Laboratory-confirmed pediatric COVID-19 in patients with rheumatic diseases: A case series in a tertiary hospital

Lupus ◽  
2021 ◽  
pp. 096120332199842
Author(s):  
Bianca P Ihara ◽  
Claudia AA Strabelli ◽  
Juliana R Simon ◽  
Vivianne SL Viana ◽  
Adriana ME Sallum ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Case Series ◽  
Tertiary Hospital

scholarly journals Children and adolescents with rheumatic diseases and tuberculosis in a tertiary hospital in Rio de Janeiro – case series

2021 ◽  
Author(s):  
Lenita de Melo Lima ◽  
Rafaela Baroni Aurilio ◽  
Ana Alice Ibiapina Amaral Parente ◽  
Adriana Rodrigues Fonseca ◽  
Claudia Stella Pereira ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Rheumatic Diseases ◽  
Rio De Janeiro ◽  
Case Series ◽  
Tertiary Hospital

scholarly journals OP0097 LISTERIA MONOCYTOGENES. DESCRIPTION AND ANALYSIS OF CASES IN AN IMMUNODEPRESSED POPULATION BY RHEUMATIC DISEASES

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 53.2-54
Author(s):  
M. Lisbona Muñoz ◽  
P. León ◽  
G. Lopez Antequera ◽  
E. Rubio-Romero
Keyword(s):  
Listeria Monocytogenes ◽  
Rheumatic Disease ◽  
Pregnant Women ◽  
Rheumatic Diseases ◽  
Case Series ◽  
Similar Proportion ◽  
Neurological Manifestations ◽  
Biological Dmards ◽  
Parametric Data ◽  
The Impact

Background:Listeria monocytogenes is a gram-positive bacteria that cause the invasive disease listeriosis. Human clinical syndromes are infrequent, mostly appearing in immunosuppressed individuals, newborns, the elderly, pregnant women, and occasionally healthy patients.Objectives:We describe and analyze Listeria-related demographics and clinical features to determine the predisposing conditions for severe infections in an immunodepressed population by rheumatic diseases.Methods:Descriptive Observational Study. A retrospective analysis of 143 patients were performed affected by listeriosis, with positive isolation of Listeria monocytogenes from blood, treated in the H.U. Virgen del Rocío (Seville- Spain) between 2003-2019. Of them 9 were rheumatic patients. The type of clinical manifestation was analyzed, paying special attention to the characteristics associated with patients with neurological complications or unfavorable outcome (death and / or abortion in pregnant women), immunosuppression (associated with cancer or rheumatic disease) was assessed as independent variables, chronic diseases (Hypertension, Diabetes Mellitus, dyslipidemia, COPD, Renal Insufficiency and Ischemic Heart Disease) as well as other baseline characteristics of the patient. (age, sex, pregnancy) and their toxic habits (tobacco and alcohol).Results:The sample includes a similar proportion of men (70 cases) and women (73 cases), of all ages. Of the total patients, most (85%) required hospital admission, with a duration median (non-parametric data) of 11 days. 78% of the cases admitted showed a favorable evolution. However, 15.4% resulted in death and 5.6% in abortion. This percentage of abortions represented 29% of the total pregnant women admitted Of all the patients admitted, a third (33%) were immunocompromised, including patiets with cancer (79%) and rheumatic diseases (21%). Include lupus (33%), RA (22%), APs (11%), polymyalgia rheumatica (11%), panuveitis (11%) and ANCA vasculitis MPO specificity (11%). All of them required admission although the majority showed a favorable evolution, except one of the patient. which resulted in death, in which case in addition to lupus he presented with prostate cancer. Regarding the baseline treatment of these patients, 7 underwent treatment with synthetic DMARDs and three with biological DMARDs (1 Adalimumab, 1 Infliximab and 1 Rituximab) As a result of the listeria infection, most of them had fever or digestive symptoms and two of they experienced neurological manifestations (meningoencephalitis) None of these last two (with lupus and RA) had biological DMARDs.Conclusion:Listeriosis is an uncommon but potentially serious infection usually in older people, pregnant women and immunocompromised patients. In our sample, 33% of the patients were immunocompromised. Of the 9 patients. affected by listeria with rheumatic disease we find a death for meningoencephalitis. Given the impact of this infection in immunosuppressed patients should pay attention in our patients with fever and neurological manifestations.Reference:[1]Eleftherios Mylonakis et al. A Case Series and Review of 222 Cases. Medicine 2002; 81: 260-269.[2]Alcoba Lez M et al.Meningitis por Listeria monocytogenes en el adulto en España. Presentación de 10 casos y revisión de la literatura. Rev Clin Esp 2002; 202 (12): 638-643.[3]Eleftherios Mylonakis et al. Central Nervous Sistem Infection with Listeria monocytogenes. 33 Years’ Experience at a General Hospital and Review of 776 Episodes from tha Literature. Medicine 1998; 77: 313-336.Disclosure of Interests:None declared

