Prevalence and risk factors of peripheral artery disease in black Africans with HIV infection: a cross-sectional hospital-based study

We evaluated angiogenin as a prospective biomarker in peripheral artery disease (PAD) patients with and without claudication symptoms. A pilot study suggested an elevation of angiogenin in critical limb ischemia. However, in PAD patients, the predictive value of angiogenin has not yet been evaluated. For this purpose, 342 patients with PAD (age: 69 ± 10 years, 34.5% women) were followed-up for 7 years in a cross-sectional study. Angiogenin was measured by enzyme-linked immunosorbent assay. All-cause and cardiovascular mortality were analyzed by Cox regression. Angiogenin levels were higher in men ( P = .001) and were associated with patient waist-to-hip ratio ( P < .001), fasting triglycerides ( P = .011), and inversely with estimated glomerular filtration rate ( P = .009). However, angiogenin showed no association with age, characteristics of diabetes, markers of lipid metabolism, or C-reactive protein. Angiogenin did not correlate with markers of angiogenesis such as vascular endothelial growth factor, angiopoietin-2, or tie-2. Furthermore, angiogenin was not associated with PAD Fontaine stages or with patient ankle-brachial index in addition to all-cause mortality (hazard ratio [HR] = 1.09 [95% CI: 0.89-1.34]) or cardiovascular morality (HR = 1.05 [0.82-1.35]). These results suggest that angiogenin does not provide further information regarding outcome prediction in patients with PAD.

Download Full-text

Effect of frailty on physical activity levels and walking capacity in patients with peripheral artery disease: A cross-sectional study

Journal of Vascular Nursing ◽

10.1016/j.jvn.2021.07.001 ◽

2021 ◽

Author(s):

Breno Quintella Farah ◽

Mayara Ferreira Santos ◽

Gabriel Grizzo Cucato ◽

Hélcio Kanegusuku ◽

Luciana Maria Malosá Sampaio ◽

...

Keyword(s):

Physical Activity ◽

Peripheral Artery Disease ◽

Cross Sectional Study ◽

Activity Levels ◽

Sectional Study ◽

Peripheral Artery ◽

Cross Sectional ◽

Walking Capacity ◽

Physical Activity Levels ◽

Artery Disease

Download Full-text

ANGIOGRAPHIC EVALUATION AND CLINICAL RISK FACTORS OF CORONARY ARTERY DISEASE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)61828-3 ◽

2014 ◽

Vol 63 (12) ◽

pp. A1825

Author(s):

Atsushi Tosaka ◽

Takayuki Ishihara ◽

Osamu iida ◽

Yoshimitsu Soga ◽

Yoichi Sugimura

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Peripheral Artery Disease ◽

Clinical Risk Factors ◽

Peripheral Artery ◽

Clinical Risk ◽

Artery Disease

Download Full-text

Are primary care physicians aware of peripheral artery disease risk reduction and management in the Saudi healthcare transformation era? A health cluster observational study

Vascular ◽

10.1177/17085381211044397 ◽

2021 ◽

pp. 170853812110443

Author(s):

Sultan Alsheikh ◽

Hesham AlGhofili ◽

Omar A Alayed ◽

Abdulkareem Aldrak ◽

Kaisor Iqbal ◽

...

Keyword(s):

Risk Factors ◽

Primary Care ◽

Saudi Arabia ◽

Risk Reduction ◽

Peripheral Artery Disease ◽

Primary Care Physicians ◽

Primary Care Providers ◽

Care Providers ◽

Peripheral Artery ◽

Artery Disease

Introduction Patients with peripheral artery disease (PAD) are often underdiagnosed and undertreated. This study aimed to assess the knowledge of the recommended target levels of blood pressure, low-density lipoprotein cholesterol, glycosylated hemoglobin A1C, and knowledge and attitude about PAD risk reduction therapies among physicians working in primary care settings in Saudi Arabia. Methods This observational cross-sectional study included family medicine consultants, residents, and general practitioners working in a health cluster in the capital city of Saudi Arabia using a self-administered questionnaire. Results Of the 129 physicians who completed the survey, 55% had completed PAD-related continuing medical education hours within the past 2 years. Despite this, the knowledge score of the recommended target levels was high in only 13.2% of the participants. Antiplatelet therapy was prescribed by 68.2% of the participants. Conclusion Here we identified the knowledge and action gaps among primary care providers in Saudi Arabia. Physicians had an excellent attitude about screening for and counseling about risk factors. However, they showed less interference in reducing these risk factors. We recommend addressing these knowledge gaps early in medical school and residency programs.

