The longitudinal relationship between the patient-reported Multiple Sclerosis Impact Scale and the clinician-assessed Multiple Sclerosis Functional Composite

2007 ◽  
Vol 14 (2) ◽  
pp. 255-258 ◽  
Author(s):  
L. Costelloe ◽  
K. O'Rourke ◽  
C. McGuigan ◽  
C. Walsh ◽  
N. Tubridy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Important Change ◽  
Physical Change ◽  
Cross Sectional ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite ◽  
Impact Scale ◽  
Patient Reported ◽  
Baseline Effect ◽  
Minimally Important Change

Background To examine the longitudinal relationship between the patient-rated Multiple Sclerosis Impact Scale (MSIS-29) and the doctor-reported Multiple Sclerosis Functional Composite (MSFC). Methods Two-hundred and four MS patients at baseline and 150 patients one to three years later had MSFC and MSIS-29 assessments. Cross-sectional correlations between these measures and correlations of change in scores were examined. Minimally important change (MIC) in the MSFC was defined at either 0.5 or 0.32 SD from baseline. Effect sizes (ES) were calculated. Results Validity: The MSIS-29 physical correlated moderately with the total MSFC score and the 25-foot timed walk and 9-hole peg test. Correlations of the MSIS-29 physical with the PASAT, and the MSFC with the MSIS-29 psychological were weak. Responsiveness: When MIC in the MSFC was defined as 0.5, mean MSIS-29 physical change was 11.26 (ES = 0.53). At MSFC change of 0.32, mean MSIS-29 physical change was 10.4 (ES = 0.52). Change in MSFC scores correlated weakly with change in the MSIS-29 scores. Stability: In patients with stable MSFC scores, the mean MSIS-29 physical scores improved minimally over time with negligible ES. Conclusions Although the MSIS-29 physical demonstrates moderate cross-sectional correlation with the MSFC, the weak correlations of change scores between the two instruments indicate that they measure different aspects of the effects of multiple sclerosis morbidity. Multiple Sclerosis 2008; 14: 255—258. http://msj.sagepub.com

scholarly journals Nutritional status of multiple sclerosis (MS) patients attending Kasr Alainy MS unit: an exploratory cross-sectional study

2021 ◽  
Vol 96 (1) ◽  
Author(s):  
Zeinab E. Afifi ◽  
Rania I. Shehata ◽  
Asmaa F. El Sayed ◽  
El Sayed M. Hammad ◽  
Marwa R. Salem
Keyword(s):  
Multiple Sclerosis ◽  
Nutritional Status ◽  
Dietary Habits ◽  
Care Service ◽  
Structured Interview ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Level Measurement ◽  
Impact Scale

Abstract Background Nutrition was claimed to be a factor in MS causation, course, complications, and management. Several studies were conducted to assess the nutritional status of MS patients; however, few studies were conducted to assess this problem in Egypt. Therefore, the purpose of the current study was to assess the nutritional status of a sample of MS patients. Methods The researchers conducted an exploratory cross-sectional study among 76 relapsing-remitting MS (RRMS) patients attending Kasr Alainy Multiple Sclerosis Unit (KAMSU) from October 2018 to January 2019 to assess the nutritional status of a sample of MS patients. Data were collected using a structured interview questionnaire including an inquiry about the socioeconomic status, and nutritional status using anthropometric measurements, patient-generated subjective global assessment (PG-SGA), semi-quantitative food frequency questionnaires (SQFFQ), and hemoglobin level measurement. Assessment of fatigue was done using the Modified Fatigue Impact Scale 5-items version. Results The mean age of the study participants was 30 ± 6 years. The disease duration ranged from 2 to 264 months. Malnutrition was prevalent among 67.1% (27.6 % overweight, 36.8% obese, and 2.6% underweight). Half of the investigated patients were anemic. According to the PG-SGA, more than half of the studied patients (53.9%) were classified as moderately or suspected malnourished. The unhealthy dietary habits such as taking only a few meals, junk food intake and skipping breakfast were observed in considerable proportions of the group. The SQFFQ revealed overconsumption of energy and fat, and less than acceptable consumption of dietary fibers by most of the studied patients. Conclusions Overweight, obesity, anemia, and unhealthy dietary habits were prevalent among the RRMS patients attending the KAMSU. Nutrition care service is extremely needed for this group of patients.

scholarly journals Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199604
Author(s):  
Sabina David Ruban ◽  
Claudia Christina Hilt ◽  
Thor Petersen
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Short Form ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cognitive Fatigue ◽  
Cross Sectional ◽  
Impact Scale ◽  
Assessment And Treatment

Background Multiple sclerosis is a chronic disease leading to reduced quality of life. Objectives To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability. Methods 79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records. Results All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life. Conclusion Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.

