The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis

1999 ◽  
Vol 5 (5) ◽  
pp. 323-326 ◽  
Author(s):  
A Feinstein ◽  
P O'Connor ◽  
T Gray ◽  
K Feinstein
Keyword(s):  
Multiple Sclerosis ◽  
General Health Questionnaire ◽  
Psychiatric Morbidity ◽  
Depression Scale ◽  
Preliminary Evidence ◽  
Anxiety And Depression ◽  
Self Harm ◽  
Clinically Significant ◽  
Frequent Accompaniment

Our objective was to assess the point prevalence and effects of clinically significant anxiety in patients with Multiple Sclerosis (MS). One hundred and fifty two consecutive patients with MS attending an outpatient clinic underwent neurological examination and were assessed for psychopathology with the Hospital Anxiety and Depression Scale, the 28 item General Health Questionnaire and a questionnaire probing suicidal thoughts or intent. Clinically significant anxiety, either with or without depression, was endorsed by 25% of patients, three times the rate for depression. Females were significantly more anxious than males. Anxiety co-morbid with depression, rather than anxiety or depression alone, was associated with increased thoughts of self harm, more somatic complaints and greater social dysfunction. Patients with increased psychopathology were not more likely to be taking psychotropic medication. The results provide preliminary evidence that anxiety, which may be often overlooked clinically, is a frequent accompaniment to depression, thereby adding to the morbidity associated with MS. The implications of the findings to MS patients' quality of life are emphasised.

scholarly journals Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 596
Author(s):  
Greta Veličkaitė ◽  
Neringa Jucevičiūtė ◽  
Renata Balnytė ◽  
Ovidijus Laucius ◽  
Antanas Vaitkus
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Neuropathic Pain ◽  
Short Form ◽  
Depression Scale ◽  
Structured Interview ◽  
Anxiety And Depression ◽  
Control Group ◽  
And Control

Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life in Lithuanian MS patients and to compare this data with that of a control group. Materials and Methods: Data were collected prospectively at the Department of Neurology, Lithuanian University of Health Sciences Kaunas Clinics. A face-to-face structured interview and a questionnaire were used to collect demographic and clinical data of the MS (n = 120) and control (n = 120) groups. The Expanded Disability Status Scale (EDSS) was used to quantify disability in the MS group. Scores ≥4/10 in the Douleur Neuropathique 4 questionnaire were classified as neuropathic pain. Patients were evaluated using the anxiety and depression subsets of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the physical and mental component subsets of the Short Form-12 questionnaire (PSC-12 and MSC-12). Results: The MS and control groups did not differ in pain prevalence (76.7% vs. 65.9%, p = 0.064) or intensity. Lhermitte sign, lower limb, and face pain were more common in the MS group, whereas subjects in the control group were more often affected by lower back, neck, and joint pain. Neuropathic pain and pain lasting longer than 2 years were more common among pain-affected MS patients than among controls. MS patients with pain had higher EDSS, HADS-D, and HADS-A and lower PSC-12 scores than those without pain; however, no difference was found regarding the duration of MS or age. Males with MS and pain had higher MSC-12 and HADS-D scores in comparison to the same subset of females. Conclusions: Pain affects approximately three out of four patients with MS in Lithuania and is negatively associated with the mental and physical aspects of quality of life.

Patients' and family caregivers' (FC) quality of life (QOL) and mood during hospitalization for hematopoietic stem cell transplantation (HCT).

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 160-160
Author(s):  
Areej El-Jawahri ◽  
Lara Traeger ◽  
Justin Eusebio ◽  
Kailyn Kuzmuk ◽  
Harry Vandusen ◽  
...  
Keyword(s):  
Mixed Models ◽  
Psychiatric Morbidity ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Long Term Outcomes ◽  
Hematopoietic Stem ◽  
Sf 36

