Proportion of Unmarried Siblings of Homosexual and Non Homosexual Gender-Dysphoric Patients*

1992 ◽  
Vol 37 (3) ◽  
pp. 163-167 ◽  
Author(s):  
Ray Blanchard ◽  
Peter M. Sheridan
Keyword(s):  
Logistic Regression ◽  
Common Law ◽  
Male Gender ◽  
The Other ◽  
Heterosexual Relationships ◽  
Homosexual Male ◽  
Sexual Histories ◽  
Male Patients ◽  
Romantic Interest

Among the siblings of homosexuals, a lack of sexual and romantic interest in women may be independent of erotic feelings for men. This study investigated the sexual histories of siblings of gender-dysphoric outpatients. The patients were classified into three groups: non homosexual males, homosexual males and homosexual females. Their siblings consisted of 301 brothers and 284 sisters over the age of 25. Logistic regression showed that the brothers of the homosexual male patients were significantly less likely to have been married, either legally or common-law, than the brothers of the other gender-dysphoric groups, even with age and relative birth order taken into account. This finding suggests that the low propensity for long term heterosexual relationships seen in homosexual male gender-dysphoric patients also tends to appear in their brothers.

scholarly journals COVID-19 mortality risk factors in older people in a long-term care center

2020 ◽  
Author(s):  
Eva Heras ◽  
Pablo Garibaldi ◽  
Maite Boix ◽  
Oliver Valero ◽  
Jorge Castillo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Barthel Index ◽  
Long Term Care ◽  
Male Gender ◽  
Bivariate Analysis ◽  
Multivariate Logistic Regression ◽  
Term Care ◽  
Independent Risk Factors

Abstract Objectives: Despite high rates of COVID-19 infection and increased related mortality have been reported among older adults admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection, and clinical, laboratory, treatment, and outcome data during infection were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases during the study period. The median age was 85 years; 62% were female. The case fatality rate was 20%. In the bivariate analysis, male gender, fever, respiratory symptoms, severe cognitive decline, a low Barthel index, and lymphocytopenia were significantly associated with mortality. Multivariate logistic regression analysis identified male gender, low Barthel index, no pharmacological treatment, and lymphocytopenia as independent risk factors associated with mortality.Conclusions and Implications: Male gender, low Barthel index, no pharmacological treatment and lymphocytopenia are independent risk factors for COVID-19 mortality in institutionalized elderly patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

scholarly journals COVID-19 mortality risk factors in older people in a long-term care center.

2020 ◽  
Author(s):  
Eva Heras ◽  
Pablo Garibaldi ◽  
Maite Boix ◽  
Oliver Valero ◽  
Jorge Castillo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Barthel Index ◽  
Long Term Care ◽  
Male Gender ◽  
Bivariate Analysis ◽  
Multivariate Logistic Regression ◽  
Term Care ◽  
Independent Risk Factors

Abstract Objectives: Despite high rates of COVID-19 infection and increased related mortality have been reported among older adults admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection, and clinical, laboratory, treatment, and outcome data during infection were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases during the study period. The median age was 85 years; 62% were female. The case fatality rate was 20%. In the bivariate analysis, male gender, fever, respiratory symptoms, severe cognitive decline, a low Barthel index, and lymphocytopenia were significantly associated with mortality. Multivariate logistic regression analysis identified male gender, low Barthel index, no pharmacological treatment, and lymphocytopenia as independent risk factors associated with mortality.Conclusions and Implications: Male gender, low Barthel index, no pharmacological treatment and lymphocytopenia are independent risk factors for COVID-19 mortality in institutionalized elderly patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

Sex related differences in therapy and outcome of patients with low-stage LEAD in a real-world cohort

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L.-M Makowski ◽  
J Feld ◽  
J Koeppe ◽  
J Illner ◽  
L Kuehnemund ◽  
...  
Keyword(s):  
Real World ◽  
Male Gender ◽  
Funding Source ◽  
Main Diagnosis ◽  
Index Hospitalization ◽  
Risk Profiles ◽  
Coronary Syndrome ◽  
Male Patients

