Biological Entanglement–Like Effect After Communication of Fish Prior to X-Ray Exposure

The phenomenon by which irradiated organisms including cells in vitro communicate with unirradiated neighbors is well established in biology as the radiation-induced bystander effect (RIBE). Generally, the purpose of this communication is thought to be protective and adaptive, reflecting a highly conserved evolutionary mechanism enabling rapid adjustment to stressors in the environment. Stressors known to induce the effect were recently shown to include chemicals and even pathological agents. The mechanism is unknown but our group has evidence that physical signals such as biophotons acting on cellular photoreceptors may be implicated. This raises the question of whether quantum biological processes may occur as have been demonstrated in plant photosynthesis. To test this hypothesis, we decided to see whether any form of entanglement was operational in the system. Fish from 2 completely separate locations were allowed to meet for 2 hours either before or after which fish from 1 location only (group A fish) were irradiated. The results confirm RIBE signal production in both skin and gill of fish, meeting both before and after irradiation of group A fish. The proteomic analysis revealed that direct irradiation resulted in pro-tumorigenic proteomic responses in rainbow trout. However, communication from these irradiated fish, both before and after they had been exposed to a 0.5 Gy X-ray dose, resulted in largely beneficial proteomic responses in completely nonirradiated trout. The results suggest that some form of anticipation of a stressor may occur leading to a preconditioning effect or temporally displaced awareness after the fish become entangled.

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A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect.

10.2172/897804 ◽

2007 ◽

Author(s):

Melvyn Folkard ◽

Borivoj Vojnovic ◽

Giuseppe Schettino ◽

Kirk Atkinson ◽

Kevin, M. Prise ◽

...

Keyword(s):

Bystander Effect ◽

X Ray ◽

Radiation Induced ◽

Radiation Induced Bystander Effect ◽

Variable Energy

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Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro

Antioxidants ◽

10.3390/antiox10020231 ◽

2021 ◽

Vol 10 (2) ◽

pp. 231

Author(s):

Amparo Olivares ◽

Miguel Alcaraz-Saura ◽

Daniel Gyingiri Achel ◽

Juan de Dios Berná-Mestre ◽

Miguel Alcaraz

Keyword(s):

Cell Survival ◽

Rosmarinic Acid ◽

Bystander Effect ◽

In Vitro Assays ◽

X Rays ◽

Direct Exposure ◽

Radiation Induced ◽

Radiation Induced Bystander Effect

In radiation oncology, the modulation of the bystander effect is a target both for the destruction of tumor cells and to protect healthy cells. With this objective, we determine whether the radioprotective capacity of rosmarinic acid (RA) can affect the intensity of these effects. Genoprotective capacity was obtained by determining the micronuclei frequencies in in vivo and in vitro assays and the cell survival was determined by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay in three cell lines (PNT2, TRAMPC1 and B16F10), both in direct exposure to X-rays and after the production of radiation-induced bystander effect. The administration of RA in irradiated cells produced a decrease in the frequency of micronuclei both in vivo and in vitro, and an increase in cell survival, as expression of its radioprotective effect (p < 0.001) attributable to its ability to scavenge radio-induced free radicals (ROS). However, RA does not achieve any modification in the animals receiving serum or in the cultures treated with the irradiated medium, which expresses an absence of radioprotective capacity. The results suggest that ROS participates in the formation of signals in directly irradiated cells, but only certain subtypes of ROS, the cytotoxic products of lipid peroxidation, participate in the creation of lesions in recipient cells.

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Manipulation of radiation-induced bystander effect in prostate adenocarcinoma by dose and tumor differentiation grade: In vitro study

International Journal of Radiation Biology ◽

10.3109/09553002.2015.959667 ◽

2015 ◽

Vol 91 (2) ◽

pp. 166-171 ◽

Cited By ~ 6

Author(s):

Slavisa Tubin ◽

Maurizio Valeriani ◽

Gerardo Salerno ◽

Stefano Bracci ◽

Antonella Stoppacciaro ◽

...

Keyword(s):

Bystander Effect ◽

In Vitro Study ◽

Prostate Adenocarcinoma ◽

Vitro Study ◽

Tumor Differentiation ◽

Radiation Induced ◽

Radiation Induced Bystander Effect

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Radiation Induced Bystander Effect: From <i>in Vitro</i> Studies to Clinical Application

International Journal of Medical Physics Clinical Engineering and Radiation Oncology ◽

10.4236/ijmpcero.2016.51001 ◽

2016 ◽

Vol 05 (01) ◽

pp. 1-17 ◽

Cited By ~ 9

Author(s):

Maria Widel

Keyword(s):

Clinical Application ◽

Bystander Effect ◽

Radiation Induced ◽

Radiation Induced Bystander Effect

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The Impact of Left Atrial Size in Catheter Ablation of Atrial Fibrillation Using Remote Magnetic Navigation

Cardiology Research and Practice ◽

10.1155/2018/3096261 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8

Author(s):

Xiao-yu Liu ◽

Hai-feng Shi ◽

Jie Zheng ◽

Ku-lin Li ◽

Xiao-xi Zhao ◽

...

Keyword(s):

Atrial Fibrillation ◽

Catheter Ablation ◽

Left Atrial ◽

Magnetic Navigation ◽

Remote Magnetic Navigation ◽

X Ray ◽

Group A ◽

Group B ◽

The Impact

Objective. The objective of this study was to investigate the impact of left atrial (LA) size for the ablation of atrial fibrillation (AF) using remote magnetic navigation (RMN). Methods. A total of 165 patients with AF who underwent catheter ablation using RMN were included. The patients were divided into two groups based on LA diameter. Eighty-three patients had small LA (diameter <40 mm; Group A), and 82 patients had a large LA (diameter ≥40 mm; Group B). Results. During mapping and ablation, X-ray time (37.0 (99.0) s vs. 12 (30.1) s, P<0.001) and X-ray dose (1.4 (2.7) gy·cm2 vs. 0.7 (2.1) gy·cm2, P=0.013) were significantly higher in Group A. No serious complications occurred in any of the patients. There was no statistical difference in the rate of first anatomical attempt of pulmonary vein isolation between the two groups (71.1% vs. 57.3%, P=0.065). However, compared with Group B, the rate of sinus rhythm was higher (77.1% vs. 58.5%, P<0.001) during the follow-up period. More patients in Group A required a sheath adjustment (47/83 vs. 21/82, P<0.001), presumably due to less magnets positioned outside of the sheath. In vitro experiments with the RMN catheter demonstrated that only one magnet exposed created the sheath affects which influenced the flexibility of the catheter. Conclusions. AF ablation using RMN is safe and effective in both small and large LA patients. Patients with small LA may pose a greater difficulty when using RMN which may be attributed to the fewer magnets beyond the sheath. As a result, the exposure of radiation was increased. This study found that having at least two magnets of the catheter positioned outside of the sheath can ensure an appropriate flexibility of the catheter.

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