Role of intravenous immunoglobulin in the treatment of acute relapses of neuromyelitis optica: experience in 10 patients

2013 ◽  
Vol 20 (4) ◽  
pp. 501-504 ◽  
Author(s):  
Liene Elsone ◽  
Jay Panicker ◽  
Kerry Mutch ◽  
Mike Boggild ◽  
Richard Appleton ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Neuromyelitis Optica ◽  
Retrospective Review ◽  
Intravenous Immunoglobulins ◽  
Prompt Treatment

Prompt treatment of neuromyelitis optica (NMO) relapses with steroids or plasma exchange (PLEX) often prevents irreversible disability. The objective of this study is to report the use of intravenous immunoglobulins (IVIG) as treatment for acute relapses in NMO. A retrospective review of 10 patients treated with IVIG for acute relapses was conducted. IVIG was used in the majority of cases because of lack of response to steroids with/without PLEX. Improvement was noted in five of 11 (45.5%) events; the remaining had no further worsening. One patient, a 79-year-old woman, had a myocardial infarction seven days after IVIG. IVIG may have a role in treating acute NMO relapses.

scholarly journals The effect of prenatal and postnatal treatment with intravenous immunoglobulin on severity of neonatal hemochromatosis: the tale of two brothers (case report)

2020 ◽  
Author(s):  
Veronica Mugarab Samedi ◽  
Michelle D Ryan ◽  
Essa Al Awad ◽  
Adel Elsharkawy
Keyword(s):  
Liver Transplantation ◽  
Intravenous Immunoglobulin ◽  
Rare Condition ◽  
Intravenous Immunoglobulins ◽  
Prenatal Treatment ◽  
Case Presentation ◽  
Neonatal Hemochromatosis ◽  
Postnatal Treatment ◽  
Antenatal Treatment

Abstract Background: Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. Case Presentation: We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity. Conclusion: A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure and avoid the need for liver transplantation Keywords: Neonatal hemochromatosis, Intravenous immunoglobulin, prenatal treatment

scholarly journals Role of Plasma Exchange in a Steroid- and IVIG-Refractory Patient with Acute Disseminated Encephalomyelitis: A Case Report

2020 ◽  
Vol 47 (5) ◽  
pp. 420-423 ◽  
Author(s):  
Parmatma Prasad Tripathi ◽  
Rekha Hans ◽  
Ratti Ram Sharma ◽  
Divjot Singh Lamba ◽  
Preeti Paul ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Steroid Therapy ◽  
Neurological Deficit ◽  
Demyelinating Disease ◽  
Acute Disseminated Encephalomyelitis ◽  
Complete Loss ◽  
High Dose

Background: Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease usually affecting children and is treated with high-dose steroid therapy. Case Report: An 8-year boy presented with limbs weakness and complete loss of vision and was resistant to steroid therapy. He was further treated with plasma exchange and showed full recovery from the neurological deficit. Conclusion: Therapeutic plasma exchange appears to be effective in ADEM patients in reversing the neuropathological process especially refractory to steroids and intravenous immunoglobulin.

scholarly journals Resistant Chorea Successfully Treated with Intravenous Immunoglobulin: A Case Report

2021 ◽  
pp. 117-120
Author(s):  
Ahmet Sami Güven ◽  
Mehmet Burhan Oflaz ◽  
Ali Kaya ◽  
Fatih Bolat ◽  
Utku Aygüneş ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Effective Treatment ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin A ◽  
Intravenous Immunoglobulins ◽  
Dopamine Antagonists ◽  
Streptococcal Infections ◽  
Common Cause

Sydenham’s chorea (SC) is common cause of acquired chorea in childhood. SC occurs mainly in children with untreated streptococcal infections. An effective list of therapeutic options has been used to treat this disorder: antiepileptic drugs (valproic acid, carbamazepine etc.), haloperidol, chlorpromazine, amphetamines, steroids, plasma exchange and intravenous immunoglobulins (IVIG). We report a 12-year-old girl with carditis and severely generalized chorea and successfully treated with IVIG. This case report shows that IVIG is an effective treatment for the chorea cases resistant to anticonvulsants, dopamine antagonists and steroids, although larger studies are needed to confirm this conclusion.

Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic’s disease

2009 ◽  
Vol 150 (46) ◽  
pp. 2101-2109 ◽  
Author(s):  
Péter Csécsei ◽  
Anita Trauninger ◽  
Sámuel Komoly ◽  
Zsolt Illés
Keyword(s):  
Neuromyelitis Optica ◽  
Water Channel ◽  
Diagnostic Procedures ◽  
Diagnosis And Treatment ◽  
Clinical Settings ◽  
Permanent Disability ◽  
Therapeutic Decisions ◽  
Novel Concept ◽  
The Brain

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

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