Download Full-text

Abstract 91: Are At Risk Outpatient Cardiology Patients being Appropriately Evaluated for Lower Extremity PAD as Recommended by ACC/AHA Guidelines?

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.5.suppl_1.a91 ◽

2012 ◽

Vol 5 (suppl_1) ◽

Author(s):

Rajesh M Kabadi ◽

Ankitkumar Patel ◽

Rajani Sharma ◽

Rita Schmidt ◽

Elias Iliadis

Keyword(s):

Risk Factors ◽

At Risk ◽

High Risk ◽

Lower Extremity ◽

Peripheral Artery Disease ◽

Ankle Brachial Index ◽

Heart Association ◽

Low Risk ◽

Peripheral Artery ◽

Artery Disease

Background: Lower extremity peripheral artery disease (PAD) is a common syndrome that afflicts many individuals and leads to significant morbidity. Once appropriate at risk patients are identified, ankle-brachial index (ABI) testing is a relatively quick and inexpensive test that is recommended for proper assessment of PAD, per the recommendations outlined in the American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines for the Management of Peripheral Artery Disease (PAD) (JACC, 2006). Outpatient cardiology practices often take care of individuals at risk for PAD and have the opportunity to test and appropriately treat this condition. Methods: A randomly selected group of 367 outpatients seen in a large academic cardiology practice from September 2011 underwent retrospective chart review. Risk factors for PAD that were assessed include history of smoking, hypertension, diabetes, hyperlipidemia, homocysteine levels, and CRP. Those that had three or more risk factors were classified as high risk and those with less than that were classified as low risk and frequency of ABI testing was evaluated. Fishers exact test was utilized for statistical analysis. Results: Fifty-one percent (N=187) of our population were classified as high risk for PAD, forty-three percent (N=158) were low risk, and six percent (N=22) were known to already have PAD. Amongst the high risk individuals, only six percent (N=12) had ABI testing performed while there were three percent (N=6) of low risk individuals that had this test (p=-0.34). Conclusions: There was no difference in ABI testing between high and low risk populations. Limitations of this study include lack of information regarding other diagnostic modalities that may have been used in place of ABI testing. Quality improvement may be achieved by increased use of such testing as this would allow for quicker identification of the disease, prompter treatment, and better outcomes, at a minimal cost.

Download Full-text

Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease

Vascular Medicine ◽

10.1177/1358863x20945794 ◽

2020 ◽

Vol 25 (5) ◽

pp. 411-418

Author(s):

Brian D Duscha ◽

William E Kraus ◽

William S Jones ◽

Jennifer L Robbins ◽

Lucy W Piner ◽

...

Keyword(s):

Skeletal Muscle ◽

Peripheral Artery Disease ◽

Anaerobic Threshold ◽

Cardiopulmonary Exercise Testing ◽

Capillary Density ◽

Exercise Intolerance ◽

Peripheral Artery ◽

Cross Sectional ◽

Control Subjects ◽

Artery Disease

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm2, p = 0.05), peak VO2 (15.7 ± 3.9 vs 24.3 ± 5.2 mL/kg/min, p ⩽ 0.001), and VO2 at AT (11.5 ± 2.6 vs 16.1 ± 2.8 mL/kg/min, p ⩽ 0.001) compared to control subjects. In patients with PAD, but not control subjects, capillary density was related to VO2 at AT ( r = 0.343; p = 0.038), time to AT ( r = 0.381; p = 0.020), and time after AT to test termination ( r = 0.610; p ⩽ 0.001). Capillary density was also related to time to claudication ( r = 0.332; p = 0.038) and time after claudication to test termination ( r = 0.584; p ⩽ 0.001). In conclusion, relationships between capillary density, AT, and claudication symptoms indicate that, in PAD, exercise limitations are likely partially dependent on limited skeletal muscle capillary density and oxidative metabolism.

Download Full-text