10 ◽  
Serum Markers ◽  
Left Ventricular ◽  
Infliximab Therapy ◽  
Lv Function ◽  
Doppler Flowmetry ◽  
Tnf Α

Aim. To assess the complex dynamics of the main parameters of cardiovascular status and serum markers of endothelial dysfunction (ED) in patients with rheumatoid arthritis (RA), who were treated with infliximab.Material and methods. The main group (MG) included 50 patients with seropositive RA, who received a combination of methotrexate and infliximab. The examination took place at baseline, as well as two, six, and 14 weeks after the treatment started. Comparison groups (CG) included healthy volunteers (n=25) and RA patients treated with methotrexate only (n=110). Serum levels of tumor necrosis factor-α (TNO-α), interleukin-10 (IL-10), tissue plasminogen activator (TPA), and von Willebrand factor (vWf) were measured, using ELISA. Left ventricular (LV) function and microvascular status were assessed with echocardiography and laser Doppler flowmetry (LDF), respectively.Results. The E/A ratio was reduced in all subgroups, and at Week 14 of infliximab therapy, it slightly increased. At baseline, LDF parameters, such as neurogenic arteriole tone and intravascular resistance, were increased. Infliximab therapy was associated with a moderate decline of these parameters. Throughout the study, serum vWf concentration was higher in MG patients than in healthy controls. TPA activity was reduced at baseline (496±173 pg/ml), increasing at Week 14 up to 705±157 pg/ml. Baseline concentrations of TNF-α and UL-10 were substantially elevated (357,1±34 and 453±42 pg/ml, respectively). At Week 6, TNF-α concentration decreased significantly. At Week 14, not only TNF-α level decreased, reaching 94±28 pg/ml, but also the ratio TNF-α/IL-10 decreased (from 0,78±0,5 to 0,4±0,2).Conclusion. In RA patients, infliximab was highly effective for the functional cytokine dysbalance correction, also demonstrating pleiotropic effects, such as correction of microvascular and endothelial dysfunction. 

Long-term rheumatoid arthritis and endothelial dysfunction

2004 ◽  
Vol 176 (1) ◽  
pp. 197-198 ◽  
Author(s):  
Carlos Gonzalez-Juanatey ◽  
Miguel A Gonzalez-Gay
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction

Care Pathway for TNF α-Blockers for Patients with Rheumatoid Arthritis at the Royal National Hospital for Rheumatic Diseases

2005 ◽  
Vol 9 (3) ◽  
pp. 116-122
Author(s):  
Nicholas Shenker ◽  
Chris Fokke ◽  
Elizabeth Michell
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Diseases ◽  
Care Pathway ◽  
Clinical Excellence ◽  
National Hospital ◽  
Tnf Α ◽  
Nice Guidance ◽  
Integrated Care Pathway ◽  
Necrosis Factor

Tumour necrosis factor (TNF) blockers are effective in the treatment of rheumatoid arthritis. These drugs are expensive, however, and there is uncertainty over their long-term safety. The National Institute for Clinical Excellence has issued guidance over the use of these drugs in rheumatoid arthritis. The Royal National Hospital for Rheumatic Diseases developed an integrated care pathway following the patient's journey from referral to the TNF services until the administration and continued monitoring of their response in accordance with NICE Guidance, taking into account local issues. This paper reviews the development and implementation of this pathway.

Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity

2003 ◽  
Vol 170 (1) ◽  
pp. 177-180 ◽  
Author(s):  
Sven Hänsel ◽  
Grit Lässig ◽  
Frank Pistrosch ◽  
Jens Passauer
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Disease Activity ◽  
Young Patients ◽  
Low Disease Activity

scholarly journals Nitric Oxide: Link between Inflammation and Endothelial Dysfunction in Rheumatoid Arthritis

2016 ◽  
Vol 26 (03) ◽  
pp. 165-169 ◽  
Author(s):  
Nidhi Garg ◽  
Ashit Syngle ◽  
Pawan Krishan
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Disease Activity ◽  
Proinflammatory Cytokines ◽  
Inflammatory Disease ◽  
No Production ◽  
Tnf Α ◽  
Relationship Of ◽  
The Relationship

