Some immunological parameters in workers occupationally exposed to n-hexane

1996 ◽  
Vol 15 (1) ◽  
pp. 56-58 ◽  
Author(s):  
A. Karakaya ◽  
B. Yücesoy ◽  
S. Burgaz ◽  
HU Sabir ◽  
AE Karakaya
Keyword(s):  
Exposed Group ◽  
Quantitative Relation ◽  
Significant Suppression ◽  
Immunological Parameters ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Significant Difference ◽  
Occupationally Exposed ◽  
White Blood Cell Counts ◽  
Two Populations

1 To estimate the quantitative relation between exposure to airborne n-hexane and various markers of immune function, 35 male workers were examined and compared with unexposed controls. 2 Urinary 2,5-hexanedione concentrations were signifi cantly higher in the exposed group than in the unexposed. 3 A significant suppression was observed in the serum immunoglobulin (IgG, IgM and IgA) levels between two populations. Also, a significant correlation was found between urinary 2,5-hexanedione concentrations and serum Ig level of the exposed group. 4 No significant difference between white blood cell counts was found in the two groups.

scholarly journals Systemic Immune Profile in Patients With CRSwNP

2019 ◽  
pp. 014556131989316
Author(s):  
Rafaela Veloso-Teles ◽  
Rui Cerejeira ◽  
Rosa Roque-Farinha ◽  
Christian von Buchwald
Keyword(s):  
Serum Levels ◽  
Atopic Disease ◽  
Differential Count ◽  
Immunological Parameters ◽  
Immune Profile ◽  
Prick Test ◽  
Cell Counts ◽  
Significant Difference ◽  
White Blood Cell Counts ◽  
Igg1 Subclass

The immune pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains obscure. Our aim was to compare humoral immunity and white blood cell counts in patients with CRSwNP and controls. A prospective case–control study was carried out in 37 patients with CRSwNP and 34 controls without CRS. Clinical data were gathered through a systematic interview. Computed tomography scan, skin prick test, spirometry, and immunological parameters (leukocyte differential count, immunoglobulin classes, and immunoglobulin [Ig] G subclasses) in serum specimens were obtained. Statistical analysis was performed using SPSS v.23. The prevalence of chronic lower respiratory diseases was greater in the CRSwNP group ( P < .001), but atopic disease had no significant difference. A significantly higher eosinophil ( P < .001) and basophil relative count ( P = .022) and a lower relative neutrophil count ( P = .013) were found among CRSwNP group. Patients with CRSwNP had higher IgG1 ( P = .022), but lower IgG2 ( P = .014) and IgG3 ( P = .018) serum levels compared to controls; IgG4, total IgG, IgA, IgM, and IgE serum levels did not differ between groups, as well as the prevalence of immunoglobulin classes or IgG subclasses deficiency. The variation observed in peripheral relative leukocyte count and the systemic IgG1 subclass shift are similar to what is known to happen in nasal polyp tissue. A unique systemic immune profile seems to be present in patients with CRSwNP.

scholarly journals Postoperative Analgesic Efficacy of Tramadol and Diclofenac Sodium in ‎Goats

2020 ◽  
Vol 17 (3) ◽  
pp. 22-27
Author(s):  
S. Buhari ◽  
J. Amaje ◽  
Z. M. Bello ◽  
S. Ahmad ◽  
N. Abubakar ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Diclofenac Sodium ◽  
Analgesic Efficacy ◽  
Study Groups ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Fracture Management ◽  
Significant Difference ◽  
White Blood Cell Counts

Postoperative analgesic effects of tramadol and diclofenac in goats presented for diaphyseal femoral fracture management were compared. Eight adult goats aged 10 to 24 months (16±5.2 months) were used. The first group of 4 goats received 3 mg/kg of tramadol intramuscularly (IM), and 2.5 mg/kg of diclofenac sodium was administered to the second group of 4 goats before induction of anesthesia IM. Mechanical pain scores, clinico-physiological and red and white blood cell counts were evaluated over a period of twelve hours post drug administration. The study groups were not revealed to the postoperative pain assessors until the end of the study. There was no significant difference in the rectal temperature values and the analgesiometer readings between the tramadol and diclofenac groups (p<0.05). The variations in the pulse rate, respiratory rate, red and white blood cell counts between the groups fluctuated within the normal physiological limits.It was therefore concluded that preoperative intramuscular administration of tramadol at 3 mg/kg provided similar effective postoperative analgesia with diclofenac at 2.5 mg/kg IM following femoral diaphyseal fracture management in goats.

