scholarly journals Phytobiotics with Adsorbent to Mitigate Toxicity of Multiple Mycotoxins on Health and Growth of Pigs

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 442
Author(s):  
Debora Muratori Holanda ◽  
Young Ihn Kim ◽  
Wanpuech Parnsen ◽  
Sung Woo Kim
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Alanine Aminotransferase ◽  
Hepatic Function ◽  
Negative Effects ◽  
Serum Total Protein ◽  
Urea Nitrogen ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Mycotoxin Adsorbent

Phytobiotics with a mycotoxin adsorbent were used to mitigate negative effects of multiple mycotoxins in diets fed to pigs. In experiment 1, 120 pigs (11.6 kg body weight; BW) were assigned to five treatments (three pigs/pen) and fed for 28 days. Treatments were CON (control), MTD (CON + 2.5 mg/kg of deoxynivalenol), DP (MTD + phytobiotics at 0.1%), and DPA1 and DPA2 (MTD + phytobiotics and adsorbent at 0.1% and 0.2%, respectively). In experiment 2, 96 pigs (28.5 kg BW) were assigned to four treatments (three pigs/pen) and fed for 26 days. Treatments were CON, MTAF (CON + 0.19 mg/kg of aflatoxin and 8 mg/kg of fumonisins), AFP (MTAF + phytobiotics at 0.1%), and AFPA (MTAF + phytobiotics and adsorbent at 0.1%). Growth performance was measured weekly, and blood was sampled at the end of study to measure hepatic function and inflammatory status (TNF-α). Data were analyzed using the MIXED procedure. In experiment 1, pigs fed MTD, DP, DPA1, and DPA2 had smaller (p < 0.05) BW than CON. Pigs fed DPA2 had greater (p < 0.05) BW than MTD. Pigs fed DP and DPA2 tended to have lower (p < 0.1) serum total protein than CON. Pigs fed MTD and DPA2 tended to have higher (p < 0.1) alanine aminotransferase than CON. Similarly, pigs fed MTD, DP, and DPA2 tended to have higher (p < 0.1) urea nitrogen/creatinine than CON. In experiment 2, pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) BW than CON. Pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) ADFI than CON. Pigs fed AFPA had higher (p < 0.05) aspartate aminotransferase than CON and MTAF. Pigs fed AFP and AFPA had higher (p < 0.05) alanine aminotransferase than CON. Pigs fed MTAF, AFP, and AFPA had lower (p < 0.05) urea nitrogen/creatinine than CON. Pigs fed AFPA had higher (p < 0.05) TNF-α than CON and MTAF. In conclusion, feeding an additional 2.5 mg/kg of deoxynivalenol or 0.19 mg/kg of aflatoxin with 8 mg/kg of fumonisins reduced the growth of pigs. Deoxynivalenol compromised the hepatic function of pigs. Phytobiotics with adsorbent could partly overcome the detrimental effects of mycotoxins.

scholarly journals EXPERIMENTAL DEHYDRATION: CHEMICAL CHANGES IN THE BLOOD OF THE DOG CONTRASTED WITH THOSE FOLLOWING OBSTRUCTION OF THE CARDIAC END OF THE STOMACH

1929 ◽  
Vol 49 (6) ◽  
pp. 945-953 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Urine Output ◽  
Average Duration ◽  
Chemical Study ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Urea Nitrogen

A comparative chemical study of the blood and the urine of the dog with experimental dehydration and with obstruction of the cardiac end of the stomach is reported. The average duration of life is slightly longer with dehydration than with obstruction. The urine output per kilo of body weight is almost twice as great in dehydration as with obstruction. The increase in non-protein nitrogen and urea nitrogen is much the same in the two groups although somewhat more marked with obstruction. The chlorides of the blood are markedly increased with dehydration and slightly decreased with obstruction. The increase in fibrinogen and total protein is twice as great with obstruction as with dehydration. These findings indicate that there must be some factor or factors in addition to dehydration producing the toxemia of cardiac obstruction.

scholarly journals Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens

2010 ◽  
Vol 66 (10) ◽  
pp. 675-679 ◽  
Author(s):  
Poźniak B. ◽  
Yuan H. ◽  
J. Yi ◽  
Guo C. ◽  
Deng S. ◽  
...  
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Clinical Manifestations ◽  
Weight Ratio ◽  
Serum Biochemical Parameters ◽  
Serum Total Protein ◽  
Weight Gains ◽  
Serum Biochemical

