The experimental study of tissue integration into porous titanium implants

2020 ◽  
pp. 112070002094348
Author(s):  
Rashid Tikhilov ◽  
Igor Shubnyakov ◽  
Alexey Denisov ◽  
Vladimir Konev ◽  
Iosif Gofman ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Bone Defect ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Control Group ◽  
Additive Technology ◽  
Tissue Integration ◽  
3D Printed ◽  
Tissue Attachment ◽  
Highly Porous

Introduction: Due to a lack of uniform shapes and sizes of bone defects in hip and knee joint pathology, their fixing could benefit from using individually manufactured 3D-printed highly porous titanium implants. The objective of this study was to evaluate the extent of bone and muscle tissue integration into porous titanium implants manufactured using additive technology. Materials and methods: Porous and non-porous titanium plates were implanted into the latissimus dorsi muscle and tibia of 9 rabbits. On days 1, 60 and 90 animals were examined with x-rays. On day 60 histological tests were carried out. On day 90 the tensile strength at the implant-tissue interface was tested. Results: Histological analysis of muscle samples with porous titanium implants showed integration of connective tissue and blood vessels into the pores. Bone defect analysis demonstrated bone ingrowth into the pores of titanium with a minimal amount of fibrous tissue. The tensile strength of the muscular tissue attachment to the porous titanium was 28 (22–30) N which was higher than that of the control group 8.5 (5–11) N. Bone tissue attachment strength was 148 (140–152) N in the experimental group versus 118 (84–122) N in the control group. Conclusions: Using additive technology in manufacturing 3D-printed highly porous titanium implants improves bone and muscle integration compared with the non-porous material of the control group. This could be a promising approach to bone defect repair in revision and reconstruction surgery.

scholarly journals BONE AND SOFT TISSUES INTEGRATION IN POROUS TITANIUM IMPLANTS (EXPERIMENTAL RESEARCH)

2018 ◽  
Vol 24 (2) ◽  
pp. 95-107 ◽  
Author(s):  
R. M. Tikhilov ◽  
I. I. Shubnyakov ◽  
A. O. Denisov ◽  
V. A. Konev ◽  
I. V. Gofman ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Latissimus Dorsi ◽  
Fibrous Tissue ◽  
Porous Titanium ◽  
Additive Technologies ◽  
Titanium Implants ◽  
Knee Joints ◽  
Control Group ◽  
Muscular Tissue ◽  
Tissue Integration

Aim. It’s common that revision arthroplasty of the large joints demands replacing of bone defects of irregular geometrical shapes and simultaneous restoring of support ability and ability to integrate surrounding muscular and tendinous structures into an implant that is required for a complete restoration of joint function.The purpose.To experimentally study the process of integration for muscular and bone tissue as well as tendinous and ligamentous structures into porous titanium materials.Material and methods. During in vivo experiment the authors created a standardized bone defect in 6 rabbits of chinchilla breed at the point of patella ligament attachment as well as a delamination area of muscular tissue in latissimus dorsi. Both knee joints and both latissimus dorsi were used in each animal. Study group included titanium implants with three-dimensional mesh structure. Control group — solid titanium implants with standard porosity. Titanium implants were produced by additive technologies with preliminary prototyping. The porosity corresponded to trabecular metal, striations — 0.45, pores size —100–200 microns. Study and control components were implanted in the identical conditions into the corresponding anatomical sites. Postoperative AP and lateral roentgenograms of knee joints were performed for all animals. Morphological research was conducted on day 60 after the implantation and strength properties were studied at day 90 after the implantation.Results.The authors observed bony ingrowth into implant pores with minimal volume of fibrous tissue, a distinct connective integration was reported represented by a dense fibrous tissue in the pores of components implanted into the muscular tissue. Testing of fixation strength of the study implants demonstrated a clearly superior strength of soft and bone tissue integration into the experimental mesh implants produced using additive technologies.

3D-printed Poly-Lactic Co-Glycolic Acid (PLGA) scaffolds in non-critical bone defects impede bone regeneration in rabbit tibia bone

2021 ◽  
pp. 1-7
Author(s):  
Jin Xi Lim ◽  
Min He ◽  
Alphonsus Khin Sze Chong
Keyword(s):  
Computed Tomography ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Volume Ratio ◽  
Bone Defects ◽  
Control Group ◽  
Micro Computed Tomography ◽  
Rabbit Tibia ◽  
3D Printed ◽  
Critical Bone Defects

