Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy

2020 ◽  
pp. 153473462092391
Author(s):  
Georgios Koukourakis ◽  
Georgios Pissakas ◽  
Christos G. Ganos ◽  
Gregory Sivolapenko ◽  
Dimitrios Kardamakis
Keyword(s):  
Demographic Data ◽  
Life Quality ◽  
Skin Toxicity ◽  
Radiation Dermatitis ◽  
The Novel ◽  
Herbal Products ◽  
Acute Skin Toxicity ◽  
Radiation Induced ◽  
Aloe Gel ◽  
Intent To Treat

The aim of this study is to investigate the preventive role of 3 herbal formulation products on reducing the incidence of radiation-induced dermatitis in patients undergoing radiotherapy for either breast or head and neck cancer. A total of 59 patients participated in the study. The novel herbal products, a combination of beeswax, olive oil, Calendula and Hypericum oils and Aloe gel, were daily and regularly being used by the patients during radiotherapy and 2 weeks after treatment end. Acute skin toxicity was scored weekly during radiotherapy and after treatment for a further 4-week follow-up period. Demographic data were analyzed by descriptive statistics. Statistical analyses of the study objectives were based on an intent-to-treat principle. Most of the patients presented with grade I (RTOG/EORTC) toxicity in the first weeks of radiotherapy, progressed to grade II but reverted to grade I toxicity up until the study end. A total of 94.9% of the patients had Dermatology Life Quality Index up to 1, and 66.1% remained in this scale. The application of the novel natural product combinations proved to be statistically significantly effective in reducing the intensity of radiation dermatitis, positively affecting the quality of life of the patients.

scholarly journals Predictors of radiation-induced acute skin toxicity in breast cancer at a single institution: Role of fractionation and treatment volume

2018 ◽  
Vol 3 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Arti Parekh ◽  
Avani D. Dholakia ◽  
Daniel J. Zabranksy ◽  
Fariba Asrari ◽  
Melissa Camp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skin Toxicity ◽  
Single Institution ◽  
Acute Skin Toxicity ◽  
Treatment Volume ◽  
Radiation Induced

Factors influencing fatigue in breast cancer patients undergoing breast irradiation.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 96-96
Author(s):  
Edward Belk Perry ◽  
Sudhanshu Bharat Mulay ◽  
Jayesh Kamath ◽  
Robert J. Dowsett ◽  
Jacob Neuwirth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Conservation ◽  
Skin Toxicity ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity ◽  
Prevalence Of Depression ◽  
History Of ◽  
Radiation Induced ◽  
Hs Crp ◽  
Apoptosis And Inflammation

96 Background: We are conducting an exploratory, prospective study to investigate factors associated with radiation-induced fatigue in women with early breast cancer undergoing radiation therapy (RT) for breast conservation. Our hypothesis is that fatigue associated with adjuvant RT is related to tissue damage by apoptosis and inflammation, and to baseline psychological profiles. Methods: All subjects were assessed immediately before RT (T1), mid-point of RT (T2), end of RT (T3), 6 months (T4) and 1 year (T5) after completing RT. Clinical evaluations of skin toxicity, laboratory measures, fatigue, distress, depression, anxiety, sleep, energy and pain were assessed using validated measures. Results: Thirty-one subjects (target 50) have been enrolled to date; 23 have completed T3 and are presented here. 35% had a history of depression and 17% are currently depressed; 22% had past and current anxiety. BCTOS breast pain, tenderness and sensitivity increased during RT and were consistent with functional pain scores. No clinically relevant changes in energy or distress were seen. Despite a notable prevalence of depression and anxiety at baseline, there were no relevant changes in depression or anxiety. Most IL-1β, IL-4, IL-6 and IL-10 levels were undetectable. 39% of subjects showed increases in fatigue and were 14 years younger than non-fatigued subjects. Fatigued subjects had more frequent past (44%) and current (33%) depression than non-fatigued subjects (29% and 7%, respectively), and woke up tired more frequently (44% versus 0%). Current depression, but not fatigue, was associated with decreased a.m. cortisol levels during RT. 56% of fatigued subjects had an RTOG Acute Skin Toxicity score > 1 and 78% had BCTOS breast-specific pain subscales scores ≥ 3 during RT vs. 21% and 14% of non-fatigued subjects, respectively. Serum caspase-1 (inflammation) and caspase-3 (apoptosis), hs-CRP and TNF-α were increased but not associated with fatigue. Conclusions: Our preliminary findings suggest that radiation-associated fatigue is complex and, as hypothesized, is dependent on a patient’s psychological profile in the setting of skin toxicity and insomnia. If this data holds at study completion, it may guide clinical interventions.

