Sentinel Surveillance of HIV-1 Infection in Tamilnadu, India

1994 ◽  
Vol 5 (6) ◽  
pp. 445-446 ◽  
Author(s):  
Suniti Solomon ◽  
S Anuradha ◽  
M Ganapathy ◽  
Jagadeeswaril
Keyword(s):  
Hiv Infection ◽  
Blood Donors ◽  
Preventive Intervention ◽  
Sentinel Surveillance ◽  
Steady Increase ◽  
Hiv Seropositivity ◽  
Control Programmes ◽  
And Control ◽  
Hiv 1 ◽  
Sentinel Population

The objective was to determine the time trends in the prevalence of HIV infection and to evaluate appropriate preventive intervention in different population groups. Sentinel surveillance of HIV-1 infection by anonymous unlinked technique was carried out in Tamilnadu from December 1989 to March 1993. The sentinel population monitored were attendees of STD clinics, blood donors and antenatal mothers. The results of HIV seropositivity were compared for each 6-month period. During the study period there was 10-fold rise of HIV seropositivity among STD patients (1% to 10%), 2-fold rise among antenatal attendees (0.37% to 0.76%), and 3-fold rise in blood donors (0.24% to 0.72%). There was a steady increase in the incidence of HIV infection among those with high risk bheaviour (STD attendees) as well as in the general population. This information is of value in planning and evaluation of preventive and control programmes in India.

scholarly journals Prevalence of and risk factors for HIV infection in blood donors and various population subgroups in Ethiopia

2002 ◽  
Vol 128 (2) ◽  
pp. 221-228 ◽  
Author(s):  
R. E. J. H. SENTJENS ◽  
Y. SISAY ◽  
H. VRIELINK ◽  
D. KEBEDE ◽  
H. J. ADÈR ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Sexual Behaviour ◽  
Blood Donors ◽  
Transmitted Disease ◽  
Urban Residents ◽  
Sexual Transmitted Disease ◽  
Low Prevalence ◽  
Anti Hiv ◽  
Hiv 1

The aim was to determine the prevalence of HIV infection and risk factors for HIV infection in various population subgroups in Ethiopia. Serum panels from blood donors (n = 2610), from various population subgroups in Ethiopia were tested for anti-HIV-1/2 by ELISA. All ELISA repeatedly reactive samples were subjected for confirmation by immunoblot (IB) and anti-HIV-1 and anti-HIV-2 specific ELISAs. 155/2610 (5·9%) blood donors were HIV-1 infected. Of pregnant women, 84/797 (10·5%) were HIV-1 infected, and 1/797 (0·1%) was HIV-2 infected. 1/240 (0·4%) individuals from the rural population were HIV-1 infected. 198/480 (41·3%) female attendees, and 106/419 (25·3%) male attendees at sexual transmitted disease (STD) clinics were HIV-1 infected. One (0·2%) male, and 2 (0·4%) female STD patients were infected with both HIV-1 and HIV-2. It was concluded that the prevalence of HIV-1 infection varied from 0·4% among urban residents to 25·3–41·3% among STD attendees. There is a low prevalence of HIV-2 present in Ethiopian subjects. Risky sexual behaviour is significantly associated with HIV-infection in Ethiopia.

HIV Sentinel Surveillance in Thailand — An Example for Developing Countries

1995 ◽  
Vol 8 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Ralph R Frerichs ◽  
Kumnuan Ungchusak ◽  
Myo T Htoon ◽  
Roger Detels
Keyword(s):  
Sex Workers ◽  
Female Sex Workers ◽  
Blood Donors ◽  
Lower Class ◽  
Sentinel Surveillance ◽  
Surveillance Program ◽  
Drug Addicts ◽  
Female Sex ◽  
Hiv Epidemic ◽  
And Control

The intent of the HIV sentinel surveillance program in Thailand, as in other countries, is to provide early warning of pending epidemics so that public health of ficials can intensify prevention and control activities to protect their communities. While the intention is clear, questions remain as to how sentinel groups should be selected and if they predict future HIV occurrence. Every six months, serum is collected in Thailand from a sample of six sentinel groups in all provinces of Thailand for determining the prevalence of HIV infection. Among the sentinel groups, the HIV epidemic is rapidly increasing in female sex-workers, males at STD clinics, and females at antenatal clinics, increasing less rapidly among blood donors, and remaining high among IV drug addicts. Two sentinel groups were found to be useful for predicting the future spread of the epidemic to women attending clinics: lower-class female sex-workers and males attending STD clinics.

Absence of HIV Infection in Blood Donors with Indeterminate Western Blot Tests for Antibody to HIV-1

1990 ◽  
Vol 322 (4) ◽  
pp. 217-222 ◽  
Author(s):  
J. Brooks Jackson ◽  
Kristine L. MacDonald ◽  
Jane Cadwell ◽  
Carolyn Sullivan ◽  
William E. Kline ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Western Blot ◽  
Blood Donors ◽  
Hiv 1 ◽  
Indeterminate Western Blot

scholarly journals Contemporary diagnosis of HIV infection in pediatrician’s practice

2020 ◽  
Vol 11 (3) ◽  
pp. 73-80
Author(s):  
Jean-Claude Hakizimana ◽  
Dmitry O. Ivanov ◽  
Elena B. Yastrebova ◽  
Ruslan A. Nasyrov ◽  
Denis A. Gusev ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Laboratory Diagnostics ◽  
Primary Diagnostics ◽  
Study Evaluation ◽  
P24 Antigen ◽  
Return Visits ◽  
The Cost ◽  
And Control ◽  
Late Detection ◽  
Hiv 1

