scholarly journals Preliminary Study on the Effect of 4DCT-Ventilation-Weighted Dose on the Radiation Induced Pneumonia Probability (RIPP)

Dose-Response ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 155932582110177
Author(s):  
Han Bai ◽  
Wenhui Li ◽  
Yaoxiong Xia ◽  
Lan Li ◽  
Jingyan Gao ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Spearman Correlation ◽  
Hounsfield Units ◽  
Conventional Dose ◽  
Dose Volume ◽  
Original Plan ◽  
Study Population ◽  
Radiation Induced ◽  
Preliminary Study ◽  
Mean Lung Dose

Purpose: The purpose of the present study was to evaluate the feasibility of using 4-dimensional computed tomography (4DCT)-ventilation-weighted dose analysis to predict radiation-induced pneumonia probability (RIPP). Methods and Materials: The study population for this retrospective analysis included 16 patients with stage III lung cancer. Each patient’s 4DCT images, including end-inhale and end-exhale sequences, were used for the deformable image registration, and the Hounsfield units (HU) density-change was used to calculate the ventilation. A previously established equation was used to convert the original dose (OD) D 0, i in the lungs in the original plan (OP) to the weighted-dose (WD) D w, i in the weighted plan (WP). The patients were divided into 2 groups, one with radiation-induced pneumonia (RIP), and one without. The Spearman correlation analysis was used to analyze the correlation of RIP with ΔV20 (ΔV x = V w, x in the WP – V 0, x in the OP), ΔMLD (ΔMLD = mean lung dose (MLD) in the WP – MLD in the OP), and ΔV5. Results: The results showed that 5 of the 16 patients were suffering from acute RIP, 4 of which had higher ΔV20 and ΔMLD values than the rest of the patients. The results of the Spearman correlation analysis for those 4 patients were as follows: RIP vs. ΔV20, r = 0.5123; RIP vs. ΔMLD, r = 0.5119; RIP vs. ΔV5, r = 0.1904. Conclusions: The 4DCT-ventilation-based weighted-dose analysis showed some correlation between RIPP and both ΔV20 and ΔMLD, when comparing the weighted-dose and the conventional dose-volume histogram (DVH) analyses.

Expression Levels of MicroRNA-125b in Serum Exosomes of Patients with Asthma of Different Severity and its Diagnostic Significance

2019 ◽  
Vol 20 (10) ◽  
pp. 781-784 ◽  
Author(s):  
Meizhen Zhao ◽  
Li Juanjuan ◽  
Fan Weijia ◽  
Xie Jing ◽  
Huang Qiuhua ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Roc Curve ◽  
Quantitative Polymerase Chain Reaction ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Spearman Correlation ◽  
Diagnostic Efficacy ◽  
Expression Levels ◽  
Serum Exosomes

Background: This study aimed to investigate the expression levels of microRNA (miRNA)-125b in serum exosomes and its diagnostic efficacy for asthma severity. Methods: The study included 80 patients with untreated asthma and 80 healthy volunteers. The patients were divided into 4 groups according to disease severity: 20 with the intermittent state, 20 with the mildly persistent state, 20 with the moderately persistent state, and 20 with the severely persistent state. The expression levels of miRNA-125b in serum exosomes of each group were detected using a quantitative polymerase chain reaction and compared. The Spearman correlation analysis was used to study the correlation between the expression levels of miRNA-125b in serum exosomes and asthma severity. The diagnostic efficacy of the expression levels of miRNA-125b in exosomes for asthma severity was evaluated using the Receiver Operating Characteristic (ROC) curve. Results: The expression levels of miRNA-125b in serum exosomes of patients with intermittent, mildly persistent, moderately persistent, and severely persistent asthma were all higher than those in the healthy control group, with statistically significant differences. The expression levels of miRNA-125b were also statistically significantly different among patients in each group. The Spearman correlation analysis showed a positive correlation of the relative expression of miRNA-125b in serum exosomes with asthma severity. The area under the ROC curve of the diagnostic efficacy of miRNA-125b in serum exosomes for patients with intermittent, mildly, moderately, and severely persistent asthma was 0.7770, 0.8573, 0.9111, and 0.9995, respectively. Conclusion: The expression levels of miRNA-125b in serum exosomes had a high diagnostic efficacy and might serve as a noninvasive diagnostic marker for asthma severity.