160 Background: While the long-term outcomes of HCT survivors have been described, the acute impact of hospitalization for HCT on patients’ and FC QOL and mood has received little attention. Methods: We conducted a longitudinal study of patients (and FC) hospitalized for HCT. At baseline (6 days pre-HCT), day+1, and day+8 of HCT, we assessed QOL (Functional Assessment of Cancer Therapy-Bone Marrow Transplantation FACT-BMT), fatigue (FACT-Fatigue), and mood (Hospital Anxiety and Depression Scale HADS). We used the SF-36 to examine FC QOL [physical component scale (PCS), and mental component scale (MCS)]. Using multivariable linear mixed models, we examined predictors of QOL changes during hospitalization. Results: We enrolled 97% of consecutively eligible patients undergoing autologous (n=30), myeloablative (n=30) or reduced intensity (n=30) allogeneic HCT. Patients’ QOL markedly declined and fatigue increased throughout hospitalization (Table). The proportion of patients meeting criteria for depression (HADS-D > 7) more than doubled from baseline to day+8 (15.6% to 37.8%, P < 0.0001) whereas the proportion of patients with anxiety remained stable (22.2%, P = 0.8). Depression (β= -2.24, F=42.2, p < 0.0001) and anxiety (β= -0.63, F=4.4, p = 0.03) at baseline independently predict worse QOL throughout hospitalization. The FC QOL declined during patient’s hospitalization (PCS: 83.1 to 79.6, P= 0.03, MCS: 71.6 to 67.4, P = 0.04). Conclusions: Patients undergoing HCT reported a rapid and steep deterioration in QOL along with substantially worse fatigue and depression during hospitalization. Greater decrements in QOL were predicted by depression and anxiety highlighting the importance of assessing pre-HCT psychiatric morbidity. [Table: see text]

Severity of chronic pain and its relationship to quality of life in multiple sclerosis

2005 ◽  
Vol 11 (3) ◽  
pp. 322-327 ◽  
Author(s):  
Lorraine V Kalia ◽  
Paul W OConnor
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Chronic Pain ◽  
Short Form ◽  
Depression Scale ◽  
Pain Severity ◽  
Anxiety And Depression ◽  
Mcgill Pain Questionnaire ◽  
Neurogenic Pain

Introduction: This study used reliable and validated instruments to compare pain severity in multiple sclerosis (MS) to that in other chronic painful conditions, and to examine relationships between chronic pain in MS and health-related quality of life (HRQOL). Methods: Ninety-nine MS patients completed a self-administered survey comprised of the Medical Outcomes 36-Item Short-Form Health Survey, the Short-Form McGill Pain Questionnaire, and the Hospital Anxiety and Depression Scale. Results: Pain severity was not different between MS patients with pain and rheumatoid arthritis (P=0.77) or osteoarthritis (P=0.98) patients. Chronic pain in MS was less often neurogenic than non-neurogenic, although severity of neurogenic pain was greater than that of non-neurogenic pain (P=0.048). Chronic pain in MS was found to have no significant relationship to age, disease duration or disease course. Instead, we found that pain was correlated with aspects of HRQOL, particularly mental health (r=0.44, P<0.0001) versus physical functioning (r=0.19, P>0.05). Chronic pain was significantly related to anxiety and depression for females but not for males with MS. Conclusions: Chronic pain in MS is as severe as pain in arthritic conditions and is associated with reduced HRQOL. Thus, pain can be a significant symptom for MS patients and the need for treatment may be underestimated.

scholarly journals Coping with Multiple Sclerosis Scale

2016 ◽  
Vol 18 (4) ◽  
pp. 192-200 ◽  
Author(s):  
Holly A. Parkerson ◽  
Melissa D. Kehler ◽  
Donald Sharpe ◽  
Heather D. Hadjistavropoulos
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Factor Structure ◽  
Depression Scale ◽  
World Health ◽  
Anxiety And Depression ◽  
World Health Organization Quality ◽  
Impact Scale ◽  
Health Organization

Background: The Coping with Multiple Sclerosis Scale (CMSS) was developed to assess coping strategies specific to multiple sclerosis (MS). Despite its wide application in MS research, psychometric support for the CMSS remains limited to the initial factor analytic investigation by Pakenham in 2001. Methods: The current investigation assessed the factor structure and construct validity of the CMSS. Participants with MS (N = 453) completed the CMSS, as well as measures of disability related to MS (Multiple Sclerosis Impact Scale), quality of life (World Health Organization Quality of Life Brief Scale), and anxiety and depression (Hospital Anxiety and Depression Scale). Results: The original factor structure reported by Pakenham was a poor fit to the data. An alternate seven-factor structure was identified using exploratory factor analysis. Although there were some similarities with the existing CMSS subscales, differences in factor content and item loadings were found. Relationships between the revised CMSS subscales and additional measures were assessed, and the findings were consistent with previous research. Conclusions: Refinement of the CMSS is suggested, especially for subscales related to acceptance and avoidance strategies. Until further research is conducted on the revised CMSS, it is recommended that the original CMSS continue to be administered. Clinicians and researchers should be mindful of lack of support for the acceptance and avoidance subscales and should seek additional scales to assess these areas.

