Eva Ortega Freyre
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Alfredo Tellez Valencia
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Dealmy Delgadillo Guzmán
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Irais Castillo Maldonado
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Laura Ernestina Barragán Ledezma
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...
:
Exposure to organophosphorus pesticides is an important public health issue due to a
large number of occupationally exposed populations, as well as their effects mainly at the level of
the nervous, reproductive, and immune systems. It has been reported that one of the molecular
mechanisms by which adverse effects of exposure to organophosphorus pesticides can be explained is oxidative stress, which leads to alterations at the cellular level that, if chronic, could affect the functionality of different organs and tissues. These data constitute the basis of the relevant
literature on its toxicity. The induction of oxidative damage, which has been referred to, increases
the occurrence of processes such as eryptosis and/or hemolysis in erythrocytes that promote greater
susceptibility to clinical conditions such as anemia, dehydration, and chronic kidney disease. Thus,
it is mentioned that the determination of oxidative damage parameters could be useful to monitor
occupationally exposed peopleby exploring their oxidative status. This review focuses on presenting the state of knowledge in recent years on the toxicity of organophosphorus pesticides and their
relationship with the oxidative damage evaluated in erythrocytes.