The Pharmacology of Antiulcer Drugs

DICP ◽  
1989 ◽  
Vol 23 (10_suppl) ◽  
pp. S10-S16 ◽  
Author(s):  
Aryeh Hurwitz ◽  
Charles A. Carter

The use of medications for the treatment of gastrointestinal ulcers has evolved to a great extent since the early days of therapy with diet and antacids. Today a number of different agents are available to treat the causative factors of ulcer formation. Currently, antacids, histamine2-receptor antagonists, and sucralfate are considered frontline therapies suitable for most patients. The future also looks promising for newer agents, such as omeprazole and prostaglandin analogs. The purpose of this article is to provide practitioners with an understanding of the pharmacology of these agents so that their rational use can be achieved more efficiently and effectively.

2021 ◽  
Vol 13 (20) ◽  
pp. 4090
Author(s):  
Amit Kumar Batar ◽  
Hideaki Shibata ◽  
Teiji Watanabe

An estimation of where forest fragmentation is likely to occur is critically important for improving the integrity of the forest landscape. We prepare a forest fragmentation susceptibility map for the first time by developing an integrated model and identify its causative factors in the forest landscape. Our proposed model is based upon the synergistic use of the earth observation data, forest fragmentation approach, patch forests, causative factors, and the weight-of-evidence (WOE) method in a Geographical Information System (GIS) platform. We evaluate the applicability of the proposed model in the Indian Himalayan region, a region of rich biodiversity and environmental significance in the Indian subcontinent. To obtain a forest fragmentation susceptibility map, we used patch forests as past evidence of completely degraded forests. Subsequently, we used these patch forests in the WOE method to assign the standardized weight value to each class of causative factors tested by the Variance Inflation Factor (VIF) method. Finally, we prepare a forest fragmentation susceptibility map and classify it into five levels: very low, low, medium, high, and very high and test its validity using 30% randomly selected patch forests. Our study reveals that around 40% of the study area is highly susceptible to forest fragmentation. This study identifies that forest fragmentation is more likely to occur if proximity to built-up areas, roads, agricultural lands, and streams is low, whereas it is less likely to occur in higher altitude zones (more than 2000 m a.s.l.). Additionally, forest fragmentation will likely occur in areas mainly facing south, east, southwest, and southeast directions and on very gentle and gentle slopes (less than 25 degrees). This study identifies Himalayan moist temperate and pine forests as being likely to be most affected by forest fragmentation in the future. The results suggest that the study area would experience more forest fragmentation in the future, meaning loss of forest landscape integrity and rich biodiversity in the Indian Himalayan region. Our integrated model achieved a prediction accuracy of 88.7%, indicating good accuracy of the model. This study will be helpful to minimize forest fragmentation and improve the integrity of the forest landscape by implementing forest restoration and reforestation schemes.


2021 ◽  
Vol 7 (Extra-D) ◽  
pp. 22-27
Author(s):  
Sergej N. Bezugly ◽  
Galia G. Mikhaleva ◽  
Irina V. Savelieva ◽  
Oksana S. Shumilina ◽  
Natalia Yu. Zhilina

The article includes consideration of the norms on land damage under the criminal legislation of the CIS countries, analysis of approaches to the legal regulation of land protection in criminal legislation. It is determined that not all criminal laws have the special rules protecting the land only. We analyzed the signs of land damage, revealed the specifics of objective signs of land damage, as well as analyzed the advantages and disadvantages of legal regulation in comparison. It is concluded that relations on the protection and rational use of land, ensuring environmental safety are very important for the uninterrupted provision of the population with a sufficient number of safe and affordable products in the future.


When considering principles for selection of indicators, i.e. biological variables, for monitoring marine pollution, it must be regarded as important to search for effects on the highest possible level of organization. For a global monitoring programme there are, however, many practical limitations in the number of useful indicators. The paper suggests skeletal deformities in fish as one possible indicator for this purpose in the future and gives a review on the occurrence, effects, causative factors and possible mechanisms of skeletal deformities in fish.


Drugs ◽  
2015 ◽  
Vol 75 (11) ◽  
pp. 1229-1253 ◽  
Author(s):  
Giuseppe De Luca ◽  
Stefano Savonitto ◽  
Arnoud W. J. van’t Hof ◽  
Harry Suryapranata

2009 ◽  
Vol 46 (6) ◽  
pp. 16-26 ◽  
Author(s):  
S. Guseva ◽  
N. Skobeleva ◽  
N. Breners ◽  
O. Borscevskis

Determination of Service Areas of Urban Transformer Substations and Distribution Using Geometrical Templates In the work, a general and theoretically substantiated approach is proposed for the arrangement and determination of service areas for the future transformer substations (TSs). The modelling of TS service area has been performed, with geometrical templates designed to arrange TSs in the city building territory. The sizes of templates have been obtained depending on the TS capacity and load density in TS service area. The geometrical templates are to help in TS arrangement in view of rational use of the city territory and to re-arrange the existing stations for the reconstruction time. As a result, the urban power supply system will develop not chaotically but in a purposeful manner.


Author(s):  
Victoria Barkasi ◽  
◽  
Tetiana Filippyeva ◽  

The aim of the article is to study the advantages of media education technologies in the training of future foreign language teachers due to the fact that the current stage of society highlights the education of the individual who must effectively select and concentrate information, process it and create new, separate useful from unnecessary ways and programs for their solution. Therefore, today it is not enough to use video, audio, press and information and communication technologies when teaching future foreign language teachers only for the development of oral and written speech. It is necessary to pay attention to the development of visual and critical media literacy of students, based on the main objectives of media education. The article considers the problems of formation of professional competence of the future teacher of a foreign language by means of media education. The author analyzes the principles and functions of media education as the main components of professional media education of the future foreign language teacher. The peculiarities of the introduction and rational use of the latest media educational technologies in the professional training of future foreign language teachers are revealed. Their influence on the educational process and the need to update the role of the teacher in modern conditions of pedagogical activity are analyzed. The relevance of the article is determined by the dynamic trends in the introduction of media in the educational process. The integrated use of media education technologies motivates future foreign language teachers to master their profession, gives them the opportunity to acquire and develop new skills and abilities. The inclusion of the study of media education technologies in the initial program of the Faculty of Foreign Languages will promote the rational use of media education in future professional activities, critical evaluation of information, the ability to analyze and recognize media texts, and learn about new trends in teaching their subject. Improving knowledge in the field of media educational technologies, acquiring knowledge of pedagogical development of personality and awareness of the role and place of teachers in the educational process provides an opportunity to intensify and motivate student learning activities and gain initial pedagogical experience.


2021 ◽  
pp. 695-714
Author(s):  
Duane K. Miller ◽  
Curtis L. Decker

Abstract Welded connections are a common location for failures for many reasons, as explained in this article. This article looks at such failures from a holistic perspective. It discusses the interaction of manufacturing-related cracking and service failures and primarily deals with failures that occur in service due to stresses caused by externally applied loads. The purpose of this article is to enable a failure analyst to identify the causative factors that lead to welded connection failure and to identify the corrective actions needed to overcome such failures in the future. Additionally, the reader will learn from the mistakes of others and use principles that will avoid the occurrence of similar failures in the future. The topics covered include failure analysis fundamentals, welded connections failure analysis, welded connections and discontinuities, and fatigue. In addition, several case studies that demonstrate how a holistic approach to failure analysis is necessary are presented.


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