The aim of the study was to investigate the effects of different doses of acetylsalicylic acid (ASA) and sodium salicylate (SS) administration on weight gains and serum biochemical parameters in broiler chickens. This study was performed to investigate the safety of ASA and SS in chickens in conditions of moderate overdose. Seventy five broiler chickens (Sanhuangji breed) were divided into control and experimental groups. The chickens were administered orally with ASA or SS in the following daily doses: 50, 100 and 200 mg/kg for 20 days. In the course of the experiment weight gains were recorded. On day 14 and day 20 the chickens were sampled for blood biochemical analysis. Investigated parameters included serum total protein, albumin, uric acid, creatinine, potassium, sodium and calcium contents as well as alanine transaminase activity. After the last samplings the chickens were dissected and liver and kidney to body weight ratios were recorded. It was demonstrated that SS at a dose of 200 mg/kg increased serum total protein level. ASA increased serum proteins at a dose of 100 mg/kg but not at a higher dose. At the dose of 200 mg/kg ASA increased the kidney to body weight ratio. In all salicylate treated groups the liver weights were lower as compared to the control. No clinical manifestations of intolerance were observed. It is assumed that chickens tolerate ASA and SS well, even in doses producing distinct side effects in several mammalian species.

scholarly journals Maintaining Weight and Nutritional Status with Ninjinyoueito in Elderly Patients with Chronic Wasting Diseases

2021 ◽  
Author(s):  
Yumi Nakagawa ◽  
Katsunori Kagohashi ◽  
Ayako Shioya ◽  
Kensuke Kinoshita ◽  
Hiroshi Tsuji ◽  
...  
Keyword(s):  
Body Weight ◽  
Retrospective Study ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Total Protein ◽  
Chronic Wasting Disease ◽  
Serum Levels ◽  
Nutritional Condition ◽  
Wasting Disease ◽  
Serum Total Protein

Objectives: To obtain information on the nutritional maintenance effects of Ninjinyoueito (NYT) in elderly patients with chronic wasting disease, a retrospective study was conducted. Methods: we investigated changes in bodyweight and serum levels of total protein and albumin in patients who received NYT for more than 6 months for chronic wasting diseases in our hospital from April 2009 and October 2019. Results: During the study period, 11 patients (median age: 75 years) had NYT for 6 months or more. The median administration period of NYT was 14 months. The bodyweight, serum total protein, and albumin at the time of last observation were not statistically different from those at the time of the start of NYT administration (p=0.1755, p=0.7659, p=0.5498, respectively). Conclusions: Our study suggested the possibility of maintaining nutritional condition by NYT in elderly patients with chronic wasting disease of various etiologies. More evidence will be required to confirm our results. Keywords: body weight; nutritional status; ninjinyoueito; elderly patients; chronic wasting diseases

scholarly journals Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

2020 ◽  
Vol 22 (98) ◽  
pp. 132-137
Author(s):  
W. S. Said ◽  
V. V. Stybel ◽  
B. V. Gutyj ◽  
O. B. Pryima ◽  
I. Y. Mazur
Keyword(s):  
Body Weight ◽  
Functional State ◽  
Total Protein ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Experimental Studies ◽  
Control Group ◽  
Activity Of Enzymes ◽  
Experimental Group

The aim of the study was to investigate the effect of toxocariasis invasion on protein-synthesizing function and functional state of the liver of dogs. For experimental studies, 12 dogs aged from two to four months were used and two groups of six animals were formed in each: control and experimental. Puppies of the experimental group were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive eggs of T. canis per kg of body weight. The control puppies were clinically healthy. Protein-synthesizing function of the liver of dogs in experimental toxocariasis was studied by the level of total protein and its fractions. It was found that on the 25th day of the experiment the level of total protein in the blood of the experimental group of dogs was 56.9 ± 1.47 g/l, while in the control group – 63.8 ± 2.92 g/l. The lowest level of the studied indicator was on the 30th day of the experiment in the blood of the experimental group of dogs, where it decreased by 9.6 %. The results of a study of protein fractions in the blood of dogs infested with toxocara showed that the percentage of albumin is likely to decrease. However, in the blood of infected dogs in this period of research there was a probable increase in globulin levels. The study of the effect of toxocariasis invasion on the activity of enzymes in blood serum is a test for the morphological and functional state of tissues and organs. Based on the studies, it was found that with the development of toxocariasis invasion in dogs there is an increase in alanine aminotransferase in their serum. On the 25th and 30th day of the experiment, the activity of the enzyme in the serum of infected dogs was the highest, where compared with the control group of dogs, the activity of ALT increased by 51.2 and 59.1 %, respectively. Similar changes in activity were observed in the determination of aspartate aminotransferase, where, respectively, on the 15th, 20th and 25th day of the experiment, the activity of AST in the serum of infected dogs increased by 19.3, 27.5 and 39.1 %.