Abstract Background During the last decades, the prevalence of lower extremity artery disease (LEAD) strongly increased worldwide in both, males and females. Sex-related differences relating to therapy and outcome events are a current matter of debate. Purpose Aim of our study was to examine patients with low-stage LEAD in an unselected “real-world” cohort with regard to risk profiles, therapeutic approach and its impact on the progression to chronic limb threatening ischemia (CLTI) and death. Methods We analyzed 42,197 unselected patients of the AOK (Allgemeine Ortskrankenkasse) health insurance that were hospitalized between 01.01.2014–31.12.2015 for a main diagnosis of LEAD at Rutherford stage 1–3. Data files included a baseline period of 2 years previous index hospitalization and a follow-up period of up to 5 years. Results In our dataset, one third of the LEAD patients were female (32.4% female vs. 67.6% male), being 6 years older (median age: 72.6 years female vs. 66.4 years male). Male patients had higher ratio of diabetes mellitus (40.1% female vs. 42.4% male), nicotine abuse (40.8% female vs. 50.7% male) and chronic coronary syndrome (40.6% female vs. 48.2 male). On the other hand, hypertension (90.3% female vs. 86.9% male), obesity (26.7% female vs. 24.9% male) and chronic kidney disease (29.2% female vs. 26.1% male; all p<0.001) was more often co-prevalent in females. Previous vascular procedures of the lower limbs (LL) (10.2% female vs. 11.8% male) and the receipt of guideline-recommended medication (statins: 45.9% female vs. 50.3% male; blood thinner: 37.1% female vs. 42.7% male; all p<0.001) at baseline was higher in male patients. During index hospitalization, revascularization was performed in 82.8% of all patients, while carried out more often in male patients (81.8% female vs. 83.3% male, p<0.001). After adjustment for risk profiles, female sex was associated with decreased adjusted long-term mortality (HR 0.76; 95%-CI 0.72–0.80). Moreover, male gender was linked with an increased risk of the combined endpoint of CLTI (Rutherford stage 4–6 or amputation of the LL or death; HR 0.89; 95%-CI 0.86–0.93). Interestingly, the prescription of guideline-recommended medication (statins: 63.8% female vs. 65.8% male; blood thinner: 60.2% female vs. 63.5% male; all p<0.001) and performed vascular procedures (33.1% female vs. 36.4% male; p<0.001) was increased in male patients during follow-up. Conclusion Female patients with low stage LEAD are older and show less rate of revascularization procedures of the LL and prescription of guideline-recommended medication at baseline and during follow-up. Nevertheless, male gender was an independent risk factor for all-cause mortality and the combined endpoint CLTI during 5 years of long-term follow-up. Further analyses with focus on sex-related differences on health-services supply and outcome quality are needed to correspond to the individual needs of male and female LEAD patients. Kaplan Meier analysis of the endpoints Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National grant

Long Term Response After Lenalidomide Treatment for Patients with Multiple Myeloma Relapsed After at Least Two Lines of Therapy.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4946-4946
Author(s):  
Francesco Spina ◽  
Vittorio Montefusco ◽  
Claudia Crippa ◽  
Barbara Oliviero ◽  
Massimo Offidani ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Patient Characteristics ◽  
The Other ◽  
Multivariate Logistic Regression ◽  
Term Response ◽  
Time Point