BACKGROUND: An increasing number of bone graft materials are commercially available and vary in their composition, mechanism of action, costs, and indications. OBJECTIVE: A commercially available PLGA scaffold produced using 3D printing technology has been used to promote the preservation of the alveolar socket after tooth extraction. We examined its influence on bone regeneration in long bones of New Zealand White rabbits. METHODS: 5.0-mm-diameter circular defects were created on the tibia bones of eight rabbits. Two groups were studied: (1) control group, in which the bone defects were left empty; (2) scaffold group, in which the PLGA scaffolds were implanted into the bone defect. Radiography was performed every two weeks postoperatively. After sacrifice, bone specimens were isolated and examined by micro-computed tomography and histology. RESULTS: Scaffolds were not degraded by eight weeks after surgery. Micro-computed tomography and histology showed that in the region of bone defects that was occupied by scaffolds, bone regeneration was compromised and the total bone volume/total volume ratio (BV/TV) was significantly lower. CONCLUSION: The implantation of this scaffold impedes bone regeneration in a non-critical bone defect. Implantation of bone scaffolds, if unnecessary, lead to a slower rate of fracture healing.

Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone

2018 ◽  
Vol 6 (15) ◽  
pp. 2274-2288 ◽  
Author(s):  
Xiao-Fan Hu ◽  
Ya-Fei Feng ◽  
Geng Xiang ◽  
Wei Lei ◽  
Lin Wang
Keyword(s):  
Lactic Acid ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Bone Implant ◽  
3D Printed

PLGA-coating on 3D-printed porous titanium implants promoted the angiogenesis and osteointegration at bone-implant interface in diabetes by releasing lactic acid.

Octacalcium phosphate coating for 3D printed cranioplastic porous titanium implants

2020 ◽  
Vol 383 ◽  
pp. 125192 ◽  
Author(s):  
Igor V. Smirnov ◽  
Roman V. Deev ◽  
Ilya I. Bozo ◽  
Alexander Yu. Fedotov ◽  
Alex N. Gurin ◽  
...  
Keyword(s):  
Octacalcium Phosphate ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Phosphate Coating ◽  
3D Printed

Initial stability of a highly porous titanium cup in an acetabular bone defect model

2018 ◽  
Vol 23 (4) ◽  
pp. 665-670 ◽  
Author(s):  
Kensei Yoshimoto ◽  
Yasuharu Nakashima ◽  
Miyo Wakiyama ◽  
Daisuke Hara ◽  
Akihiro Nakamura ◽  
...  
Keyword(s):  
Bone Defect ◽  
Porous Titanium ◽  
Defect Model ◽  
Acetabular Bone ◽  
Acetabular Bone Defect ◽  
Initial Stability ◽  
Highly Porous

scholarly journals Immunomodulation of surface biofunctionalized 3D printed porous titanium implants

2020 ◽  
Vol 15 (3) ◽  
pp. 035017 ◽  
Author(s):  
F Razzi ◽  
L E Fratila-Apachitei ◽  
N Fahy ◽  
Y M Bastiaansen-Jenniskens ◽  
I Apachitei ◽  
...  
Keyword(s):  
Porous Titanium ◽  
Titanium Implants ◽  
3D Printed

Fabrication of bioactive 3D printed porous titanium implants with Sr ion-incorporated zeolite coatings for bone ingrowth

2018 ◽  
Vol 6 (20) ◽  
pp. 3254-3261 ◽  
Author(s):  
Shuang Wang ◽  
Ruiyan Li ◽  
Dongdong Li ◽  
Zhi-Yong Zhang ◽  
Guancong Liu ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
3D Printed ◽  
Strontium Ion ◽  
Zeolite Coatings

Strontium ion incorporated zeolites are uniformly fabricated on a 3D printed porous titanium scaffold for bone ingrowth.

Review of the Powder Metallurgical Production of Net-Shaped Titanium Implants

2016 ◽  
Vol 704 ◽  
pp. 311-317 ◽  
Author(s):  
Alexander Laptev ◽  
Ana Paula Cysne Barbosa ◽  
Natália Daudt ◽  
Martin Bram
Keyword(s):  
Additive Manufacturing ◽  
New Technologies ◽  
Short Review ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Replica Technique ◽  
Metallurgical Production ◽  
Powder Compacts ◽  
Sintered State ◽  
Highly Porous

The paper gives a short review of P/M routes which were developed or adapted by the authors for the net-shape manufacturing of titanium implants. Special attention is paid to the production of highly porous bone implants, where the porosity is achieved by the application of temporary space holder particles, which are removed before or during sintering by decomposition or dissolution. In this case, shaping was done either by machining of powder compacts in the green and sintered state or by metal injection moulding (MIM). The challenges of these shaping technologies and current solutions are discussed. To complete the review, two promising new technologies for the net-shape production of highly porous titanium implants, the replica technique and additive manufacturing are briefly introduced.

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