The Capitalist State: Structural Variation and Its Implications for Radical Change

This case study explores the strategic business opportunities, for Lane Crawford, an iconic luxury department store, to transition in a circular economy towards sustainability. A new experimentation framework was developed and conducted among cross departmental employees, during a Design Lab, with intention to co-create novel Circular Economy business concepts towards a new vision: the later was a reframe of the old system based on the principles of sustainability; to move beyond a linear operational model towards a circular economy that can contribute to a regenerative society. This work draws on both academic and professional experience and was conducted through professional practice. It was found that innovative co-created concepts, output from the Design Lab, can create radical change in a circular economy that is holistically beneficial and financially viable; looking forward to extract greater value a)Internal organization requires remodeling to transform towards a circular economy; b)Requirement for more horizonal teams across departments vs solely vertical; c)New language and relationships are required to be able to transition towards a circular economy; d)Some form of physical and virtual space requirements, for cross-disciplinary teams to come together to co-create; e)Ability to iterate, learn and evolve requires agency across the business

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Structural variation in the songs of Atlantic walruses breeding in the Canadian High Arctic

Aquatic Mammals ◽

10.1578/016754203101024121 ◽

2003 ◽

Vol 29 (2) ◽

pp. 297-318 ◽

Cited By ~ 19

Author(s):

Becky Sjare ◽

Ian Stirling ◽

Cheryl Spencer

Keyword(s):

Structural Variation ◽

High Arctic ◽

Canadian High Arctic

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The Distinction between [P] and [S]

10.23943/princeton/9780691161006.003.0018 ◽

2017 ◽

Author(s):

Galen Strawson

Keyword(s):

Personal Identity ◽

Radical Change ◽

Legal Responsibility ◽

The Difference ◽

Definition Of ◽

Over Time

This chapter examines the difference between John Locke's definition of a person [P], considered as a kind of thing, and his definition of a subject of experience of a certain sophisticated sort [S]. It first discusses the equation [P] = [S], where [S] is assumed to be a continuing thing that is able to survive radical change of substantial realization, as well as Locke's position about consciousness in relation to [P]'s identity or existence over time as [S]. It argues that Locke is not guilty of circularity because he is not proposing consciousness as the determinant of [S]'s identity over time, but only of [S]'s moral and legal responsibility over time. Finally, it suggests that the terms “Person” and “Personal identity” pull apart, in Locke's scheme of things, but in a perfectly coherent way.

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The Problem of Policy Coordination in a Newly Decentralised Government: A Study of Policy Implementation in the Province of Bali, Indonesia

Mediterranean Journal of Social Sciences ◽

10.2478/mjss-2018-0140 ◽

2018 ◽

Vol 9 (5) ◽

pp. 83-95

Author(s):

Luqman H. Zainuri

Keyword(s):

Policy Implementation ◽

Local Governments ◽

Political System ◽

Local Economic Development ◽

National Level ◽

Radical Change ◽

Policy Coordination ◽

Politics And Government ◽

Government Relations ◽

Societal Needs

Abstract The aim of this article is to describe inter government relations resulted from disorganized political change from Autocratic political system to the Democratic one. This purpose is described through a challenge against Governor’s moratorium policy in 2010 made by three Heads of Districts within the province of Bali over the issuance of principle of building permit of new hotels and tourist accomodations. The method by which this research is conducted is exploratory. The research found that the problems of coordination in the policy emanate from a radical change in politics and government from centralised to decentralised government and termination of President Soeharto from the office. The un-coordinated political transition at the national level being faced by Indonesia has brought about serious problems on coordination of inter government institutions of the local governments. In effect, to the large extent, the performance of local governments -as it has been the case in the province of Bali-is contra productive in fulfilling societal needs of public services as well as local-economic development.

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CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)

Clinical & Investigative Medicine ◽

10.25011/cim.v31i4.4821 ◽

2008 ◽

Vol 31 (4) ◽

pp. 19

Author(s):

I Pasic ◽

A Shlien ◽

A Novokmet ◽

C Zhang ◽

U Tabori ◽

...

Keyword(s):

Genomic Instability ◽

Large Scale ◽

Structural Variation ◽

Age Of Onset ◽

Cancer Susceptibility ◽

Small Sample Size ◽

Snp Array ◽

Tumour Suppressor Gene ◽

Small Sample ◽

International Hapmap Project

Introduction: OS, a common Li-Fraumeni syndrome (LFS)-associated neoplasm, is a common bone malignancy of children and adolescents. Sporadic OS is also characterized by young age of onset and high genomic instability, suggesting a genetic contribution to disease. This study examined the contribution of novel DNA structural variation elements, CNVs, to OS susceptibility. Given our finding of excessive constitutional DNA CNV in LFS patients, which often coincide with cancer-related genes, we hypothesized that constitutional CNV may also provide clues about the aetiology of LFS-related sporadic neoplasms like OS. Methods: CNV in blood DNA of 26 patients with sporadic OS was compared to that of 263 normal control samples from the International HapMap project, as well as 62 local controls. Analysis was performed on DNA hybridized to Affymetrix genome-wide human SNP array 6.0 by Partek Genomic Suite. Results: There was no detectable difference in average number of CNVs, CNV length, and total structural variation (product of average CNV number and length) between individuals with OS and controls. While this data is preliminary (small sample size), it argues against the presence of constitutional genomic instability in individuals with sporadic OS. Conclusion: We found that the majority of tumours from patients with sporadic OS show CN loss at chr3q13.31, raising the possibility that chr3q13.31 may represent a “driver” region in OS aetiology. In at least one OS tumour, which displays CN loss at chr3q13.31, we demonstrate decreased expression of a known tumour suppressor gene located at chr3q13.31. We are investigating the role ofchr3q13.31 in development of OS.

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The Future of Global Great Power Competition after the Coronavirus

Insight Turkey ◽

10.25253/99.2020222.06 ◽

2020 ◽

pp. 79-92

Author(s):

Burhanettin Duran

Keyword(s):

World War Ii ◽

International System ◽

Radical Change ◽

Economic Effects ◽

World War ◽

Health Security ◽

Self Sufficiency ◽

The Future ◽

Policy Agendas ◽

The U.S

Due to the COVID-19 pandemic, the domestic and foreign policy agendas of all countries have been turned upside down. The pandemic has brought new problems and competition areas to states and to the international system. While the pandemic politically calls to mind the post-World War II era, it can also be compared with the 2008 crisis due to its economic effects such as unemployment and the disruption of global supply chains. A debate immediately began for a new international system; however, it seems that the current international system will be affected, but will not experience a radical change. That is, a new international order is not expected, while disorder is most likely in the post-pandemic period. In an atmosphere of global instability where debates on the U.S.-led international system have been worn for a while, in the post-pandemic period states will invest in self-sufficiency and redefine their strategic areas, especially in health security. The decline of U.S. leadership, the challenging policies of China, the effects of Chinese policies on the U.S.-China relations and the EU’s deepening crisis are going to be the main discussion topics that will determine the future of the international system.

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