Revisiting The Multiple Sclerosis Functional Composite: proceedings from the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures

2012 ◽  
Vol 18 (8) ◽  
pp. 1074-1080 ◽  
Author(s):  
D Ontaneda ◽  
N LaRocca ◽  
T Coetzee ◽  
RA Rudick
Keyword(s):  
Multiple Sclerosis ◽  
Outcome Measure ◽  
Task Force ◽  
Critical Path ◽  
Washington Dc ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite ◽  
Score Method ◽  
National Multiple Sclerosis Society ◽  
Disability Outcome

This article describes proceedings from a meeting of the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures (the TF). The TF was appointed by the NMSS Research Programs Advisory Committee with the goal of pooling and analyzing existing datasets to explore the utility of novel disability outcome measures based on the Multiple Sclerosis Functional Composite (MSFC) approach. The TF seeks to determine the suitability of the MSFC approach as a primary clinical outcome measure for registration trials in MS. The TF met in Washington, DC, Dec. 14 and 15, 2011, and provided unanimous support for a collaborative approach involving representatives from academic medicine, the pharmaceutical industry, regulatory agencies, the NMSS and the Critical Path Institute. There was also unanimous agreement that analysis of existing datasets would be useful in making progress toward the objective. The TF placed high value on determining the clinical meaning of individual component measures for the MSFC, and in establishing optimal analysis methods for MSFC so that scores would be more interpretable than the originally recommended z-score method. The background for a collaborative project aimed at developing an improved disability outcome measure is described in this paper.

Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales

2014 ◽  
Vol 20 (12) ◽  
pp. 1616-1623 ◽  
Author(s):  
Judith M Sonder ◽  
Lisanne J Balk ◽  
Libertje VAE Bosma ◽  
Chris H Polman ◽  
Bernard MJ Uitdehaag
Keyword(s):  
Multiple Sclerosis ◽  
Patient Reported Outcome ◽  
Study Data ◽  
Walking Ability ◽  
Impact Scale ◽  
Patient Reported ◽  
Proxy Responses ◽  
Physical Impact ◽  
The Impact

Background: Patient-reported outcome scales (PROs) are useful in monitoring changes in multiple sclerosis (MS) over time. Although these scales are reliable and valid measures in longitudinal studies in MS patients, it is unknown what the impact is when obtaining longitudinal data from proxies. Objective: The objective of this paper is to compare longitudinal changes in patient and proxy responses on PROs assessing physical impact of MS and walking ability. Methods: In a prospective observational study, data on the Multiple Sclerosis Impact Scale (MSIS-29 physical) and Multiple Sclerosis Walking Scale (MSWS-12) were obtained from 137 patient-proxy couples at baseline and at two-year follow-up. Demographic and disease-related variables explaining agreement or disagreement between patients and proxies were investigated using linear regression analyses. Results: Full agreement was found in 56% (MSIS) and 62% (MSWS) of the patient-proxy couples. Complete disagreement was very rare for both scales (2% MSIS, 5% MSWS). When patients were more positive than proxies, a higher age, longer disease duration, longer patient-proxy relationship and increased levels of depression, anxiety and caregiver burden in proxies were observed. Conclusion: In the majority of the patient-proxy couples there was agreement. Proxies can serve as a valuable source of information, but caution remains essential when using scores from proxies.

Multiple sclerosis functional composite predicts thalamic atrophy in multiple sclerosis

2021 ◽  
Vol 429 ◽  
pp. 118095
Author(s):  
Rocco Capuano ◽  
Alvino Bisecco ◽  
Alessandro D'Ambrosio ◽  
Manuela Altieri ◽  
Renato Docimo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite

Der Multiple Sclerosis Functional Composite korreliert mit der sozialmedizinischen Leistungsempfehlung zur Erwerbsfähigkeit von Rehabilitanden mit Multipler Sklerose

2019 ◽  
Vol 88 (10) ◽  
pp. 644-651
Author(s):  
Tobias Leniger ◽  
Maike Heiker ◽  
Andrea Ghadimi
Keyword(s):  
Multiple Sclerosis ◽  
Return To Work ◽  
Z Score ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite

