scholarly journals Impact of parental multiple sclerosis on early childhood development: A retrospective cohort study

2015 ◽  
Vol 21 (9) ◽  
pp. 1172-1183 ◽  
Author(s):  
Neda Razaz ◽  
Helen Tremlett ◽  
W. Thomas Boyce ◽  
Martin Guhn ◽  
KS Joseph ◽  
...  
Keyword(s):  
Mental Health ◽  
Multiple Sclerosis ◽  
Early Childhood ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Early Childhood Development ◽  
Developmental Outcomes ◽  
Population Based ◽  
Childhood Development

Background: Exposure to parental chronic illness is associated with several adverse developmental outcomes. Objectives: We examined the association between parental multiple sclerosis (MS) and childhood developmental outcomes. Methods: We conducted a population-based retrospective cohort study in Manitoba, Canada, using linked databases. The outcome was childhood development at 5 years of age, expressed as vulnerability (absent vs. present) on the Early Development Instrument (EDI). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Children with an MS parent ( n=153) were similar to children of unaffected parents ( n=876) on all EDI domains. However, mental health morbidity was more common among MS parents compared with non-MS parents 49.5% vs. 35.3%. Among MS parents, mental health morbidity was associated with children’s vulnerability on the social competence (OR, 5.73 [95% CI:1.11–29.58]) and emotional maturity (OR, 3.03 [95% CI:1.03–8.94]) domains. The duration of child’s exposure to parental MS was associated with vulnerability on the physical health domain (OR, 1.49 [95%CI:1.03–2.15]). Conclusion: Parental MS was not associated with adverse early childhood developmental outcomes. However, children of parents with mental health morbidity, and those with longer duration of exposure to parental MS, were at higher risk for early childhood developmental vulnerability.

A population-based retrospective cohort study to assess the mental health of patients after a non-intentional burn compared with uninjured people

Burns ◽  
2018 ◽  
Vol 44 (6) ◽  
pp. 1417-1426 ◽  
Author(s):  
Janine M. Duke ◽  
Sean M. Randall ◽  
James H. Boyd ◽  
Fiona M. Wood ◽  
Mark W. Fear ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Population Based

Evidence that infant and early childhood developmental impairments are associated with hallucinatory experiences: results from a large, population-based cohort study

2021 ◽  
pp. 1-9
Author(s):  
Eleanor Carey ◽  
Colm Healy ◽  
Yael Perry ◽  
Diane Gillan ◽  
Andrew J. O. Whitehouse ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Developmental Delays ◽  
Early Childhood Development ◽  
Population Based ◽  
Childhood Development ◽  
Fine Motor ◽  
Childhood And Adolescence ◽  
Gross Motor ◽  
Early Developmental

Abstract Background Cognitive and motor dysfunction are hallmark features of the psychosis continuum, and have been detected during late childhood and adolescence in youth who report psychotic experiences (PE). However, previous investigations have not explored infancy and early childhood development. It remains unclear whether such deficits emerge much earlier in life, and whether they are associated with psychotic, specifically hallucinatory, experiences (HE). Methods This study included data from Gen2 participants of The Raine Study (n = 1101), a population-based longitudinal cohort study in Western Australia. Five areas of childhood development comprising: communication; fine motor; gross motor; adaptive (problem-solving); and personal-social skills, were assessed serially at ages 1, 2 and 3 years. Information on HE, depression and anxiety at ages 10, 14 and 17 years was obtained. HE were further subdivided into those with transient or recurrent experiences. Mixed effects logistic regression models and cumulative risk analyses based on multiple domain delays were performed. Results Early poorer development in multiple areas was noted from ages 1, 2 and 3 years among youth who reported HE. Early developmental delays significantly increased the risk for later HE. This association was particularly marked in the recurrent HE group, with over 40% having early developmental delays in multiple domains. There was no significant association between early childhood development and later anxiety/depression apart from lower gross motor scores at age 3. Conclusions The findings suggest that early pan-developmental deficits are associated with later HE, with the effect strongest for young people who report recurrent HE throughout childhood and adolescence.

scholarly journals Comparison of adverse perinatal outcomes between Asians and Caucasians: a population-based retrospective cohort study in Ontario

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Na Zeng ◽  
Erica Erwin ◽  
Wendy Wen ◽  
Daniel J. Corsi ◽  
Shi Wu Wen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Preterm Birth ◽  
Cesarean Section ◽  
Gestational Age ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Perinatal Outcomes ◽  
Population Based ◽  
Adverse Perinatal Outcomes

Abstract Background Racial disparities in adverse perinatal outcomes have been studied in other countries, but little has been done for the Canadian population. In this study, we sought to examine the disparities in adverse perinatal outcomes between Asians and Caucasians in Ontario, Canada. Methods We conducted a population-based retrospective cohort study that included all Asian and Caucasian women who attended a prenatal screening and resulted in a singleton birth in an Ontario hospital (April 1st, 2015-March 31st, 2017). Generalized estimating equation models were used to estimate the independent adjusted relative risks and adjusted risk difference of adverse perinatal outcomes for Asians compared with Caucasians. Results Among 237,293 eligible women, 31% were Asian and 69% were Caucasian. Asians were at an increased risk of gestational diabetes mellitus, placental previa, early preterm birth (< 32 weeks), preterm birth, emergency cesarean section, 3rd and 4th degree perineal tears, low birth weight (< 2500 g, < 1500 g), small-for-gestational-age (<10th percentile, <3rd percentile), neonatal intensive care unit admission, and hyperbilirubinemia requiring treatment, but had lower risks of preeclampsia, macrosomia (birth weight > 4000 g), large-for-gestational-age neonates, 5-min Apgar score < 7, and arterial cord pH ≤7.1, as compared with Caucasians. No difference in risk of elective cesarean section was observed between Asians and Caucasians. Conclusion There are significant differences in several adverse perinatal outcomes between Asians and Caucasians. These differences should be taken into consideration for clinical practices due to the large Asian population in Canada.

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