Weight Loss and Dietary Interventions for Hidradenitis Suppurativa: A Systematic Review

Hidradenitis suppurativa (HS) is a common inflammatory disorder characterized by recurrent, painful, and malodorous abscesses and nodules predominantly in skin folds. HS is associated with substantial morbidity and poor quality of life. There are no curative therapies, and the only approved biologic drug has variable efficacy and requires high doses, making adjunct treatments crucial. An important risk factor for disease severity is obesity. Our primary objective was to conduct a systematic review examining weight loss and dietary interventions, in HS. Our secondary objective was to examine nutritional supplements in HS.A systematic literature search was conducted using Medline, EMBASE, and the Cochrane Database. We included all study types in adults (>18 years), with a minimum sample size of 5, examining the effects of any dietary or weight loss intervention on HS severity. Two authors screened n = 1279 articles of which 9 met inclusion criteria. All included studies were observational and all interventions were associated with various measures of decreased HS severity. Patient-controlled weight loss and bariatric surgery were associated with HS regression, though a subset of patients with significant increase in panniculi experienced exacerbations and required excision of excess skin. Diets demonstrating benefit eliminated dairy and brewer’s yeast. Nutritional supplements including zinc gluconate, vitamin D, and riboflavin had a suppressive, rather than curative, effect on HS lesions in single studies. Overall, the reviewed interventions show promise as potential adjunct treatments in a HS management plan. Prospective randomized controlled trials should validate these findings.

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Weight loss and dietary interventions for hidradenitis suppurativa: A systematic review

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2019.06.552 ◽

2019 ◽

Vol 81 (4) ◽

pp. AB148

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Hidradenitis Suppurativa ◽

Dietary Interventions

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Faculty Opinions recommendation of Weight loss and dietary interventions for hidradenitis suppurativa: A systematic review.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736618230.793577136 ◽

2020 ◽

Author(s):

Iltefat Hamzavi

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Hidradenitis Suppurativa ◽

Dietary Interventions

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Effectiveness and Characterization of Severely Energy-Restricted Diets in People with Class III Obesity: Systematic Review and Meta-Analysis

Behavioral Sciences ◽

10.3390/bs9120144 ◽

2019 ◽

Vol 9 (12) ◽

pp. 144 ◽

Cited By ~ 3

Author(s):

Gabrielle Maston ◽

Alice A. Gibson ◽

H. Reza Kahlaee ◽

Janet Franklin ◽

Elisa Manson ◽

...

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Prediction Interval ◽

Meta Analysis ◽

Average Weight ◽

Class Iii ◽

Dietary Interventions ◽

Initial Body Weight ◽

Class Iii Obesity

Severely energy-restricted diets are used in obesity management, but their efficacy in people with class III obesity (body mass index ≥40 kg/m2) is uncertain. The aims of this systematic review and meta-analysis were to determine the effectiveness and characteristics of severely energy-restricted diets in people with class III obesity. As there was a lack of publications reporting long-term dietary interventions and randomised controlled trial designs, our original publication inclusion criteria were broadened to include uncontrolled study designs and a higher upper limit of energy intake. Eligible publications reported studies including adults with class III obesity and that assessed a diet with daily energy intake ≤5000 kJ for ≥4 weeks. Among 572 unique publications from 4 databases, 11 were eligible and 10 were suitable for meta-analysis. Our original intention was to classify comparison arms into short-term (<6 months) and long-term (>1 year) interventions. Due to the lack of long-term data found, comparison arms were classified according to the commonalities in dietary intervention length among the included publications, namely dietary interventions of 4 weeks’ duration and those of ≥6 weeks’ duration. After a 4-week severely energy-restricted diet intervention, the pooled average weight loss was 9.81 (95% confidence interval 10.80, 8.83) kg, with a 95% prediction interval of 6.38 to 13.25 kg, representing a loss of approximately 4.1 to 8.6% of initial body weight. Diets ≥6 weeks’ duration produced 25.78 (29.42, 22.15) kg pooled average weight loss, with a 95% prediction interval of 13.77 to 37.80 kg, representing approximately 10.2 to 28.0% weight loss. Daily dietary prescriptions ranged from 330 to 5000 kJ (mean ± standard deviation 2260 ± 1400 kJ), and had wide variations in macronutrient composition. The diets were administered mostly via liquid meal replacement products. While the included publications had a moderate risk of bias score, which may inflate reported weight loss outcomes, the published data to date suggest that severely energy-restricted diets, delivered via diets of varying composition, effectively produce clinically relevant weight loss (≥10% of initial body weight) when used for 6 weeks or more in people with class III obesity.

