Relationship Between Serum Eicosapentaenoic Acid to Arachidonic Acid Ratio and Atherosclerotic Risk Factors in Patients With Peripheral Artery Disease

2020 ◽  
pp. 153857442096713
Author(s):  
Toshiya Nishibe ◽  
Alan Dardik ◽  
Masayasu Nishibe ◽  
Masaki Kano ◽  
Ryumon Matsumoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arachidonic Acid ◽  
Eicosapentaenoic Acid ◽  
Peripheral Artery Disease ◽  
Older Age ◽  
Smoking History ◽  
Peripheral Artery ◽  
Acid Ratio ◽  
Artery Disease ◽  
Atherosclerotic Risk Factors

Background: The eicosapentaenoic acid to arachidonic acid ratio (EPA/AA) is attracting attention as a risk factor for peripheral artery disease (PAD). However, there have been few studies investigating the relationship between the EPA/AA ratio and atherosclerotic risk factors in patients with PAD. The purpose of the present study was to analyze atherosclerotic risk factors in patients with PAD to identify those factors associated with a low EPA/AA ratio. Methods. The data of patients treated for symptomatic PAD at Tokyo Medical University Hospital and Eniwa Midorino Clinic between April 2014 and March 2018 were retrospectively analyzed. Results. A total of 149 patients were tested for blood levels of n-3 and n-6 polyunsaturated fatty acids, including EPA and AA. 73 patients had a low EPA/AA ratio (<0.4) and 76 patients had a high EPA/AA ratio (≥ 0.4). Univariate analysis showed that older age (≥ 75 years), female sex, smoking history, body mass index (BMI), and hemoglobin A1C (HbA1C) were associated with the low EPA/AA ratio. Multivariable analysis showed that older age (odds ratio [OR], 0.34; 95% confidential interval [CI], 0.15-0.76; p = 0.008), BMI (OR, 0.87; 95% CI, 0.77-0.98; p = 0.027), smoking history (OR, 2.67; 95% CI, 1.09-6.55; p = 0.007), and HbA1C (OR, 0.46; 95% CI, 0.29-0.72; p = 0.020) were independently associated with the low EPA/AA ratio. Conclusions. The EPA/AA ratio was related to existing arteriosclerotic risk factors in patients with PAD; it was positively correlated with older age, increasing BMI, and higher HbA1C, whereas it was negatively correlated with smoking history. These results suggest that the EPA/AA ratio may be closely intertwined with other atherosclerotic risk factors and have an influence on cardiovascular health.

Reduced Plasma Eicosapentaenoic Acid–Arachidonic Acid Ratio in Peripheral Artery Disease

Angiology ◽  
2012 ◽  
Vol 64 (2) ◽  
pp. 112-118 ◽  
Author(s):  
Masahiko Fujihara ◽  
Mitsuhiro Fukata ◽  
Keita Odashiro ◽  
Toru Maruyama ◽  
Koichi Akashi ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Eicosapentaenoic Acid ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Acid Ratio ◽  
Artery Disease

scholarly journals Relationship Between Risk Factors and Carotid Artery Stenosis Prevalence in Patients With Lower Extremity Peripheral Arterial Disease

2020 ◽  
Vol 1 (2) ◽  
pp. 21-25
Author(s):  
Dedy Pratama ◽  
Haidir Bima ◽  
Aria Kekalih ◽  
Raden Suhartono
Keyword(s):  
Risk Factors ◽  
Carotid Artery ◽  
Lower Extremity ◽  
Peripheral Artery Disease ◽  
Carotid Artery Stenosis ◽  
Artery Stenosis ◽  
Smoking History ◽  
Peripheral Artery ◽  
Media Thickness ◽  
Artery Disease

Introduction: One of degenerative disease is atherosclerosis. Peripheral artery disease (PAD) and carotid artery stenosis (CS) broadly covers vascular disease, both of which can be caused by atherosclerosis. Given the general etiology of peripheral atherosclerosis that can occur in different vascular locations, the presence of disease in one place increases the frequency of symptomatic and asymptomatic disease in another. Because both have the same cause, there is a hypothesis that the two are correlated. The purpose of this study was to determine the risk factors associated with carotid artery stenosis (CS) in patients with lower extremity peripheral artery disease (PAD) and to determine the prevalence of carotid artery stenosis (CS) and the thickness of intimal media thickness (IMT) in patients with lower extremity peripheral artery disease (PAD). Method: This research was conducted at Cipto Mangunkusumo General Hospital during February-May 2018. This study was prospective. Data were taken from secondary data based on history and laboratory results, while the degree of stenosis and intimal media thickness were carried out by carotid duplex ultrasound (DUS) with united imaging ultrasound using a probe 8.5 Mhz. The receiver operating characteristic curve was used to assess the best cut point with sensitivity, specificity, positive predictive value, and negative predictive value. Results: A total of 50 subjects with an age range between 49-80 years (63.8 ± 8.8 years), of which there were 31 male males (62%) and 19 females (38%). There was a correlation between hypercholesterolemia and smoking history with the degree of carotid stenosis (p <0.05), while risk factors for the degree of IMT was not found. The prevalence of mild carotid artery stenosis (CS) was 26 (52%), moderate carotid artery stenosis 15 (30%), severe carotid artery stenosis 9 (18%). In comparison, the IMT value in this study obtained 9 (18%) mild IMT, 22 (44%) moderate IMT, and 19 (38%) severe IMT. Conclusion: In patients with severe PAD, the highest incidence of carotid artery stenosis (CS) was in the mild category (52%). The highest rate of intimal media thickness (IMT) was a medium-size IMT (44%). Carotid artery stenosis (CS) was associated with hypertension, diabetes, hypercholesterolemia, smoking, and a family history of atherosclerosis. In statistical analysis, hypercholesterolemia and smoking history had a relationship with the severity of carotid stenosis. Keywords: Atherosclerosis, carotid artery stenosis (CS), carotid duplex ultrasound (DUS), intimal media thickness (IMT), peripheral arterial disease (PAD)