AbstractNitric oxide (NO) plays an important role in inflammatory joint disease and endothelial function. Endothelial dysfunction has been attributed to a reduction in NO bioactivity in rheumatoid arthritis (RA). However, the relationship of NO with inflammation and endothelial dysfunction in RA has not yet been investigated.To investigate the relationship of nitrite with inflammation and endothelial dysfunction in RA.Total 28 patients satisfying 2010 Rheumatoid Arthritis Classification Criteria were recruited for the study. Serum nitrite estimation was performed by Griess reaction. Flow-mediated dilation (FMD) assessed using AngioDefender. Inflammatory disease activity measures included disease activity score of 28 joints (DAS28), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Proinflammatory cytokines (TNF-α, IL-6, and IL-1) measured using standard ELISA kits. Twenty-five healthy controls matched for age and sex were included for comparison.The serum nitrite level in patients with RA was markedly elevated as compared with controls (p < 0.05). FMD was significantly impaired in RA patients than controls (p < 0.05). DAS28 was significantly higher in RA patients (p < 0.05). Levels of ESR, CRP, TNF-α, IL-1, and IL-6 were significantly higher in RA patients than controls (p < 0.05). Significant positive correlation was observed between nitrite and CRP (r = 0.46, p < 0.05), TNF-α (r = 0.53, p < 0.05), and inverse correlation with FMD (r =0.62, p < 0.05).Inflammatory disease activity and endothelial dysfunction in RA are associated with increased concentration of proinflammatory cytokines and NO. Inflammatory triggered release of cytokines induced NO production that mediates endothelial dysfunction. These findings suggest a role for NO in inflammation-induced endothelial dysfunction in RA.

scholarly journals Correlation Between Tumor Necrosis Factor-α Levels, Free Fatty Acid Levels, and Soluble Vascular Cell Adhesion Molecule-1 Levels in Rheumatoid Arthritis Patients

2018 ◽  
Vol 12 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Fazria Nasriati ◽  
Rudy Hidayat ◽  
Budiman Budiman ◽  
Ikhwan Rinaldi
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Negative Correlation ◽  
Acute Infection ◽  
Data Distribution ◽  
Cardiovascular Complications ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Tnf Α ◽  
Factor Α

Background:The mortality of Rheumatoid Arthritis (RA) is quite high, which is largely due to cardiovascular complications caused by endothelial dysfunction. One of the important inflammatory mediators that contribute to RA joints arthritis of TNF-α, also proven to play a role in endothelial dysfunction and play a role in increasing intracellular lipolysis, thus increasing circulating FFA levels.Objectives:To determine the correlation between TNF-α levels with VCAM-1 levels, correlation of TNF-α levels with FFA levels, and correlation of FFA levels with VCAM-1 levels.Methods:Cross sectional and retrospective design studies of adult RA patients treated at Cipto Mangunkusumo Hospital (RSCM), without metabolic disturbances, acute infection, cardiovascular disorders, or other autoimmune diseases. The cross-sectional data was collected from October to November 2017, while retrospective samples were collected since August 2016. TNF-α, VCAM-1, and FFA levels were assessed by serum blood test by ELISA method. Correlation analysis is done by Pearson analysis when the data distribution is normal and with Spearman analysis when the data distribution is not normal.Results:A total of 35 subjects were enrolled in the study. Most (97.1%) were women with an average age of 45.29 years, median disease duration of 48 months, and most had moderate disease activity (65.7%). No significant correlation was found between TNF-α levels and VCAM-1 levels (p = 0.677; r = +0.073). as well betwen TNF-α levels and FFA levels (p = 0.227; r = -0.21). The correlation between FFA and VCAM-1 levels showed significant correlation with negative correlation and weak correlation (p = 0.036; r = -0.355).Conclusions:(1) There was no correlation between TNF-α levels and VCAM-1 levels in RA patients; (2) There was no correlation between TNF-α levels and FFA levels in RA patients; (3) There was a negative correlation between FFA levels and VCAM-1 levels in RA patients.

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