Thyroid hormones and lipid profile in Labrador Retriever male dogs

2017 ◽  
Author(s):  
K. Megha ◽  
M. Swamy ◽  
L. Ranganath ◽  
Suguna Rao ◽  
N. Shridhar ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Thyroid Hormones ◽  
Lipid Profile ◽  
Total Protein ◽  
Middle Age ◽  
Age Groups ◽  
Labrador Retriever ◽  
Age Group ◽  
Serum Total Protein

A study was conducted to assess the thyroid hormones and lipid profile in Labrador Retriever male dogs presented to the Veterinary College Hospital, Bengaluru for routine health check up and vaccination. Based on their age, they were randomly divided into Group I, Group II and Group III that consisted of one to three years age (young age), more than three years to six years age (middle age) and more than six to nine years age (old age), respectively. In all the dogs the body weight was recorded. The profile of thyroid hormones such as thyroid stimulating hormone (TSH), triiodothyronine (T3) and  Thyroxine (T4) were estimated by using ELISA kits. The lipid profile parameters such as triglycerides, cholesterol and HDL cholesterol were estimated by using biochemical reagent kits. The values of LDL and VLDL cholesterol were calculated by using Friedewald formula. Further, the blood glucose level was estimated using the Glucochek® glucometer and serum total protein level by using reagent kit. Results revealed that the increased body weight was observed as age advanced. The T3 levels did not vary significantly among different age groups. Whereas, in the advanced age groups there was reduction in T4 levels and increase in TSH levels which was suggestive of hypothyroidism. Triglycerides, cholesterol, LDL and VLDL levels were significantly higher in older dogs followed by middle age group compared to young age group. However, the alterations in blood glucose and serum total protein levels were non significant between different age groups. It was concluded that the Labrador Retriever male dogs could be more prone to hypothyroidism and hyperlipidemia and therefore master health check-up could be taken up at least once in a year as a precautionary measure to avoid complications of hypothyroidism and hyperlipidemia.

Toxicological Interactions of Cassia Senna and Nerium oleander in the Diet of Rats

2002 ◽  
Vol 30 (04) ◽  
pp. 579-587 ◽  
Author(s):  
M. A. Al-Yahya ◽  
A. H. Al-Farham ◽  
S. E. I. Adam
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Total Protein ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Wistar Rats ◽  
Feed Utilization ◽  
Nerium Oleander ◽  
Serum Aspartate Aminotransferase ◽  
Male Wistar Rats

The toxic effects of diet containing 10% of C. senna L. fruits or 10% of N. oleander L. leaves or their 1 : 1 mixture (5%+5%) on male Wistar rats treated for 6 weeks were investigated. Diarrhea was a prominent sign of C. senna L. toxicosis. In both phytotoxicities, there were decreases in body weight gains, inefficiency of feed utilization, dullness and enterohepatonephropathy. These findings accompanied by leukopenia and anemia were correlated with alterations of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and concentrations of total protein, albumin, urea and other serum constituents. In both phytotoxicities, the ability of the liver to excrete bilirubin remained unchanged. Feeding the mixture of C. senna L. fruits and N. oleander L. leaves caused more serious effects and death of rats. The implications of these findings are discussed.