Hypoglycemia caused by insulinoma. A review of a case series treated at a tertiary hospital

2018 ◽  
Vol 218 (6) ◽  
pp. 321-322
Author(s):  
A. Simó-Servat ◽  
J. Puig de la Bellacasa Suils ◽  
M. Pérez Maraver
Keyword(s):  
Case Series ◽  
Tertiary Hospital

Mucoepidermoid Carcinomas of the Larynx

2022 ◽  
pp. 000348942110694
Author(s):  
Holden W. Richards ◽  
Caitlin Bertelsen ◽  
Bronwyn Hamilton ◽  
David Sauer ◽  
Joshua Schindler
Keyword(s):  
Radiation Therapy ◽  
Radical Neck Dissection ◽  
Case Series ◽  
Tumor Grade ◽  
Tertiary Hospital ◽  
Additional Treatment ◽  
Partial Laryngectomy ◽  
High Grade ◽  
Intermediate Grade ◽  
Postoperative Radiation Therapy

Objectives: Discussions regarding the specific management and outcomes for laryngeal MEC are limited to very small, single-institution case series. To look further into the diagnosis and management of these uncommon non-squamous cell carcinomas of the larynx, we present 3 recent cases of laryngeal MEC treated at our institution. Methods: Patients at a tertiary hospital treated for MEC between October 2019 and December 2020 were retrospectively identified. Chart review, imaging analysis, and histologic slide creation were completed for all patients. Results: We identified and treated 2 patients with high-grade supraglottic and 1 patient with intermediate-grade glottic MEC. These patients presented to our clinic with a primary complaint of either gradual, worsening dysphonia, dysphagia, or both. All patients underwent laryngovideostroboscopy as well as panendoscopy with directed submucosal biopsy, which was consistent with MEC. MRI was performed in 2 of the cases further elucidating the extent of submucosal spread. PET-CT was performed in all 3 cases, and none demonstrated evidence of regional or distal metastases. Surgically, high-grade MEC lesions were treated with a total laryngectomy. The intermediate MEC lesion was managed with a supracricoid partial laryngectomy (SCPL). Surgical margins were free of tumor in all cases with no nodal metastases by modified radical neck dissection. Radiation therapy was offered to both high-grade MEC patients and declined by one. Radiation was not recommended to the patient with intermediate-grade MEC as we believed that the risk of additional treatment outweighed the benefit. Conclusion: We believe that MEC of the larynx should be considered in patients with atypical submucosal laryngeal masses. Laryngovideostroboscopy, MRI, and PET imaging may be valuable in determining the extent of the lesions and planning appropriate surgery. Postoperative radiation therapy should be considered a per tumor grade in other more studied sites, as there is no data on efficacy in laryngeal MEC.

P061 Kawasaki disease: a case series from a tertiary Hospital in Kenya

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
C Njeru ◽  
A Migowa
Keyword(s):  
Kawasaki Disease ◽  
Incidence Rate ◽  
Low Dose ◽  
Clinical Signs ◽  
Case Series ◽  
Cervical Lymphadenopathy ◽  
Patient Characteristics ◽  
Tertiary Hospital ◽  
High Dose ◽  
True Incidence

