Numerical analysis of non-aligned inputs M-type micromixers with different shaped obstacles for biomedical applications

2021 ◽  
pp. 095440892110516
Author(s):  
Muhammad Irfan ◽  
Imran Shah ◽  
Usama M Niazi ◽  
Muhsin Ali ◽  
Sadaqat Ali ◽  
...  
Keyword(s):  
Structural Design ◽  
Biomedical Applications ◽  
Structural Changes ◽  
Nanoparticle Synthesis ◽  
Fluid Mixing ◽  
The Novel ◽  
Flow Conditions ◽  
Mixing Index ◽  
Mixing Performance ◽  
Passive Micromixer

Fluid mixing in lab-on-a-chip devices at laminar flow conditions result in a low mixing index. The reason is dominant diffusion over the convection process. The mixing index can be improved by certain changes in the micromixer structural design like introducing obstacles in the path of fluid flow. These obstacles will make dominant the advection process over the diffusion process. The main contribution of this work is based on proposing the novel hybrid type micromixer design for enhancing the mixing quality. Three non-aligned M-type and non-aligned M-type with obstacles passive type micromixers are analyzed by COMSOL5.5. These designs are hybrid types because different structural changes are combined in a single design for mixing improvement. First of all the straight non-aligned inlets, M-type passive micromixer (SMTM) is analyzed. It is observed that mixing performance is improved because of M-shaped mixing units and non-aligned inlets. This improvement is deemed to be not enough so different shaped obstacles are introduced in the micromixer design. These designs based on obstacles are named horizontal rectangular M-type micromixer, square M-type micromixer, and vertical rectangular M-type micromixer. The mixing index for SMTM, square M-type micromixer, horizontal rectangular M-type micromixer, and vertical rectangular M-type micromixer at Reynolds number Re = 60 is respectively given by 71.1%, 83.21%, 84.45%, and 89.99%. The mixing index of vertical rectangular M-type micromixer was 59.34% − 87.65% for Re = 0.5–100. Vertical rectangular M-type micromixer is concluded with the better-mixing capability design among the proposed ones. Based on these simulation results, the vertical rectangular M-type micromixer design can be utilized for mixing purposes in biomedical applications like nanoparticle synthesis and biomedical sample preparation for drug delivery.

scholarly journals Novel 3-D T-Shaped Passive Micromixer Design with Helicoidal Flows

Processes ◽  
2019 ◽  
Vol 7 (9) ◽  
pp. 637 ◽  
Author(s):  
Mahmut Burak Okuducu ◽  
Mustafa M. Aral
Keyword(s):  
Fluid Flow ◽  
Fluid Mixing ◽  
Mixing Efficiency ◽  
Flow Profile ◽  
Complex Flow ◽  
Mixing Index ◽  
Micro Channels ◽  
Mixing Dynamics ◽  
Passive Micromixer ◽  
Novel Design

Laminar fluid flow and advection-dominant transport produce ineffective mixing conditions in micromixers. In these systems, a desirable fluid mixing over a short distance may be achieved using special geometries in which complex flow paths are generated. In this paper, a novel design, utilizing semi-circular ridges, is proposed to improve mixing in micro channels. Fluid flow and scalar transport are investigated employing Computational Fluid Dynamics (CFD) tool. Mixing dynamics are investigated in detail for alternative designs, injection, and diffusivity conditions. Results indicate that the convex alignment of semi-circular elements yields a specific, helicoidal-shaped fluid flow along the mixing channel which in turn enhances fluid mixing. In all cases examined, homogenous concentration distributions with mixing index values over 80% are obtained. When it is compared to the classical T-shaped micromixer, the novel design increases mixing index and mixing performance values by the factors of 8.7 and 3.3, respectively. It is also shown that different orientations of ridges adversely affect the mixing efficiency by disturbing the formation of helicoidal-shaped flow profile.