scholarly journals Pre-treatment Depression and Anxiety Disorder in Men with Cancer of the Prostate in South Western Nigeria

2021 ◽  
pp. 46-53
Author(s):  
Adegun Patrick Temi ◽  
Dada Mobolaji Usman ◽  
Idowu Ademola ◽  
Omonisi Abidemi Emmanuel ◽  
Oluwole Lateef Olutoyin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Anxiety Disorder ◽  
Psychiatric Morbidity ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Life Questionnaire ◽  
Depression And Anxiety ◽  
Pre Treatment ◽  
Cancer Of The Prostate

Aim: The aim of the study is to determine the pre-treatment prevalence and associated factors of anxiety and depression in men with cancer of the prostate. Study Design: This is a prospective, cross-sectional study. Place and Duration:  The urology unit of Ekiti State University Teaching Hospital, Ado-Ekiti. Ekiti State, Nigeria. The study period was from 1st January 2018 to 31st December 2019. Methodology: A total of 46 consented male participants recently diagnosed with cancer of the prostate (CAP) were assessed for depression and anxiety disorders using the Hospital Anxiety and Depression Scale (HADS). Participants also completed a sociodemographic questionnaire, an 8-item International Prostate Symptoms Score (IPSS) and a quality of life questionnaire (BS). Results: Forty-three and half percent (43.5%) of the participants suffered depression; anxiety disorder occurred in 21.7% of the participants. Only 2.2% of the participants had anxiety disorder without depression, while 23.9% had depression without anxiety disorder. Significant level of poor quality of life (QoL) was found among participants with depression and anxiety disorder. Having one psychiatric morbidity was associated with having another. Age of participants and other sociodemographic parameters were not associated with psychiatric morbidity. Conclusion: There is a high prevalence of anxiety disorder and depression among patients with cancer of the prostate. Assessment of these disorders should be included in the management of patients with prostate cancer to enhance early detection and prompt treatment for better patients’ clinical outcome.

A nxiety and depression influence the relation between disability status and quality of life in multiple sclerosis

2003 ◽  
Vol 9 (4) ◽  
pp. 397-403 ◽  
Author(s):  
A CJW Janssens ◽  
P A van Doorn ◽  
J B de Boer ◽  
N F Kalkers ◽  
F GA van der Meché ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Sf 36 ◽  
Disability Status

Disability status, depression and anxiety are important determinants of quality of life (Q oL) in patients with multiple sclerosis (MS). We investigated whether anxiety and depression influence the relation between disability status and Q oL in our cohort of recently diagnosed patients. Disability status [Expanded Disability Status Scale (EDSS)], anxiety and depression [Hospital A nxiety and Depression Scale (HADS)], and Q oL (SF-36) were prospectively obtained in 101 MS patients. The relation between EDSS and SF-36 scales was examined using regression analyses, without and with adjustment for anxiety and depression. Interaction effects were investigated by comparing the relation between EDSS and Q oL in patients with high and low anxiety and depression. In the unadjusted analyses, EDSS was significantly related to all SF-36 physical and mental health scales. A fter adjustment for anxiety and depression, EDSS was significantly related only to the SF-36 physical functioning, role-physical functioning and bodily pain scales. The relation between EDSS and these SF-36 scales was consistently higher in patients with more symptoms of anxiety or depression, suggesting that anxiety and depression strengthened the association of EDSS in these SF-36 physical health scales. A fter adjustment for anxiety and depression, EDSS was not significantly related to the SF-36 mental health scales and the general health scale. This finding is compatible with the hypothesis that anxiety and depression are intermediate factors in the association of EDSS with these SF-36 scales. Screening for symptoms of anxiety and depression is recommended in studies that use Q oL as an outcome measure of treatment or intervention efficacy.

scholarly journals Relação do uso de álcool e transtornos mentais comuns com a qualidade de vida de pacientes na atenção primária em saúde

2019 ◽  
Vol 24 (3) ◽  
pp. 1051-1063
Author(s):  
Marcos Vinicius Ferreira dos Santos ◽  
Mônica Rodrigues Campos ◽  
Sandra Lúcia Correia Lima Fortes
Keyword(s):  
General Health Questionnaire ◽  
Depression Scale ◽  
World Health ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
World Health Organization Quality ◽  
Disorder Identification ◽  
Organization Quality ◽  
Health Organization