Abstract Background Kawasaki disease (kDa) is a childhood vasculitides that affects small and medium-sized arteries. It is self-limiting but when left untreated can cause coronary artery aneurysms in about 25% of children1. The diagnosis is clinical and is made with the criteria of fever for at least five days, and at least four out of five other clinical signs: bilateral non-exudative conjunctivitis, oral mucous membrane changes, peripheral extremity changes, polymorphous rash, and cervical lymphadenopathy. Incomplete kDa is diagnosed with fever for at least five days and at least 2–3 of the principal signs, with suggestive lab investigations and lack of an alternative diagnosis1. kDa is named after Dr Tomisaku Kawasaki who first described it in 1967 in Japan2. The highest incidence of kDa continues to be reported among Asian children, with an incidence rate of 264.8 per 100 000 population aged 0–4 years as per Japan’s latest nationwide survey3. In Africa, the true incidence is unknown but several case reports have been published. A 2016 paper by Gorrab et al.4 found that the annualized incidence rate of kDa in the Maghreb children living in Quebec (18.49/year/100 000 children under 5 years of age) was 4–12 times higher than reported in their countries of origin- Tunisia, Morocco, and Algeria (0.95, 4.52, and 3.15, respectively) suggesting a likelihood of under-diagnosis. This case series sought to highlight the characteristics, presentation, and management of patients diagnosed with kDa in a tertiary hospital in Kenya. Methods This was a retrospective cross-sectional study carried out by reviewing the charts of all the patients with a discharge diagnosis of kDa from January 2013 to December 2017 at the Aga Khan University Hospital, Nairobi. Their demographics, presentation, diagnostic work-up, and management are reported. Analysis was done by descriptive statistics using the Microsoft Excel 2016 Application. Results A total of 15 cases were identified and the patient characteristics and presentation are as tabulated below: In addition to elevated inflammatory markers (C reactive protein and/or Erythrocyte Sedimentation Rate), a significant number of the patients also had sterile pyuria (9/9), hypoalbuminemia (8/10), thrombocytosis (8/15), and anaemia (11/15). Nine out of eleven had negative blood cultures. Fourteen out of the fifteen patients had echocardiograms done during admission. Only one patient was found to have abnormal findings of bilaterally dilated coronaries arteries. Five patients had at least one documented repeat echocardiogram. Fourteen patients received Intravenous Immunoglobulin (IVIG), with 13 of them responding to treatment. No adverse effects were reported after treatment. One patient did not improve and needed a second dose of IVIG and intravenous methylprednisone (30 mg/kg). Fourteen patients received aspirin but dosing varied from high (80–90 mg/kg/day) to moderate (30–50 mg/kg/day) to low dose (3 mg/kg/day). One patient on high-dose aspirin was noted to have developed symptoms consistent with aspirin-induced bronchospasm and was changed to low dose. Conclusion This case series highlights the presence of kDa in the Kenyan pediatric population with patient characteristics similar to what is reported globally. Diagnosis was made after a mean of about 7 days, possibly due to low awareness of the disease among healthcare professionals. Management with IVIG in most cases was successful but more guidance is needed around the use of steroids and the dosing of aspirin.

Neuromyelitis optica spectrum disorder in a tertiary hospital in the Philippines: a case series

2019 ◽  
Vol 31 ◽  
pp. 124-130 ◽  
Author(s):  
Adrian I. Espiritu ◽  
Bryan Vincent Q. Mesina ◽  
Athena Angellie DL. Puerto ◽  
Nikolai Gil D. Reyes ◽  
Ludwig F. Damian ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Case Series ◽  
Tertiary Hospital ◽  
The Philippines ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

Pregnancy after liver transplantation. How safe? A retrospective case-series study in a large tertiary hospital

2015 ◽  
Vol 29 (13) ◽  
pp. 2120-2124 ◽  
Author(s):  
Chrysoula Margioula-Siarkou ◽  
Ioannis Kalogiannidis ◽  
Stamatios Petousis ◽  
Constantin Kubanangidi ◽  
Ioannis Fouzas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Case Series ◽  
Tertiary Hospital ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Case Series Study ◽  
Series Study

scholarly journals Tibiocalcaneal arthrodesis in fixed equinus deformity with ring fixator

2019 ◽  
Vol 13 (2) ◽  
pp. 166-171
Author(s):  
Rafael Bispo de Souza ◽  
Antônio Carlos Faloni Nunes Pereira ◽  
Rafael Costa Nerys ◽  
Jefferson Soares Martins ◽  
Edegmar Nunes Costa
Keyword(s):  
Quality Of Life ◽  
Case Series ◽  
Tertiary Hospital ◽  
Limb Function ◽  
Level Of Evidence ◽  
Ring Fixator ◽  
Tibiocalcaneal Arthrodesis ◽  
Sf 36 ◽  
Equinus Deformity

Objective: To evaluate the limb function and quality of life of patients with posttraumatic fixed equinus deformity treated at a tertiary hospital after arthrodesis with the Ilizarov external fixator. Methods: A study was conducted from January 2015 to June 2018 in which 6 patients were evaluated at outpatient follow-up in the late postoperative period. First, an identification questionnaire was administered to assess limb function using the American Orthopedic Foot and Ankle Society (AOFAS) scale, and quality of life was assessed using the SF-36 questionnaire. Results: A total of 66.6% of the sample had an AOFAS score below 70 (mean total = 57.5), which is considered poor. The mean SF-36 score was low (below 60) in all domains evaluated. The pain domain had the highest score (mean = 57.2). Conclusions: Even after surgery to correct the deformity, patients had impaired function and quality of life. Level of Evidence IV; Therapeutic Studies; Case Series.

Sign in / Sign up

Export Citation Format

Share Document