Resting-State fMRI Study of ADHD and Internet Gaming Disorder

2019 ◽  
pp. 108705471988302 ◽  
Author(s):  
Doug Hyun Han ◽  
Sujin Bae ◽  
Jisun Hong ◽  
Sun Mi Kim ◽  
Yong Don Son ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Clinical Symptoms ◽  
Brain Activity ◽  
Internet Gaming Disorder ◽  
Resting State Fmri ◽  
Response To Treatment ◽  
Gaming Disorder ◽  
Internet Gaming ◽  
Fmri Study ◽  
One Year

Objective: We aimed to understand whether Attention Deficit Hyperactivity Disorder (ADHD) and Internet gaming disorder (IGD) share similar brain functional connectivity (FC) between the frontal and subcortices. Method: We compared changes in clinical symptoms and brain activity using functional magnetic resonance imaging (fMRI) in 26 patients with ADHD but without IGD, 29 patients with ADHD and IGD, and 20 patients with IGD but without ADHD. Results: The functional connectivity (FC) from the cortex to subcortex in both groups was decreased relative to that in age-matched healthy participants. One-year treatment for ADHD and IGD symptoms increased the FC between the cortex and subcortex in all ADHD participants and all IGD participants with good prognoses compared with those in all ADHD participants and all IGD participants with poor prognoses. Conclusion: Patients with ADHD and IGD shared similar brain FC at baseline and FC changes in response to treatment.

scholarly journals Dorsal and ventral striatal functional connectivity shift with the medial frontal gyrus in internet gaming disorder: Potential mechanisms underlying addictive engagement

2020 ◽  
Author(s):  
Guang-Heng Dong ◽  
Haohao Dong ◽  
Min Wang ◽  
Jialin Zhang ◽  
Weiran Zhou ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Animal Models ◽  
Longitudinal Data ◽  
Internet Gaming Disorder ◽  
Dorsal Striatum ◽  
Resting State Fmri ◽  
Gaming Disorder ◽  
Internet Gaming ◽  
Medial Frontal Gyrus ◽  
Dynamic Causal Model

AbstractBackgroundAnimal models suggest transitions from non-addictive to addictive behavioral engagement are associated with ventral-to-dorsal striatal shifts. However, few studies have examined such features in humans, especially in internet gaming disorder (IGD), a behavioral addiction.MethodsFour-hundred-and-eighteen subjects (174 with IGD; 244 with recreational game use (RGU)) were recruited. Resting-state fMRI data were collected and functional connectivity (FC) analyses were performed based on ventral and dorsal striatal seeds. Correlations and follow-up spectrum dynamic causal model (spDCM) analyses were performed to examine relationships between ventral/dorsal striatum to medial frontal gyrus (MFG) and IGD severity. Longitudinal data from 40 subjects (22 IGD; 18 RGU) were also analysed to investigate further.ResultsInteractions were observed between group (IGD, RGU) and striatal regions (ventral, dorsal). IGD relative to RGU subjects showed lower ventral-striatum-to-MFG (mostly involving supplementary motor area (SMA)) and higher dorsal-striatum-to-MFG functional connectivity. spDCM revealed that left dorsal-striatum-to-MFG connectivity was correlated with IGD severity. Longitudinal data further support for ventral-to-dorsal striatal MFG relationships in IGD.ConclusionsConsistent with animal models of substance addictions, ventral-to-dorsal striatal transitions in involvement coritico-striatal circuitry may underlie IGD and its severity. These findings suggest possible neurobiological mechanisms that may be targeted in treatments for IGD.

scholarly journals Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study

2016 ◽  
Vol 22 (4) ◽  
pp. 192-200 ◽  
Author(s):  
Chiao-Yun Chen ◽  
Ju-Yu Yen ◽  
Peng-Wei Wang ◽  
Gin-Chung Liu ◽  
Cheng-Fang Yen ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Functional Connectivity ◽  
Frontal Lobe ◽  
Resting State ◽  
Internet Gaming Disorder ◽  
Resting State Fmri ◽  
Gaming Disorder ◽  
Internet Gaming ◽  
Left Dlpfc ◽  
The Right

Aims: A possible addiction mechanism has been represented by altered functional connectivity (FC) in the resting state. The aim of this study was to evaluate the FCs of the insula and nucleus accumbens among subjects with Internet gaming disorder (IGD). Methods: We recruited 30 males with IGD and 30 controls and evaluated their FC using functional magnetic imaging scanning under resting, a state with relaxation, closed eyes, with inducement to think of nothing systematically, become motionless, and instructed not to fall asleep. Results: Subjects with IGD had a lower FC with the left insula over the left dorsolateral prefrontal cortex (DLPFC) and orbital frontal lobe and a higher FC with the insula with the contralateral insula than controls. The inter-hemispheric insula connectivity positively correlated with impulsivity. Further, they had lower FC with the left nucleus accumbens over the left DLPFC and with the right nucleus accumbens over the left DLPFC, and insula and a higher FC with that over the right precuneus. Conclusion: The elevated inter-hemispheric insula FC is found to be associated with impulsivity and might explain why it is involved in IGD. The attenuated frontostriatal suggests that the emotion-driven gaming urge through nucleus accumbens could not be well regulated by the frontal lobe of subjects with IGD.

scholarly journals Dorsal and ventral striatal functional connectivity shifts play a potential role in internet gaming disorder

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Guang-Heng Dong ◽  
Haohao Dong ◽  
Min Wang ◽  
Jialin Zhang ◽  
Weiran Zhou ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Longitudinal Data ◽  
Internet Gaming Disorder ◽  
Dorsal Striatum ◽  
Resting State Fmri ◽  
Gaming Disorder ◽  
Internet Gaming ◽  
Dynamic Causal Model ◽  
Changes Over Time