scholarly journals Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study

2015 ◽  
Vol 88 (1055) ◽  
pp. 20150414 ◽  
Author(s):  
Benoîte Méry ◽  
Alexis Vallard ◽  
Jane-Chloé Trone ◽  
Cécile Pacaut ◽  
Jean-Baptiste Guy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skin Toxicity ◽  
Anthropometric Parameters ◽  
Cancer Radiotherapy ◽  
Assessment Study ◽  
Breast Cancer Radiotherapy ◽  
Acute Skin Toxicity

scholarly journals Comparison of sensorineural hearing loss characteristics in different hemodialysis vascular accesses

2020 ◽  
Author(s):  
Behieh Kohansall ◽  
Nasser Saeedi ◽  
Moeinoddin Hossein Beigi ◽  
Azam Moslemi ◽  
Akram Valizadeh
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Vascular Access ◽  
Demographic Data ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Sensorineural Hearing ◽  
Moderate Degree ◽  
Cross Sectional ◽  
Significant Difference

Background and Aim: Sensorineural hearing loss (SNHL) is one of the complications in hemodialysis patients. Vascular access (VA) represents a lifeline for these patients affecting their life quality and clinical outcomes. Arterio­venous fistula is the gold standard of VAs with minor complications and better hemodialysis adequacy. There is no study investigating hearing differences in hemodialysis VAs. Hence, this study aimed to compare SNHL characteristics amongst hemodialysis VAs. Methods: This cross-sectional study conducted on 64 patients aged 18−60 years received regular hemodialysis in 2019. Demographic data and comorbid conditions were recorded based on patients’ case records and electronic databases. After a physical examination, otoscopy, tympa­nometry, and conventional audiometry, patients were divided into fistula (n = 26), permanent catheter (n = 36), and temporary catheter (n = 2) groups according to vascular access type. Results: Prevalence rate of SNHL was 63.89%, 50% and 50% in the permanent catheter, fistula and temporary catheter groups, respectively. Most patients had mild sloping-SNHL in the per­manent catheter and fistula groups as against moderate degree in the other group. There was no significant difference in hearing thresholds, deg­ree and audiogram shape among VA groups. No significant relation was found between age, sex, hemodialysis duration and disease duration with hearing loss in all groups (p > 0.05). Conclusion: More patients had SNHL in per­manent catheter group. Vascular access types, longer duration of hemodialysis and disease dur­ation do not seem to be associated with SNHL. However, further investigation is needed to cla­rify the relationship. Keywords: Sensorineural hearing loss; vascular access; chronic renal failure; hemodialysis

scholarly journals Hypofractionated radiotherapy in ten fractions for postmastectomy patients: a phase II study compared with another hypofractionation schedule with sixteen fractions

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Huayong Jiang ◽  
Lingling Meng ◽  
Huijuan Zhang ◽  
Xiangkun Dai ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Phase Ii ◽  
Phase Ii Study ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Skin Toxicity ◽  
Trial Registration ◽  
Hypofractionated Radiotherapy ◽  
Free Survival ◽  
Acute Skin Toxicity

Abstract Background The purpose of this phase II study was to evaluate the feasibility of hypofractionated radiotherapy (HFRT) with a dose of 36.5 Gy in 10 fractions in postmastectomy patients. Methods From March 2014 to December 2015, 85 patients with locally advanced breast cancer were eligible to participate in this study with a schedule of 36.5 Gy in 10 fractions. Intensity-modulated radiation therapy (IMRT) was delivered to the chest wall with or without the supraclavicular region. The primary endpoint was radiation-related toxicities. The secondary endpoints were locoregional failure-free survival (LRFFS), disease-free survival (DFS) and overall survival (OS). And the outcomes were compared with our retrospective study of 72 patients with 42.5 Gy in 16 fractions. Results The median follow-up was 69.0 (range 66.5-71.5) months in the 36.5 Gy group and 93.0 (range 91.9-94.1) months in the 42.5 Gy group, respectively. Radiation-related toxicities were mainly grade 1, although a few patients had grade 2 plexopathy (1.2%) and acute skin toxicity (1.2%) in the 36.5 Gy group, and grade 2 acute skin toxicity (5.6%) and lymphedema (4.2%) in the 42.5 Gy group. There were no significant differences between the groups in acute and late toxicities. For all the patients, the 5-year LRFFS, DFS and OS were 97.7 and 100.0%, 93.1 and 90.3%, 98.8 and 97.2%, respectively, without significant differences between the groups. Conclusion Postmastectomy HFRT with a schedule of 36.5 Gy in 10 fractions was feasible, with mild toxicities and excellent 5-year clinical outcome. Trial registration Trial registration number: ChiCTR-ONRC-14004391. Date of registration: 9/3/2014.

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