SARS-CoV-2 Immunohistochemistry In Placenta

2021 ◽  
pp. 106689692110677
Author(s):  
Dinesh Rakheja ◽  
Kristina Treat ◽  
Charles F. Timmons ◽  
Deyssy Carrillo ◽  
Sara E. Miller ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Nucleocapsid Protein ◽  
Placental Pathology ◽  
Virus Infections ◽  
Quick Method ◽  
Placental Infection ◽  
Immunohistochemical Assay ◽  
Highly Sensitive

Compared to the parental SARS-CoV-2 virus, infections by the now dominant Delta variant of SARS-CoV-2 appear to be more common and more severe in pregnant women. The need for a robust, cheap, and quick method for diagnosing placental infection by SARS-CoV-2 has thus become more acute. Here, we describe a highly sensitive and specific immunohistochemical assay for SARS-CoV-2 nucleocapsid protein for routine use in placental pathology practice.

scholarly journals Impact of SARS-CoV-2 on the clinical outcomes and placental pathology of pregnant women and their infants: A Systematic Review

Heliyon ◽  
2021 ◽  
pp. e06393
Author(s):  
Irina Oltean ◽  
Jason Tran ◽  
Sarah Lawrence ◽  
Brittany Ann Ruschkowski ◽  
Na Zeng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Clinical Outcomes ◽  
Placental Pathology

Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling

2021 ◽  
pp. 109352662110251
Author(s):  
James Roberts ◽  
Jeanette D Cheng ◽  
Elizabeth Moore ◽  
Carla Ransom ◽  
Minhui Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Immunohistochemical Staining ◽  
Placental Pathology ◽  
Fibrin Deposition ◽  
Placental Infection ◽  
Fetal Infection

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.

scholarly journals High Endemicity and Low Molecular Diversity of Hepatitis B Virus Infections in Pregnant Women in a Rural District of North Cameroon

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80346 ◽  
Author(s):  
Alexandra Ducancelle ◽  
Pierre Abgueguen ◽  
Jacques Birguel ◽  
Wael Mansour ◽  
Adeline Pivert ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Molecular Diversity ◽  
Rural District ◽  
Virus Infections ◽  
B Virus ◽  
Hepatitis B Virus Infections

scholarly journals Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania

2017 ◽  
Vol 125 (1) ◽  
pp. 134-140 ◽  
Author(s):  
Blair J. Wylie ◽  
Emmanuel Matechi ◽  
Yahya Kishashu ◽  
Wafaie Fawzi ◽  
Zul Premji ◽  
...  
Keyword(s):  
Air Pollution ◽  
Pregnant Women ◽  
Dar Es Salaam ◽  
Household Air Pollution ◽  
Placental Pathology

scholarly journals 590: Placental pathology associated with household air pollution in a cohort of pregnant women from Dar es Salaam, Tanzania

2016 ◽  
Vol 214 (1) ◽  
pp. S316 ◽  
Author(s):  
Blair J. Wylie ◽  
Emmanuel Matechi ◽  
Yahya Kishashu ◽  
Wafaie Fawzi ◽  
Brent Coull ◽  
...  
Keyword(s):  
Air Pollution ◽  
Pregnant Women ◽  
Dar Es Salaam ◽  
Household Air Pollution ◽  
Placental Pathology

scholarly journals Maternal and neonatal response to COVID-19

2020 ◽  
Vol 319 (2) ◽  
pp. E315-E319 ◽  
Author(s):  
Thea N. Golden ◽  
Rebecca A. Simmons
Keyword(s):  
Preterm Birth ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Newborn Health ◽  
Maternal And Newborn Health ◽  
Placental Infection ◽  
Neonatal Response ◽  
Maternal Disease ◽  
Maternal And Newborn

The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to maternal and newborn health has yet to be determined. Several reports suggest pregnancy does not typically increase the severity of maternal disease; however, cases of preeclampsia and preterm birth have been infrequently reported. Reports of placental infection and vertical transmission are rare. Interestingly, despite lack of SARS-CoV-2 placenta infection, there are several reports of significant abnormalities in placenta morphology. Continued research on pregnant women infected with SARS-CoV-2 and their offspring is vitally important.

scholarly journals A Model of Tuberculosis Screening for Pregnant Women in Resource-Limited Settings Using Xpert MTB/RIF

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Eleanor R. Turnbull ◽  
Nzali G. Kancheya ◽  
Jennifer B. Harris ◽  
Stephanie M. Topp ◽  
German Henostroza ◽  
...  
Keyword(s):  
Pregnant Women ◽  
World Health ◽  
Diagnostic Tools ◽  
Tuberculosis Screening ◽  
Pilot Studies ◽  
Resource Limited ◽  
Highly Sensitive ◽  
Mother And Child ◽  
Health Organization ◽  
Diagnostic Technologies

Timely diagnosis and treatment of maternal tuberculosis (TB) is important to reduce morbidity and mortality for both the mother and child, particularly in women who are coinfected with HIV. The World Health Organization (WHO) recommends the integration of TB/HIV screening into antenatal services but available diagnostic tools are slow and insensitive, resulting in delays in treatment initiation. Recently the WHO endorsed Xpert MTB/RIF, a highly sensitive, real-time PCR assay forMycobacterium tuberculosisthat simultaneously detects rifampicin resistance directly from sputum and provides results within 100 minutes. We propose a model for same-day TB screening and diagnosis of all pregnant women at antenatal care using Xpert MTB/RIF. Pilot studies are urgently required to evaluate strategies for the integration of TB screening into antenatal clinics using new diagnostic technologies.

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