AbstractAnimal models suggest transitions from non-addictive to addictive behavioral engagement are associated with ventral-to-dorsal striatal shifts. However, few studies have examined such features in humans, especially in internet gaming disorder (IGD), a proposed behavioral addiction. We recruited 418 subjects (174 with IGD; 244 with recreational game use (RGU)). Resting-state fMRI data were collected and functional connectivity analyses were performed based on ventral and dorsal striatal seeds. Correlations and follow-up spectrum dynamic causal model (spDCM) analyses were performed to examine relationships between the ventral/dorsal striatum and middle frontal gyrus (MFG). Longitudinal data were also analysed to investigate changes over time. IGD relative to RGU subjects showed lower ventral-striatum-to-MFG (mostly involving supplementary motor area (SMA)) and higher dorsal-striatum-to-MFG functional connectivity. spDCM revealed that left dorsal-striatum-to-MFG connectivity was correlated with IGD severity. Longitudinal data within IGD and RGU groups found greater dorsal striatal connectivity with the MFG in IGD versus RGU subjects. These findings suggest similar ventral-to-dorsal striatal shifts may operate in IGD and traditional addictions.

scholarly journals Comparison of Behavioral Changes and Brain Activity between Adolescents with Internet Gaming Disorder and Student Pro-Gamers

2020 ◽  
Vol 17 (2) ◽  
pp. 441
Author(s):  
Ki Hyeon Kwak ◽  
Hyun Chan Hwang ◽  
Sun Mi Kim ◽  
Doug Hyun Han
Keyword(s):  
Orbitofrontal Cortex ◽  
Parietal Lobe ◽  
Brain Activity ◽  
Demographic Data ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Depression And Anxiety ◽  
Internet Gaming ◽  
Problematic Behaviors ◽  
One Year

While pro-gamers play according to defined living habits and planned schedules, adolescents with internet gaming disorder (IGD) exhibit irregular lifestyles and unregulated impulsive gaming behavior. Fourteen IGD adolescents and 12 pro-gaming students participated in this study. At baseline and after one year, demographic data, the Child Behavior Check List (CBCL), depressed mood, anxiety, and resting-state functional magnetic resonance imaging were assessed. Over the year, IGD adolescents played games as per their usual schedule, while pro-gamer students played according to their school’s team schedule. After one year, the pro-gamers’ scores had decreased in the CBCL-total (total problematic behaviors), CBCL-externalizing (under-controlled behavior, like impulsivity and aggression), and CBCL-internalizing (over-controlled behavior like depression and anxiety) compared to those of the IGD adolescents. Both groups displayed increased brain activity in the parietal lobe (a component of the attention network) over the years. Compared to pro-gamers, IGD adolescents showed higher brain activity within the left orbitofrontal cortex. Brain activity within the orbitofrontal cortex was associated with CBCL-externalizing scores. These results suggest that gaming had increased the attention network’s brain activity, but a well-organized support system could lead to different results, in terms of improved behaviors and suppressing brain activity within the orbitofrontal cortex.

A selective involvement of putamen functional connectivity in youth with internet gaming disorder

2015 ◽  
Vol 1602 ◽  
pp. 85-95 ◽  
Author(s):  
Soon-Beom Hong ◽  
Ben J. Harrison ◽  
Orwa Dandash ◽  
Eun-Jung Choi ◽  
Seong-Chan Kim ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Internet Gaming

scholarly journals The Predictive Value of Emotional Intelligence for Internet Gaming Disorder: A 1-Year Longitudinal Study

2019 ◽  
Vol 16 (15) ◽  
pp. 2762 ◽  
Author(s):  
Della L. Dang ◽  
Meng Xuan Zhang ◽  
Karlas Kin-hei Leong ◽  
Anise M. S. Wu
Keyword(s):  
Emotional Intelligence ◽  
Longitudinal Study ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Trait Emotional Intelligence ◽  
Cross Sectional ◽  
Coping Flexibility ◽  
Internet Gaming ◽  
One Year ◽  
And Coping

This one-year longitudinal study examined trait emotional intelligence as a predictor of Internet gaming disorder (IGD). To date, only cross-sectional research has been conducted to test the protective effects of emotional intelligence against IGD tendency. Based on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study aimed to address the research gap by examining not only the direct effects of trait emotional intelligence, but also its indirect effects (via depressive symptoms and coping flexibility) on IGD, with both a cross-sectional and longitudinal design. The participants were 282 Chinese university students (mean age = 20.47; 39.4% males) who voluntarily completed an anonymous questionnaire at both baseline (W1) and one-year follow-up (W2). Path analysis results revealed that trait emotional intelligence had a protective but indirect effect on IGD tendency in both our cross-sectional and longitudinal data. Depression was found to have a significant, full mediating effect on the relationship between: (i) trait emotional intelligence and IGD tendency (W2) and (ii) coping flexibility and IGD tendency (W2), after adjusting for IGD tendency at the baseline (W1). Gender invariance of the path coefficient was also observed in the prospective model. This study provided longitudinal evidence to support the I-PACE model. Interventions should address both IGD and depressive symptoms, and school-based workshops to increase emotional intelligence and coping flexibility are also recommended.

scholarly journals Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder

2015 ◽  
Vol 21 (3) ◽  
pp. 743-751 ◽  
Author(s):  
Jin-Tao Zhang ◽  
Yuan-Wei Yao ◽  
Chiang-Shan R. Li ◽  
Yu-Feng Zang ◽  
Zi-Jiao Shen ◽  
...  
Keyword(s):  
Young Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Resting State Functional Connectivity ◽  
Internet Gaming
Sign in / Sign up

Export Citation Format

Share Document