Serum Carnitine Levels, Lipid Profile, and Metabolic Status of Patients on Continuous Ambulatory Peritoneal Dialysis

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 440-443 ◽  
Author(s):  
Theodoros Pliakogiannis ◽  
Christos Chatzidimitriou ◽  
Athanasios Evangeliou ◽  
Hans Josef Söhles ◽  
Kleonikos Kalaitzidis
Keyword(s):  
Body Weight ◽  
Peritoneal Dialysis ◽  
Lipid Profile ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Total Protein ◽  
Skinfold Thickness ◽  
Metabolic Status ◽  
Serum Total Protein ◽  
Relative Body Weight ◽  
Triceps Skinfold Thickness

The purpose of our study was to evaluate the influence of serum carnitine levels on the metabolic status and lipid profile of patients on continuous ambulatory peritoneal dialysis (CAPD). We studied the lipid profile, the metabolic status (triceps, skinfold thickness, midarm muscle circumference, relative body weight, serum total protein, albumin), and serum carnitine levels in 22 patients (11 male, 11 female) on CAPD. The results are summarized as follows: mean serum total camitine (TC) was normal, free carnitine (FC) was reduced, while acylcarnitine (AC) was elevated in our patients (p<0.001). A positive correlation was found between TC (p<0.02), FC (p<0.05), and serum total protein. A positive correlation was also found between TC (p<0.05), AC (p<0.02), ACIFC (p<0.02), and relative body weight, and TC (p<0.001), FC (p<0.02), AC (p<0.01), ACIFC (p<0.02), and triglycerides. No correlation was found between carnitine and midarm muscle circumference, triceps skinfold thickness, albumin, total cholesterol, and HDL. or LDL-cholesterol. Further studies are needed to confirm our results.

scholarly journals Utilization of whole pods of Albizia saman in diets of growing rabbits

2021 ◽  
Vol 33 (2) ◽  
pp. 197-202
Author(s):  
O. O. Oduguwa
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Packed Cell Volume ◽  
Blood Cells ◽  
Dry Matter ◽  
Protein Efficiency Ratio ◽  
Efficiency Ratio ◽  
Serum Total Protein ◽  
Dietary Treatments ◽  
Albizia Saman

The effect of graded levels of whole pods of Albizia saman (Rain tree) on the performance nutrient utilization and haematology of growing rabbits were studied. Four experimental diets were formulated which contained 100, 200 and 300g whole pods of A. saman of diet. Forty-eight growing hybrid rabbits with average initial weight of 828.2g were used for the experiment. They were alloted on weight equalization basis to four dietary treatments that is 12 animals per treatment. The animals were housed individually and fed ad libitum with the respective diets through the eight weeks experimental period. Data on body weight, feed intake, feed to gain ratio and protein efficiency ratio were monitored. Metabolic trials were also carried out in the course of the experiment and the digestibility of dry matter and the proximate contents of the feed were determined. Some haematological indices of the experimental animals were also assayed, these include: packed cell volume, haemoglobin, red blood cells, white blood cells, serum total protein, serum albumin and serum creatine. Results showed that the dietary treatments had significant effect (P<0.05) on body weight, feed intake, feed to gain ratio and protein efficiency ratio. Rabbits fed 100g kg-1 A. saman diet had similar performance with those on the control diet (0g kg-1 A. saman) and performed better (P<0.05) than those fed 200g kg-1 and 300g kg-1 A. saman diets. The digestibility values of dry matter and other proximate fractions of the dietary treatments were not significantly different (P>0.05). However, when only the A. saman diets were considered, rabbits fed 100g kg-1 had the highest but non-significant digestibility values for all the measurement taken. The mean values for packed cell volume, haemoglobin, serum total protein and serum albumin decreased with increasing level of inclusion of A. saman. There was no significant difference (P>0.05) in the values of red blood cells and serum creatine. It was concluded that inclusion of whole pods of A. saman up to 100g kg-1 level in the diets of growing rabbits gave best results with no adverse effect on performance and nutrient digestibility.   

scholarly journals Performance evaluation of a formulated infant food on some biological indices in Wistar rats

2019 ◽  
Vol 30 (2) ◽  
pp. 117-121
Author(s):  
Chris Oche Ikese ◽  
Simon Terver Ubwa ◽  
Peter Agorye Adie ◽  
Steven Inegedu Audu ◽  
Godwin Ejeke
Keyword(s):  
Body Weight ◽  
Performance Evaluation ◽  
Blood Cell ◽  
Total Protein ◽  
Wistar Rats ◽  
Infant Food ◽  
Feeding Trial ◽  
Serum Total Protein ◽  
Biological Indices ◽  
Normal Rat