Resumo Objetivou-se mensurar a Qualidade de Vida (QV) de pacientes da Atenção Primária em Saúde do município do Rio de Janeiro e verificar sua associação com Transtornos Mentais Comuns (TMC), uso de álcool e aspectos sociodemográficos. Trata-se de um estudo transversal com 624 pacientes em 2012/2013 e aplicação dos instrumentos: “General Health Questionnaire”, “Hospital Anxiety and Depression Scale”, “Screening for Somatoform Symptoms”, “Alcohol Use Disorder Identification Test” e “World Health Organization Quality of Life Instrument (bref version)”. Realizou-se análise bivariada (Teste-t) e regressões lineares múltiplas para cada domínio de QV. Os escores QV para os domínios físico, psicológico, relações sociais e meio-ambiente foram: 61,2; 62,6; 66 e 50,9. Na análise multivariada, a QV associou-se negativamente aos TMC, principalmente no domínio psicológico (β = -15,75; p-valor = 0,00), e a dependência no domínio físico (β = -5,38; p-valor = 0,05). Houve associação positiva e significativa da QV com consumo de risco (β = 5,77) e nocivo (β = 6,15) no domínio meio ambiente, e com o primeiro no domínio psicológico (β = 7,08). TMC e a dependência de álcool estão associados à perda da QV, porém outros padrões de consumo, mesmo sendo nocivos, se associaram a maior QV.

Evaluation of quality of life and psychiatric morbidity in patients with malignant tumours of the skull base

2006 ◽  
Vol 120 (12) ◽  
pp. 1049-1054 ◽  
Author(s):  
P Martinez-Devesa ◽  
M L Barnes ◽  
C J Alcock ◽  
R S C Kerr ◽  
C A Milford
Keyword(s):  
Quality Of Life ◽  
Skull Base ◽  
Psychiatric Morbidity ◽  
Depression Scale ◽  
Anterior Skull Base ◽  
Anxiety And Depression ◽  
Life Questionnaire ◽  
Malignant Tumours ◽  
Hospital Anxiety

In general, patients with malignant tumours of the skull base have a poor prognosis. Treatment may have a disfiguring physical and disabling mental effect on patients.To evaluate the effect of treatment on physical and mental quality of life in patients with skull base malignancy, we conducted a cross-sectional patient survey of 18 patients treated for such tumours, using the University of Washington (version 4) quality of life questionnaire and the hospital anxiety and depression scale.The total quality of life score (median value) was 980 (550–1125). Patients with anterior skull base malignancy scored lower than those with lateral skull base malignancy (p=0.003).In general, the worst individual domain scores were: mood (64 per cent); activity (69 per cent); and, specifically for patients with anterior skull base malignancy, taste (54 per cent, p=0.004) and anxiety (60 per cent, p=0.034).One-third of skull base cancer patients were at risk of suffering from mental distress and psychiatric morbidity (indicated as a score of more than seven on the hospital anxiety and depression scale).

Anxiety, depression and perceived health status in patients with epilepsy

2016 ◽  
Vol 33 (S1) ◽  
pp. S326-S327
Author(s):  
F. Smaoui ◽  
E. Turki ◽  
N. Halouani ◽  
M. Turki ◽  
I. Bouchhima ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
General Health Questionnaire ◽  
Depression Scale ◽  
Perceived Health ◽  
Anxiety And Depression ◽  
Perceived Health Status ◽  
Significant Difference ◽  
Patients With Epilepsy

IntroductionEpilepsy is a chronic disease often disabling, source of stigma and poor quality of life.ObjectivesDetermine the prevalence of anxiety and depression in patients with epilepsy and the associated factors.MethodsWe conducted a prospective, descriptive and analytical study among 20 patients followed for epilepsy in our department of neurology. The study was conducted from February to April 2015. We used a preestablished form to collect the socio-demographic and clinic profile of the patients. The assessment of anxiety and depression was made via the HADS “Hospital Anxiety and Depression Scale” and the perceived health status via GHQ scale “General Health Questionnaire”.ResultsThe average age of our patients was 35.9 years. The average GHQ score was 27.7. It was higher in women without a statistically significant difference. It was positively correlated with the number of attacks during the last 12 months (P = 0.042), poor treatment adherence (P = 0.007), the feeling of disability (P = 0.021) and the feeling of stigma (P = 0.008). Anxiety was estimated in 35% of cases and 45% were depressed. Depression was significantly associated to the celibacy (P = 0.012), the feeling of stigma (P = 0.038) and the GHQ score (P = 0.016). Anxiety was correlated with the absence of hobbies (P = 0.02) and the GHQ score (P = 0.008).ConclusionIt is important to detect these psychiatric disorders and to manage generators factors to ensure a better quality of life and social integration for these patients with epilepsy.Disclosure of interestThe authors have not supplied their declaration of competing interest.

