Modulation of Endothelium by Heparin and Related Polyelectrolytes

1996 ◽  
Vol 2 (3) ◽  
pp. 200-208 ◽  
Author(s):  
Jawed Fareed ◽  
Walter Jeske ◽  
Demetra Callas ◽  
Debra Hoppensteadt ◽  
Jeanine Walenga
Keyword(s):  
Animal Models ◽  
Endothelial Function ◽  
Beneficial Effect ◽  
Tissue Factor ◽  
Vascular Endothelium ◽  
Human Studies ◽  
Flowing Blood

The vascular endothelium is an important me diator of the hemostatic balance. In addition to shielding subendothelial tissue factor from flowing blood, endothe lial cells produce a number of substances which favor an antithrombotic state including TFPI and tPA. The ability of polyelectrolytes such as heparin and defibrotide to modulate endothelial function is examined using animal models and human studies. Like heparin, defibrotide is observed to increase plasma TFPI antigen levels. Addi tionally, defibrotide administration is observed to in crease plasma tPa antigen levels and to decrease PAI, TF and endothelin levels. Modulation of endothelial function by defibrotide may account for its beneficial effect in PAOD.

scholarly journals The effects of betalain-rich cacti (dragon fruit and cactus pear) on endothelial and vascular function: a systematic review of animal and human studies

2020 ◽  
Vol 11 (8) ◽  
pp. 6807-6817
Author(s):  
Alex Cheok ◽  
Trevor W. George ◽  
Ana Rodriguez-Mateos ◽  
Paul W. Caton
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Endothelial Function ◽  
Vascular Function ◽  
Human Studies ◽  
Cactus Pear ◽  
Dragon Fruit

This systematic review assesses the evidence for the effects of edible cacti (dragon fruit and cactus pear) on vascular and endothelial function based on animal models and human studies.

Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling

2021 ◽  
Vol 36 (4) ◽  
pp. 523-543
Author(s):  
Vanessa Trindade Bortoluzzi ◽  
Carlos Severo Dutra Filho ◽  
Clovis Milton Duval Wannmacher
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Redox Signaling ◽  
Human Studies

Beneficial effect of azilsartan and amlodipine on endothelial function in hypertensive patients

2016 ◽  
Vol 252 ◽  
pp. e53 ◽  
Author(s):  
T. Nishida ◽  
M. Ayaori ◽  
K. Shiotani ◽  
H. Uto-Kondo ◽  
M. Sasaki ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Beneficial Effect ◽  
Hypertensive Patients

Behavioral and biochemical investigations to explore the efficacy of quercetin and folacin in experimental diabetes induced vascular endothelium dysfunction and associated dementia in rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Poonam Sharma ◽  
Khushboo Aggarwal ◽  
Rajendra Awasthi ◽  
Giriraj T. Kulkarni ◽  
Bhupesh Sharma
Keyword(s):  
Executive Functioning ◽  
Endothelial Function ◽  
Reversal Learning ◽  
Vascular Endothelium ◽  
Complex I ◽  
Thiobarbituric Acid ◽  
Health Concern ◽  
Full Potential ◽  
Citrate Buffer ◽  
Endothelium Dysfunction

Abstract Objectives Vascular dementia (VaD), being strongly associated with metabolic conditions is a major health concern around the world. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of quercetin and folacin in diabetes induced vascular endothelium dysfunction and related dementia. Methods Single dose streptozotocin (STZ) (50 mg/kg i.p) was administered to albino Wistar rats (male, 200–250 g) by dissolving in citrate buffer. Morris water maze (MWM) and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitrite/nitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), mitochondrial enzyme complex (I, II, and IV), inflammatory markers (interleukin-IL-6, IL-10, tumor necrosis factor-TNF-α, and myeloperoxidase-MPO), and acetylcholinesterase activity-AChE were also assessed. Quercetin (30 mg kg−1/60 mg kg−1) and folacin (30 mg kg−1/60 mg kg−1) were used as the treatment drugs. Donepezil (0.5 mg kg−1) was used as a positive control. Results STZ administered rats showed reduction in learning, memory, reversal learning, executive functioning, impairment in endothelial function, increase in brains’ oxidative stress; inflammation; AChE activity, and decrease in mitochondrial complex (I, II, and IV) activity. Administration of quercetin and folacin in two different doses, significantly attenuated the STZ induced diabetes induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusions STZ administration caused diabetes and VaD which was attenuated by the administration of quercetin and folacin. Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD conditions.

scholarly journals Etiologies of insomnia in Parkinson's disease – Lessons from human studies and animal models

2022 ◽  
pp. 113976
Author(s):  
Aviv D. Mizrahi-Kliger ◽  
Lucia K. Feldmann ◽  
Andrea A. Kuhn ◽  
Hagai Bergman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Human Studies

scholarly journals Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin

2003 ◽  
Vol 197 (11) ◽  
pp. 1585-1598 ◽  
Author(s):  
Shahrokh Falati ◽  
Qingde Liu ◽  
Peter Gross ◽  
Glenn Merrill-Skoloff ◽  
Janet Chou ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Thrombus Formation ◽  
Recipient Mouse ◽  
Wild Type ◽  
Activated Platelets ◽  
Injury Model ◽  
Platelet Thrombus ◽  
Flowing Blood

Using a laser-induced endothelial injury model, we examined thrombus formation in the microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy to analyze this complex physiologic process in a system that includes the vessel wall, the presence of flowing blood, and the absence of anticoagulants. We observe P-selectin expression, tissue factor accumulation, and fibrin generation after platelet localization in the developing thrombus in arterioles of wild-type mice. However, mice lacking P-selectin glycoprotein ligand 1 (PSGL-1) or P-selectin, or wild-type mice infused with blocking P-selectin antibodies, developed platelet thrombi containing minimal tissue factor and fibrin. To explore the delivery of tissue factor into a developing thrombus, we identified monocyte-derived microparticles in human platelet–poor plasma that express tissue factor, PSGL-1, and CD14. Fluorescently labeled mouse microparticles infused into a recipient mouse localized within the developing thrombus, indicating that one pathway for the initiation of blood coagulation in vivo involves the accumulation of tissue factor– and PSGL-1–containing microparticles in the platelet thrombus expressing P-selectin. These monocyte-derived microparticles bind to activated platelets in an interaction mediated by platelet P-selectin and microparticle PSGL-1. We propose that PSGL-1 plays a role in blood coagulation in addition to its known role in leukocyte trafficking.

Colon Health and Resistant Starch: Human Studies and Animal Models

2013 ◽  
pp. 267-278
Author(s):  
Suzanne Hendrich ◽  
Diane F. Birt ◽  
Li Li ◽  
Yinsheng Zhao
Keyword(s):  
Animal Models ◽  
Resistant Starch ◽  
Human Studies

Mesenchymal stem cells strategies in cancer immunotherapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Animal Models ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Human Studies ◽  
Research Focus ◽  
Cancer Treatments ◽  
The Future ◽  
New Research

Mesenchymal stem cells (MSCs) have been a new research focus for cancer treatment. Future cancer sufferers will considerably profit from their use in the future. Tumor-directed migratory and integration capacities of MSCs are exceptional, making them potential carriers for the delivery of anticancer medicines, notably cytokines. Their usage in the clinic has lasted around 10 years. The use of mesenchymal stem cells (MSCs) to create successful cancer treatments has been demonstrated in everything from animal models to human studies.

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