Abstract Abstract 4946 Multiple myeloma (MM) treatment greatly improved in the last decade due to the introduction of new drugs such as thalidomide, bortezomib and lenalidomide. Lenalidomide is the more recent, and is active in relapsed MM patients, but the data on long term responses are still lacking. For such a reason, we conducted a retrospective multicenter study to evaluate the existence of long term responders to lenalidomide. Eleven Italian hematology centers participated to the study. Consecutive patients relapsing after >=2 lines of therapy receiving a treatment with lenalidomide were considered eligible. Patients treated with >=2 cycles of lenalidomide were considered evaluable for response defined as per International Uniform Response Criteria. Long term response was defined as a response equal or better than PR lasting >=12 months. Overall (OS) and progression free survival (PFS) were analyzed with Kaplan-Meier method and log-rank test. Cumulative incidence (CI) of relapse was analyzed with CI method with competing risks. Group characteristics were compared by Mann-Whitney test. A multivariate logistic regression analysis was applied to assess which patient characteristics might predict a long term response to lenalidomide. Ninety-five patients were enrolled, 81 had a complete data set and were evaluable. Median age was 65 years (range 42-89), 33 (41%) patients had >=70 years, 48 (59%) had IgG, 22 (27%) IgA, 10 (12%) light chain and 1 IgD MM (1%). All patients relapsed after >=2 lines of chemotherapy, 29 (36%) received >3 lines; 53 (65%) had failed an autologous (autoSCT) and 11 (14%) an allogeneic transplant (alloSCT). All patients were treated with lenalidomide daily for 21 days every 28 per course. Seventy-three patients (90%) were treated with a dose of 25 mg/die, 8 received 15 or 10 mg/die due to hematologic toxicity. Median administered courses were 6 (range 3-29); 28 patients (35%) received >=12 months of treatment. Overall response rate was 85.5%. Two (2.5%) patients obtained sCR, 8 (10%) CR, 11 (14%) VGPR, 48 (59%) PR, 7 (9%) SD, and 5 (6%) PD. One- and 2-years OS (median not reached) was 83 and 64%, 1- and 2-years PFS (median 514 days) was 62% and 45%. One- and 2-year CI of relapse was 34% and 54%. Age, isotype, stage, previous lines of therapy, autoSCT, alloSCT and lenalidomide dose did not impact OS and PFS. Twenty-eight (35%) patients obtained PR or a better response lasting >=12 months. One patient (3.5%) died and 7 (25%) relapsed after long term response. The 2-year OS and PFS was 93% and 64%; median OS and PFS were not reached by long term responders. Pre-treatment characteristics and lenalidomide dose did not significantly affect their survival outcomes. The group of 53 patients relapsed before 12 months had 2-years OS (median not reached) and PFS (median 320 days) of 56% and 23%, respectively. Twenty-three patients (43%) progressed and/or died. Older age (>=70 years) influenced PFS (p=0.04) and there was a trend also for OS (p=0.07); the other patient characteristics had no impact on survival. Response to lenalidomide, even if short lasting, improved OS (p<0.001) and PFS (p<0.001) in these patients. Long term responder characteristics were compared with the other patients to explore potential differences. The two groups were similar and had no significant differences except for lines of therapy (3.5 in long responders vs 3.1 in control group, p=0.01). A landmark analysis with 3-months response time-point showed that responders had a 45% probability to maintain response at 12 months. A multivariate logistic regression analysis with 3-months landmark response time-point considered the long response as outcome of interest and age, stage, lines of therapy, autoSCT, lenalidomide dose and response level as covariates. This analysis showed that response quality at 3 months is the only factor which significantly predicts long term response (p=0.001). The higher the level of response 3 months after the start of treatment, the higher the chance of long term response and survival benefit. In conclusion, myeloma patients treated with lenalidomide in third or subsequent line had a 35% probability of achieving a long term response. Such a response was associated with a prolonged OS and PFS. Of note, the quality of response after 3 months of treatment is the unique factor which may significantly predict the long term response. Prospective studies and the search for biomarkers are required to implement our retrospective analysis. Disclosures Patriarca: Celgene: Speakers Bureau; Janssen-Cilag: Speakers Bureau. Guglielmelli:Celgene: Honoraria. Corradini:Celgene: Honoraria; Roche: Honoraria; Novartis: Honoraria, Speakers Bureau.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

Hidden “holes” in the capital of banks and the supply of credit to the real sector of economy

2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov
Keyword(s):  
Credit Risk ◽  
The Other ◽  
Real Sector ◽  
Capital Management ◽  
Loan Loss ◽  
Short Term ◽  
The Real ◽  
Ex Post ◽  
The One

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.

Interrelationships between municipal spatial policy strategy and airport operation and development. Lodz Airport case study

2018 ◽  
Vol 59 (1) ◽  
pp. 65-79
Author(s):  
Katarzyna Nikorowicz-Zatorska
Keyword(s):  
Land Use ◽  
Urban Planning ◽  
Cultural Development ◽  
The Other ◽  
Local Authorities ◽  
Spatial Management ◽  
The One ◽  
Surrounding Areas

Abstract The present paper focuses on spatial management regulations in order to carry out investment in the field of airport facilities. The construction, upgrades, and maintenance of airports falls within the area of responsibility of local authorities. This task poses a great challenge in terms of organisation and finances. On the one hand, an active airport is a municipal landmark and drives local economic, social and cultural development, and on the other, the scale of investment often exceeds the capabilities of local authorities. The immediate environment of the airport determines its final use and prosperity. The objective of the paper is to review legislation that affects airports and the surrounding communities. The process of urban planning in Lodz and surrounding areas will be presented as a background to the problem of land use management in the vicinity of the airport. This paper seeks to address the following questions: if and how airports have affected urban planning in Lodz, does the land use around the airport prevent the development of Lodz Airport, and how has the situation changed over the time? It can be assumed that as a result of lack of experience, land resources and size of investments on one hand and legislative dissonance and peculiar practices on the other, aviation infrastructure in Lodz is designed to meet temporary needs and is characterised by achieving short-term goals. Cyclical problems are solved in an intermittent manner and involve all the municipal resources, so there’s little left to secure long-term investments.