The objective of the study: evaluation of the effectiveness of clinico-epidemiological and laboratory diagnostics of HIV infection in pediatric practice. Materials and methods. Under the supervision of pediatricians of the Department of motherhood and childhood of the St. Petersburg AIDS Center, there were 388 HIV-infected children aged from one month to 17 years inclusive. Due to the reasons of late detection and HIV dissidence of parents, 18 children (4%) died cumulatively among the children observed in St. Petersburg center for AIDS. The object of the immunohistochemical study was randomly selected HIV-infected children who applied to the center for prevention and control of AIDS for return visits. Material for testing for the presence of HIV-1 P24 antigen was taken from the back wall of the nasopharynx. Results. When analyzing the ways of HIV infection in children registered at the maternity and childhood Department of the Saint Petersburg AIDS Center, it turned out that 363 children were infected perinatally (93,6%), 23 (5,9%) sexually infected and 2 children through injecting drugs (0.5%). The proposed method of immunocytochemistry for the diagnosis of HIV infection in children can find its application, especially for primary diagnostics, which may simplify and reduce the cost of laboratory diagnostics.

Behavioural risk factors for HIV infection amongst blood donors in London

1996 ◽  
Vol 6 (1) ◽  
pp. 31-36 ◽  
Author(s):  
F. M. Cowan ◽  
A. M. Johnson ◽  
J. Wadsworth ◽  
M. Brennan
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Blood Donors ◽  
Behavioural Risk Factors

Autoantibodies to Phospholipids and to the Coagulation Proteins in AIDS

1997 ◽  
Vol 77 (05) ◽  
pp. 0856-0861 ◽  
Author(s):  
N Abuaf ◽  
S Laperche ◽  
B Rajoely ◽  
R Carsique ◽  
A Deschamps ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Blood Donors ◽  
Heterogeneous Mixture ◽  
Systemic Lupus ◽  
Hematological Disorders ◽  
False Positive Test ◽  
Glycoprotein I ◽  
Coagulation Proteins ◽  
Hiv 1

SummaryIn HIV-1 infection, an increased prevalence of anticardiolipin autoantibodies (aCL) and lupus anticoagulant (LA) has been described. In order to see if these antibodies are isolated or, like in autoimmune diseases, associated with hematological disorders and with antibodies to other phospholipids and to proteins of coagulation, we investigated 3 groups of patients: 1. 342 HIV-1 infected patients, 2. 145 control patients including 61 systemic lupus erythematosus (SLE) patients, 58 patients with a connective tissue disease, 15 patients with stroke, 11 patients with syphilis and 3.100 blood donors. In HIV-1 infection antiprothrombin (aPrT) antibodies were present in 25% of patients, the prevalence of antiphosphatidylcholine antibodies (aPC) (50%) was almost as high as aCL (64%), and 39% had both antibodies. Absorption on liposomes of the latter revealed an heterogeneous mixture of aCL and aPC or cross-reacting antibodies. In contrast with SLE, anti-β2-glycoprotein I (4%), LA (1%), biological false positive test for syphilis (0.3%), thrombosis (p <0.001) were uncommon. In HIV-1 infection, antiphospholipid antibodies do not associate with features linked to them in SLE or syphilis.

scholarly journals Integrated analysis of lncRNA, miRNA and mRNA profiles reveals potential lncRNA functions during early HIV infection

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lianwei Ma ◽  
Hui Zhang ◽  
Yue Zhang ◽  
Hailong Li ◽  
Minghui An ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Immune Activation ◽  
Expression Profiles ◽  
Critical Role ◽  
Differentially Expressed ◽  
Integrated Analysis ◽  
Target Mrnas ◽  
Immunodeficiency Virus ◽  
Mirna Sequencing ◽  
Hiv 1

Abstract Background Long noncoding RNAs (lncRNAs) can regulate gene expression in a cis-regulatory fashion or as “microRNA sponges”. However, the expression and functions of lncRNAs during early human immunodeficiency virus (HIV) infection (EHI) remain unclear. Methods 3 HAART-naive EHI patients and 3 healthy controls (HCs) were recruited in this study to perform RNA sequencing and microRNA (miRNA) sequencing. The expression profiles of lncRNAs, mRNAs and miRNAs were obtained, and the potential roles of lncRNAs were analysed based on discovering lncRNA cis-regulatory target mRNAs and constructing lncRNA–miRNA–mRNA competing endogenous RNA (ceRNA) networks. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on 175 lncRNA-associated differentially expressed (DE) mRNAs to investigate the potential functions of DE lncRNAs in ceRNA networks. Results A total of 242 lncRNAs, 1240 mRNAs and 21 mature known miRNAs were determined as differentially expressed genes in HAART-naive EHI patients compared to HCs. Among DE lncRNAs, 44 lncRNAs were predicted to overlap with 41 target mRNAs, and 107 lncRNAs might regulate their nearby DE mRNAs. Two DE lncRNAs might regulate their cis-regulatory target mRNAs BTLA and ZAP70, respectively, which were associated with immune activation. In addition, the ceRNA networks comprised 160 DE lncRNAs, 21 DE miRNAs and 175 DE mRNAs. Seventeen DE lncRNAs were predicted to regulate HIF1A and TCF7L2, which are involved in the process of HIV-1 replication. Twenty DE lncRNAs might share miRNA response elements (MREs) with FOS, FOSB and JUN, which are associated with both immune activation and HIV-1 replication. Conclusions This study revealed that lncRNAs might play a critical role in HIV-1 replication and immune activation during EHI. These novel findings are helpful for understanding of the pathogenesis of HIV infection and provide new insights into antiviral therapy.

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