Immunoglobulin levels in workers exposed to hexachlorobenzene

The serum immunoglobulin (IgG, IgM and IgA) concentrations of 52 chlorinated-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had mean hexachlorobenzene (HCB) blood levels of 3.84 mg/dl with a range of 0.1 to 16 mg/dl. Increased IgG and IgM levels were found in the HCB- exposed workers (P50.05 and P50.01, respectively). Hepatic function was evaluated by serum aspartate (AST) and alanine aminotransferase (ALT) activities, as well as by bilirubin levels. IgM concentrations were positively correlated with three of the studied parameters, namely, length of exposure (r=0.367) and the activities of both AST (r=0.367) and ALT (r=0.507).

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An Immunological Study on Workers Occupationally Exposed to Cadmium

Human & Experimental Toxicology ◽

10.1177/096032719401300202 ◽

1994 ◽

Vol 13 (2) ◽

pp. 73-75 ◽

Cited By ~ 14

Author(s):

A. Karakaya ◽

B. Yücesoy ◽

O.S. Sardas

Keyword(s):

Serum Immunoglobulin ◽

Quantitative Relation ◽

Immunological Study ◽

Control Groups ◽

Exposed Workers ◽

Blood Cadmium ◽

Occupationally Exposed ◽

Urine Cadmium ◽

And Control ◽

Immunoglobulin Levels

1 To assess the quantitative relation between exposure to airborne cadmium and various markers of immune function, 37 male workers were examined and compared with unexposed controls. 2 Blood cadmium concentrations were signficantly , higher in the exposed workers than in the unexposed, as was urine cadmium. 3 No differences in the serum immunoglobulin (IgG, IgM and IgA) levels between two popularions were observed, There was also no significant correlation between blood cadmium concentrations and serum immunoglobulin levels of both exposed and control groups, It has been found also that while monocyte counts signficantly increased, lymphocyte, neutrophil and oesinophil counts remained unchanged.

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Measurement of the respiratory burst and chemotaxis in polymorphonuclear leukocytes from mercury-exposed workers

Human & Experimental Toxicology ◽

10.1177/096032719501400308 ◽

1995 ◽

Vol 14 (3) ◽

pp. 281-286 ◽

Cited By ~ 24

Author(s):

Rcr Perlingeiro ◽

Mls Queiroz

Keyword(s):

Polymorphonuclear Leukocytes ◽

Neutrophil Migration ◽

Threshold Level ◽

Neutrophil Function ◽

Normal Range ◽

Safe Level ◽

Urinary Mercury ◽

Exposed Population ◽

Exposed Workers ◽

Age And Sex

The chemotactic and nitroblue tetrazolium reducing activ ities of neutrophils from 48 mercury-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had a mean (± s.d.) urinary mer cury concentration of 24.0 ± 20.1 μg g-1 creatinine and in 44 of these workers urinary mercury levels were below the accepted threshold level (TLV) of 50 μg g-1 creatinine. The two neutrophil functions were significantly reduced in the mercury-exposed workers compared with the con trols. In 28 of these workers, chemotaxis was re-evaluated 6 months later. During the intervening 6 months, the level of hygiene was improved throughout the plant and uri nary mercury concentrations were determined monthly in each worker. Despite a significant reduction in urinary mercury concentrations, neutrophil migration did not return to within the normal range. These results suggest that 'safe' level mercury exposure may lead to impairment of neutrophil function.

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Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis

Frontiers in Immunology ◽

10.3389/fimmu.2021.664526 ◽

2021 ◽

Vol 12 ◽

Author(s):

Samer R. Khan ◽

Anna C. van der Burgh ◽

Robin P. Peeters ◽

P. Martin van Hagen ◽

Virgil A. S. H. Dalm ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Immunoglobulin A ◽

Serum Immunoglobulin ◽

Specific Reference ◽

Reference Ranges ◽

Serum Immunoglobulins ◽

Mean Differences ◽

Immunoglobulin Levels ◽

Age And Sex

BackgroundAn up-to-date overview of determinants of serum immunoglobulins in adults is pivotal for clinical practice and research, but currently lacking. We therefore performed a systematic review and meta-analysis to identify determinants of serum immunoglobulin levels.MethodsEmbase, Web of Science, Medline, Cochrane, and Google Scholar were searched from inception to July 11th, 2019 for articles reporting on determinants of serum immunoglobulin A, G or M (IgA, IgG or IgM) in adult humans. Random and fixed effect models were applied to obtain pooled mean differences (MDs) and 95% confidence intervals (CIs) for the association of age and sex with serum immunoglobulins.ResultsWe retrieved 117 articles reporting on determinants of serum immunoglobulins, of which 28 could be meta-analyzed. Older compared to younger individuals had higher IgA (MD: 0.38; CI: 0.18 – 0.58), but lower IgM levels (MD: -0.40; 95%: -0.66 – -0.14). Men had higher IgA (MD: 0.22; CI: 0.03 – 0.42), but lower IgM levels (MD: -0.21; CI: -0.32 – -0.10) than women. Age and sex did not influence IgG. Caucasian ethnicity was associated with lower IgA, IgG, and IgM. Smoking and corticosteroid use were associated with lower IgG. Positive associations were reported of probiotics with IgG, alcohol with IgA, hypertension with IgA and IgG, and acute psychological stress with IgA, IgG, and IgM.ConclusionsOlder age and male sex are associated with higher IgA, but lower IgM, and urge investigation of age- and sex-specific reference ranges of immunoglobulins. Other identified determinants were ethnicity, diet, lifestyle and cardio-metabolic factors.