scholarly journals Prevalence and risk factors of peripheral artery disease in black Africans with HIV infection: a cross-sectional hospital-based study

2018 ◽  
Vol Volume 14 ◽  
pp. 401-408 ◽  
Author(s):  
Félicité Kamdem ◽  
Yacouba Mapoure ◽  
Ba Hamadou ◽  
Fanny Souksouna ◽  
Marie Solange Doualla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Black Africans ◽  
Artery Disease

Are primary care physicians aware of peripheral artery disease risk reduction and management in the Saudi healthcare transformation era? A health cluster observational study

Vascular ◽  
2021 ◽  
pp. 170853812110443
Author(s):  
Sultan Alsheikh ◽  
Hesham AlGhofili ◽  
Omar A Alayed ◽  
Abdulkareem Aldrak ◽  
Kaisor Iqbal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Care ◽  
Saudi Arabia ◽  
Risk Reduction ◽  
Peripheral Artery Disease ◽  
Primary Care Physicians ◽  
Primary Care Providers ◽  
Care Providers ◽  
Peripheral Artery ◽  
Artery Disease

Introduction Patients with peripheral artery disease (PAD) are often underdiagnosed and undertreated. This study aimed to assess the knowledge of the recommended target levels of blood pressure, low-density lipoprotein cholesterol, glycosylated hemoglobin A1C, and knowledge and attitude about PAD risk reduction therapies among physicians working in primary care settings in Saudi Arabia. Methods This observational cross-sectional study included family medicine consultants, residents, and general practitioners working in a health cluster in the capital city of Saudi Arabia using a self-administered questionnaire. Results Of the 129 physicians who completed the survey, 55% had completed PAD-related continuing medical education hours within the past 2 years. Despite this, the knowledge score of the recommended target levels was high in only 13.2% of the participants. Antiplatelet therapy was prescribed by 68.2% of the participants. Conclusion Here we identified the knowledge and action gaps among primary care providers in Saudi Arabia. Physicians had an excellent attitude about screening for and counseling about risk factors. However, they showed less interference in reducing these risk factors. We recommend addressing these knowledge gaps early in medical school and residency programs.

Abstract 91: Are At Risk Outpatient Cardiology Patients being Appropriately Evaluated for Lower Extremity PAD as Recommended by ACC/AHA Guidelines?

2012 ◽  
Vol 5 (suppl_1) ◽  
Author(s):  
Rajesh M Kabadi ◽  
Ankitkumar Patel ◽  
Rajani Sharma ◽  
Rita Schmidt ◽  
Elias Iliadis
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
High Risk ◽  
Lower Extremity ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Heart Association ◽  
Low Risk ◽  
Peripheral Artery ◽  
Artery Disease

Background: Lower extremity peripheral artery disease (PAD) is a common syndrome that afflicts many individuals and leads to significant morbidity. Once appropriate at risk patients are identified, ankle-brachial index (ABI) testing is a relatively quick and inexpensive test that is recommended for proper assessment of PAD, per the recommendations outlined in the American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines for the Management of Peripheral Artery Disease (PAD) (JACC, 2006). Outpatient cardiology practices often take care of individuals at risk for PAD and have the opportunity to test and appropriately treat this condition. Methods: A randomly selected group of 367 outpatients seen in a large academic cardiology practice from September 2011 underwent retrospective chart review. Risk factors for PAD that were assessed include history of smoking, hypertension, diabetes, hyperlipidemia, homocysteine levels, and CRP. Those that had three or more risk factors were classified as high risk and those with less than that were classified as low risk and frequency of ABI testing was evaluated. Fishers exact test was utilized for statistical analysis. Results: Fifty-one percent (N=187) of our population were classified as high risk for PAD, forty-three percent (N=158) were low risk, and six percent (N=22) were known to already have PAD. Amongst the high risk individuals, only six percent (N=12) had ABI testing performed while there were three percent (N=6) of low risk individuals that had this test (p=-0.34). Conclusions: There was no difference in ABI testing between high and low risk populations. Limitations of this study include lack of information regarding other diagnostic modalities that may have been used in place of ABI testing. Quality improvement may be achieved by increased use of such testing as this would allow for quicker identification of the disease, prompter treatment, and better outcomes, at a minimal cost.

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