Method of predicting the mean lung dose based on a patient׳s anatomy and dose-volume histograms

2017 ◽  
Vol 42 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Anna Zawadzka ◽  
Marta Nesteruk ◽  
Beata Brzozowska ◽  
Paweł F. Kukołowicz
Keyword(s):  
Lung Dose ◽  
Dose Volume Histograms ◽  
Dose Volume ◽  
The Mean ◽  
Mean Lung Dose

Dose Volume Parameter Analysis on Late Radiation Induced Pericardial Effusion

2015 ◽  
Vol 93 (3) ◽  
pp. E162
Author(s):  
Q. Liu ◽  
J. Wang ◽  
Y. Wang ◽  
Y.J. Wu ◽  
N. Li ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Parameter Analysis ◽  
Dose Volume ◽  
Radiation Induced

scholarly journals Clinical profiles, outcomes and risk factors among type 2 diabetic inpatients with diabetic ketoacidosis and hyperglycemic hyperosmolar state: a hospital-based analysis over a 6-year period

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-yan Wu ◽  
Dun-min She ◽  
Fang Wang ◽  
Gang Guo ◽  
Ran Li ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Diabetic Ketoacidosis ◽  
Protective Factor ◽  
Diabetic Patients ◽  
Spearman Correlation ◽  
C Peptide ◽  
Arterial Blood ◽  
Hyperglycemic Hyperosmolar State ◽  
Type 2 Diabetic

Abstract Objective Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most common hyperglycemic emergencies (HEs) associated with diabetes mellitus. Individuals with HEs can present with combined features of DKA and HHS. The objective of this study is to assess the clinical characteristics, therapeutic outcomes, and associated predisposing factors of type 2 diabetic patients with isolated or combined HEs in China. Methods We performed a retrospective analysis of 158 patients with type 2 diabetes (T2DM), complicated with DKA, HHS, or DKA combined with HHS (DKA-HHS) in Shanghai Tongji Hospital, China from 2010 to 2015. Admission clinical features, therapeutic approaches and treatment outcomes of those patients were extracted and analyzed. Results Of the 158 patients with T2DM, 65 (41.1%) patients were DKA, 74 (46.8%) were HHS, and 19 (12.0%) were DKA-HHS. The most common precipitants were infections (111, 70.3%), newly diagnosed diabetes (28,17.7%) and non-compliance to medications (9, 5.7%). DKA patients were divided into mild, moderate and severe group, based on arterial blood gas. Spearman correlation analysis revealed that C-reaction protein (CRP) was positively correlated with severity of DKA, whereas age and fasting C peptide were inversely correlated with severity of DKA (P < 0.05). The mortality was 10.8% (17/158) in total and 21.6% (16/74) in the HHS group, 5.9% (1/17) in DKA-HHS. Spearman correlation analysis indicated that death in patients with HHS was positively correlated to effective plasma osmolality (EPO), renal function indicators and hepatic enzymes, while inversely associated with the continuous subcutaneous insulin infusion (CSII) therapy. Logistic regression analysis suggested that elevated blood urea nitrogen (BUN) on admission was an independent predisposing factor of mortality in HHS, while CSII might be a protective factor for patients with HHS. Furthermore, the receiver-operating characteristic (ROC) curve analysis indicated that BUN had the largest area under the ROC curves for predicting death in patients with HHS. Conclusions Our findings showed elevated CRP and decreased fasting C-peptide might serve as indicator for severe DKA. Elevated BUN might be an independent predictor of mortality in patients with HHS, whereas CSII might be a protective factor against death in HHS.

scholarly journals Comparison of dose volume histograms for supine and prone position in patients irradiated for prostate cancer—A preliminary study

2011 ◽  
Vol 16 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Tomasz Bajon ◽  
Tomasz Piotrowski ◽  
Andrzej Antczak ◽  
Bartosz Bąk ◽  
Barbara Błasiak ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prone Position ◽  
Dose Volume Histograms ◽  
Dose Volume ◽  
Preliminary Study

Analyzing the association between dose-volume parameters and radiation-induced brain edema in patients with brain tumor receiving stereotactic radiosurgery

2020 ◽  
Vol 34 (22n24) ◽  
pp. 2040134
Author(s):  
Yang-Wei Hsieh ◽  
Chin-Shiuh Shieh ◽  
Tai-Lin Huang ◽  
Shyh-An Yeh ◽  
Yi-Kuan Tseng ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Stereotactic Radiosurgery ◽  
Brain Edema ◽  
Magnetic Resonance Images ◽  
Planning System ◽  
Volume Index ◽  
Treatment Planning System ◽  
Dose Volume ◽  
Study Results ◽  
Radiation Induced

In this paper, three-dimensional images were used to analyze the association between dose-volume parameters and radiation-induced brain edema in patients with a brain tumor after receiving stereotactic radiosurgery (SRS). The computed tomography (CT), magnetic resonance images (MRI) and treatment parameters were transferred through the treatment planning system (Multiplan, version 5.1.3). The correlation between the dose of radiation therapy and brain edema was evaluated by image processing methods, such as image normalization, registration, filtering, segmentation, and feature extraction. The association was evaluated by volume index and intersection index. The study results suggest that the volume receiving radiation dose above 30% of the prescribed dose is highly associated with the brain edema in brain tumor patients after SRS. The small number of patients limits the study. Further investigation with larger populations and long-term epidemiological studies are required.

Sign in / Sign up

Export Citation Format

Share Document