P–478 Quality of life assessment in women undergoing assisted reproduction. A study of FertiQol and HADS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
N Figueras-Puigderrajols ◽  
A Ballesteros ◽  
D Guerra
Keyword(s):  
Quality Of Life ◽  
Depression Scale ◽  
Well Being ◽  
Self Esteem ◽  
Mobile App ◽  
Life Assessment ◽  
Fertility Treatment ◽  
Anxiety And Depression ◽  
Gamete Donation

Abstract Study question The present study aims to explore infertility-related psychosocial outcomes, including fertility quality of life (QoL), as well as anxiety and depression levels, in women diagnosed with infertility. Summary answer Differences on fertility-related QoL appeared when comparing treatment types (gamete donation vs own gamete). Furthermore, statistically significant associations were found between QoL and anxious-depressive symptomatology. What is known already Those who wish to have children and do not achieve their objective just like other peers can see their goals and expectations with pessimism, generating concern and a series of negative emotions. Several psychological implications of infertility have been described, such as increased levels of stress, anxiety, depression, decreased self-esteem, mood and hope, or poor relationship adjustment. The emotional impact of infertility in people’s life cycle can be so strong that reducing it only to biological aspects would lead to a dangerous situation of neglect. For this reason, QoL assessment in ART becomes an important need. Study design, size, duration FertiQol stands as the most widely used tool to assess infertility-related QoL, overcoming the limitations of other instruments that only target specific medical conditions. The present is a multi-site cross-sectional study over patients with infertility (n = 104), aiming to explore their fertility-QoL, as well as their anxiety and depression levels, which are symptoms that have been previously associated.Questionnaire administration, and sociodemographic and medical data gathering took place between January 2019 and December 2020. Participants/materials, setting, methods Participants were 104 female patients (M.age= 39.8) undergoing or expecting a fertility treatment. The FertiQol Spanish version was administered through mobile app, and its paper version distributed at medical/psychological appointments. QoL was self-reported through FertiQol, assessing the influence of infertility problems in various areas (e.g. impact on self-esteem, emotions, general health, family, partners, social relationships, work, life projects...). Additionally, HADS (Hospital Anxiety and Depression Scale) was provided as a measurement of anxiety and depression levels. Main results and the role of chance Regarding treatments, 50.6% of participants were currently undergoing gamete donation while 44.3% were undergoing treatments that involved using their own gametes. After comparing QoL between these treatment types, results showed that patients who underwent egg donation, compared to those who used their own eggs, reported statistically significantly lower scores of QoL in the Social Subscale (p = .03), but not in the other psychological outcomes. Also, statistically significant negative correlations were found between HADS and all core FertiQol subscales (p&lt; .05). Results are consistent with previous studies showing similar associations between fertility QoL and anxiety and depression, as well as with increased psychological negative implications of gamete donation. The majority of participants reported non-pathological scores of anxiety and depression when considering the cut off value of 8 for HADS, thus suggesting the presence of a relatively healthy sample. The number of treatments that patients had previously taken and the years of infertility were not associated with any of the psychological variables. Limitations, reasons for caution Some limitations to consider are presence of co-morbid diagnosis, differences in medication, or patient’s cultural backgrounds.Also, conclusions should be interpreted cautiously since the design doesn’t allow causal inferences. Further investigations should consider a continuous assessment to explore changes in psychological well-being at different points of intervention, specially with gamete donation. Wider implications of the findings: The great advantage we’ve seen so far when using FertiQol is the possibility to identify more accurately the true impact on other aspects of patient’s well-being besides the emotional area.ART professionals, including psychologists and counselors,will have more information within a small amount of time about QoL when using this tool. Trial registration number 1503-BCN–019-DG

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