scholarly journals Chemotherapy-Induced Reduction of Neutrophil-to-Lymphocyte Ratio Is Associated With Better Survival in Pancreatic Adenocarcinoma: A Meta-Analysis

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482097713
Author(s):  
Xin Luo ◽  
Bo Yu ◽  
Nan Jiang ◽  
Qiong Du ◽  
Xuan Ye ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Retrospective Studies ◽  
Web Of Science ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Impact ◽  
Lymphocyte Ratio ◽  
Prisma Statement ◽  
Pre Treatment

Objectives: Numerous studies have suggested that an increase in neutrophil-to-lymphocyte ratio (NLR) before treatment is associated with worse survival in pancreatic adenocarcinoma (PAC). The aim of this study was to investigate the prognostic value of treatment-induced NLR change among PAC patients so as to better identify the characteristics of those who can benefit more from treatment. Methods: This meta-analysis was undertaken using the PRISMA statement. Previously published studies between the correlation of NLR change and patients’ survival were searched in Pubmed, Embase, and Web of Science databases. RevMan 5.3 was used to conduct statistical analysis. Results: A total of 1213 patients with PAC from 6 retrospective studies were included in this meta-analysis. Four studies investigated the HR of pre-treatment NLR, demonstrating its prognostic impact on overall survival (OS) (HR = 2.21, 95%CI: 1.45-3.36). One study reported that an elevated post-treatment NLR was associated with poorer OS (HR = 1.28, 95%CI = 1.08-1.52). Pooled analysis indicated that NLR reduction might predict favorable survival in both the overall population (HR = 1.52, 95% CI: 1.34–1.73) and the subgroup treated with chemotherapy (HR = 1.50, 95% CI: 1.32-1.70). Conclusion: Treatment-induced NLR change can act as an early predictor for PAC. Patients with reduced NLR after chemotherapy are expected to have better survival.

scholarly journals Prognostic Function of Neutrophil-to-Lymphocyte Ratio in Patients with GEP-NEN: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Yajie Wang ◽  
Bei Wen ◽  
Yuxin Zhang ◽  
Kangdi Dong ◽  
Shubo Tian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Neuroendocrine Neoplasm ◽  
Free Survival ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Relationship

Abstract Purpose: A high neutrophil-to-lymphocyte ratio (NLR) might be related to unfavorable prognosis. We sought to conduct a systematic review and meta-analysis of published studies exploring the relationship between NLR with the prognosis in patients with gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).Methods: The databases PubMed, Embase, and Web of Science were searched using words like 'neutrophil lymphocyte ratio', neuroendocrine tumors', and others through May 2020. We evaluated the significance of NLR on overall survival (OS) and recurrence-free survival (RFS) of patients with GEP-NEN in our study.Results: We gathered thirteen cohorts with 1598 cases. The pooled analysis revealed that a higher NLR related to worse OS (hazards ratio (HR): 4.59, 95% confidence interval (CI) 3.35-6.29, P < 0.00001) and poor RFS (HR: 4.05, 95% CI: 2.78–5.90, P＜0.00001) in patients with GEP-NEN.Conclusion: A high NLR can be considered a high-risk prognostic factor in GEP-NEN.

scholarly journals Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies

2017 ◽  
Vol 41 (6) ◽  
pp. 2411-2418 ◽  
Author(s):  
Qi-tao Huang  ◽  
Lin Zhou ◽  
Wen-juan Zeng ◽  
Qian-qian Ma ◽  
Wei Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Progression Free Survival ◽  
Neutrophil To Lymphocyte Ratio ◽  
Ca 125 ◽  
Published Data ◽  
Lymphocyte Ratio ◽  
Pre Treatment ◽  
Meta Analyses

Background and Aims: Published data on the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer. Materials and Methods: We conducted a systematic literature search using the electronic databases PubMed, Web of Science, and Embase up to May 2016. Hazard ratio (HR) and odd ratio (OR) with 95% confidence interval (95% CI) were calculated. Subgroup analyses were carried out to explore the source of heterogeneity. Statistical analysis was performed using Stata 10.0. Results: A total of 12 studies, consisting of 3,854 patients, which met our criterion were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (OS) (HR: 1.69, 95% CI 1.29-2.22) and shorter progression free survival (PFS) (HR 1.63, 95% CI 1.27–2.09). Additionally, increased NLR was also significantly correlated with advanced FIGO stage (OR 2.32, 95% CI1.79-3.00), higher serum level of CA-125 (OR 3.33, 95% CI 2.43-4.58), more extensive ascites (OR 3.54, 95% CI 2.31-5.42) as well as less chemotheraputic response (OR 0.53, 95% CI 0.40-0.70). The findings from most of subgroup meta-analyses were consistent with those from the overall meta-analyses. Conclusions: Elevated pre-treatment NLR could served as a predicative factor of poor prognosis for ovarian cancer patients.

Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

Immunotherapy ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 631-643 ◽  
Author(s):  
Vincenzo Di Nunno ◽  
Veronica Mollica ◽  
Lidia Gatto ◽  
Matteo Santoni ◽  
Laura Cosmai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Meta Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Impact ◽  
Lymphocyte Ratio

scholarly journals Prognostic significance of the neutrophil-to-lymphocyte ratio in peripheral T-cell lymphoma: a meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jia Liu ◽  
Shengnan Zhang ◽  
Ruihua Mi ◽  
Lin Chen ◽  
Qingsong Yin
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
T Cell Lymphoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cochrane Library ◽  
Prognostic Impact ◽  
Peripheral T Cell Lymphoma ◽  
Lymphocyte Ratio

AbstractThe neutrophil-to-lymphocyte ratio (NLR) as an inflammatory marker may represent changes between inflammation and host immunity that affect the prognosis of peripheral T-cell lymphoma (PTCL). To comprehensively evaluate the NLR in PTCL, we performed a meta-analysis to investigate the relationship between the NLR and overall survival (OS) and progression-free survival (PFS). PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) were searched for all relevant studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained from each study. Heterogeneity among the included studies was checked to determine whether fixed or random effects model was used. In total, 8 studies with 921 patients were included for the meta-analysis. High NLR significantly correlated with worse OS (HR = 2.20, 95% CI 1.71–2.83, P < 0.05) regardless of region (Asian or non-Asian), sample size (< 60 or ≥ 60), median age (< 60 or ≥ 60), disease type, or cut-off value (NLR < 3.9 or NLR ≥ 3.9). In terms of PFS, the NLR had no prognostic impact for patients with PTCL (HR = 1.12, 95% CI 0.57–2.20, P = 0.742). Our findings suggest that PTCL patients with high NLR are more likely to have worse OS compared to those with low NLR. Therefore, the NLR can serve as a prognostic marker in PTCL.

Sign in / Sign up

Export Citation Format

Share Document