Simulation of the Mixing in a Novel Fully Wiped Co-Rotating Non-Twin Screws

2012 ◽  
Vol 560-561 ◽  
pp. 1091-1096 ◽  
Author(s):  
Bai Ping Xu ◽  
Hui Wen Yu
Keyword(s):  
Probability Distributions ◽  
The Novel ◽  
Mixing Index ◽  
Mixing Performance ◽  
Twin Screw ◽  
Mixing Ability ◽  
Superposition Technique ◽  
Dispersive Mixing ◽  
Twin Screws ◽  
Screw Group

This work aims at simulation of the mixing performance in the novel co-rotating non-twin screw group developed by the authors. The simulation concerns the incompressible fluid obeying Carreau flow model. Using the mesh superposition technique, the mixing performance in such novel mixing sections, as well as in the conventional twin screw groups with one and two tips, are simulated. Adopting the particle tracking technique, distributive mixing is visualized by the evolution of the mixing of a cluster of particles in addition to using the segregation scale. Dispersive mixing is evaluated using mixing index in combination with the probability distributions of cumulative mixing index. The computational results reveal that the novel screw group is superior in mixing ability.

scholarly journals Effect of Thermal Energy and Ultrasonication on Mixing Efficiency in Passive Micromixers

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 891
Author(s):  
Fahizan Mahmud ◽  
Khairul Fikri Tamrin ◽  
Shahrol Mohamaddan ◽  
Nobuo Watanabe
Keyword(s):  
Thermal Energy ◽  
Reynolds Numbers ◽  
Fluid Mixing ◽  
Structural Deformation ◽  
Energy Sources ◽  
Mixing Efficiency ◽  
Mixing Index ◽  
Mixing Performance ◽  
Lower Reynolds Number ◽  
Better Than

Micromixing is a key process in microfluidics technology. However, rapid and efficient fluid mixing is difficult to achieve inside the microchannels due to unfavourable laminar flow. Active micromixers employing ultrasound and thermal energy are effective in enhancing the micromixing process; however, integration of these energy sources within the devices is a non-trivial task. In this study, ultrasound and thermal energy have been extraneously applied at the upstream of the micromixer to significantly reduce fabrication complexity. A novel Dean micromixer was laser-fabricated to passively increase mixing performance and compared with T- and Y-micromixers at Reynolds numbers between 5 to 100. The micromixers had a relatively higher mixing index at lower Reynolds number, attributed to higher residence time. Dean micromixer exhibits higher mixing performance (about 27% better) than T- and Y-micromixers for 40 ≤ Re ≤ 100. Influence of ultrasound and heat on mixing is more significant at 5 ≤ Re ≤ 20 due to the prolonged mechanical effects. It can be observed that mixing index increases by about 6% to 10% once the temperature of the sonicated fluids increases from 30 °C to 60 °C. The proposed method is potentially useful as direct contact of the inductive energy sources may cause unwanted substrate damage and structural deformation especially for applications in biological analysis and chemical synthesis.

Unravelling the dissolution mechanism of polyphosphate glasses by 31P NMR spectroscopy: ligand competition and reactivity of intermediate complexes

2021 ◽  
Author(s):  
Dahiana Andrea Avila Salazar ◽  
Peter Bellstedt ◽  
Atsuhiro Miura ◽  
Yuki Oi ◽  
Toshihiro Kasuga ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Nmr Spectroscopy ◽  
Biomedical Applications ◽  
Structural Changes ◽  
31P Nmr ◽  
Dissolution Mechanism ◽  
31P Nmr Spectroscopy ◽  
Glass Dissolution ◽  
Polyphosphate Glasses

Phosphate glass dissolution can be tailored via compositional and subsequent structural changes, which is of interest for biomedical applications such as therapeutic ion delivery. Here, solid-state 31P nuclear magnetic resonance...

Evaluation of the mixing performance in a planar passive micromixer with circular and square mixing chambers

2017 ◽  
Vol 24 (6) ◽  
pp. 2599-2610 ◽  
Author(s):  
Ranjitsinha R. Gidde ◽  
Prashant M. Pawar ◽  
Babruvahan P. Ronge ◽  
Nitin D. Misal ◽  
Ranjit B. Kapurkar ◽  
...  
Keyword(s):  
Mixing Performance ◽  
Passive Micromixer ◽  
Mixing Chambers

scholarly journals Asymmetrical Induced Charge Electroosmotic Flow on a Herringbone Floating Electrode and Its Application in a Micromixer