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ASSESSMENT OF SERUM IMMUNOGLOBULIN LEVELS IN PREMATURELY BORN INFANTS AND YOUNG CHILDREN – ROLE OF TERM-ADJUSTED AGE CORRECTION

10.26226/morressier.57bc1758d462b80290b4d3f1 ◽

2016 ◽

Author(s):

Aleksandra Szczawinska-popłonyk

Keyword(s):

Young Children ◽

Serum Immunoglobulin ◽

Age Correction ◽

Immunoglobulin Levels ◽

Prematurely Born Infants ◽

Infants And Young Children

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Serum immunoglobulin levels, complement components 3 and 4, HLA-B27 allele and spondyloarthropathy in patients with non-infectious anterior uveites

Reumatología Clínica (English Edition) ◽

10.1016/j.reumae.2020.07.007 ◽

2021 ◽

Author(s):

Bárbara Torres Rives ◽

Goitybell Martínez Téllez ◽

Minerva Mataran Valdés ◽

Teresa Collazo Mesa ◽

Rosa Colás González ◽

...

Keyword(s):

Serum Immunoglobulin ◽

Hla B27 ◽

Complement Components ◽

Immunoglobulin Levels

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Phytobiotics with Adsorbent to Mitigate Toxicity of Multiple Mycotoxins on Health and Growth of Pigs

Toxins ◽

10.3390/toxins13070442 ◽

2021 ◽

Vol 13 (7) ◽

pp. 442

Author(s):

Debora Muratori Holanda ◽

Young Ihn Kim ◽

Wanpuech Parnsen ◽

Sung Woo Kim

Keyword(s):

Body Weight ◽

Total Protein ◽

Alanine Aminotransferase ◽

Hepatic Function ◽

Negative Effects ◽

Serum Total Protein ◽

Urea Nitrogen ◽

Inflammatory Status ◽

Tnf Α ◽

Mycotoxin Adsorbent

Phytobiotics with a mycotoxin adsorbent were used to mitigate negative effects of multiple mycotoxins in diets fed to pigs. In experiment 1, 120 pigs (11.6 kg body weight; BW) were assigned to five treatments (three pigs/pen) and fed for 28 days. Treatments were CON (control), MTD (CON + 2.5 mg/kg of deoxynivalenol), DP (MTD + phytobiotics at 0.1%), and DPA1 and DPA2 (MTD + phytobiotics and adsorbent at 0.1% and 0.2%, respectively). In experiment 2, 96 pigs (28.5 kg BW) were assigned to four treatments (three pigs/pen) and fed for 26 days. Treatments were CON, MTAF (CON + 0.19 mg/kg of aflatoxin and 8 mg/kg of fumonisins), AFP (MTAF + phytobiotics at 0.1%), and AFPA (MTAF + phytobiotics and adsorbent at 0.1%). Growth performance was measured weekly, and blood was sampled at the end of study to measure hepatic function and inflammatory status (TNF-α). Data were analyzed using the MIXED procedure. In experiment 1, pigs fed MTD, DP, DPA1, and DPA2 had smaller (p < 0.05) BW than CON. Pigs fed DPA2 had greater (p < 0.05) BW than MTD. Pigs fed DP and DPA2 tended to have lower (p < 0.1) serum total protein than CON. Pigs fed MTD and DPA2 tended to have higher (p < 0.1) alanine aminotransferase than CON. Similarly, pigs fed MTD, DP, and DPA2 tended to have higher (p < 0.1) urea nitrogen/creatinine than CON. In experiment 2, pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) BW than CON. Pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) ADFI than CON. Pigs fed AFPA had higher (p < 0.05) aspartate aminotransferase than CON and MTAF. Pigs fed AFP and AFPA had higher (p < 0.05) alanine aminotransferase than CON. Pigs fed MTAF, AFP, and AFPA had lower (p < 0.05) urea nitrogen/creatinine than CON. Pigs fed AFPA had higher (p < 0.05) TNF-α than CON and MTAF. In conclusion, feeding an additional 2.5 mg/kg of deoxynivalenol or 0.19 mg/kg of aflatoxin with 8 mg/kg of fumonisins reduced the growth of pigs. Deoxynivalenol compromised the hepatic function of pigs. Phytobiotics with adsorbent could partly overcome the detrimental effects of mycotoxins.

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