Zusammenfassung Ziel der Studie Der Multiple Sclerosis Functional Composite (MSFC) bewertet mit den Untertests Lauf- und Handfunktion sowie Kognition die Funktionseinschränkungen der Multiplen Sklerose (MS). In der medizinischen Rehabilitation könnte der MSFC sich als hilfreiches Assessmentinstrument für die sozialmedizinische Leistungsempfehlung zur Erwerbsfähigkeit (SLE) am Ende der stationären Rehabilitation erweisen. Ziel der Studie war, eine Korrelation des MSFC mit der SLE zu überprüfen, deren Gültigkeit sechs Monate nach der Rehabilitation erfragt wurde. Methodik In einer retrospektiven, unizentrischen Längsschnittstudie wurde der MSFC zu Beginn (t0) und zum Ende (t1) der stationären Rehabilitation bei 84 Rehabilitanden mit MS im erwerbsfähigen Alter erhoben. Der MSFC (Gesamtscore, Untertests) wurde mit der SLE am Ende der Rehabilitation korreliert (positive SLE: ≥ 3h täglich, negative SLE: < 3h täglich). Sechs Monate nach der Rehabilitation wurde der Return to Work (RTW) erfragt (positiver RTW: ≥ 3h täglich, negativer RTW: < 3h täglich). Ergebnis 70 der 84 Rehabilitanden (83 %) erhielten eine positive SLE. Sie zeigten hinsichtlich epidemiologischer, MS- und rehabilitations-spezifischer Charakteristika keinen Unterschied zu den 14 Rehabilitanden mit negativer SLE. Rehabilitanden mit positiver SLE wiesen im Vergleich zu denen mit negativer SLE signifikant bessere MSFC-Werte im Gesamtscore (z-Score: + 0,11 vs. −0,55, p < 0,001), in den Untertests Kognition (PASAT-3: 42,3 Punkte vs. 27,7 Punkte; p < 0,001) und Lauffunktion (T25FW: 5,1 s vs. 6,7s; p = 0,002) auf. Hingegen war die Handfunktion (NHPT: 23,4 s vs. 26,5s; p = 0,064) ohne signifikanten Unterschied. Beide Gruppen zeigten im Verlauf der Rehabilitation (t0; t1) nichtsignifikante Verbesserungen (Gesamtscore, Untertests). Bei 31 der 84 Rehabilitanden (37 %) konnte der RTW nach sechs Monaten erhoben werden. 90 % der 31 Rehabilitanden beurteilten die SLE als zutreffend. Eine positive SLE korrelierte signifikant mit einem positiven RTW nach sechs Monaten (r = 0,411; p = 0,022). Keine signifikante Assoziation bestand zwischen dem MSFC(t1) (Gesamtscore, Untertests) und dem RTW nach sechs Monaten. Schlussfolgerung Auf Funktionsebene korreliert der MSFC im Gesamtscore (z-Score ≥ 0) signifikant mit einer positiven SLE bei Entlassung, deren Validität mit dem RTW sechs Monate nach der Rehabilitation belegt wurde. Maßgeblich waren die Untertests Kognition und Lauffunktion. In der medizinischen Rehabilitation der MS bietet sich daher der Einsatz des MSFC an, um basierend auf dem ermittelten Funktionsniveau eine fundierte Teilhabeempfehlung in Form der SLE zu entwickeln.

scholarly journals Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study

2020 ◽  
Vol 6 (1) ◽  
pp. 205521732090172 ◽  
Author(s):  
Richard S Nicholas ◽  
Martin L Heaven ◽  
Rodden M Middleton ◽  
Manoj Chevli ◽  
Ruth Pulikottil-Jacob ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
United Kingdom ◽  
Disease Severity ◽  
Medical Costs ◽  
Medical Interventions ◽  
The United Kingdom ◽  
Status Score ◽  
Impact Scale ◽  
Patient Reported ◽  
Disability Status

Objectives To investigate through survey and data linkage, healthcare resource use and costs (except drugs), including who bears the cost, of multiple sclerosis in the United Kingdom by disease severity and type. Methods The United Kingdom Multiple Sclerosis Register deployed a cost of illness survey, completed by people with multiple sclerosis and linked this with data within the United Kingdom Multiple Sclerosis Register and from their hospital records. Resource consumption was categorised as being medical or non-medical and costed by National Health Service and social services estimates for 2018. Results We calculated £509,003 in non-medical costs over a year and £435,488 in medical costs generated over 3 months. People with multiple sclerosis reported self-funding 75% of non-medical costs with non-medical interventions having long-term potential benefits. Costs increased with disability as measured by patient-reported Expanded Disability Status Score and Multiple Sclerosis Impact Scale, with Multiple Sclerosis Impact Scale physical being a more powerful predictor of costs than the patient-reported Expanded Disability Status Score. Two distinct groups were identified: medical and non-medical interventions ( n = 138); and medical interventions only ( n = 399). The medical and non-medical group reported increased disease severity and reduced employment but incurred 80% more medical costs per person than the medical-only group. Conclusions The importance of disability in driving costs is illustrated with balance between medical and non-medical costs consistent with the United Kingdom health environment. People with multiple sclerosis and their families fund a considerable proportion of non-medical costs but non-medical interventions with longer term impact could affect future medical costs.

Use of the Multiple Sclerosis Functional Composite to predict disability in relapsing MS

Neurology ◽  
2001 ◽  
Vol 56 (10) ◽  
pp. 1324-1330 ◽  
Author(s):  
R. A. Rudick ◽  
G. Cutter ◽  
M. Baier ◽  
E. Fisher ◽  
D. Dougherty ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite
Sign in / Sign up

Export Citation Format

Share Document