The Use of Intravenous Chlorimipramine in the Treatment of Obsessive Compulsive Disorder*

1984 ◽  
Vol 29 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Lorne B. Warneke
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Route Of Administration ◽  
Response To Therapy ◽  
Intravenous Route ◽  
Review Of The Literature ◽  
Case Histories ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Oral Form ◽  
Traditional Approaches

Obsessional disorder has always remained a difficult illness for psychiatrists to treat with response to therapy, both psychotherapy and chemotherapy, being low. A review of the traditional approaches to the treatment of obsessional disorder is done, including a brief review of the literature on intravenous chlorimipramine. Five case histories of patients with previously non-responsive obsessional disorder are summarized. All five cases were treated in hospital with a series of infusions of intravenous chlorimipramine. The drug and route of administration was extremely well tolerated with rapid and dramatic relief of obsessional symptoms as well as improvement of mood in all cases. The theoretical action of chlorimipramine is discussed as well as possible reasons why the intravenous route appears to be superior to the oral form.

Two cases of transvestophilia arising following behavioural psychotherapy treatment of obsessive compulsive disorder

1996 ◽  
Vol 13 (4) ◽  
pp. 164-166
Author(s):  
S Rani ◽  
Lynne Drummond
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Case Histories ◽  
Obsessive Compulsive ◽  
Deviant Behaviour ◽  
Compulsive Disorder ◽  
Sexual Aberration

AbstractEarly psychodynamic formulations of obsessive compulsive disorder (OCD)suggest that its aetiology lies in repressed sexual impulses. Despite this, sexual aberration has rarely been reported in conjunction with OCD or arising following treatment. This paper describes two case histories of patients with severe, chronic OCD whose sexually deviant behaviour increased following successful behavioural psychotherapy. Classical Freudian, behavioural cognitive and neuropsychological models for this finding are discussed.

scholarly journals Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Leila Kouti ◽  
Mehdi Sayyah ◽  
Parisa Mosallanezhad ◽  
Sara Kooti ◽  
Maryam Aghakoochakzadeh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Drug Therapy ◽  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serum Levels ◽  
Response To Therapy ◽  
Augmentation Therapy ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Effect Of Treatment

Objectives. Some studies have shown that increased nitric oxide (NO) concentrations may be associated with obsessive-compulsive disorder (OCD). In a few animal researches, enhanced synthesis of NO had reversed the effect of selective serotonin reuptake inhibitors (SSRIs). The present study tries to find the effect of treatment with SSRIs on NO serum levels and its product peroxynitrite.Patients and Methods. Patients diagnosed with OCD who are candidates of receiving SSRIs entered this study. Two blood samples were taken from subjects, prior to drug therapy and after the patients had shown some improvements due to their regimen. Serum NO and peroxynitrite levels were measured and their correlation with SSRI use was assessed.Results. 31 patients completed this study. Mean concentrations of NO and peroxynitrite prior to drug therapy were28.63±16.9and5.73±2.5 μmol/L, respectively. These values were 18.87±7.55and2.15±0.94 μmol/L at the second blood test. Withpvalues < 0.05, these differences were considered significant.Conclusion. Patients, who showed improvement of OCD symptoms after a mean duration of SSRI monotherapy of3.531±0.64months, had lower values of NO and peroxynitrite in their sera compared to their levels prior to therapy. Such results can be helpful in finding a predictive factor of response to therapy and augmentation therapy with future drugs that target NO synthesis.

The Paradox of Quetiapine in Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2005 ◽  
Vol 10 (5) ◽  
pp. 356-361 ◽  
Author(s):  
Constantin Tranulis ◽  
Stéphane Potvin ◽  
Martin Gourgue ◽  
Gérard Leblanc ◽  
Adham Mancini-Marïe ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Dopamine Antagonists ◽  
Clinical Use ◽  
Atypical Neuroleptics ◽  
Review Of The Literature ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Prognostic Implications

AbstractSchizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.

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