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 391 ◽  
Author(s):  
Qingming Hu ◽  
Jianhua Guo ◽  
Zhongliang Cao ◽  
Hongyuan Jiang
Keyword(s):  
Electrode Surface ◽  
Slip Velocity ◽  
Fluid Velocity ◽  
Laminar Flows ◽  
Fluid Mixing ◽  
Electrode Pair ◽  
Great Opportunity ◽  
Mixing Performance ◽  
Induced Charge ◽  
Floating Electrode

Enhancing mixing is of significant importance in microfluidic devices characterized by laminar flows and low Reynolds numbers. An asymmetrical induced charge electroosmotic (ICEO) vortex pair generated on the herringbone floating electrode can disturb the interface of two-phase fluids and deliver the fluid transversely, which could be exploited to accomplish fluid mixing between two neighbouring fluids in a microscale system. Herein we present a micromixer based on an asymmetrical ICEO flow induced above the herringbone floating electrode array surface. We investigate the average transverse ICEO slip velocity on the Ridge/Vee/herringbone floating electrode and find that the microvortex generated on the herringbone electrode surface has good potential for mixing the miscible liquids in microfluidic systems. In addition, we explore the effect of applied frequencies and bulk conductivity on the slip velocity above the herringbone floating electrode surface. The high dependence of mixing performance on the floating electrode pair numbers is analysed simultaneously. Finally, we investigate systematically voltage intensity, applied frequencies, inlet fluid velocity and liquid conductivity on the mixing performance of the proposed device. The microfluidic micromixer put forward herein offers great opportunity for fluid mixing in the field of micro total analysis systems.

The effect on the fatigue strength of bone cement of adding sodium fluoride

2001 ◽  
Vol 215 (2) ◽  
pp. 251-253 ◽  
Author(s):  
C Minari ◽  
M Baleanil ◽  
L Cristofolini ◽  
F Baruffaldi
Keyword(s):  
Fatigue Strength ◽  
Bone Cement ◽  
Sodium Fluoride ◽  
Biomedical Applications ◽  
Cement Mantle ◽  
Fatigue Tests ◽  
Fatigue Performance ◽  
Bone Cements ◽  
The Novel ◽  
Pmma Bone Cement

New bone cements that include several additives are currently being investigated and tested. One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success. The influence of NaF on the fatigue performance of the cement as used in biomedical applications was tested in this paper. In fact fatigue failure of the cement mantle is a major factor limiting the longevity of a cemented implant. An experimental bone cement with added NaF (12wt%) was investigated. The fatigue strength of the novel bone cement was evaluated in comparison with the cement without additives; fatigue tests were conducted according to current standards. The load levels were arranged based on a validated, statistically based optimization algorithm. The curve of stress against number of load cycles and the endurance limit were obtained and compared for both formulations. The results showed that the addition of NaF (12 wt %) to polymethylmethacrylate (PMMA) bone cement does not affect the fatigue resistance of the material. Sodium fluoride can safely be added to the bone cement without altering the fatigue performance of the PMMA bone cement.

scholarly journals Fe3O4 Nanoparticle-Reinforced Magnesium Nanocomposites Processed via Disintegrated Melt Deposition and Turning-Induced Deformation Techniques

Metals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1225 ◽  
Author(s):  
Michael Johanes ◽  
Sravya Tekumalla ◽  
Manoj Gupta
Keyword(s):  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
The Novel ◽  
Metallic Materials ◽  
Turning Process ◽  
Recent Past ◽  
Deformation Method ◽  
Property Profile ◽  
Melt Deposition ◽  
Superior Property

Magnesium nanocomposites, with nano-scale ceramic reinforcements, have attracted a great deal of attention for several engineering and biomedical applications in the recent past. In this work, superparamagnetic iron oxide nanoparticles, Fe3O4, with their unique magnetic properties and the ability of being bio-compatible and non-toxic, are reinforced to magnesium to form Mg/(1, 2, and 3 wt %) Fe3O4 nanocomposites. These nanocomposites were fabricated using the conventional disintegrated melt deposition (DMD) technique followed by extrusion. Further, the materials were also processed using the novel turning-induced-deformation technique where the chips from turning process are collected, cold compacted, and hot extruded. The materials processed via the two techniques were compared in terms of microstructure and properties. Overall, the Mg/Fe3O4 nanocomposites, processed via both routes, exhibited a superior property profile. Further, the turning-induced deformation method showed promising results in terms of improved properties of the nanocomposites and serves as a great route for the recycling of metallic materials.

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