Pengaruh Financial Leverage terhadap Financial Performance pada Sektor Industri Manufaktur yang Terdaftar di Bursa Efek Indonesia (BEI) Periode 2015

2018 ◽  
Vol 9 (2) ◽  
pp. 33-48
Author(s):  
Rivaldy Februansyah ◽  
Ika Yanuarti
Keyword(s):  
Financial Performance ◽  
Manufacturing Sector ◽  
Linear Regression Analysis ◽  
The Other ◽  
Debt Ratio ◽  
Financial Leverage ◽  
Coverage Ratio ◽  
Equity Ratio ◽  
Internal Fund

The manufacturing sector is one of the most dominant economic sectors in in achieving growth and development in Indonesia. It needs adequate fund to develop its business. The sources of fund are from internal and external. The firm usually optimized the usage of internal fund prior to external fund. The internal fund comes from equity while the external funds are from debt and stock. Debt is also known as financial leverage. There is a phenomenon that the usage of debt increased the firm’s financial performance, since interest on debt could lower the payment of tax (tax shield). On the other side, the higher the financial leverage the higher the risk of bankruptcy. This research aims to analyze whether financial leverage has an influence on financial performance in the manufacturing sector listed on the Indonesia Stock Exchange (IDX) period 2015. The method of analysis used in this research is multiple linear regression analysis. This research uses quantitative approach with a sample of 140 listed companies in the manufacturing industry. The firm’s financial performance could be measured by the financial ratios. Financial Leverage ratios are ratios that measure the ability of firm’s to meet its financial obligation and the level of usage debt as compared to equity. There are several financial leverage ratios that used in this research, such as Debt Ratio (DR), Debt to Equity Ratio (DER), Interest Coverage Ratio (ICR), and Long Term Debt Ratio (LTDR). Financial performance indicates the ability of firm to generate profit and measured by Profitability Ratio. Return on Asset (ROA) is one of the Profitability Ratio. The statistical result shows that Debt Ratio (DR) negatively affect Return on Asset (ROA) and Interest Coverage Ratio (ICR) positively affect Return on Asset (ROA). Meanwhile, Debt to Equity Ratio (DER) and Long Term Debt Ratio (LTDR) did not affect Return on Asset (ROA). On the other hand, result shows that Debt Ratio (DR), Debt to Equity Ratio (DER), Interest Coverage Ratio (ICR), and Long Term Debt Ratio (LTDR) affect Return on Asset (ROA) simultaneously. Keywords: Financial Leverage, Debt Ratio (DR), Debt to Equity Ratio (DER), Interest Coverage Ratio (ICR), Long Term Debt Ratio (LTDR), Financial Performance, Return on Assets (ROA)

The effects of long-term vigorous endurance exercise on the coronary arteries

2019 ◽  
Vol 67 (2) ◽  
Keyword(s):  
Endurance Training ◽  
Coronary Atherosclerosis ◽  
Calcium Score ◽  
The Other ◽  
Disease Phenotype ◽  
Male Athletes ◽  
Artery Disease ◽  
Future Work ◽  
Summary Data

Moderate endurance training is known to improve cardiovascular risk factors, and prolongs life expectancy. On the other hand, there has been some discussion whether “too much” exercise might have a contrarious effect by accelerating coronary atherosclerosis. The goal of this review was to evaluate the current literature on the effects of long-term vigorous endurance training on the coronary vasculature. In summary, data point to an increased calcium score, and a higher burden of atherosclerotic plaque in male athletes compared to sedentary controls. However, the plaques found in athletes were more prone to be calcified. The pathogenesis and clinical relevance of this athlete coronary artery disease phenotype remains incompletely understood and represents an area of important future work.

The effects of long-term vigorous endurance exercise on the coronary arteries

2019 ◽  
Vol 67 (2) ◽  
Keyword(s):  
Endurance Training ◽  
Coronary Atherosclerosis ◽  
Calcium Score ◽  
The Other ◽  
Disease Phenotype ◽  
Male Athletes ◽  
Artery Disease ◽  
Future Work ◽  
Summary Data

Moderate endurance training is known to improve cardiovascular risk factors, and prolongs life expectancy. On the other hand, there has been some discussion whether “too much” exercise might have a contrarious effect by accelerating coronary atherosclerosis. The goal of this review was to evaluate the current literature on the effects of long-term vigorous endurance training on the coronary vasculature. In summary, data point to an increased calcium score, and a higher burden of atherosclerotic plaque in male athletes compared to sedentary controls. However, the plaques found in athletes were more prone to be calcified. The pathogenesis and clinical relevance of this athlete coronary artery disease phenotype remains incompletely understood and represents an area of important future work.

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