Abstract Performance evaluation of a formulated infant food on some biological indices in Wistar rats was investigated. For rats fed separately with normal rat feed, formulated infant food and proprietary food, serum total protein and albumin were determined by colorimetric method, red blood cell (RBC) and differential white blood cell (WBC) counts were determined with a haemocytometer, packed cell volume (PCV) was by micro-haematocrit, haemoglobin (HGB) was determined using cyanomethaemoglobin method while mean cell volume (MCV) and mean cell haemoglobin (MCH) were calculated. The results obtained showed that, for Wistar rats fed with normal rat feed, the baseline values prior to the commencement of feeding trial for serum total protein, albumin, body weight, PCV, WBC, platelet count (PLT), RBC, HGB, lymphocyte count (LYM), MCH, MCV, neutrophil (NEU), and eosinophil (EOS) were 82.9 g/dL, 44.75 g/dL, 142.80g, 41.14%, 7.60×103 μL−1, 404.85×103 μL−1, 5.68×106 μL−1, 10.80 g/dL, 50.28 %, 18.42 pg, 59.28 fL, 45.57 %, and 2.57 % respectively. After the feeding trial, the serum total protein, albumin, body weight, PCV, WBC, PLT, RBC, HGB, LYM, MCH, MCV, NEU, and EOS in Wistar rats fed with the formulated infant food (the experimental group) were 79.6 g/dL, 50.65 g/dL, 169.18g, 40.14%, 5.77 ×103 μL−1, 309.85 ×103 μL−1, 6.85×106 μL−1, 12.45 g/dL, 52.85 %, 18.24 pg, 58.64 fL, 42.00 %, and 2.14% respectively and these were in most cases, either greater or comparable with their corresponding mean values of 69.1 g/dL, 44.40 g/dL, 177.97 g, 30.24%, 4.18×103 μL−1, 188.14×103 μL−1, 5.29×106 μL−1, 10.74 g/dL, 53.14 %, 20.37 pg, 57.61 fL, 38.85 %, and 4.57 % respectively in Wistar rats fed with the proprietary infant formula (the control group). This shows that the potential infant food has a more positive effect on most of the biological indices assessed than the proprietary infant food or a comparable effect at the least.

scholarly journals Protective Effect of Cordia Myxa Extract on Changes in Body Weight, Serum Proteins, Albumin and Liver Histology of Adult Male Rats Induced by Cadmium Chloride Toxicity

2019 ◽  
Vol 13 (2) ◽  
pp. 43-49
Author(s):  
Mojtaba Shahriari ◽  
◽  
Davood Moghadamnia ◽  
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Total Protein ◽  
Sham Group ◽  
Male Rats ◽  
Serum Total Protein ◽  
The Mean ◽  
Group 2 ◽  
Histologic Changes ◽  
Group 1

Background: The present study investigated the protective effect of C. myxa extract on the liver biochemical and histologic changes induced by cadmium chloride (CdCl2) in adult male rats. Methods: We used 48 adults male Wistar rats, divided into 6 groups of 8. Control group received water and normal food. Sham group 1 received 2 mg/kg of CdCl2 for 35 days intraperitoneally. In Addition, Sham Group 2 received 125 mg/kg extract of C. myxa fruit for 35 days by gavage method. The experimental groups 1, 2 and 3 received 125, 250 and 500 mg/kg of C. myxa extract for 21 days through gavage, followed by 2 mg/kg of CdCl2 given intraperitoneally for 14 days. After the experimentation period, blood samples were taken and the serum total protein and albumin concentrations measured. Also, liver tissue sections were prepared, stained and examined by light microscopy to evaluate the histologic changes. Results: The mean body weight, serum total protein, albumin in sham group 1 showed a significant decrease in comparison with those in the controls and Sham Group 2. The mean body weight and serum total protein in Experimental Groups 2 and 3 showed a significant increase compared to those in Sham Group 1. The mean serum albumin in Experimental Group 3 showed a significant increase compared to that in Sham Group 1 (P <0.05). Conclusion: The extract of C. myxa fruit demonstrated protective effects on changes in body weight, serum biochemical factors and liver histology induced by the adverse effect of CdCl2 in adult male rats.

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