scholarly journals Weight Gain in First-Episode Psychosis

2003 ◽  
Vol 48 (4) ◽  
pp. 272-276 ◽  
Author(s):  
Jean Addington ◽  
Chrystal Mansley ◽  
Donald Addington
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
First Episode Psychosis ◽  
First Episode ◽  
First Year ◽  
Optimum Treatment ◽  
Episode Psychosis ◽  
Second Generation Antipsychotics ◽  
Potential Weight

Objective: To examine the extent of weight gain in the first year of treatment in an early psychosis program. Method: Subjects were 114 individuals who had experienced a first episode of psychosis and had completed 1 year in a comprehensive first-episode program. Weight and body mass index were calculated on entry to the program and at 6 and 12 months. Most of the subjects were all being prescribed second-generation antipsychotics. Results: Significant increases in mean weight were observed in these young individuals over the course of the first year of treatment. Conclusions: If we are to work toward optimum treatment for first-episode subjects then potential weight gain needs to be addressed at the beginning of treatment and monitored during treatment.

scholarly journals Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol

2005 ◽  
Vol 187 (6) ◽  
pp. 537-543 ◽  
Author(s):  
Robert B. Zipursky ◽  
Hongbin Gu ◽  
Alan I. Green ◽  
Diana O. Perkins ◽  
Mauricio F. Tohen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Time Course ◽  
Atypical Antipsychotics ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Study Completion ◽  
Clinically Significant ◽  
Potentially Clinically Significant

BackgroundSubstantial weight gain is common with many atypical antipsychotics.AimsTo evaluate the extent, time course and predictors of weight gain and its effect on study retention among people with first-episode psychosis treated with olanzapine or haloperidol.MethodSurvival analysis assessed time to potentially clinically significant weight gain (⩾7%) and the effect of weight gain on study retention. Weight gain during the 2-year study was summarised using last-observation-carried-forward (LOCF), observed cases and study completion approaches.ResultsAfter 2 years of treatment, LOCF mean weight gain was 10.2 kg (s.d.=10.1) for olanzapine (n=131) and 4.0 kg (s.d.=7.3) for haloperidol (n=132); observed cases mean weight gain was 15.4 kg (s.d.=10.0) for olanzapine and 7.5 kg (s.d.=9.2) for haloperidol. Change in body mass index was significantly predicted only by treatment group (P < 0.0001).ConclusionsOlanzapine was associated with significantly greater weight gain than haloperidol, with both leading to greater weight gain than previously described.

scholarly journals Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

2012 ◽  
Vol 42 (9) ◽  
pp. 1893-1901 ◽  
Author(s):  
N. Hepgul ◽  
C. M. Pariante ◽  
S. Dipasquale ◽  
M. DiForti ◽  
H. Taylor ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Childhood Maltreatment ◽  
First Episode Psychosis ◽  
First Episode ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Episode Psychosis

BackgroundThe high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls.MethodBody mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors.ResultsPatients with childhood maltreatment had higher BMI [25.0 (s.e.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (s.e.=0.6) mg/dl] when compared with healthy controls [23.4 (s.e.=0.4) kg/m2, p=0.030 and 0.2 (s.e.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (s.e.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (s.e.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue.ConclusionsChildhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.

scholarly journals Circulating lipids associate with future weight gain in individuals with an at-risk mental state and in first-episode psychosis

2020 ◽  
Author(s):  
Santosh Lamichhane ◽  
Alex M. Dickens ◽  
Partho Sen ◽  
Heikki Laurikainen ◽  
Jaana Suvisaari ◽  
...  
Keyword(s):  
At Risk ◽  
Weight Gain ◽  
High Risk ◽  
Psychotic Disorders ◽  
First Episode Psychosis ◽  
Molecular Signature ◽  
First Episode ◽  
Baseline Serum ◽  
Average Life Span ◽  
Episode Psychosis

AbstractPatients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic co-morbidities. Identification of individuals with psychotic disorders with a high risk of rapid weight gain, and the associated development of metabolic complications, is an unmet need as regards public health. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 controls (CTR), 44 first-episode psychosis (FEP) patients and 22 individuals at clinical-high-risk (CHR) for psychosis, from two study centers (Turku/Finland and London/UK). Baseline serum samples were analyzed by lipidomics, while body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols with low double bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of two triacylglycerols (TG(48:0) and TG(45:0)), was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals, and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic co-morbidities.

Early intervention with second-generation antipsychotics in first-episode psychosis: results of an 8-week naturalistic study

2010 ◽  
Vol 4 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Richard C. Josiassen ◽  
Rita A. Shaughnessy ◽  
Dawn M. Filymer ◽  
Ann Marie Donohue ◽  
Margit Kacso ◽  
...  
Keyword(s):  
Early Intervention ◽  
Second Generation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Naturalistic Study ◽  
Episode Psychosis ◽  
Second Generation Antipsychotics

The effect of second-generation antipsychotics on basal ganglia and thalamus in first-episode psychosis patients

2019 ◽  
Vol 29 (12) ◽  
pp. 1408-1418
Author(s):  
Auria Albacete ◽  
Carolina Makowski ◽  
M. Mallar Chakravarty ◽  
Ridha Joober ◽  
Ashok K. Malla ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Second Generation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Second Generation Antipsychotics

scholarly journals Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase

2015 ◽  
Vol 207 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Lucia R. Valmaggia ◽  
Majella Byrne ◽  
Fern Day ◽  
Matthew R. Broome ◽  
Louise Johns ◽  
...  
Keyword(s):  
Minority Group ◽  
First Episode Psychosis ◽  
First Episode ◽  
First Year ◽  
Compulsory Treatment ◽  
Duration Of Untreated Psychosis ◽  
Short Term ◽  
Prodromal Phase ◽  
Episode Psychosis ◽  
Poor Outcomes

BackgroundIt is unknown whether prodromal services improve outcomes in those who go on to develop psychosis, and whether these patients are demographically different from the overall first-episode population.AimsTo compare sociodemographic features, duration of untreated psychosis, hospital admission and frequency of compulsory treatment in the first year after the onset of psychosis in patients who present to prodromal services with patients who did not present to services until the first episode of psychosis.MethodWe compared two groups of patients with first-episode psychosis: one who made transition after presenting in the prodromal phase and the other who had presented with a first episode.ResultsThe patients who had presented before the first episode were more likely to be employed and less likely to belong to an ethnic minority group. They had a shorter duration of untreated psychosis, and were less likely to have been admitted to hospital and to have required compulsory treatment.ConclusionsPatients who develop psychosis after being engaged in the prodromal phase have a better short-term clinical outcome than patients who do not present until the first episode. Patients who present during first episodes may be more likely to have sociodemographic features associated with relatively poor outcomes.

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