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Physical function after dietary weight loss in overweight and obese adults with osteoarthritis: a systematic review and meta-analysis

Public Health Nutrition ◽

10.1017/s1368980020002529 ◽

2020 ◽

pp. 1-16

Author(s):

Emily J Webb ◽

Peter G Osmotherly ◽

Surinder K Baines

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Physical Function ◽

Quality Criteria ◽

Self Report ◽

Excess Body Weight ◽

Lifestyle Interventions ◽

Dietary Interventions ◽

Dietary Weight Loss ◽

Meal Replacements

Abstract Objective: Osteoarthritis (OA) is associated with functional limitations that can impair mobility and reduce quality of life in affected individuals. Excess body weight in OA can exacerbate impaired physical function, highlighting the importance of weight management in this population. The aim of this systematic review was to compare the effects of different dietary interventions for weight loss on physical function in overweight and obese individuals with OA. Design: A comprehensive search of five databases was conducted to identify relevant articles for inclusion. Studies were included that examined the effect of dietary weight loss interventions, with or without exercise, on physical function in adults with OA who were overweight or obese. Quality and risk of bias were assessed using the Quality Criteria Checklist for primary research. Primary and secondary outcomes were extracted, including change in weight and physical function which included performance-based and self-report measures. Results: Nineteen relevant studies were included, which incorporated lifestyle interventions (n 8), diet in combination with meal replacements (DMR; n 5) and very low-energy diets (VLED; n 6) using meal replacements only. Pooled data for eight RCT indicated a mean difference in Western Ontario and McMaster Universities Arthritis Index (WOMAC) physical function of 12·4 and 12·5 % following DMR or VLED interventions, respectively; however, no statistically significant change was detected for lifestyle interventions. Conclusions: Our findings suggest that partial use of meal replacements is as effective as their sole use in the more restrictive VLED. Both dietary interventions are more effective than lifestyle programmes to induce significant weight loss and improvements in physical function.

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Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0245794 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0245794

Author(s):

Nathalie LeVasseur ◽

Wei Cheng ◽

Sasha Mazzarello ◽

Mark Clemons ◽

Lisa Vandermeer ◽

...

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Cancer Patients ◽

Standard Care ◽

Meta Analysis ◽

Lifestyle Interventions ◽

Dietary Interventions ◽

Anthropometric Measures ◽

Combination Strategies ◽

Diet And Exercise

Background Excess weight has been associated with increased morbidity and a worse prognosis in adult patients with early-stage cancer. The optimal lifestyle interventions to optimize anthropometric measures amongst cancer patients and survivors remain inconsistent. Objective To conduct a systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs) comparing the effects of exercise and dietary interventions alone or in combination on anthropometric measures of adult cancer patients and survivors. Methods A systematic search of Medline, Embase and the Cochrane Trials Registry was performed. Outcomes of interest included changes in weight, body mass index (BMI), and waist circumference. Screening and data collection were performed by two reviewers. Bayesian NMAs were performed. Results Overall, 98 RCTs were included; 75 were incorporated in NMAs (n = 12,199). Groups of intervention strategies included: 3 exercise interventions, 8 dietary interventions, 7 combination interventions of diet and exercise and standard care. Median intervention duration was 26 weeks. NMA suggested that diet alone (mean difference [MD] -2.25kg, 95% CrI -3.43 to -0.91kg) and combination strategies (MD -2.52kg, 95% CrI -3.54 to -1.62kg) were associated with more weight loss compared to standard care. All dietary interventions achieved a similar magnitude of weight loss (MD range from -2.03kg to -2.52kg). Both diet alone and combination strategies demonstrated greater BMI reductions versus standard care, and each of diet alone, exercise alone and combination strategies demonstrated greater reductions in waist circumference than standard care. Conclusion Diet and exercise alone or in combination are effective lifestyle interventions to improve anthropometric measures in cancer patients and survivors. All reputable diets appear to be similarly effective to achieve weight loss.

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MicroRNAs associated with exercise and diet: a systematic review

Physiological Genomics ◽

10.1152/physiolgenomics.00095.2014 ◽

2015 ◽

Vol 47 (1) ◽

pp. 1-11 ◽

Cited By ~ 34

Author(s):

Elena Flowers ◽

Gloria Y. Won ◽

Yoshimi Fukuoka

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Behavioral Interventions ◽

Circulating Microrna ◽

Dietary Interventions ◽

Cross Sectional ◽

Circulating Micrornas ◽

Scientific Databases ◽

Cross Sectional Design ◽

Intensity Of Exercise

MicroRNAs are posttranscriptional regulators of gene expression. MicroRNAs reflect individual biologic adaptation to exposures in the environment. As such, measurement of circulating microRNAs presents an opportunity to evaluate biologic changes associated with behavioral interventions (i.e., exercise, diet) for weight loss. The aim of this study was to perform a systematic review of the literature to summarize what is known about circulating microRNAs associated with exercise, diet, and weight loss. We performed a systematic review of three scientific databases. We included studies reporting on circulating microRNAs associated with exercise, diet, and weight loss in humans. Of 1,219 studies identified in our comprehensive database search, 14 were selected for inclusion. Twelve reported on microRNAs associated with exercise, and two reported on microRNAs associated with diet and weight loss. The majority of studies used a quasiexperimental, cross-sectional design. There were numerous differences in the type and intensity of exercise and dietary interventions, the biologic source of microRNAs, and the methodological approaches used quantitate microRNAs. Data from several studies support an association between circulating microRNAs and exercise. The evidence for an association between circulating microRNAs and diet is weaker because of a small number of studies. Additional research is needed to validate previous observations using methodologically rigorous approaches to microRNA quantitation to determine the specific circulating microRNA signatures associated with behavioral approaches to weight loss. Future directions include longitudinal studies to determine if circulating microRNAs are predictive of response to behavioral interventions.

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