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

scholarly journals Three Manual Noncommercial Methods to Prepare Equine Platelet-Rich Plasma

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1478
Author(s):  
Lorenzo G. T. M. Segabinazzi ◽  
Giorgia Podico ◽  
Michael F. Rosser ◽  
Som G. Nanjappa ◽  
Marco A. Alvarenga ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Platelet Rich Plasma ◽  
Upright Position ◽  
Platelet Counts ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Platelet Concentration ◽  
Manual Methods ◽  
White Blood Cell Counts ◽  
Over Time

In light of PRP’s increasing popularity in veterinary practice, this study aimed to compare three manual methods to prepare and cool equine PRP. The blood of 18 clinically healthy mares was collected via venipuncture in a blood transfusion bag (method 1), blood tubes (method 2), and a syringe (method 3). In method 1, samples were double centrifuged; method 2 involved one centrifugation, and in method 3 the syringe was kept in an upright position to sediment for 4 h. After processing with three methods, PRP and platelet-poor plasma (PPP) were extracted and assessed for red (RBC) and white blood cell counts (WBC), platelet counts, and viability. In a subset of mares (n = 6), samples were processed with the three methods, and PRP was evaluated at 6 and 24 h postcooling at 5 °C. Method 1 resulted in the highest and method 3 in the lowest platelet concentration (p < 0.05), and the latter also had greater contamination with WBC than the others (p < 0.001). Platelet viability was similar across treatments (p > 0.05). Cooling for 24 h did not affect platelet counts in all methods (p > 0.05); however, platelet viability was reduced after cooling PRP produced by method 3 (p = 0.04), and agglutination increased over time in all methods (p < 0.001). The three methods increased (1.8–5.6-fold) platelet concentration in PRP compared to whole blood without compromising platelet viability. In conclusion, all three methods concentrated platelets and while cooling affected their viability. It remains unknown whether the different methods and cooling would affect PRP’s clinical efficacy.

Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory actions in elderly type 2 diabetics

2021 ◽  
pp. 096228022110259
Author(s):  
Shintaro Yamamuro ◽  
Tomohiro Shinozaki ◽  
Satoshi Iimuro ◽  
Yutaka Matsuyama
Keyword(s):  
Cardiovascular Disease ◽  
Blood Cell ◽  
Indirect Effects ◽  
Time Varying ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Anti Inflammatory ◽  
White Blood Cell Counts ◽  
Inflammatory Action

Modern causal mediation theory has formalized several types of indirect and direct effects of treatment on outcomes regarding specific mediator variables. We reviewed and unified distinct approaches to estimate the “interventional” direct and indirect effects for multiple mediators and time-varying variables. This study was motivated by a clinical trial of elderly type-2 diabetic patients in which atorvastatin was widely prescribed to control patients’ cholesterol levels to reduce diabetic complications, including cardiovascular disease. Among atorvastatin’s preventive side-effects (pleiotropic effects), we focus on its anti-inflammatory action as measured by white blood cell counts. Hence, we estimate atorvastatin’s interventional indirect effects through cholesterol lowering and through anti-inflammatory action, and interventional direct effect bypassing these two actions. In our analysis, total effect (six-year cardiovascular disease risk difference) estimated by standard plug-in g-formula of −3.65% (95% confidence interval: −10.29%, 4.38%) is decomposed into indirect effect via low-density lipoprotein cholesterol (−0.90% [−1.91%, −0.07%]), via white blood cell counts (−0.03% [−0.22%, 0.11%]), and direct effect (−2.84% [−9.71%, 5.41%]) by the proposed parametric mediational g-formula. The SAS program and its evaluation via simulated datasets are provided in the Supplemental materials.

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